{"id":"https://openalex.org/W7223567366","doi":"https://doi.org/10.1016/j.htct.2026.106861","title":"EFFICACY AND SAFETY OF HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION AS FIRST-LINE TREATMENT FOR SEVERE APLASTIC ANEMIA IN CHILDREN: A SYSTEMATIC REVIEW","display_name":"EFFICACY AND SAFETY OF HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION AS FIRST-LINE TREATMENT FOR SEVERE APLASTIC ANEMIA IN CHILDREN: A SYSTEMATIC REVIEW","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223567366","doi":"https://doi.org/10.1016/j.htct.2026.106861"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:1b13b811f3714eb28a078836c27757fb","doi":"https://doi.org/10.1016/j.htct.2026.106861","is_oa":false,"landing_page_url":"https://doaj.org/article/1b13b811f3714eb28a078836c27757fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 106861- (2026)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159188519","display_name":"Pedro Henrique Rodrigues VIANA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Henrique Rodrigues VIANA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080022502","display_name":"Lucas de Barros Anast\u00e1cio","orcid":"https://orcid.org/0000-0002-7458-3005","observed_orcids":["https://orcid.org/0000-0002-7458-3005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas De Barros ANAST\u00e1CIO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82999874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haploidentical-hematopoietic-stem-cell-transplantation","display_name":"haploidentical hematopoietic stem cell transplantation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/severe-aplastic-anemia","display_name":"severe aplastic anemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9110000133514404},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.652999997138977},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/post-transplant-cyclophosphamide","display_name":"post-transplant cyclophosphamide","score":0.8809999823570251},{"id":"https://openalex.org/keywords/myeloid-engraftment","display_name":"myeloid engraftment","score":0.8500000238418579},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.972000002861023},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/matched-related-donor-transplantation","display_name":"matched related donor transplantation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.4860000014305115},{"id":"https://openalex.org/keywords/graft-versus-tumor-effect","display_name":"graft-versus-tumor effect","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8167999982833862},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.6437000036239624},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.616599977016449},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5705999732017517},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5052000284194946},{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.4537999927997589},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4366999864578247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42980000376701355},{"id":"https://openalex.org/C2777596629","wikidata":"https://www.wikidata.org/wiki/Q10858520","display_name":"Inclusion and exclusion criteria","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3822999894618988},{"id":"https://openalex.org/C2780525284","wikidata":"https://www.wikidata.org/wiki/Q7882181","display_name":"Bone marrow failure","level":4,"score":0.367000013589859},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.3206999897956848},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3068999946117401},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.3061999976634979},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2962999939918518},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C114538912","wikidata":"https://www.wikidata.org/wiki/Q290507","display_name":"Savior sibling","level":4,"score":0.25209999084472656},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:1b13b811f3714eb28a078836c27757fb","doi":"https://doi.org/10.1016/j.htct.2026.106861","is_oa":false,"landing_page_url":"https://doaj.org/article/1b13b811f3714eb28a078836c27757fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 106861- (2026)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3032062081","https://openalex.org/W2378676025","https://openalex.org/W2565516774","https://openalex.org/W2990796421","https://openalex.org/W2949528376","https://openalex.org/W2412296040","https://openalex.org/W7108449101","https://openalex.org/W1764338921","https://openalex.org/W4394925439","https://openalex.org/W2582084403"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-26T00:00:00"}