{"id":"https://openalex.org/W7223649693","doi":"https://doi.org/10.1021/acs.biochem.6c00557","title":"Slower Motions and Dramatic Conformational Populations Present in A:G Mismatched DNA Phosphates","display_name":"Slower Motions and Dramatic Conformational Populations Present in A:G Mismatched DNA Phosphates","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223649693","doi":"https://doi.org/10.1021/acs.biochem.6c00557"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.6c00557","doi":"https://doi.org/10.1021/acs.biochem.6c00557","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biochem.6c00557","pdf_url":"https://pubs.acs.org/bichaw/article-pdf/doi/10.1021/acs.biochem.6c00557/68984597/acs.biochem.6c00557.pdf","source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/bichaw/article-pdf/doi/10.1021/acs.biochem.6c00557/68984597/acs.biochem.6c00557.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159693617","display_name":"Theodora Osborne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77310417","display_name":"Evangel University","ror":"https://ror.org/05shfp710","country_code":"US","type":"education","lineage":["https://openalex.org/I77310417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodora Osborne","raw_affiliation_strings":["Evangel University , 1111 N Glenstone Ave , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangel University , 1111 N Glenstone Ave , , ,","institution_ids":["https://openalex.org/I77310417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159678605","display_name":"Hunter Kimberlin-Poore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119942284","display_name":"Missouri State University","ror":"https://ror.org/01d2sez20","country_code":"US","type":"education","lineage":["https://openalex.org/I119942284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter Kimberlin-Poore","raw_affiliation_strings":["Missouri State University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Missouri State University , , , ,","institution_ids":["https://openalex.org/I119942284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061613058","display_name":"Gary A. Meints","orcid":"https://orcid.org/0000-0001-6967-7966","observed_orcids":["https://orcid.org/0000-0001-6967-7966"]},"institutions":[{"id":"https://openalex.org/I119942284","display_name":"Missouri State University","ror":"https://ror.org/01d2sez20","country_code":"US","type":"education","lineage":["https://openalex.org/I119942284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary A. Meints","raw_affiliation_strings":["Missouri State University , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-6967-7966","affiliations":[{"raw_affiliation_string":"Missouri State University , , , ,","institution_ids":["https://openalex.org/I119942284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061613058"],"corresponding_institution_ids":["https://openalex.org/I119942284"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75951353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.6869999766349792},{"id":"https://openalex.org/keywords/dna-conformational-dynamics","display_name":"DNA conformational dynamics","score":0.7020000219345093},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8209999799728394},{"id":"https://openalex.org/keywords/muts","display_name":"MutS","score":0.6930000185966492},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.5090000033378601},{"id":"https://openalex.org/keywords/heteroduplex","display_name":"heteroduplex","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6629999876022339},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5706999897956848},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5680999755859375},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.545199990272522},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5418000221252441},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5289999842643738},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.48429998755455017},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4794999957084656},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46650001406669617},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41589999198913574},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3359000086784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31869998574256897},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29010000824928284},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2854999899864197},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.27889999747276306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27090001106262207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26339998841285706},{"id":"https://openalex.org/C195116880","wikidata":"https://www.wikidata.org/wiki/Q4859565","display_name":"Sticky and blunt ends","level":4,"score":0.2621999979019165},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.2567000091075897},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.biochem.6c00557","doi":"https://doi.org/10.1021/acs.biochem.6c00557","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biochem.6c00557","pdf_url":"https://pubs.acs.org/bichaw/article-pdf/doi/10.1021/acs.biochem.6c00557/68984597/acs.biochem.6c00557.pdf","source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acs.biochem.6c00557","doi":"https://doi.org/10.1021/acs.biochem.6c00557","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biochem.6c00557","pdf_url":"https://pubs.acs.org/bichaw/article-pdf/doi/10.1021/acs.biochem.6c00557/68984597/acs.biochem.6c00557.pdf","source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312445","display_name":"Missouri State University","ror":"https://ror.org/01d2sez20"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223649693.pdf","grobid_xml":"https://content.openalex.org/works/W7223649693.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1030900860","https://openalex.org/W1491876634","https://openalex.org/W1504024377","https://openalex.org/W1982856746","https://openalex.org/W1996663284","https://openalex.org/W2003729258","https://openalex.org/W2011043383","https://openalex.org/W2024322354","https://openalex.org/W2027982808","https://openalex.org/W2034823280","https://openalex.org/W2037898576","https://openalex.org/W2050904973","https://openalex.org/W2051520616","https://openalex.org/W2058461284","https://openalex.org/W2065331255","https://openalex.org/W2066314749","https://openalex.org/W2066558081","https://openalex.org/W2074726831","https://openalex.org/W2093074341","https://openalex.org/W2095395495","https://openalex.org/W2112331024","https://openalex.org/W2124295966","https://openalex.org/W2127751112","https://openalex.org/W2136615212","https://openalex.org/W2142096492","https://openalex.org/W2143675334","https://openalex.org/W2333131333","https://openalex.org/W2598523950","https://openalex.org/W2600380703","https://openalex.org/W2951392003","https://openalex.org/W3048419264","https://openalex.org/W3094281091","https://openalex.org/W3135587559","https://openalex.org/W4211074093","https://openalex.org/W4221057562","https://openalex.org/W4313812449","https://openalex.org/W4366823925","https://openalex.org/W4386632261","https://openalex.org/W4404202525","https://openalex.org/W4410205410"],"related_works":["https://openalex.org/W2333131333","https://openalex.org/W3130512877","https://openalex.org/W2803676560","https://openalex.org/W1990169533","https://openalex.org/W4386632261","https://openalex.org/W3170494377","https://openalex.org/W3126973234","https://openalex.org/W4211088429","https://openalex.org/W2060342115","https://openalex.org/W4402395095"],"abstract_inverted_index":{"Abstract":[0],"Mismatches":[1],"such":[2,84,196],"as":[3,18,20,85,197],"A:G":[4,140],"base":[5,142],"pairs":[6],"arise":[7],"in":[8,127,151,185],"DNA":[9,50],"primarily":[10],"due":[11],"to":[12,36,55,177],"improper":[13],"nucleotide":[14],"incorporation":[15],"during":[16,190],"replication":[17,54],"well":[19],"formation":[21],"of":[22,26,31,62,90,107,130,161,172],"a":[23,124,186],"heteroduplex.":[24],"Repair":[25,41,67],"these":[27],"mismatches":[28,51],"and":[29,52,71,75,88,94,132,169],"prevention":[30],"deleterious":[32],"mutations":[33],"is":[34,43,101,159],"vital":[35],"an":[37,139],"organism\u2019s":[38],"survival.":[39],"Mismatch":[40],"(MMR)":[42],"the":[44,81,91,95,104,136,148,152,170,173],"primary":[45],"repair":[46,92,194],"pathway":[47],"for":[48,135],"general":[49],"follows":[53],"maintain":[56],"genomic":[57],"integrity;":[58],"however,":[59],"some":[60],"details":[61],"mismatch":[63],"recognition":[64],"are":[65,150],"unknown.":[66],"invariably":[68],"requires":[69],"precise":[70],"localized":[72],"DNA\u2013protein":[73],"interactions":[74],"binding":[76],"processes":[77],"that":[78,103],"depend":[79],"on":[80],"specific":[82],"properties,":[83],"conformational":[86,105,133],"structure":[87],"dynamics,":[89],"protein":[93],"damaged":[96],"dsDNA":[97],"substrate.":[98],"Therefore,":[99],"it":[100],"likely":[102],"properties":[106],"damaged,":[108],"mismatched":[109,141],"or":[110],"modified":[111],"DNAs":[112],"will":[113],"be":[114,183],"different":[115],"than":[116,164],"canonical":[117],"duplexed":[118],"DNA.":[119],"The":[120],"work":[121],"herein":[122],"demonstrates":[123],"dramatic":[125],"shift":[126],"time":[128,154],"scale":[129,155],"motions":[131,149],"populations":[134],"phosphate":[137,187],"flanking":[138],"pair.":[143],"31P":[144],"NMR":[145],"results":[146,166],"show":[147],"intermediate":[153],"(10\u20133":[156],"s),":[157,168],"which":[158],"orders":[160],"magnitude":[162],"slower":[163],"prior":[165],"(10\u20135\u201310\u20139":[167],"population":[171],"BII":[174],"substate":[175],"shifts":[176],"\u223c":[178],"99%.":[179],"These":[180],"perturbations":[181],"could":[182],"utilized":[184],"tracking":[188],"mechanism":[189],"indirect":[191],"readout":[192],"by":[193],"enzymes":[195],"MutS.":[198]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-27T00:00:00"}