{"id":"https://openalex.org/W7223671483","doi":"https://doi.org/10.1097/mph.0000000000003306","title":"Successful Treatment of an Infant With Severe Combined Immunodeficiency and Ganciclovir-Resistant Cytomegalovirus Disease With Maribavir Followed By Subsequent Graft Recovery","display_name":"Successful Treatment of an Infant With Severe Combined Immunodeficiency and Ganciclovir-Resistant Cytomegalovirus Disease With Maribavir Followed By Subsequent Graft Recovery","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223671483","doi":"https://doi.org/10.1097/mph.0000000000003306","pmid":"https://pubmed.ncbi.nlm.nih.gov/42932182"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0000000000003306","doi":"https://doi.org/10.1097/mph.0000000000003306","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000003306","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067614603","display_name":"Shareef K. Shaheen","orcid":"https://orcid.org/0000-0001-9429-2451","observed_orcids":["https://orcid.org/0000-0001-9429-2451"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shareef Shaheen","raw_affiliation_strings":["Penn State College of Medicine, Hershey, PA"],"raw_orcid":"https://orcid.org/0000-0001-9429-2451","affiliations":[{"raw_affiliation_string":"Penn State College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064496709","display_name":"Carrie Eichelberger","orcid":"https://orcid.org/0000-0002-5081-4323","observed_orcids":["https://orcid.org/0000-0002-5081-4323","https://orcid.org/0009-0002-0314-0407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie Eichelberger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0314-0407","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009447047","display_name":"Robert J. Greiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Greiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159586586","display_name":"Katherine Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048976743","display_name":"Kevin M. Mulieri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Mulieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053090961","display_name":"Patrick J. Gavigan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Gavigan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070669648","display_name":"Jessica E. Ericson","orcid":"https://orcid.org/0000-0002-8765-2065","observed_orcids":["https://orcid.org/0000-0002-8765-2065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica E. Ericson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8765-2065","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86585499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-combined-immunodeficiency","display_name":"severe combined immunodeficiency","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ganciclovir-resistance","display_name":"ganciclovir resistance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/maribavir","display_name":"maribavir","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.9549999833106995},{"id":"https://openalex.org/keywords/foscarnet","display_name":"foscarnet","score":0.9599999785423279},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.4519999921321869},{"id":"https://openalex.org/keywords/immunologic-recovery","display_name":"immunologic recovery","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.8291000127792358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8040000200271606},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.6906999945640564},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.6177999973297119},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5874000191688538},{"id":"https://openalex.org/C2776724271","wikidata":"https://www.wikidata.org/wiki/Q420387","display_name":"Foscarnet","level":5,"score":0.5450999736785889},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5138000249862671},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4814000129699707},{"id":"https://openalex.org/C2777662283","wikidata":"https://www.wikidata.org/wiki/Q747711","display_name":"Betaherpesvirinae","level":5,"score":0.47749999165534973},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45350000262260437},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4104999899864197},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.3089999854564667},{"id":"https://openalex.org/C2779468541","wikidata":"https://www.wikidata.org/wiki/Q1334408","display_name":"Severe combined immunodeficiency","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/mph.0000000000003306","doi":"https://doi.org/10.1097/mph.0000000000003306","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000003306","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:42932182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42932182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2070516950","https://openalex.org/W2762629706","https://openalex.org/W2916338609","https://openalex.org/W3091060236","https://openalex.org/W3158963093","https://openalex.org/W4206172462","https://openalex.org/W4211129967","https://openalex.org/W4294147594","https://openalex.org/W4307437000","https://openalex.org/W4387575036","https://openalex.org/W4392391449","https://openalex.org/W4403403188","https://openalex.org/W4404711474","https://openalex.org/W4410015483","https://openalex.org/W4410832819","https://openalex.org/W7122493137"],"related_works":["https://openalex.org/W2564036663","https://openalex.org/W7135397738","https://openalex.org/W7162668605","https://openalex.org/W4399347874","https://openalex.org/W2521932686","https://openalex.org/W7093123374","https://openalex.org/W7139945059","https://openalex.org/W4406563114","https://openalex.org/W4312220901","https://openalex.org/W2129282759"],"abstract_inverted_index":{"BACKGROUND:":[0],"Refractory":[1],"and":[2,41,52,64],"resistant":[3],"cytomegalovirus":[4,33],"infection":[5],"occurring":[6],"in":[7,66,95],"young":[8,96],"infants":[9],"has":[10],"few":[11],"effective":[12],"treatments.Observations:":[13],"A":[14],"2-month-old":[15],"infant":[16],"with":[17,38,59],"severe":[18],"combined":[19],"immunodeficiency":[20],"experienced":[21],"graft":[22],"failure":[23],"following":[24],"umbilical":[25],"cord":[26],"hematopoietic":[27],"stem":[28],"cell":[29],"transplant":[30,73],"due":[31],"to":[32,80],"(CMV)":[34],"infection.":[35],"Following":[36],"treatment":[37],"foscarnet,":[39],"ganciclovir,":[40],"viral-specific":[42],"cytotoxic":[43],"T-lymphocyte":[44],"therapy,":[45],"ganciclovir":[46],"resistance":[47],"developed,":[48],"viremia":[49],"was":[50,57],"persistent,":[51],"CMV":[53,62,92],"disease":[54,63],"developed.":[55],"Maribavir":[56,84],"added":[58],"resolution":[60],"of":[61],"improvement":[65],"the":[67],"viral":[68],"load.":[69],"Evaluation":[70],"for":[71,90],"repeat":[72],"revealed":[74],"late":[75],"engraftment,":[76],"which":[77],"ultimately":[78],"led":[79],"immunologic":[81],"recovery.":[82],"CONCLUSIONS:":[83],"is":[85],"a":[86],"novel":[87],"antiviral":[88],"therapy":[89],"refractory":[91],"infection,":[93],"including":[94],"infants.":[97]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}