{"id":"https://openalex.org/W7223674530","doi":"https://doi.org/10.3389/fmicb.2026.1995937","title":"Feed additives as systems-level modulators of the ruminant host\u2013microbiome interaction: a multi-omics perspective on efficiency, resistance, and reproduction","display_name":"Feed additives as systems-level modulators of the ruminant host\u2013microbiome interaction: a multi-omics perspective on efficiency, resistance, and reproduction","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223674530","doi":"https://doi.org/10.3389/fmicb.2026.1995937"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1995937","doi":"https://doi.org/10.3389/fmicb.2026.1995937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1995937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1995937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1995937/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135417922","display_name":"Oluwatobi E Fijabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwatobi Fijabi","raw_affiliation_strings":["Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046117488","display_name":"Olanrewaju B. Morenikeji","orcid":"https://orcid.org/0000-0003-2608-3302","observed_orcids":["https://orcid.org/0000-0003-2608-3302"]},"institutions":[{"id":"https://openalex.org/I11786554","display_name":"Virginia State University","ror":"https://ror.org/04esvpn06","country_code":"US","type":"education","lineage":["https://openalex.org/I11786554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olanrewaju B. Morenikeji","raw_affiliation_strings":["Department of Biology, Virginia State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Virginia State University","institution_ids":["https://openalex.org/I11786554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060862581","display_name":"S. L. Ivey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanna Lodge Ivey","raw_affiliation_strings":["Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025118407","display_name":"Clint A Loest","orcid":"https://orcid.org/0000-0002-6240-5762","observed_orcids":["https://orcid.org/0000-0002-6240-5762"]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clint Loest","raw_affiliation_strings":["Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058357180","display_name":"Modoluwamu D. Idowu","orcid":"https://orcid.org/0009-0002-8389-5374","observed_orcids":["https://orcid.org/0009-0002-8389-5374"]},"institutions":[{"id":"https://openalex.org/I63920570","display_name":"Tennessee Technological University","ror":"https://ror.org/05drmrq39","country_code":"US","type":"education","lineage":["https://openalex.org/I63920570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Modoluwamu Idowu","raw_affiliation_strings":["School of Agriculture, Tennessee Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Agriculture, Tennessee Technological University","institution_ids":["https://openalex.org/I63920570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007853865","display_name":"Ryan L. Ashley","orcid":"https://orcid.org/0000-0003-1936-6048","observed_orcids":["https://orcid.org/0000-0003-1936-6048"]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Ashley","raw_affiliation_strings":["Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University","institution_ids":["https://openalex.org/I10052268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050789062","display_name":"Ibukun Michael Ogunade","orcid":"https://orcid.org/0000-0003-3875-6156","observed_orcids":["https://orcid.org/0000-0003-3875-6156"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibukun M. Ogunade","raw_affiliation_strings":["Division of Animal Science, West Virginia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Animal Science, West Virginia University","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134901660","display_name":"Godstime Taiwo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10052268","display_name":"New Mexico State University","ror":"https://ror.org/00hpz7z43","country_code":"US","type":"education","lineage":["https://openalex.org/I10052268"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Godstime Taiwo","raw_affiliation_strings":["Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Range Sciences, College of Agricultural, Consumer, and Environmental Sciences, New Mexico State University","institution_ids":["https://openalex.org/I10052268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5134901660"],"corresponding_institution_ids":["https://openalex.org/I10052268"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88931056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feed-additives","display_name":"feed additives","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rumen-microbiota","display_name":"rumen microbiota","score":0.859000027179718},{"id":"https://openalex.org/keywords/prevotella","display_name":"Prevotella","score":0.7710000276565552},{"id":"https://openalex.org/keywords/butyrivibrio","display_name":"Butyrivibrio","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ruminococcus","display_name":"Ruminococcus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibrobacter","display_name":"Fibrobacter","score":0.9990000128746033},{"id":"https://openalex.org/keywords/feed-efficiency","display_name":"feed efficiency","score":0.9319999814033508},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7950000166893005},{"id":"https://openalex.org/keywords/resistome","display_name":"resistome","score":0.906000018119812},{"id":"https://openalex.org/keywords/reproductive-fitness","display_name":"reproductive fitness","score":0.621999979019165},{"id":"https://openalex.org/keywords/hepatic-transcriptomics","display_name":"hepatic transcriptomics","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mirna-regulatory-network","display_name":"miRNA regulatory network","score":0.8930000066757202},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.921999990940094},{"id":"https://openalex.org/keywords/reproductive-tract-microbiome","display_name":"reproductive tract microbiome","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8281999826431274},{"id":"https://openalex.org/C2776666601","wikidata":"https://www.wikidata.org/wiki/Q3457855","display_name":"Resistome","level":5,"score":0.7218999862670898},{"id":"https://openalex.org/C2781003712","wikidata":"https://www.wikidata.org/wiki/Q842175","display_name":"Ruminant","level":3,"score":0.6758999824523926},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5942999720573425},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.5866000056266785},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5821999907493591},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3978999853134155},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.37860000133514404},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36809998750686646},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3483000099658966},{"id":"https://openalex.org/C187029079","wikidata":"https://www.wikidata.org/wiki/Q958679","display_name":"Cognitive reframing","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34150001406669617},{"id":"https://openalex.org/C2778568511","wikidata":"https://www.wikidata.org/wiki/Q1261446","display_name":"Monogastric","level":4,"score":0.3255000114440918},{"id":"https://openalex.org/C69562835","wikidata":"https://www.wikidata.org/wiki/Q3054637","display_name":"Microbial ecology","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C509243982","wikidata":"https://www.wikidata.org/wiki/Q2836947","display_name":"Animal feed","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C112964050","wikidata":"https://www.wikidata.org/wiki/Q103459","display_name":"Livestock","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.27730000019073486},{"id":"https://openalex.org/C13376991","wikidata":"https://www.wikidata.org/wiki/Q587698","display_name":"Ectotherm","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C127196793","wikidata":"https://www.wikidata.org/wiki/Q1439377","display_name":"Fosmid","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C2780065859","wikidata":"https://www.wikidata.org/wiki/Q5441186","display_name":"Feed additive","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C2778312467","wikidata":"https://www.wikidata.org/wiki/Q132809","display_name":"Clostridia","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmicb.2026.1995937","doi":"https://doi.org/10.3389/fmicb.2026.1995937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1995937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1995937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e255cdad438c4f38a794c0137e0bda3d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e255cdad438c4f38a794c0137e0bda3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1995937","doi":"https://doi.org/10.3389/fmicb.2026.1995937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1995937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1995937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.958299994468689,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223674530.pdf","grobid_xml":"https://content.openalex.org/works/W7223674530.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W1491904717","https://openalex.org/W1953702613","https://openalex.org/W2004465286","https://openalex.org/W2015303573","https://openalex.org/W2015527152","https://openalex.org/W2028322866","https://openalex.org/W2045738221","https://openalex.org/W2049772720","https://openalex.org/W2055313665","https://openalex.org/W2075860675","https://openalex.org/W2085696605","https://openalex.org/W2094626198","https://openalex.org/W2150391934","https://openalex.org/W2162674813","https://openalex.org/W2171449826","https://openalex.org/W2295502830","https://openalex.org/W2604213216","https://openalex.org/W2749417525","https://openalex.org/W2775648451","https://openalex.org/W2787195591","https://openalex.org/W2806141241","https://openalex.org/W2809644513","https://openalex.org/W2883891290","https://openalex.org/W2886441534","https://openalex.org/W2909472027","https://openalex.org/W2909814163","https://openalex.org/W2937602058","https://openalex.org/W2942186107","https://openalex.org/W2950770130","https://openalex.org/W2970283910","https://openalex.org/W2971503017","https://openalex.org/W2975419944","https://openalex.org/W2990100956","https://openalex.org/W2990656004","https://openalex.org/W2995082488","https://openalex.org/W3007115203","https://openalex.org/W3008841625","https://openalex.org/W3011457913","https://openalex.org/W3011895843","https://openalex.org/W3012473547","https://openalex.org/W3027051073","https://openalex.org/W3028270276","https://openalex.org/W3048819284","https://openalex.org/W3082689206","https://openalex.org/W3091703897","https://openalex.org/W3093462901","https://openalex.org/W3119100893","https://openalex.org/W3121569968","https://openalex.org/W3125303060","https://openalex.org/W3155344935","https://openalex.org/W3160905321","https://openalex.org/W3169670907","https://openalex.org/W3174085703","https://openalex.org/W3202637773","https://openalex.org/W4212907025","https://openalex.org/W4213147845","https://openalex.org/W4221048562","https://openalex.org/W4226365797","https://openalex.org/W4282052144","https://openalex.org/W4292548679","https://openalex.org/W4292607763","https://openalex.org/W4294718950","https://openalex.org/W4304128787","https://openalex.org/W4308594718","https://openalex.org/W4318705708","https://openalex.org/W4376598394","https://openalex.org/W4382058758","https://openalex.org/W4385258337","https://openalex.org/W4388538908","https://openalex.org/W4388928474","https://openalex.org/W4388940374","https://openalex.org/W4389704933","https://openalex.org/W4391260546","https://openalex.org/W4391566464","https://openalex.org/W4392169114","https://openalex.org/W4392953789","https://openalex.org/W4395697041","https://openalex.org/W4402447976","https://openalex.org/W4402487567","https://openalex.org/W4403107764","https://openalex.org/W4403269282","https://openalex.org/W4403315176","https://openalex.org/W4403317578","https://openalex.org/W4404257311","https://openalex.org/W4407562857","https://openalex.org/W4408408218","https://openalex.org/W4408915944","https://openalex.org/W4410244004","https://openalex.org/W4411690658","https://openalex.org/W4411763967","https://openalex.org/W4412391113","https://openalex.org/W4413060668","https://openalex.org/W4416770088","https://openalex.org/W4416892864","https://openalex.org/W4417450271","https://openalex.org/W7119004361","https://openalex.org/W7125946634","https://openalex.org/W7125956855","https://openalex.org/W7130515068","https://openalex.org/W7138350728","https://openalex.org/W7138413743","https://openalex.org/W7159810141","https://openalex.org/W7162311516","https://openalex.org/W7171333299","https://openalex.org/W7212023520","https://openalex.org/W7213921208"],"related_works":["https://openalex.org/W7223402751","https://openalex.org/W4229657536","https://openalex.org/W4283024902","https://openalex.org/W7220935316","https://openalex.org/W7167687412","https://openalex.org/W2943838904","https://openalex.org/W4388539341","https://openalex.org/W7127084879","https://openalex.org/W4411391572","https://openalex.org/W4402713400"],"abstract_inverted_index":{"Ruminant":[0],"livestock":[1],"face":[2],"converging":[3],"pressures":[4],"from":[5,39,188],"climatic":[6],"variation,":[7],"antimicrobial":[8],"agents,":[9],"and":[10,43,74,90,99,105,167],"the":[11,17,143,154],"imperative":[12],"for":[13,145,177,199],"sustainable":[14],"intensification.":[15],"However,":[16,93],"molecular":[18,114],"imprints":[19],"through":[20,149],"which":[21],"nutritional":[22],"interventions":[23],"modulate":[24],"host\u2013microbiome":[25],"interactions":[26],"across":[27,32,78],"physiological":[28],"contexts":[29],"remain":[30],"fragmented":[31],"disciplinary":[33],"themes.":[34],"Here,":[35],"we":[36],"synthesize":[37],"evidence":[38],"metagenomics,":[40],"metatranscriptomics,":[41],"metabolomics,":[42],"host":[44],"transcriptomics":[45],"to":[46,80,120,158,161,192],"propose":[47],"that":[48],"feed":[49,84,185],"additives":[50],"operate":[51],"as":[52,112],"systems-level":[53,194],"modulators":[54],"of":[55,156],"a":[56,113,130,189,193,197],"functionally":[57],"integrated":[58,181],"rumen\u2013liver\u2013immune\u2013reproductive":[59],"axis,":[60],"rather":[61,136],"than":[62,137],"acting":[63],"on":[64],"isolated":[65,139],"metabolic":[66],"pathways.":[67],"Prevotella":[68],",":[69,71,73],"Butyrivibrio":[70],"Ruminococcus":[72],"Fibrobacter":[75],"recurrently":[76],"emerged":[77],"studies":[79],"be":[81,162],"associated":[82],"with":[83,133],"efficiency,":[85],"immune":[86],"modulation,":[87],"resistome":[88,126],"dynamics,":[89],"reproductive":[91,168],"fitness.":[92],"their":[94],"relationship":[95],"is":[96],"context":[97],"dependent":[98],"not":[100],"causal.":[101],"Furthermore,":[102],"hepatic":[103],"transcriptomic":[104],"microRNA":[106],"(miRNA)-mediated":[107],"regulatory":[108],"networks":[109],"could":[110,183],"serve":[111],"bridge":[115],"connecting":[116],"ruminal":[117],"fermentation":[118],"events":[119],"systemic":[121],"phenotypic":[122],"outcomes.":[123],"The":[124],"ruminant":[125,201],"may":[127],"also":[128,172],"represent":[129,173],"potential":[131],"interface":[132],"public":[134],"health":[135],"an":[138],"ecological":[140],"phenomenon,":[141],"given":[142],"capacity":[144],"horizontal":[146],"gene":[147],"transfer":[148],"mobile":[150],"genetic":[151],"elements,":[152],"although":[153],"extent":[155],"transmission":[157],"humans":[159],"remains":[160],"quantified.":[163],"Early-life":[164],"microbial":[165],"programming":[166],"tract":[169],"microbiome":[170],"composition":[171],"tractable":[174],"intervention":[175],"windows":[176],"precision":[178,200],"management.":[179],"This":[180],"framework":[182],"reframe":[184],"additive":[186],"research":[187],"single":[190],"pathway":[191],"perspective,":[195],"offering":[196],"basis":[198],"production.":[202]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}
