{"id":"https://openalex.org/W7223671394","doi":"https://doi.org/10.3389/fcimb.2026.2020473","title":"Editorial: Perspectives in fungal pathogenesis: 2025","display_name":"Editorial: Perspectives in fungal pathogenesis: 2025","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223671394","doi":"https://doi.org/10.3389/fcimb.2026.2020473"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.2020473","doi":"https://doi.org/10.3389/fcimb.2026.2020473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2020473","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2020473/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2020473/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061116054","display_name":"Joseph T. Nickels","orcid":"https://orcid.org/0000-0001-9984-3056","observed_orcids":["https://orcid.org/0000-0001-9984-3056"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph T. Nickels","raw_affiliation_strings":["Genesis Biotechnology Group","Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genesis Biotechnology Group","institution_ids":[]},{"raw_affiliation_string":"Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032979254","display_name":"Yuanwei Zhang","orcid":"https://orcid.org/0000-0003-0854-6123","observed_orcids":["https://orcid.org/0000-0003-0854-6123"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanwei Zhang","raw_affiliation_strings":["Nanjing Normal University, College of Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Normal University, College of Life Sciences","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068715797","display_name":"Scott E. Gygax","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Gygax","raw_affiliation_strings":["Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079368595","display_name":"Daniel A. Henk","orcid":"https://orcid.org/0000-0002-1142-3143","observed_orcids":["https://orcid.org/0000-0002-1142-3143"]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Henk","raw_affiliation_strings":["University of Bath"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bath","institution_ids":["https://openalex.org/I51601045"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061116054"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.24539999663829803,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fungal-pathogenesis","display_name":"fungal pathogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/emerging-fungal-pathogens","display_name":"emerging fungal pathogens","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sporothrix-schenckii","display_name":"Sporothrix schenckii","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sporotrichosis","display_name":"sporotrichosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.7289999723434448},{"id":"https://openalex.org/keywords/panoptosome","display_name":"PANoptosome","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/autoimmune-rheumatic-diseases","display_name":"autoimmune rheumatic diseases","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.5920000076293945},{"id":"https://openalex.org/keywords/virulence-mechanisms","display_name":"virulence mechanisms","score":0.5709999799728394},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7365999817848206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6905999779701233},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6830000281333923},{"id":"https://openalex.org/C2991700627","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Fungal disease","level":2,"score":0.6410999894142151},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.4577000141143799},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4440000057220459},{"id":"https://openalex.org/C2775839086","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Pathogenic fungus","level":3,"score":0.3725999891757965},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C2780908437","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Mycosis","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2909919671","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drugs","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcimb.2026.2020473","doi":"https://doi.org/10.3389/fcimb.2026.2020473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2020473","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2020473/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:42c58455dd444c76ad48879461bb1e4b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/42c58455dd444c76ad48879461bb1e4b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.2020473","doi":"https://doi.org/10.3389/fcimb.2026.2020473","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2020473","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2020473/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223671394.pdf","grobid_xml":"https://content.openalex.org/works/W7223671394.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2031317225","https://openalex.org/W2523840231","https://openalex.org/W2766843384","https://openalex.org/W2768639053","https://openalex.org/W3089323764","https://openalex.org/W3111846615","https://openalex.org/W3120229614","https://openalex.org/W3127236674","https://openalex.org/W4205564523","https://openalex.org/W4213415086","https://openalex.org/W4281562847","https://openalex.org/W4387564088","https://openalex.org/W4396665991","https://openalex.org/W4399321742","https://openalex.org/W4411427823","https://openalex.org/W4411706518","https://openalex.org/W4415204621","https://openalex.org/W4415457138","https://openalex.org/W7114774275","https://openalex.org/W7154892912"],"related_works":["https://openalex.org/W2063684466","https://openalex.org/W4412903527","https://openalex.org/W1134281348","https://openalex.org/W6893101708","https://openalex.org/W56339353","https://openalex.org/W4401122060","https://openalex.org/W3121275760","https://openalex.org/W2765511392","https://openalex.org/W4416781674","https://openalex.org/W4289176924"],"abstract_inverted_index":{"Pathogenic":[0],"microbes":[1],"exploit":[2],"both":[3,37],"host":[4,12,39,277,937],"and":[5,40,53,101,133,176,183,286,309,318,341,355,376,400,410,442,456,464,484,494,507,513,530,543,559,593,616,630,643,667,689,719,731,762,779,785,822,831,858,867,876,901,911,921,927,948,957,960,970,986],"microbial":[6,268],"systems":[7],"to":[8,14,108,116,161,172,247,267,373,388,510,533,590,702,709,806,808,834,852],"cause":[9],"disease,":[10],"hijacking":[11],"pathways":[13,853],"enhance":[15],"their":[16,489,531,614,728,928],"virulence":[17,490,789,897,944],"(Konig":[18],"et":[19,44,47,70,149,186,271,289,321,425,467,555,562,680,734,796,818,825],"al.,":[20,45,48,71,150,187,272,290,322,426,468,556,563,681,735,797,819,826],"2021;Strickland":[21],"&":[22,461],"Shi,":[23],"2021).":[24,85,820],"Virulence":[25],"thus":[26],"arises":[27],"from":[28,299,704,750,906,965],"the":[29,38,41,61,102,120,168,173,194,198,202,212,218,225,248,276,294,325,396,419,479,514,525,534,566,579,599,768,801,836,888,895,899,919,953,973,983],"coordinated":[30],"activity":[31],"of":[32,81,96,119,193,197,205,250,303,421,482,497,516,527,537,552,569,651,722,760,803,842,898,955,988],"complex":[33],"molecular":[34,326,397,495,587],"networks":[35],"in":[36,66,135,145,275,363,412,448,518,640,670,714,791,865,878,887],"microbe":[42],"(Camilli":[43],"2021;Mendes-Giannini":[46],"2005).":[49],"Although":[50],"Candida":[51,57,433,474,528],"albicans":[52,399],"Nakaseomyces":[54,401],"glabratus":[55,402],"(formerly":[56],"glabrata)":[58],"are":[59,76,114,265,624,787],"among":[60],"most":[62],"common":[63],"fungal":[64,74,127,140,545,591,663,724,754,925,933,943,990],"pathogens":[65,926],"immunocompromised":[67,146,254,413,687],"individuals":[68,147,255,671,688],"(Katsipoulaki":[69,424],"2024),":[72],"other":[73,485],"species":[75,128,529,546,638,666],"increasingly":[77],"emerging":[78,432],"as":[79,155,230,232,370,504,604],"drivers":[80],"disease":[82,109,130,141,209,228,344,375,684,934],"progression":[83],"(Wiederhold,":[84],"This":[86,683],"series":[87,917],"brings":[88],"together":[89],"six":[90],"articles":[91,931],"that":[92,142,158,241,293,335,350,741,774],"expand":[93,565],"our":[94,649],"understanding":[95,204,613,650],"newly":[97,621],"recognized":[98],"pathogenic":[99,122,492,594,652,664,989],"fungi":[100,572,653],"mechanisms":[103,226,327],"by":[104,211,257,345,418,431,573,586,627,633,662],"which":[105,125],"they":[106],"contribute":[107],"progression.":[110],"Collectively,":[111],"these":[112,483,602,850],"studies":[113,386],"intended":[115],"advance":[117],"knowledge":[118],"fundamental":[121],"processes":[123],"through":[124,315],"diverse":[126],"increase":[129],"burden,":[131],"morbidity,":[132],"mortality":[134,411],"affected":[136,256],"individuals.Sporotrichosis":[137],"is":[138,584,660],"a":[139,190,300,371,404,415,549,609,771,976],"can":[143,170,547,699],"occur":[144],"(Orofino-Costa":[148],"2017).":[151,273],"Cases":[152],"typically":[153],"present":[154],"lymphocutaneous":[156],"lesions":[157],"may":[159,742,904],"progress":[160,246],"open":[162,377],"sores":[163],"or":[164,676,844],"ulcers.":[165],"When":[166],"disseminated,":[167],"infection":[169],"spread":[171],"lungs,":[174],"bones,":[175],"central":[177],"nervous":[178],"system,":[179],"becoming":[180],"life-threatening.":[181],"Yuan":[182],"colleagues":[184,287,465,560,732,823],"(Yuan":[185],"2026)":[188],"provide":[189],"comprehensive":[191],"review":[192,470,522],"chronological":[195],"evolution":[196],"literature":[199,472],"based":[200],"on":[201,224,473,478],"increasing":[203],"sporotrichosis,":[206],"an":[207,347],"infectious":[208],"caused":[210,430,661],"fungus":[213,295,392],"Sporothrix":[214],"schenckii.":[215],"They":[216,333,500,799,951],"identified":[217,601,737],"need":[219],"for":[220,253,380,453,612,814,874,978],"more":[221],"definitive":[222],"research":[223,979],"underlying":[227,328,673],"progression,":[229],"well":[231],"investigation":[233],"into":[234],"therapeutic":[235,381,961],"drug":[236,815],"discovery.":[237],"The":[238,521,619,930],"authors":[239,600,769],"emphasized":[240],"collaborative":[242],"efforts":[243],"could":[244],"accelerate":[245],"development":[249],"effective":[251],"treatments":[252],"this":[258,329,391,753,916],"deadly":[259],"disease.Individuals":[260],"with":[261,282,383,458,476,655,672,747,840],"autoimmune":[262,283,374],"rheumatic":[263],"diseases":[264],"susceptible":[266],"infections":[269,429,707,794],"(Caminer":[270],"Alterations":[274],"microbiota":[278],"have":[279,445],"been":[280,446],"associated":[281,654,839],"disorders.":[284],"Zhang":[285],"(Zhang":[288],"2025)":[291,469,564,736,827],"show":[292],"Kazachstania":[296],"pintolopesii,":[297],"isolated":[298],"monkey":[301],"model":[302],"ankylosing":[304],"spondylitis,":[305],"induces":[306],"PANoptosome":[307],"assembly":[308],"activity,":[310],"promoting":[311],"immune":[312,339,938],"cell":[313],"death":[314],"apoptosis,":[316],"pyroptosis,":[317],"necroptosis":[319],"(Sun":[320,554],"2024);":[323],"however,":[324],"effect":[330],"remain":[331],"unclear.":[332],"demonstrate":[334],"K.":[336,368],"pintolopesii":[337,369],"disrupts":[338],"homeostasis":[340],"causes":[342],"joint":[343],"activating":[346],"immune-endothelial-fibroblast":[348],"cascade":[349],"drives":[351],"inflammatory":[352,941],"cytokine":[353],"production":[354],"fibrosis.":[356],"Bioinformatic":[357],"analyses":[358,588],"further":[359],"suggest":[360,894],"T-cell":[361],"activation":[362],"osteoblasts.":[364],"These":[365,636,646,892],"findings":[366,647,893],"identify":[367,958],"contributor":[372],"new":[378,576],"avenues":[379],"strategies,":[382],"future":[384],"mechanistic":[385],"needed":[387],"define":[389,835],"how":[390],"activates":[393],"PANoptosis":[394],"at":[395,981],"level.Candida":[398],"represent":[403],"major":[405,535],"health":[406],"concern":[407],"causing":[408],"morbidity":[409],"individuals,":[414],"challenge":[416],"intensified":[417],"emergence":[420],"antifungal-resistant":[422],"strains":[423],"2024).":[427,682],"Increased":[428],"species,":[434],"including":[435,540,756,936],"C.":[436,438,440,443,804],"krusei,":[437],"parapsilosis,":[439],"tropicalis,":[441],"auris,":[444],"reported":[447],"neonatal":[449],"units,":[450],"nursing":[451],"homes":[452],"older":[454],"adults,":[455],"patients":[457,746],"cancer":[459],"(Barantsevich":[460],"Barantsevich,":[462],"2022).Fernandes":[463],"(Fernandes":[466],"recent":[471],"spp.,":[475],"emphasis":[477],"taxonomic":[480,567],"reclassification":[481],"clinically":[486],"relevant":[487],"fungi,":[488,607],"factors,":[491],"mechanisms,":[493,945],"basis":[496],"antifungal":[498,511,538],"resistance.":[499],"summarize":[501],"topics":[502],"such":[503],"biofilm":[505],"formation":[506],"its":[508],"contribution":[509],"resistance":[512,532],"role":[515,873],"adhesins":[517],"hostpathogen":[519],"interactions.":[520],"also":[523],"examines":[524],"biology":[526],"classes":[536],"agents,":[539],"azoles,":[541],"echinocandins,":[542],"polyenes.Several":[544],"infect":[548],"wide":[550],"range":[551],"plants":[553],"2020).":[557],"Singh":[558],"(Singh":[561],"nomenclature":[568],"cercosporoid":[570,606],"hyphomycetous":[571],"proposing":[574],"two":[575,620,637],"genera":[577,623],"within":[578],"family":[580],"Mycosphaerellaceae.":[581],"Their":[582],"classification":[583],"supported":[585],"linked":[589,849],"diversity":[592],"potential.":[595],"Using":[596],"multiple":[597],"approaches,":[598],"isolates":[603],"novel":[605],"providing":[608],"refined":[610],"framework":[611,773],"taxonomy":[615],"evolutionary":[617],"relationships.":[618],"proposed":[622],"Marcstadlera,":[625],"represented":[626,632],"M.":[628],"malloti,":[629],"Neoclypeosphaerella,":[631],"N.":[634],"calotropidis.":[635],"differ":[639],"conidial":[641],"loci":[642],"hila":[644],"morphology.":[645],"broaden":[648],"severe":[656],"plant":[657],"diseases.Pulmonary":[658],"aspergillosis":[659,698,749],"Aspergillus":[665],"occurs":[668],"predominately":[669],"risk":[674,739],"factors":[675,740],"impaired":[677],"immunity":[678],"(Machado":[679],"primarily":[685],"affects":[686],"pediatric":[690,745],"patients.":[691],"Accurate":[692],"diagnosis":[693],"remains":[694],"challenging":[695],"because":[696],"pulmonary":[697,748],"be":[700],"difficult":[701],"distinguish":[703,744],"non-aspergillosis":[705],"respiratory":[706,717],"due":[708],"overlapping":[710],"clinical":[711,966],"symptoms,":[712],"difficulties":[713],"obtaining":[715],"appropriate":[716],"specimens,":[718],"limited":[720],"availability":[721],"diagnostic":[723,772],"biomarker":[725],"tests.":[726],"In":[727],"study,":[729],"Yang":[730],"(Yang":[733],"independent":[738],"help":[743,776],"those":[751],"without":[752],"infection,":[755],"viral":[757],"coinfection,":[758],"absence":[759],"fever,":[761],"elevated":[763],"serum":[764],"\u03b2-D-glucan":[765],"levels.":[766],"Thus,":[767],"construct":[770],"will":[775],"physicians":[777],"diagnose":[778],"treat":[780],"aspergillosis.The":[781],"infectivity-related":[782],"kinases":[783,851],"Irk2":[784,843,875],"Irk5":[786,877],"important":[788],"determinants":[790],"Cryptococcus":[792],"neoformans":[793,805],"(Lee":[795],"2016).":[798],"support":[800],"ability":[802],"adapt":[807],"metabolic":[809,837,946],"environments,":[810],"making":[811],"them":[812,864],"targets":[813],"discovery":[816],"(Iyer":[817],"Ma":[821],"(Ma":[824],"used":[828],"integrated":[829],"proteomic":[830],"metabolomic":[832],"approaches":[833],"changes":[838],"deletion":[841,890],"Irk5.":[845],"Proteomic":[846],"KEGG":[847],"analysis":[848],"regulating":[854],"carbohydrate,":[855],"amino":[856,868],"acid,":[857],"lipid":[859],"metabolism.":[860],"Metabolomic":[861],"profiling":[862],"implicated":[863],"aminoacyl-tRNA":[866],"acid":[869],"biosynthesis.":[870],"A":[871],"potential":[872],"mitochondrial":[879,908,949],"function":[880],"was":[881],"uncovered,":[882],"noting":[883],"increased":[884],"ATP":[885,913],"levels":[886],"single-gene":[889],"strains.":[891],"reduced":[896],"irk2\u2206":[900],"irk5\u2206":[902],"mutants":[903],"result":[905],"altered":[907],"oxidative":[909],"phosphorylation":[910],"disrupted":[912],"homeostasis.In":[914],"summary,":[915],"emphasizes":[918],"dynamic":[920],"multifaceted":[922],"interactions":[923],"between":[924],"hosts.":[929],"examine":[932],"biology,":[935],"activation,":[939],"pathogen-driven":[940],"responses,":[942],"adaptation,":[947],"function.":[950],"highlight":[952],"complexity":[954],"pathogenesis":[956],"gaps":[959],"opportunities.":[962],"Integrating":[963],"insights":[964],"observations,":[967],"experimental":[968],"models,":[969],"systems-level":[971],"analyses,":[972],"collection":[974],"provides":[975],"foundation":[977],"aimed":[980],"improving":[982],"diagnosis,":[984],"treatment,":[985],"prevention":[987],"diseases.":[991]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}
