{"id":"https://openalex.org/W7223662939","doi":"https://doi.org/10.1038/s44318-026-00955-1","title":"Immune surveillance of cellular damage: lessons from Caenorhabditis elegans","display_name":"Immune surveillance of cellular damage: lessons from Caenorhabditis elegans","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223662939","doi":"https://doi.org/10.1038/s44318-026-00955-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934287"},"language":"en","primary_location":{"id":"doi:10.1038/s44318-026-00955-1","doi":"https://doi.org/10.1038/s44318-026-00955-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44318-026-00955-1","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44318-026-00955-1.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1038/s44318-026-00955-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104229315","display_name":"Annesha Ghosh","orcid":"https://orcid.org/0000-0002-8732-8492","observed_orcids":["https://orcid.org/0000-0002-8732-8492","https://orcid.org/0009-0005-6768-4253"]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Annesha Ghosh","raw_affiliation_strings":["Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India","institution_ids":["https://openalex.org/I165916956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041771324","display_name":"Jogender Singh","orcid":"https://orcid.org/0000-0002-7947-0405","observed_orcids":["https://orcid.org/0000-0002-7947-0405"]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jogender Singh","raw_affiliation_strings":["Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India. jogender@iisermohali.ac.in"],"raw_orcid":"https://orcid.org/0000-0002-7947-0405","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India. jogender@iisermohali.ac.in","institution_ids":["https://openalex.org/I165916956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041771324"],"corresponding_institution_ids":["https://openalex.org/I165916956"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54295024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.9520000219345093},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7329999804496765},{"id":"https://openalex.org/keywords/lysosomal-homeostasis","display_name":"lysosomal homeostasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/golgi-function","display_name":"Golgi function","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inter-organelle-communication","display_name":"inter-organelle communication","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lysosome-related-organelles","display_name":"lysosome-related organelles","score":0.9340000152587891},{"id":"https://openalex.org/keywords/intestinal-distension","display_name":"intestinal distension","score":0.984000027179718},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.6290000081062317},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9185000061988831},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7922000288963318},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.762499988079071},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.757099986076355},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5467000007629395},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4932999908924103},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42260000109672546},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39739999175071716},{"id":"https://openalex.org/C3019359096","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune surveillance","level":3,"score":0.37220001220703125},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.33160001039505005},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3310999870300293},{"id":"https://openalex.org/C137993225","wikidata":"https://www.wikidata.org/wiki/Q6058723","display_name":"Intrinsic immunity","level":4,"score":0.32839998602867126},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.320499986410141},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.3084000051021576},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2962000072002411},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.2851000130176544},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.25369998812675476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2535000145435333}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s44318-026-00955-1","doi":"https://doi.org/10.1038/s44318-026-00955-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44318-026-00955-1","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44318-026-00955-1.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmid:42934287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s44318-026-00955-1","doi":"https://doi.org/10.1038/s44318-026-00955-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44318-026-00955-1","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44318-026-00955-1.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3309422668","display_name":null,"funder_award_id":"HRD-17011/2/2023-HRD-DBT","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G4040014854","display_name":null,"funder_award_id":"BT/RLF/Re-entry/50/2020","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G40900061","display_name":null,"funder_award_id":"MoE-STARS/STARS-2/2023-0116","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"}],"funders":[{"id":"https://openalex.org/F4320306227","display_name":"Arthritis National Research Foundation","ror":"https://ror.org/03abbex33"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223662939.pdf","grobid_xml":"https://content.openalex.org/works/W7223662939.grobid-xml"},"referenced_works_count":250,"referenced_works":["https://openalex.org/W1483162601","https://openalex.org/W1524848610","https://openalex.org/W1798609233","https://openalex.org/W1807903810","https://openalex.org/W1913192897","https://openalex.org/W1948088416","https://openalex.org/W1949402365","https://openalex.org/W1965021143","https://openalex.org/W1967841171","https://openalex.org/W1970762617","https://openalex.org/W1971664002","https://openalex.org/W1972002218","https://openalex.org/W1974332480","https://openalex.org/W1974522038","https://openalex.org/W1975030465","https://openalex.org/W1977603207","https://openalex.org/W1979753906","https://openalex.org/W1980120566","https://openalex.org/W1981496396","https://openalex.org/W1985905314","https://openalex.org/W1986406001","https://openalex.org/W1986530960","https://openalex.org/W1988376786","https://openalex.org/W1989842618","https://openalex.org/W1993688639","https://openalex.org/W1994576130","https://openalex.org/W1998450956","https://openalex.org/W2000444249","https://openalex.org/W2003699495","https://openalex.org/W2006652226","https://openalex.org/W2008677145","https://openalex.org/W2011116889","https://openalex.org/W2012104592","https://openalex.org/W2012931780","https://openalex.org/W2013977400","https://openalex.org/W2015346570","https://openalex.org/W2020400086","https://openalex.org/W2021253753","https://openalex.org/W2022466704","https://openalex.org/W2026932718","https://openalex.org/W2028048087","https://openalex.org/W2031437584","https://openalex.org/W2031516834","https://openalex.org/W2035232303","https://openalex.org/W2036712227","https://openalex.org/W2038324706","https://openalex.org/W2038331116","https://openalex.org/W2042851093","https://openalex.org/W2046835799","https://openalex.org/W2048165620","https://openalex.org/W2048810336","https://openalex.org/W2054858711","https://openalex.org/W2058512912","https://openalex.org/W2058605720","https://openalex.org/W2059672533","https://openalex.org/W2062946341","https://openalex.org/W2067520027","https://openalex.org/W2069960805","https://openalex.org/W2070006775","https://openalex.org/W2074403519","https://openalex.org/W2074892979","https://openalex.org/W2075038734","https://openalex.org/W2076716995","https://openalex.org/W2084211225","https://openalex.org/W2084518640","https://openalex.org/W2084614729","https://openalex.org/W2084630938","https://openalex.org/W2085034589","https://openalex.org/W2087238801","https://openalex.org/W2094030767","https://openalex.org/W2094228208","https://openalex.org/W2095518178","https://openalex.org/W2095885733","https://openalex.org/W2099119962","https://openalex.org/W2104276267","https://openalex.org/W2104818214","https://openalex.org/W2112132467","https://openalex.org/W2114737175","https://openalex.org/W2116437559","https://openalex.org/W2127503164","https://openalex.org/W2130890398","https://openalex.org/W2138608045","https://openalex.org/W2138946332","https://openalex.org/W2138951501","https://openalex.org/W2141137217","https://openalex.org/W2141370830","https://openalex.org/W2142830401","https://openalex.org/W2144704426","https://openalex.org/W2145736817","https://openalex.org/W2148568814","https://openalex.org/W2158424449","https://openalex.org/W2158500407","https://openalex.org/W2158827209","https://openalex.org/W2160088874","https://openalex.org/W2161341472","https://openalex.org/W2161387562","https://openalex.org/W2161912345","https://openalex.org/W2162515800","https://openalex.org/W2164346418","https://openalex.org/W2172117086","https://openalex.org/W2178733844","https://openalex.org/W2182819013","https://openalex.org/W2254506451","https://openalex.org/W2287479634","https://openalex.org/W2317128550","https://openalex.org/W2318721507","https://openalex.org/W2327842216","https://openalex.org/W2344482801","https://openalex.org/W2344653737","https://openalex.org/W2408798126","https://openalex.org/W2461952548","https://openalex.org/W2516123799","https://openalex.org/W2519045533","https://openalex.org/W2519611848","https://openalex.org/W2522580675","https://openalex.org/W2531635260","https://openalex.org/W2552219411","https://openalex.org/W2557733382","https://openalex.org/W2560511161","https://openalex.org/W2592738762","https://openalex.org/W2602599682","https://openalex.org/W2606232917","https://openalex.org/W2611575983","https://openalex.org/W2612959023","https://openalex.org/W2618055159","https://openalex.org/W2620843886","https://openalex.org/W2730531105","https://openalex.org/W2738136165","https://openalex.org/W2785101149","https://openalex.org/W2786551169","https://openalex.org/W2789336604","https://openalex.org/W2807952216","https://openalex.org/W2883018577","https://openalex.org/W2888815313","https://openalex.org/W2894407414","https://openalex.org/W2901399106","https://openalex.org/W2902713146","https://openalex.org/W2907797728","https://openalex.org/W2909084995","https://openalex.org/W2911153671","https://openalex.org/W2911766507","https://openalex.org/W2911777499","https://openalex.org/W2913721203","https://openalex.org/W2916167844","https://openalex.org/W2919474349","https://openalex.org/W2921538673","https://openalex.org/W2938858873","https://openalex.org/W2980984091","https://openalex.org/W2988984783","https://openalex.org/W2990413391","https://openalex.org/W2991633694","https://openalex.org/W2992619341","https://openalex.org/W2995270543","https://openalex.org/W3000411860","https://openalex.org/W3004089940","https://openalex.org/W3006316914","https://openalex.org/W3012423063","https://openalex.org/W3012446152","https://openalex.org/W3017130238","https://openalex.org/W3024170109","https://openalex.org/W3035046984","https://openalex.org/W3082176770","https://openalex.org/W3087671839","https://openalex.org/W3090831677","https://openalex.org/W3096562070","https://openalex.org/W3097675557","https://openalex.org/W3108090587","https://openalex.org/W3113336728","https://openalex.org/W3113728478","https://openalex.org/W3118908793","https://openalex.org/W3126676851","https://openalex.org/W3130305184","https://openalex.org/W3136669485","https://openalex.org/W3158467801","https://openalex.org/W3163284041","https://openalex.org/W3164690696","https://openalex.org/W3165149216","https://openalex.org/W3166388960","https://openalex.org/W3175087021","https://openalex.org/W3181687372","https://openalex.org/W3195766250","https://openalex.org/W3202315780","https://openalex.org/W4206726195","https://openalex.org/W4210298079","https://openalex.org/W4210879314","https://openalex.org/W4211076456","https://openalex.org/W4214760997","https://openalex.org/W4226236220","https://openalex.org/W4232133836","https://openalex.org/W4280609606","https://openalex.org/W4283727437","https://openalex.org/W4294970362","https://openalex.org/W4308038402","https://openalex.org/W4308207588","https://openalex.org/W4310569281","https://openalex.org/W4310727066","https://openalex.org/W4311310359","https://openalex.org/W4313679371","https://openalex.org/W4319337760","https://openalex.org/W4321208460","https://openalex.org/W4366494291","https://openalex.org/W4375955443","https://openalex.org/W4381685043","https://openalex.org/W4385462186","https://openalex.org/W4385950502","https://openalex.org/W4386241518","https://openalex.org/W4386241570","https://openalex.org/W4386484171","https://openalex.org/W4387357363","https://openalex.org/W4388796502","https://openalex.org/W4389383354","https://openalex.org/W4391110787","https://openalex.org/W4391922608","https://openalex.org/W4392639058","https://openalex.org/W4395469483","https://openalex.org/W4395659497","https://openalex.org/W4399760419","https://openalex.org/W4400450102","https://openalex.org/W4402597831","https://openalex.org/W4402598151","https://openalex.org/W4402986792","https://openalex.org/W4403761073","https://openalex.org/W4403980338","https://openalex.org/W4404415449","https://openalex.org/W4404631783","https://openalex.org/W4405394420","https://openalex.org/W4405425817","https://openalex.org/W4407096242","https://openalex.org/W4407955857","https://openalex.org/W4408193834","https://openalex.org/W4409189508","https://openalex.org/W4409228613","https://openalex.org/W4409542447","https://openalex.org/W4410489677","https://openalex.org/W4411668810","https://openalex.org/W4411932078","https://openalex.org/W4412938518","https://openalex.org/W4414093394","https://openalex.org/W4414480249","https://openalex.org/W4415379685","https://openalex.org/W4417284196","https://openalex.org/W4417285454","https://openalex.org/W7118169638","https://openalex.org/W7127455972","https://openalex.org/W7134054548","https://openalex.org/W7161394134","https://openalex.org/W7161806438","https://openalex.org/W7171386935","https://openalex.org/W7202289499","https://openalex.org/W7214448729"],"related_works":["https://openalex.org/W2182819013","https://openalex.org/W7155054693","https://openalex.org/W4409542447","https://openalex.org/W4225996889","https://openalex.org/W1638819619","https://openalex.org/W2469581134","https://openalex.org/W4360612826","https://openalex.org/W2005086364","https://openalex.org/W3084888029","https://openalex.org/W2317128550"],"abstract_inverted_index":{"Innate":[0],"immune":[1,28,59,65,97,122],"systems":[2],"must":[3],"detect":[4,32],"infection":[5],"rapidly":[6],"and":[7,22,38,61,67,86,91,113,132,135,144],"reliably,":[8],"yet":[9],"pathogens":[10],"can":[11,94],"often":[12],"evade":[13],"direct":[14],"recognition":[15],"by":[16],"host":[17],"pattern-recognition":[18,172],"receptors.":[19],"An":[20],"alternative":[21],"increasingly":[23],"appreciated":[24],"strategy":[25,165],"is":[26,50],"damage-driven":[27],"surveillance,":[29],"whereby":[30],"hosts":[31],"pathogen-induced":[33],"perturbations":[34],"to":[35,74,79,141],"essential":[36],"cellular":[37,160],"tissue":[39],"functions":[40],"rather":[41],"than":[42],"microbial":[43],"molecules":[44],"themselves.":[45],"This":[46],"mode":[47],"of":[48,110,148,159],"detection":[49],"particularly":[51],"prominent":[52],"in":[53,120,151],"Caenorhabditis":[54],"elegans,":[55],"which":[56],"lacks":[57],"professional":[58],"cells":[60],"most":[62],"canonical":[63,171],"innate":[64,152],"receptors,":[66],"therefore":[68],"relies":[69],"extensively":[70],"on":[71],"monitoring":[72],"disruptions":[73],"core":[75],"homeostatic":[76],"pathways.":[77],"Perturbations":[78],"protein":[80],"translation,":[81],"proteostasis,":[82],"mitochondrial":[83],"function,":[84],"genome":[85],"nucleolar":[87],"integrity,":[88],"lysosomal":[89],"homeostasis,":[90],"Golgi":[92],"function":[93],"all":[95],"trigger":[96],"responses.":[98],"Recent":[99],"studies":[100],"have":[101],"further":[102],"uncovered":[103],"roles":[104],"for":[105,166],"inter-organelle":[106],"communication,":[107],"effector-triggered":[108],"surveillance":[109,158],"lysosome-related":[111],"organelles,":[112],"physiological":[114],"signals":[115],"such":[116],"as":[117,162],"intestinal":[118],"distension":[119],"regulating":[121],"activation.":[123],"Here,":[124],"we":[125],"integrate":[126],"these":[127],"advances":[128],"into":[129],"an":[130],"organelle-":[131],"tissue-centric":[133],"framework":[134],"explore":[136],"parallels":[137],"with":[138],"other":[139],"organisms":[140],"identify":[142],"emerging":[143],"potentially":[145],"conserved":[146],"principles":[147],"damage":[149],"sensing":[150],"immunity.":[153],"These":[154],"findings":[155],"highlight":[156],"the":[157],"homeostasis":[161],"a":[163],"central":[164],"immunity":[167],"that":[168],"operates":[169],"beyond":[170],"mechanisms.":[173]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}