{"id":"https://openalex.org/W7223673619","doi":"https://doi.org/10.64898/2026.10.20.760575","title":"A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation","display_name":"A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation","publication_year":2026,"publication_date":"2026-10-25","ids":{"openalex":"https://openalex.org/W7223673619","doi":"https://doi.org/10.64898/2026.10.20.760575"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.20.760575","doi":"https://doi.org/10.64898/2026.10.20.760575","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.20.760575","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.20.760575.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.20.760575.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146574538","display_name":"minghua li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minghua Li","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031055609","display_name":"Runze Ni","orcid":"https://orcid.org/0009-0001-0267-2228","observed_orcids":["https://orcid.org/0009-0001-0267-2228"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runze Ni","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158483206","display_name":"Kristof Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristof Williams","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5145867580","display_name":"Nathan Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Hall","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110399668","display_name":"Colby L. Parris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colby Parris","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009118263","display_name":"Carlos O. Esquivel","orcid":"https://orcid.org/0000-0003-0871-0480","observed_orcids":["https://orcid.org/0000-0003-0871-0480"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Esquivel","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130551979","display_name":"Minh Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minh Tran","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129633464","display_name":"Liying Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liying Fu","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA;","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065986871","display_name":"Vijay Subramanian","orcid":"https://orcid.org/0000-0003-2469-3094","observed_orcids":["https://orcid.org/0000-0003-2469-3094"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I2801973574","display_name":"Tampa General Hospital","ror":"https://ror.org/03tj5qd85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801973574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Subramanian","raw_affiliation_strings":["Transplant Institute, Tampa General Hospital, Tampa, FL 33606, USA","USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Institute, Tampa General Hospital, Tampa, FL 33606, USA","institution_ids":["https://openalex.org/I2801973574"]},{"raw_affiliation_string":"USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069136593","display_name":"Kiran K. Dhanireddy","orcid":"https://orcid.org/0000-0002-5223-8323","observed_orcids":["https://orcid.org/0000-0002-5223-8323"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I2801973574","display_name":"Tampa General Hospital","ror":"https://ror.org/03tj5qd85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801973574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Dhanireddy","raw_affiliation_strings":["Transplant Institute, Tampa General Hospital, Tampa, FL 33606, USA","USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Institute, Tampa General Hospital, Tampa, FL 33606, USA","institution_ids":["https://openalex.org/I2801973574"]},{"raw_affiliation_string":"USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159710237","display_name":"Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159649571","display_name":"Wei Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["WR Biotech, LLC, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WR Biotech, LLC, Tampa, FL 33612, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159697778","display_name":"Ruisheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruisheng Liu","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"USF Health Transplant Research Center (UTRC), University of South Florida, Tampa, FL 33602, USA;","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5146574538"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.890999972820282},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4099999964237213},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.6949999928474426},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.8299999833106995},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.6430000066757202},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.34299999475479126},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.4569999873638153},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.4950000047683716},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.4560000002384186},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.33799999952316284},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.43299999833106995},{"id":"https://openalex.org/keywords/electrotherapy","display_name":"electrotherapy","score":0.36899998784065247},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.7448999881744385},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6410999894142151},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5906999707221985},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5498999953269958},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.51910001039505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45719999074935913},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.42730000615119934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4097999930381775},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.39739999175071716},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3917999863624573},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.390500009059906},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3637000024318695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30239999294281006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2971999943256378},{"id":"https://openalex.org/C2993714741","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemic injury","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.27410000562667847},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26510000228881836},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.10.20.760575","doi":"https://doi.org/10.64898/2026.10.20.760575","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.20.760575","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.20.760575.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738634","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738634/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.20.760575","doi":"https://doi.org/10.64898/2026.10.20.760575","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.20.760575","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.20.760575.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223673619.pdf","grobid_xml":"https://content.openalex.org/works/W7223673619.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223109897","https://openalex.org/W4220749078","https://openalex.org/W4397046733","https://openalex.org/W4397040916","https://openalex.org/W4225420194","https://openalex.org/W3164637514","https://openalex.org/W1988314538","https://openalex.org/W4392560443","https://openalex.org/W4313199679","https://openalex.org/W1983708786"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Acute":[2],"kidney":[3,27,106],"injury":[4,30,82,103,160],"has":[5,38],"no":[6,226],"approved":[7],"drug":[8],"treatment.":[9],"A":[10],"synchronization":[11],"modulation":[12],"electric":[13],"field":[14,87],"(SMEF)":[15],"keeps":[16],"Na\u207a/K\u207a-ATPase":[17,254],"working":[18],"when":[19],"ATP":[20],"is":[21,55],"scarce,":[22],"and":[23,31,48,70,98,108,116,153,204,209,225,244,255,261,315,327],"protects":[24],"the":[25,53,86,192,298,344],"rodent":[26],"from":[28],"ischemia-reperfusion":[29],"human":[32],"kidneys":[33],"during":[34,89],"cold":[35],"storage.":[36],"It":[37],"not":[39,219,259,328],"been":[40],"tested":[41],"in":[42,46,52,163],"a":[43,313],"large":[44],"animal":[45,166],"vivo,":[47],"what":[49],"it":[50],"changes":[51],"tissue":[54,114,245,278],"unknown.":[56],"Methods":[57],"Twelve":[58],"female":[59],"Yorkshire":[60],"pigs":[61],"underwent":[62],"90":[63],"min":[64],"of":[65,73,297,312,331,346],"bilateral":[66],"renal":[67],"pedicle":[68],"occlusion":[69],"4":[71,77],"h":[72],"reperfusion":[74],"(n":[75],"=":[76,132,138,151,157,180,252,290],"per":[78],"group:":[79],"sham,":[80],"injury,":[81],"plus":[83],"SMEF),":[84],"with":[85,186,300,323],"applied":[88],"ischemia.":[90],"We":[91],"measured":[92,109],"serum":[93,121],"creatinine,":[94],"blood":[95,134],"urea":[96,135],"nitrogen":[97,136],"plasma":[99,140],"NGAL,":[100],"graded":[101],"tubular":[102],"histologically,":[104],"sequenced":[105],"RNA,":[107],"electron":[110,263],"transport":[111,264],"chain":[112,265],"protein,":[113,288],"CCL2":[115,246],"glutathione.":[117],"Results":[118],"SMEF":[119,307],"lowered":[120],"creatinine":[122],"(1.85":[123],"\u00b1":[124,128,143,147,168,172,281,285],"0.29":[125],"versus":[126,145,170,283],"2.33":[127],"0.17":[129],"mg/dl,":[130],"P":[131,150,289],"0.014),":[133],"(P":[137,156,179,251],"0.024),":[139],"NGAL":[141],"(25.8":[142],"10.7":[144],"69.9":[146],"23.8":[148],"ng/ml,":[149],"0.005)":[152],"cystatin":[154],"C":[155],"0.0016).":[158],"Tubular":[159],"was":[161,175,191,228,248,308],"lower":[162,250],"every":[164],"treated":[165],"(1.31":[167],"0.31":[169],"3.00":[171],"0.00),":[173],"as":[174],"cleaved":[176],"caspase-3":[177],"protein":[178,247,266],"0.0094).":[181],"Of":[182],"304":[183],"genes":[184],"differing":[185],"treatment,":[187],"most":[188,193],"fell.":[189],"TNFA_SIGNALING_VIA_NFKB":[190],"suppressed":[194],"hallmark":[195],"gene":[196],"set":[197],"(NES":[198],"\u22122.57,":[199],"FDR":[200],"5.0":[201],"\u00d7":[202,237,242],"10\u207b\u2079),":[203],"NF-\u03baB,":[205],"AP-1,":[206],"STAT3,":[207],"ATF4":[208],"HSF1":[210],"activities":[211],"moved":[212],"opposite":[213],"to":[214],"injury.":[215,301],"Leukocyte":[216],"markers":[217],"did":[218],"differ":[220],"significantly":[221,273],"(PTPRC,":[222],"padj":[223,235],"0.66),":[224],"infiltrate":[227],"seen.":[229],"Recruitment":[230],"signals":[231],"fell":[232],"(CCL2":[233],"\u22122.31,":[234],"1.9":[236],"10\u207b\u00b9\u00b9;":[238],"SELP":[239],"\u22121.48,":[240],"9.5":[241],"10\u207b\u2074),":[243],"24%":[249],"0.0062).":[253],"mitochondrial":[256,268,334],"transcripts":[257],"were":[258],"restored,":[260],"neither":[262],"nor":[267],"DNA":[269],"copy":[270],"number":[271],"differed":[272],"between":[274],"groups.":[275],"Treatment":[276],"preserved":[277],"glutathione":[279],"(21.43":[280],"0.32":[282],"15.76":[284],"1.58":[286],"nmol/mg":[287],"0.010);":[291],"oxidation":[292],"accounted":[293],"for":[294],"only":[295],"17%":[296],"loss":[299],"Conclusions":[302],"In":[303],"pigs,":[304],"protection":[305],"by":[306,310,329],"accompanied":[309],"suppression":[311],"stress":[314],"inflammatory":[316],"program":[317],"without":[318],"detectable":[319],"leukocyte":[320],"accumulation,":[321],"consistent":[322],"an":[324,339],"epithelial":[325],"origin,":[326],"restoration":[330],"pump":[332],"or":[333],"transcripts.":[335],"The":[336],"results":[337],"fit":[338],"intervention":[340],"that":[341],"acts":[342],"on":[343,351],"function":[345],"existing":[347],"molecules":[348],"rather":[349],"than":[350],"their":[352],"expression.":[353]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-27T00:00:00"}
