{"id":"https://openalex.org/W7223567140","doi":"https://doi.org/10.1111/apt.71062","title":"Baseline Clearance and Early Troughs Identify Candidates for Early Therapeutic Drug Monitoring During Infliximab Induction in Inflammatory Bowel Disease","display_name":"Baseline Clearance and Early Troughs Identify Candidates for Early Therapeutic Drug Monitoring During Infliximab Induction in Inflammatory Bowel Disease","publication_year":2026,"publication_date":"2026-10-25","ids":{"openalex":"https://openalex.org/W7223567140","doi":"https://doi.org/10.1111/apt.71062","pmid":"https://pubmed.ncbi.nlm.nih.gov/42928429"},"language":"en","primary_location":{"id":"doi:10.1111/apt.71062","doi":"https://doi.org/10.1111/apt.71062","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.71062","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.71062","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.71062","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029644584","display_name":"Juma A. Mohamedi","orcid":"https://orcid.org/0000-0002-7945-3007","observed_orcids":["https://orcid.org/0000-0002-7945-3007"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","TZ"],"is_corresponding":false,"raw_author_name":"Juma A. Mohamedi","raw_affiliation_strings":["Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium","Department of Pharmaceutics Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania"],"raw_orcid":"https://orcid.org/0000-0002-7945-3007","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Pharmaceutics Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088501436","display_name":"Yannick Hoffert","orcid":"https://orcid.org/0000-0002-1631-9484","observed_orcids":["https://orcid.org/0000-0002-1631-9484"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yannick Hoffert","raw_affiliation_strings":["Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071251967","display_name":"Nick Geukens","orcid":"https://orcid.org/0000-0001-5706-1072","observed_orcids":["https://orcid.org/0000-0001-5706-1072"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nick Geukens","raw_affiliation_strings":["PharmAbs, The KU Leuven Antibody Center KU Leuven  Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmAbs, The KU Leuven Antibody Center KU Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062572039","display_name":"Jean\u2010Fran\u00e7ois Rahier","orcid":"https://orcid.org/0000-0002-7738-0238","observed_orcids":["https://orcid.org/0000-0002-7738-0238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean\u2010Fran\u00e7ois Rahier","raw_affiliation_strings":["Department of Gastroenterology CHU Namur  Yvoir Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology CHU Namur  Yvoir Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065356435","display_name":"Edouard J. Louis","orcid":"https://orcid.org/0000-0002-1287-7075","observed_orcids":["https://orcid.org/0000-0002-1287-7075"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Edouard Louis","raw_affiliation_strings":["Department of Gastroenterology CHU Li\u00e8ge  Li\u00e8ge Belgium"],"raw_orcid":"https://orcid.org/0000-0002-1287-7075","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology CHU Li\u00e8ge  Li\u00e8ge Belgium","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103548181","display_name":"Filip J. Baert","orcid":"https://orcid.org/0009-0003-4370-6708","observed_orcids":["https://orcid.org/0009-0003-4370-6708"]},"institutions":[{"id":"https://openalex.org/I4210144110","display_name":"AZ Delta","ror":"https://ror.org/04b0her22","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210144110"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Filip Baert","raw_affiliation_strings":["Department of Gastroenterology AZ Delta  Roeselare Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology AZ Delta  Roeselare Belgium","institution_ids":["https://openalex.org/I4210144110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052554865","display_name":"Pieter Dewint","orcid":"https://orcid.org/0000-0002-1002-9822","observed_orcids":["https://orcid.org/0000-0002-1002-9822"]},"institutions":[{"id":"https://openalex.org/I4210143543","display_name":"AZ Maria Middelares","ror":"https://ror.org/048pv7s22","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210143543"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pieter Dewint","raw_affiliation_strings":["Department of Gastroenterology AZ Maria Middelares  Gent Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology AZ Maria Middelares  Gent Belgium","institution_ids":["https://openalex.org/I4210143543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007991769","display_name":"Guy L.Y. Lambrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131339","display_name":"Damiaan Dicht bij het leven","ror":"https://ror.org/03w1sg385","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210131339"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Lambrecht","raw_affiliation_strings":["Department of Gastroenterology AZ Damiaan  Oostende Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology AZ Damiaan  Oostende Belgium","institution_ids":["https://openalex.org/I4210131339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021791508","display_name":"Peter J. Bossuyt","orcid":"https://orcid.org/0000-0003-4027-7365","observed_orcids":["https://orcid.org/0000-0003-4027-7365"]},"institutions":[{"id":"https://openalex.org/I4210135614","display_name":"Imelda Hospital","ror":"https://ror.org/037s71n47","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210135614"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Peter Bossuyt","raw_affiliation_strings":["Department of Gastroenterology Imelda General Hospital  Bonheiden Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4027-7365","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Imelda General Hospital  Bonheiden Belgium","institution_ids":["https://openalex.org/I4210135614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051472632","display_name":"Raphael Zozimus Sangeda","orcid":"https://orcid.org/0000-0002-6574-5308","observed_orcids":["https://orcid.org/0000-0002-6574-5308"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Raphael Z. Sangeda","raw_affiliation_strings":["Department of Pharmaceutical Microbiology Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania"],"raw_orcid":"https://orcid.org/0000-0002-6574-5308","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Microbiology Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029428855","display_name":"Marc Ferrante","orcid":"https://orcid.org/0000-0003-1492-0716","observed_orcids":["https://orcid.org/0000-0003-1492-0716"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc Ferrante","raw_affiliation_strings":["Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium","Department of Gastroenterology and Hepatology UZ Leuven  Leuven Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1492-0716","affiliations":[{"raw_affiliation_string":"Department of Chronic Diseases and Metabolism KU Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology UZ Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029097636","display_name":"Denis Paul Franchimont","orcid":"https://orcid.org/0000-0001-8856-3462","observed_orcids":["https://orcid.org/0000-0001-8856-3462"]},"institutions":[{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Denis Franchimont","raw_affiliation_strings":["Department of Gastroenterology HUB H\u00f4pital Erasme  Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology HUB H\u00f4pital Erasme  Brussels Belgium","institution_ids":["https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049113823","display_name":"Claire Liefferinckx","orcid":"https://orcid.org/0000-0002-2046-4051","observed_orcids":["https://orcid.org/0000-0002-2046-4051"]},"institutions":[{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Claire Liefferinckx","raw_affiliation_strings":["Department of Gastroenterology HUB H\u00f4pital Erasme  Brussels Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2046-4051","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology HUB H\u00f4pital Erasme  Brussels Belgium","institution_ids":["https://openalex.org/I2802054198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024846292","display_name":"Erwin Dreesen","orcid":"https://orcid.org/0000-0002-0785-2930","observed_orcids":["https://orcid.org/0000-0002-0785-2930"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erwin Dreesen","raw_affiliation_strings":["Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium"],"raw_orcid":"https://orcid.org/0000-0002-0785-2930","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Pharmacological Sciences KU Leuven  Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":4.084,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95163004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8169999718666077},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8970000147819519},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6480000019073486},{"id":"https://openalex.org/keywords/exposure-response-relationship","display_name":"exposure-response relationship","score":0.6620000004768372},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.746999979019165},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.5130000114440918},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.7149999737739563},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9526000022888184},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.933899998664856},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8463000059127808},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.7717000246047974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6865000128746033},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6082000136375427},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.607200026512146},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5593000054359436},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.5579000115394592},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.5307000279426575},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5206999778747559},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C2779008522","wikidata":"https://www.wikidata.org/wiki/Q3651030","display_name":"Faecal calprotectin","level":5,"score":0.48660001158714294},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.484499990940094},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4018000066280365},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.3625999987125397},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C140206745","wikidata":"https://www.wikidata.org/wiki/Q5308895","display_name":"Drug holiday","level":3,"score":0.2757999897003174},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/apt.71062","doi":"https://doi.org/10.1111/apt.71062","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.71062","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.71062","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:42928429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/apt.71062","doi":"https://doi.org/10.1111/apt.71062","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.71062","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.71062","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320323782","display_name":"Vlaamse Interuniversitaire Raad","ror":"https://ror.org/00q3h2974"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320331563","display_name":"VLIRUOS","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223567140.pdf","grobid_xml":"https://content.openalex.org/works/W7223567140.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2018677712","https://openalex.org/W2410520654","https://openalex.org/W2770679140","https://openalex.org/W2962783208","https://openalex.org/W3038280503","https://openalex.org/W3141994374","https://openalex.org/W3157525851","https://openalex.org/W3204438512","https://openalex.org/W4200252628","https://openalex.org/W4282965418","https://openalex.org/W4284973346","https://openalex.org/W4315652391","https://openalex.org/W4315797293","https://openalex.org/W4388759824","https://openalex.org/W4390631671","https://openalex.org/W4393062584","https://openalex.org/W4395013233","https://openalex.org/W4399536699","https://openalex.org/W4402695024","https://openalex.org/W4409213406","https://openalex.org/W4410509493","https://openalex.org/W4412940280"],"related_works":["https://openalex.org/W4318539097","https://openalex.org/W4318539085","https://openalex.org/W3017832275","https://openalex.org/W3141994374","https://openalex.org/W2909587018","https://openalex.org/W3171881417","https://openalex.org/W2898464095","https://openalex.org/W2071538770","https://openalex.org/W3026787322","https://openalex.org/W4401928449"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"The":[3,91],"value":[4],"of":[5],"therapeutic":[6,30],"drug":[7,31],"monitoring":[8,32],"during":[9,33],"infliximab":[10,18,58,165,248],"induction":[11,34,249],"remains":[12],"uncertain.":[13],"We":[14,40],"evaluated":[15],"whether":[16],"baseline":[17,171,240],"clearance":[19,172,201,241],"and":[20,53,69,75,84,117,162,173,196,205,218,242],"early":[21,28,243],"exposure":[22],"metrics":[23],"identify":[24],"candidates":[25],"for":[26,141,181],"potential":[27],"proactive":[29],"in":[35,47,229,250],"inflammatory":[36],"bowel":[37],"disease.":[38,231],"METHODS:":[39],"analysed":[41],"a":[42],"multicenter":[43],"Phase":[44],"4":[45],"study":[46],"which":[48],"adults":[49],"with":[50,71,111,214],"Crohn's":[51,151,230],"disease":[52],"ulcerative":[54,104,154,169,251],"colitis":[55],"initiated":[56],"standard":[57],"therapy":[59],"(5":[60],"mg/kg":[61],"at":[62],"Weeks":[63],"0,":[64],"2,":[65],"6,":[66],"14,":[67],"22":[68],"30)":[70],"predefined":[72],"peak,":[73],"intermediate":[74],"trough":[76,176,207],"sampling.":[77],"A":[78,233],"population":[79],"pharmacokinetic":[80,136],"model":[81],"characterized":[82],"disposition":[83],"covariates.":[85],"Logistic":[86],"regression":[87],"assessed":[88],"exposure-response":[89,142],"relationships.":[90],"primary":[92],"outcome":[93],"was":[94],"week-30":[95],"combined":[96,148,182],"remission":[97,149,183],"(Crohn's":[98],"disease:":[99],"Harvey-Bradshaw":[100],"Index":[101],"\u2264":[102,109,120,208],"4;":[103],"colitis:":[105],"Partial":[106],"Mayo":[107],"score":[108],"2;":[110],"faecal":[112],"calprotectin":[113],"<":[114,222],"100":[115],"\u03bcg/g":[116],"C-reactive":[118],"protein":[119],"5":[121],"mg/L).":[122],"RESULTS:":[123],"Seventy-five":[124],"participants":[125,145],"(33":[126],"female;":[127],"median":[128],"age":[129],"39":[130],"years,":[131],"interquartile":[132],"range":[133],"28-52)":[134],"contributed":[135],"data.":[137],"Sixty-three":[138],"were":[139,227],"evaluable":[140],"analyses.":[143],"Twelve":[144],"(19%)":[146],"achieved":[147],"(7/35":[150],"disease;":[152],"5/28":[153],"colitis).":[155],"Lower":[156],"serum":[157],"albumin,":[158],"higher":[159],"body":[160],"weight,":[161],"antibodies":[163],"to":[164],"increased":[166],"clearance.":[167],"In":[168],"colitis,":[170],"model-predicted":[174],"week-6":[175,206],"concentration":[177],"showed":[178],"strong":[179],"discrimination":[180],"(area":[184],"under":[185],"the":[186],"receiver":[187],"operating":[188],"characteristic":[189],"curve":[190],"0.88,":[191],"95%":[192],"confidence":[193],"interval":[194],"0.75-1.00;":[195],"0.86,":[197],"0.69-1.00,":[198],"respectively).":[199],"Baseline":[200],">":[202],"0.28":[203],"L/day":[204],"21.6":[209],"mg/L":[210],"identified":[211,228],"high-risk":[212],"subgroups":[213],"few":[215],"remissions":[216],"(0/18":[217],"1/20,":[219],"respectively,":[220],"p":[221],"0.05).":[223],"No":[224],"robust":[225],"predictors":[226],"CONCLUSIONS:":[232],"pragmatic,":[234],"risk-stratified,":[235],"model-informed":[236],"approach":[237],"centered":[238],"on":[239],"troughs":[244],"may":[245],"guide":[246],"personalized":[247],"colitis.":[252],"External":[253],"validation":[254],"is":[255],"warranted.":[256],"TRIAL":[257],"REGISTRATION:":[258],"EudraCT":[259],"number:":[260],"2015-004618-10.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-26T00:00:00"}
