{"id":"https://openalex.org/W7223648360","doi":"https://doi.org/10.1038/s41598-026-67838-7","title":"Modified BRICS sequential regimen in advanced hepatocellular carcinoma patients with BCLC C stage: a real-world study","display_name":"Modified BRICS sequential regimen in advanced hepatocellular carcinoma patients with BCLC C stage: a real-world study","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7223648360","doi":"https://doi.org/10.1038/s41598-026-67838-7"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-67838-7","doi":"https://doi.org/10.1038/s41598-026-67838-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67838-7","pdf_url":"https://www.nature.com/articles/s41598-026-67838-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-67838-7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159734740","display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, 314000, Zhejiang, China","Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, 314000, Zhejiang, China","institution_ids":[]},{"raw_affiliation_string":"Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]},{"raw_affiliation_string":"Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045042729","display_name":"Junhui Wang","orcid":"https://orcid.org/0000-0003-2989-7192","observed_orcids":["https://orcid.org/0000-0003-2989-7192"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhui Wang","raw_affiliation_strings":["Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, 314000, Zhejiang, China","Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, 314000, Zhejiang, China","institution_ids":[]},{"raw_affiliation_string":"Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]},{"raw_affiliation_string":"Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159605270","display_name":"Yonghai Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yonghai Peng","raw_affiliation_strings":["Department of Oncology, Cangshan Hospital Area, 900 Hospital of the Joint Logistics Support Force. 350000, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Cangshan Hospital Area, 900 Hospital of the Joint Logistics Support Force. 350000, Fujian, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124456441","display_name":"Jianxin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210088331","display_name":"Quzhou City People's Hospital","ror":"https://ror.org/004qehs09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088331"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianxin Chen","raw_affiliation_strings":["Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People\u2032s Hospital, Quzhou, 324000, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5124456441","https://openalex.org/A5159605270"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210088331"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7949716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-hepatocellular-carcinoma","display_name":"advanced hepatocellular carcinoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bclc-stage-c","display_name":"BCLC stage C","score":0.9789999723434448},{"id":"https://openalex.org/keywords/metastatic-burden","display_name":"metastatic burden","score":0.847000002861023},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9027000069618225},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8356000185012817},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7156999707221985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7005000114440918},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6330999732017517},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6204000115394592},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5123000144958496},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4749000072479248},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.4742000102996826},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.39910000562667847},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.37059998512268066},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30630001425743103},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41598-026-67838-7","doi":"https://doi.org/10.1038/s41598-026-67838-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67838-7","pdf_url":"https://www.nature.com/articles/s41598-026-67838-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e3d2727cca3c49d7b67b690b5f605604","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e3d2727cca3c49d7b67b690b5f605604","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-67838-7","doi":"https://doi.org/10.1038/s41598-026-67838-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-67838-7","pdf_url":"https://www.nature.com/articles/s41598-026-67838-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223648360.pdf","grobid_xml":"https://content.openalex.org/works/W7223648360.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1971837077","https://openalex.org/W2032166347","https://openalex.org/W2170366300","https://openalex.org/W2194546364","https://openalex.org/W2578888194","https://openalex.org/W2587048937","https://openalex.org/W2606367731","https://openalex.org/W2739633277","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2782333299","https://openalex.org/W2783703728","https://openalex.org/W2787358630","https://openalex.org/W2791328450","https://openalex.org/W2792376809","https://openalex.org/W2805592007","https://openalex.org/W2956407134","https://openalex.org/W3015860015","https://openalex.org/W3025022288","https://openalex.org/W4210774372","https://openalex.org/W4220827333","https://openalex.org/W4411566005"],"related_works":["https://openalex.org/W7131676154","https://openalex.org/W4410815712","https://openalex.org/W4379282626","https://openalex.org/W4414306283","https://openalex.org/W4381436756","https://openalex.org/W3156301573","https://openalex.org/W4388416456","https://openalex.org/W4307151665","https://openalex.org/W4415297387","https://openalex.org/W4399517697"],"abstract_inverted_index":{"Patients":[0,127],"with":[1,31,47,128,158,178],"advanced":[2,48,173],"hepatocellular":[3],"carcinoma":[4],"(HCC)":[5],"have":[6],"limited":[7,179],"treatment":[8],"options":[9],"and":[10,18,28,72,89,106,112,120,169],"poor":[11],"prognosis.":[12],"This":[13],"study":[14],"evaluates":[15],"the":[16,54],"efficacy":[17,168],"safety":[19,171],"of":[20,156,187],"a":[21,32,38,65],"modified":[22,55,163],"BRICS":[23,56,164],"(Bifidobacterium-based":[24],"probiotics,":[25,69],"Radiotherapy,":[26],"Immunotherapy,":[27],"anti-angiogenic":[29,73],"therapy":[30,190],"Stereotactic":[33],"approach)":[34],"sequential":[35,189],"regimen":[36,165],"in":[37,153,172,176,191],"real-world":[39],"setting.":[40],"In":[41],"this":[42],"retrospective":[43],"study,":[44],"22":[45],"patients":[46,177],"HCC":[49],"(BCLC":[50],"stage":[51],"C)":[52],"received":[53],"regimen,":[57],"which":[58],"included":[59,77],"stereotactic":[60],"body":[61],"radiotherapy":[62],"(SBRT)":[63],"to":[64],"single":[66],"lesion,":[67],"high-dose":[68],"anti-PD-1":[70],"immunotherapy,":[71],"agents.":[74],"Efficacy":[75],"endpoints":[76],"objective":[78],"response":[79],"rate":[80,84],"(ORR),":[81],"disease":[82],"control":[83],"(DCR),":[85],"progression-free":[86],"survival":[87,91],"(PFS),":[88],"overall":[90],"(OS).":[92],"Safety":[93],"was":[94,101,108],"assessed":[95],"per":[96],"NCI-CTCAE":[97],"v4.0.":[98],"The":[99,162],"ORR":[100],"59.1%":[102],"(95%":[103,117,123],"CI:":[104,118,124],"36.4\u201379.3%),":[105],"DCR":[107],"100%.":[109],"Median":[110],"PFS":[111],"OS":[113],"were":[114],"9.5":[115],"months":[116,122],"7.78\u201311.22)":[119],"22.4":[121],"8.24\u201336.57),":[125],"respectively.":[126],"<2":[129],"metastatic":[130,180],"organs":[131],"had":[132],"significantly":[133],"better":[134],"outcomes":[135],"(median":[136],"PFS:":[137],"10.5":[138],"vs.":[139,145],"3.8":[140],"months;":[141],"median":[142],"OS:":[143],"26.4":[144],"5.2":[146],"months).":[147],"Grade":[148],"3\u20134":[149],"adverse":[150],"events":[151],"occurred":[152],"only":[154],"4.5%":[155],"patients,":[157],"no":[159],"treatment-related":[160],"deaths.":[161],"demonstrated":[166],"promising":[167],"favorable":[170],"HCC,":[174],"particularly":[175],"burden.":[181],"These":[182],"findings":[183],"support":[184],"further":[185],"investigation":[186],"multimodal":[188],"larger":[192],"prospective":[193],"studies.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-27T00:00:00"}