{"id":"https://openalex.org/W7223659902","doi":"https://doi.org/10.1200/jco-26-02432","title":"Dalmelitinib Plus Aumolertinib in Advanced NSCLC Patients With EGFR-TKI Resistance and MET Amplification: A Randomized Phase 3 Trial","display_name":"Dalmelitinib Plus Aumolertinib in Advanced NSCLC Patients With EGFR-TKI Resistance and MET Amplification: A Randomized Phase 3 Trial","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223659902","doi":"https://doi.org/10.1200/jco-26-02432","pmid":"https://pubmed.ncbi.nlm.nih.gov/42928710"},"language":"en","primary_location":{"id":"doi:10.1200/jco-26-02432","doi":"https://doi.org/10.1200/jco-26-02432","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco-26-02432","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO-26-02432","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO-26-02432","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000421284","display_name":"Ziming Li","orcid":"https://orcid.org/0000-0002-3647-8140","observed_orcids":["https://orcid.org/0000-0002-3647-8140"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziming Li","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-3647-8140","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159727466","display_name":"Xiaorong Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaorong Dong","raw_affiliation_strings":["Cancer Center, Hubei Key Laboratory of Precision Radiation Oncology, Institute of Radiation Oncology, Hubei International Scientific and Technological Cooperation Base of Precision Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Hubei Key Laboratory of Precision Radiation Oncology, Institute of Radiation Oncology, Hubei International Scientific and Technological Cooperation Base of Precision Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088577934","display_name":"Yan Yu","orcid":"https://orcid.org/0000-0002-8840-9497","observed_orcids":["https://orcid.org/0000-0002-8840-9497","https://orcid.org/0000-0001-5598-763X"]},"institutions":[{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yu","raw_affiliation_strings":["Department of Respiratory Medicine, Harbin Medical University Cancer Hospital, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0001-5598-763X","affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Harbin Medical University Cancer Hospital, Harbin, China","institution_ids":["https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112257965","display_name":"Wenxiu Yao","orcid":"https://orcid.org/0009-0008-0812-5656","observed_orcids":["https://orcid.org/0009-0008-0812-5656"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118556","display_name":"Sichuan Cancer Hospital","ror":"https://ror.org/029wq9x81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118556"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxiu Yao","raw_affiliation_strings":["Department of Thoracic Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159636588","display_name":"Yongzhong Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhong Luo","raw_affiliation_strings":["Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159705567","display_name":"Xiangjiao Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangjiao Meng","raw_affiliation_strings":["Department of Chest Radiotherapy, Shandong Cancer Hospital and Institute, Shandong First Medical University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Radiotherapy, Shandong Cancer Hospital and Institute, Shandong First Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101111015","display_name":"Xinmin Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinmin Yu","raw_affiliation_strings":["Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159618087","display_name":"Jie Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Hu","raw_affiliation_strings":["Department of Pulmonary Medicine, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086270619","display_name":"Lin Wu","orcid":"https://orcid.org/0000-0001-7078-7767","observed_orcids":["https://orcid.org/0000-0001-7078-7767"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wu","raw_affiliation_strings":["Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-7078-7767","affiliations":[{"raw_affiliation_string":"Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159725279","display_name":"Longhua Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longhua Sun","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151483829","display_name":"Zhangzhou Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210148548","display_name":"Fujian Provincial Cancer Hospital","ror":"https://ror.org/058ms9w43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148548"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangzhou Huang","raw_affiliation_strings":["Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210148548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075177256","display_name":"Dongqing Lv","orcid":"https://orcid.org/0000-0002-1132-0910","observed_orcids":["https://orcid.org/0000-0002-1132-0910"]},"institutions":[{"id":"https://openalex.org/I4210158774","display_name":"Zhejiang Taizhou Hospital","ror":"https://ror.org/05m0wv206","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158774","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongqing Lv","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Taizhou Hospital of Zhejiang Province, Taizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Taizhou Hospital of Zhejiang Province, Taizhou, China","institution_ids":["https://openalex.org/I4210158774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137310515","display_name":"Chunling Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunling Liu","raw_affiliation_strings":["Department of Thoracic Medicine, Cancer Hospital of Xinjiang Medical University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medicine, Cancer Hospital of Xinjiang Medical University, Urumqi, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159730944","display_name":"Zhenyong Zhang","orcid":"https://orcid.org/0009-0001-4498-8589","observed_orcids":["https://orcid.org/0009-0001-4498-8589"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyong Zhang","raw_affiliation_strings":["Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":"https://orcid.org/0009-0001-4498-8589","affiliations":[{"raw_affiliation_string":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159690465","display_name":"Xingya Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingya Li","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101498093","display_name":"Yongchang Zhang","orcid":"https://orcid.org/0000-0002-6829-7176","observed_orcids":["https://orcid.org/0000-0002-6829-7176"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchang Zhang","raw_affiliation_strings":["Early Clinical Trial Center, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-6829-7176","affiliations":[{"raw_affiliation_string":"Early Clinical Trial Center, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126959728","display_name":"Lixia Ma","orcid":"https://orcid.org/0009-0002-3103-5751","observed_orcids":["https://orcid.org/0009-0002-3103-5751"]},"institutions":[{"id":"https://openalex.org/I4210098607","display_name":"Jilin Province Tumor Hospital","ror":"https://ror.org/00vgek070","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098607"]},{"id":"https://openalex.org/I4210110118","display_name":"Hansoh Pharma (China)","ror":"https://ror.org/01z3hs762","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210110118"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixia Ma","raw_affiliation_strings":["Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","Department of Oncology, Jilin Cancer Hospital, Changchun, China"],"raw_orcid":"https://orcid.org/0009-0002-3103-5751","affiliations":[{"raw_affiliation_string":"Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210110118"]},{"raw_affiliation_string":"Department of Oncology, Jilin Cancer Hospital, Changchun, China","institution_ids":["https://openalex.org/I4210098607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159705315","display_name":"Jianhua Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhua Shi","raw_affiliation_strings":["Department of Internal Medicine, Linyi Cancer Hospital, Linyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Linyi Cancer Hospital, Linyi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159681839","display_name":"Ting Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wei","raw_affiliation_strings":["Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120976835","display_name":"Shujun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujun Li","raw_affiliation_strings":["Department of Lung Cancer, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lung Cancer, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159686452","display_name":"Lisi Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098607","display_name":"Jilin Province Tumor Hospital","ror":"https://ror.org/00vgek070","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098607"]},{"id":"https://openalex.org/I4210110118","display_name":"Hansoh Pharma (China)","ror":"https://ror.org/01z3hs762","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210110118"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lisi Ma","raw_affiliation_strings":["Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","Department of Oncology, Jilin Cancer Hospital, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210110118"]},{"raw_affiliation_string":"Department of Oncology, Jilin Cancer Hospital, Changchun, China","institution_ids":["https://openalex.org/I4210098607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030646788","display_name":"Wenzhao Qin","orcid":"https://orcid.org/0000-0001-5723-1844","observed_orcids":["https://orcid.org/0000-0001-5723-1844"]},"institutions":[{"id":"https://openalex.org/I4210110118","display_name":"Hansoh Pharma (China)","ror":"https://ror.org/01z3hs762","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210110118"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhao Qin","raw_affiliation_strings":["Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210110118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016802553","display_name":"Congmao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110118","display_name":"Hansoh Pharma (China)","ror":"https://ror.org/01z3hs762","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210110118"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congmao Wang","raw_affiliation_strings":["Translational Medicine Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210110118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122865393","display_name":"Xiaoqing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110118","display_name":"Hansoh Pharma (China)","ror":"https://ror.org/01z3hs762","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210110118"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Zhang","raw_affiliation_strings":["Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Center, Jiangsu Hansoh Pharmaceutical Group Co., Ltd, Shanghai, China","institution_ids":["https://openalex.org/I4210110118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004928583","display_name":"Shun L\u00fc","orcid":"https://orcid.org/0000-0001-8833-7262","observed_orcids":["https://orcid.org/0000-0001-8833-7262"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Lu","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-8833-7262","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":28,"corresponding_author_ids":["https://openalex.org/A5000421284","https://openalex.org/A5159727466"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112","https://openalex.org/I4210129222","https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84269832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"101200JCO2602432","last_page":"101200JCO2602432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aumolertinib","display_name":"aumolertinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.9049999713897705},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.8579999804496765},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8539999723434448},{"id":"https://openalex.org/keywords/third-generation-egfr-tki","display_name":"third-generation EGFR-TKI","score":0.6579999923706055},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5799999833106995},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9314000010490417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7458000183105469},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6827999949455261},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6484000086784363},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.585099995136261},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.48010000586509705},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4729999899864197},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.37059998512268066},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3163999915122986},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.31520000100135803},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.29409998655319214},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.25619998574256897},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco-26-02432","doi":"https://doi.org/10.1200/jco-26-02432","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco-26-02432","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO-26-02432","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:42928710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1200/jco-26-02432","doi":"https://doi.org/10.1200/jco-26-02432","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco-26-02432","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO-26-02432","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223659902.pdf","grobid_xml":"https://content.openalex.org/works/W7223659902.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3170763554","https://openalex.org/W4403470030","https://openalex.org/W2952892955","https://openalex.org/W4407585289","https://openalex.org/W2937226773","https://openalex.org/W2792303074","https://openalex.org/W4244741072","https://openalex.org/W4409822189","https://openalex.org/W2767615200","https://openalex.org/W4403473587"],"abstract_inverted_index":{"PURPOSE":[0],"MET":[1,52,80,86,98,103,268,280],"amplification":[2,87],"accounts":[3],"for":[4],"up":[5],"to":[6,11,113,159,196],"30%":[7],"of":[8,145,153,231],"acquired":[9],"resistance":[10],"EGFR-TKI,":[12],"especially":[13],"following":[14],"third-generation":[15,37],"EGFR-TKI":[16,38,84],"treatment,":[17],"yet":[18],"precision-targeted":[19],"therapeutic":[20],"options":[21],"remain":[22],"limited.":[23],"Early-phase":[24],"studies":[25],"demonstrated":[26],"promising":[27],"antitumor":[28],"activity":[29],"with":[30,35,46,73,184,189,237,242,248,259],"the":[31,36,172],"MET-TKI":[32],"dalmelitinib":[33],"combined":[34],"aumolertinib.":[39],"This":[40,62],"phase":[41,65],"3":[42,66],"trial":[43,67],"compared":[44],"dalmelitinib-aumolertinib":[45,114,160,185,243,252],"platinum-based":[47,116,163],"chemotherapy":[48,117,164,190],"in":[49,92,227,264,287],"EGFR":[50,78,266],"-mutated,":[51,79,267],"-amplified":[53,81,269],"advanced":[54,75,265],"NSCLC":[55,82,270],"after":[56,83,271],"EGFR-TKIs":[57],"progression.":[58,85],"PATIENTS":[59],"AND":[60],"METHODS":[61],"randomized,":[63],"open-label,":[64],"(":[68],"NCT06110663":[69],")":[70],"enrolled":[71,155],"patients":[72,156],"locally":[74],"or":[76,102,115,162],"metastatic":[77],"was":[88,122,168,181],"defined":[89],"by":[90,127],"fluorescence":[91],"situ":[93],"hybridization":[94],"as":[95,282],"a":[96,260,283],"mean":[97],"copy":[99],"number":[100],"\u22655":[101],"/":[104],"CEP7":[105],"ratio":[106],"\u22652.":[107],"Patients":[108],"were":[109,157,202,209,219],"randomly":[110],"assigned":[111,158],"(1:1)":[112],"groups.":[118],"The":[119,251],"primary":[120],"endpoint":[121],"progression-free":[123],"survival":[124,217],"(PFS)":[125],"assessed":[126],"blinded":[128],"independent":[129],"central":[130],"review":[131],"per":[132],"RECIST":[133],"1.1.":[134],"Secondary":[135],"endpoints":[136],"included":[137],"overall":[138],"survival,":[139],"objective":[140],"response":[141,146],"rate":[142],"(ORR),":[143],"duration":[144],"(DoR),":[147],"and":[148,186,204,206,212,229,244],"safety.":[149],"RESULTS":[150],"A":[151],"total":[152],"314":[154],"(n=156)":[161],"(n=158).":[165],"Median":[166,179],"follow-up":[167],"11.2":[169],"months":[170,183,188,211],"at":[171],"data":[173,218],"cutoff":[174],"date":[175],"(December":[176],"10,":[177],"2025).":[178],"PFS":[180,256],"6.2":[182],"4.4":[187,213],"(HR,":[191],"0.60;":[192],"95%":[193],"CI,":[194],"0.45":[195],"0.81;":[197],"P":[198],"<0.001).":[199],"Corresponding":[200],"ORRs":[201],"59.6%":[203],"38.6%,":[205],"median":[207],"DoRs":[208],"9.7":[210],"months,":[214],"respectively.":[215,233],"Overall":[216],"immature.":[220],"Grade":[221],"\u22653":[222],"treatment-emergent":[223],"adverse":[224],"events":[225],"occurred":[226],"50.0%":[228],"51.0%":[230],"patients,":[232],"Toxicity":[234],"profiles":[235],"differed,":[236],"more":[238,245],"hepatic":[239],"laboratory":[240],"abnormalities":[241],"hematologic":[246],"toxicities":[247],"chemotherapy.":[249],"CONCLUSION":[250],"combination":[253],"significantly":[254],"improved":[255],"versus":[257],"chemotherapy,":[258],"manageable":[261],"safety":[262],"profile":[263],"progression":[272],"on":[273],"EGFR-TKI.":[274],"These":[275],"findings":[276],"support":[277],"dual":[278],"EGFR/":[279],"inhibition":[281],"new":[284],"treatment":[285],"option":[286],"this":[288],"biomarker":[289],"selected":[290],"population.":[291]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}