{"id":"https://openalex.org/W7223659577","doi":"https://doi.org/10.1371/journal.pone.0360619","title":"Oral versus vaginal Lactobacillus supplementation for endometrial dysbiosis: A paired pre and post\u2013endometrial microbiome study","display_name":"Oral versus vaginal Lactobacillus supplementation for endometrial dysbiosis: A paired pre and post\u2013endometrial microbiome study","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223659577","doi":"https://doi.org/10.1371/journal.pone.0360619","pmid":"https://pubmed.ncbi.nlm.nih.gov/42932302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13704797"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0360619","doi":"https://doi.org/10.1371/journal.pone.0360619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0360619","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0360619&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0360619&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051109702","display_name":"Daiki Hiratsuka","orcid":"https://orcid.org/0000-0001-7128-2859","observed_orcids":["https://orcid.org/0000-0001-7128-2859"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daiki Hiratsuka","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":"https://orcid.org/0000-0001-7128-2859","affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090231940","display_name":"Ayumi Iki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayumi Iki","raw_affiliation_strings":["Tsubaki Women\u2019s Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsubaki Women\u2019s Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108961330","display_name":"Mayu Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayu Kinoshita","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127942458","display_name":"Yumiko Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Doi","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127970214","display_name":"Okikaze Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Okikaze Kato","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159730728","display_name":"Kotaro Oshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Oshima","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045306675","display_name":"Takehiro Hiraoka","orcid":"https://orcid.org/0009-0006-4030-3278","observed_orcids":["https://orcid.org/0009-0006-4030-3278"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiro Hiraoka","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110517462","display_name":"Mitsunori Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunori Matsuo","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068210602","display_name":"Mari Ichinose","orcid":"https://orcid.org/0000-0002-2974-9109","observed_orcids":["https://orcid.org/0000-0002-2974-9109"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Ichinose","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078453569","display_name":"Tomoko Makabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Makabe","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027864476","display_name":"Gentaro Izumi","orcid":"https://orcid.org/0000-0002-4546-1084","observed_orcids":["https://orcid.org/0000-0002-4546-1084"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gentaro Izumi","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007356351","display_name":"Miyuki Harada","orcid":"https://orcid.org/0000-0003-1071-5600","observed_orcids":["https://orcid.org/0000-0003-1071-5600"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyuki Harada","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023828520","display_name":"Yasushi Hirota","orcid":"https://orcid.org/0000-0003-0241-9780","observed_orcids":["https://orcid.org/0000-0003-0241-9780"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasushi Hirota","raw_affiliation_strings":["The University of Tokyo"],"raw_orcid":"https://orcid.org/0000-0003-0241-9780","affiliations":[{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091885087","display_name":"Motowo Nabeta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motowo Nabeta","raw_affiliation_strings":["Tsubaki Women\u2019s Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsubaki Women\u2019s Clinic","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023828520"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83454071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0360619","last_page":"e0360619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaginal-probiotics","display_name":"vaginal probiotics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oral-probiotics","display_name":"oral probiotics","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endometrial-microbiota","display_name":"endometrial microbiota","score":0.8399999737739563},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intrauterine-fluid","display_name":"intrauterine fluid","score":0.640999972820282},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.8199999928474426},{"id":"https://openalex.org/keywords/reproductive-outcomes","display_name":"reproductive outcomes","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.8289999961853027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6449999809265137},{"id":"https://openalex.org/C2780236403","wikidata":"https://www.wikidata.org/wiki/Q2355641","display_name":"Lactobacillus crispatus","level":4,"score":0.5870000123977661},{"id":"https://openalex.org/C2776651480","wikidata":"https://www.wikidata.org/wiki/Q1607640","display_name":"Lactobacillus rhamnosus","level":4,"score":0.5425000190734863},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4934000074863434},{"id":"https://openalex.org/C2778536940","wikidata":"https://www.wikidata.org/wiki/Q1975869","display_name":"Lactobacillus gasseri","level":4,"score":0.47510001063346863},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.4666000008583069},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44369998574256897},{"id":"https://openalex.org/C2777221637","wikidata":"https://www.wikidata.org/wiki/Q132644","display_name":"Lactobacillus acidophilus","level":4,"score":0.4334000051021576},{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.4156000018119812},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.40389999747276306},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3874000012874603},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35409998893737793},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.3188000023365021},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C2777831542","wikidata":"https://www.wikidata.org/wiki/Q537478","display_name":"Vaginal flora","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2637999951839447}],"mesh":[{"descriptor_ui":"D000282","descriptor_name":"Administration, Intravaginal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0360619","doi":"https://doi.org/10.1371/journal.pone.0360619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0360619","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0360619&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmid:42932302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42932302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13704797","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13704797/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9488c32ebeaa4855848a6c97d7dcc812","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9488c32ebeaa4855848a6c97d7dcc812","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 10 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0360619","doi":"https://doi.org/10.1371/journal.pone.0360619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0360619","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0360619&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8009361466","display_name":"\u7740\u5e8a\u671f\u80da\u6d78\u6f64\u306b\u7740\u76ee\u3057\u305f\u598a\u5a20\u6210\u7acb\u6a5f\u69cb\u306e\u89e3\u660e","funder_award_id":"JPMJFR210H","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223659577.pdf","grobid_xml":"https://content.openalex.org/works/W7223659577.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1992877842","https://openalex.org/W1996280689","https://openalex.org/W2013371150","https://openalex.org/W2130126684","https://openalex.org/W2149188810","https://openalex.org/W2528495505","https://openalex.org/W2898257263","https://openalex.org/W2983491158","https://openalex.org/W2991431315","https://openalex.org/W3042680229","https://openalex.org/W3170489391","https://openalex.org/W3182384550","https://openalex.org/W4221009865","https://openalex.org/W4226152779","https://openalex.org/W4280520979","https://openalex.org/W4282601806","https://openalex.org/W4311928122","https://openalex.org/W4380768002","https://openalex.org/W4386056589","https://openalex.org/W4391513946","https://openalex.org/W4398794743","https://openalex.org/W4400830445","https://openalex.org/W4401388346","https://openalex.org/W4403791222","https://openalex.org/W4405384102","https://openalex.org/W4408283044","https://openalex.org/W4408284928","https://openalex.org/W4417010193","https://openalex.org/W7125419963","https://openalex.org/W7133324497","https://openalex.org/W7135215998","https://openalex.org/W7163425941"],"related_works":["https://openalex.org/W4323894162","https://openalex.org/W4292806713","https://openalex.org/W2898257263","https://openalex.org/W7083168903","https://openalex.org/W7125419963","https://openalex.org/W4283723202","https://openalex.org/W3042680229","https://openalex.org/W4310532690","https://openalex.org/W4391513946","https://openalex.org/W7221267389"],"abstract_inverted_index":{"Infertility":[0],"is":[1,50],"a":[2,21,34,53,237,255],"global":[3],"health":[4],"challenge,":[5],"and":[6,43,45,84,106,123,213,233],"impaired":[7],"endometrial":[8,28,41,92,101,107,119,143,261],"receptivity":[9,42],"remains":[10,64],"an":[11,78,196],"important":[12],"contributor":[13],"to":[14,80,150,166],"treatment":[15,46,248],"failure.":[16],"Endometrial":[17],"dysbiosis,":[18],"characterized":[19],"by":[20,228],"low":[22],"proportion":[23,145],"of":[24,61,100,127,199],"Lactobacillus":[25,62,93,144,192,251],"in":[26,88,157,205,209,216,260],"the":[27,58,73,138,141,158,210,217,229],"microbiota,":[29],"has":[30],"been":[31],"proposed":[32],"as":[33,52,77,195],"potentially":[35],"modifiable":[36],"factor":[37],"that":[38],"may":[39,253],"affect":[40],"fertility,":[44],"with":[47,90,177],"Lactobacillus-containing":[48,75],"probiotics":[49],"emerging":[51],"promising":[54],"therapeutic":[55],"approach.":[56],"However,":[57],"optimal":[59],"route":[60],"supplementation":[63,71,128,181,252],"unclear.":[65],"We":[66],"compared":[67],"oral":[68,86,159,180,218,265],"versus":[69,179],"vaginal":[70,139,178,211,250],"using":[72],"same":[74],"formulation":[76],"adjunct":[79],"standardized":[81],"doxycycline/metronidazole":[82],"therapy":[83],"continued":[85],"lactoferrin":[87],"patients":[89,116,207],"baseline":[91],"<10%,":[94],"based":[95],"on":[96],"paired":[97,118],"microbiome":[98,120],"profiling":[99],"samples":[102],"(aspirated":[103],"intrauterine":[104],"fluid":[105],"tissue).":[108],"In":[109,137],"this":[110,246],"single-center":[111],"retrospective":[112],"cohort":[113],"study,":[114],"thirty-two":[115],"underwent":[117],"testing":[121],"before":[122],"after":[124],"30":[125],"days":[126],"(oral,":[129],"n":[130,134],"=":[131,135,154,170,221],"18;":[132],"vaginal,":[133],"14).":[136],"group,":[140],"median":[142,173],"increased":[146,162],"from":[147,163],"0.05%":[148],"[0.00-0.20]":[149],"99.15%":[151],"[70.45-100.00]":[152],"(p":[153,169,220],"0.001),":[155],"whereas":[156],"group":[160,212,219],"it":[161],"0.00%":[164],"[0.00-0.18]":[165],"0.30%":[167],"[0.03-66.33]":[168],"0.005).":[171],"The":[172],"change":[174],"was":[175,203],"greater":[176,256],"(+98.90%":[182],"[70.45-99.80]":[183],"vs":[184],"+":[185],"0.25%":[186],"[0.03-66.33],":[187],"p":[188],"<":[189],"0.001).":[190],"Post-treatment":[191],"\u226580%,":[193],"used":[194],"exploratory":[197],"marker":[198],"marked":[200],"microbiota":[201,262],"improvement,":[202],"observed":[204],"9/14":[206],"(64%)":[208],"3/18":[214],"(17%)":[215],"0.010).":[222],"Exploratory":[223],"reproductive":[224],"outcomes":[225],"were":[226],"limited":[227],"small":[230],"sample":[231],"size":[232],"did":[234],"not":[235],"define":[236],"reliable":[238],"clinical":[239],"threshold.":[240],"These":[241],"findings":[242],"suggest":[243],"that,":[244],"within":[245],"combined":[247],"regimen,":[249],"provide":[254],"route-associated":[257],"additional":[258],"improvement":[259],"profiles":[263],"than":[264],"administration.":[266]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-27T00:00:00"}
