{"id":"https://openalex.org/W7223563993","doi":"https://doi.org/10.1093/eurheartj/ehag785.803","title":"GLP-1 receptor agonist use and long-term outcomes in hypertrophic cardiomyopathy with obstructive sleep apnoea: A real-world cohort analysis","display_name":"GLP-1 receptor agonist use and long-term outcomes in hypertrophic cardiomyopathy with obstructive sleep apnoea: A real-world cohort analysis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223563993","doi":"https://doi.org/10.1093/eurheartj/ehag785.803"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehag785.803","doi":"https://doi.org/10.1093/eurheartj/ehag785.803","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.803","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.803/72479064/ehag785.803.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.803/72479064/ehag785.803.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159547954","display_name":"S Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Shah","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159548653","display_name":"M Abusafia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Abusafia","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159530519","display_name":"H Sheashaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Sheashaa","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159531778","display_name":"S Jadam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Jadam","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159508612","display_name":"S Ospina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ospina","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159533582","display_name":"D Kaelber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Kaelber","raw_affiliation_strings":["Metrohealth Medical Center , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metrohealth Medical Center , Cleveland ,","institution_ids":["https://openalex.org/I4210157264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159529615","display_name":"S Keen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Keen","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125038441","display_name":"Milind Y Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Desai","raw_affiliation_strings":["Cleveland Clinic Foundation , Cleveland ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation , Cleveland ,","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":1.0},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9929999709129333},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.847000002861023},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"ventricular tachycardia","score":0.765999972820282},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8640000224113464},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.609000027179718},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.6700000166893005},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9782000184059143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.781499981880188},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.7003999948501587},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6845999956130981},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.597100019454956},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.593999981880188},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5630000233650208},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.45730000734329224},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.4381999969482422},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.34049999713897705},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.31119999289512634},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2780322006","wikidata":"https://www.wikidata.org/wiki/Q7539768","display_name":"Sleep study","level":4,"score":0.25529998540878296},{"id":"https://openalex.org/C190512316","wikidata":"https://www.wikidata.org/wiki/Q1924756","display_name":"Metabolic equivalent","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehag785.803","doi":"https://doi.org/10.1093/eurheartj/ehag785.803","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.803","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.803/72479064/ehag785.803.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehag785.803","doi":"https://doi.org/10.1093/eurheartj/ehag785.803","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.803","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.803/72479064/ehag785.803.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223563993.pdf","grobid_xml":"https://content.openalex.org/works/W7223563993.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415792770","https://openalex.org/W4415799797","https://openalex.org/W4407723245","https://openalex.org/W7143519800","https://openalex.org/W7204572594","https://openalex.org/W7166825446","https://openalex.org/W4414255570","https://openalex.org/W4410482249","https://openalex.org/W7110641413","https://openalex.org/W7165871914"],"abstract_inverted_index":{"Abstract":[0],"Obstructive":[1],"sleep":[2],"apnoea":[3],"(OSA)":[4],"is":[5],"prevalent":[6],"in":[7,38,58,188,210],"hypertrophic":[8],"cardiomyopathy":[9],"(HCM)":[10],"and":[11,17,42,54,62,83,132,143,174,199,329,341],"may":[12],"contribute":[13],"to":[14,146,361],"adverse":[15,156],"cardiometabolic":[16,30],"cardiovascular":[18,157],"outcomes.":[19],"Although":[20],"glucagon-like":[21],"peptide-1":[22],"receptor":[23],"agonists":[24],"(GLP-1":[25,197],"RAs)":[26],"are":[27,186,359],"effective":[28],"for":[29,221,352,365],"risk":[31,222,225,234,275,302],"management,":[32],"their":[33],"association":[34,49],"with":[35,40,60,79,106,217,255,327,336],"long-term":[36,55,343],"outcomes":[37,57,168],"adults":[39,59,326],"HCM":[41,61,80,95,328,366],"OSA":[43,84,367],"remains":[44],"unclear.":[45],"To":[46],"evaluate":[47],"the":[48,71,97,243],"between":[50],"GLP-1":[51,91,102,202,331],"RA":[52,92,103,332],"exposure":[53,333],"clinical":[56],"OSA.":[63],"We":[64],"performed":[65,122],"an":[66],"observational":[67],"cohort":[68,99,141,193,324],"study":[69],"using":[70],"TriNetX":[72],"Global":[73],"Collaborative":[74],"Network.":[75],"Adults":[76],"(\u226518":[77],"years)":[78],"(ICD-10":[81,85],"I42.1/I42.2)":[82],"G47.33)":[86],"were":[87,115,135,169,195,208],"identified.":[88],"Exposure":[89],"was":[90,121,154,226,248,276,289,303,313,334,350],"use":[93],"after":[94,140,184,204],"diagnosis;":[96],"comparator":[98],"had":[100],"no":[101],"use.":[104],"Patients":[105],"prior":[107,219,271,299],"heart":[108,171,267,354],"transplant,":[109],"septal":[110],"reduction":[111],"therapy,":[112],"or":[113,282],"myectomy":[114],"excluded.":[116],"Propensity":[117],"score":[118],"matching":[119,185],"(1:1)":[120],"across":[123],"18":[124],"covariates":[125],"(including":[126],"age,":[127],"sex,":[128],"body":[129],"mass":[130],"index,":[131],"comorbidities).":[133],"Outcomes":[134],"assessed":[136],"from":[137],"day":[138],"1":[139],"entry":[142],"continued":[144],"up":[145],"5,475":[147,259],"days":[148,260],"(~15":[149],"years).":[150],"The":[151],"primary":[152],"outcome":[153,220],"major":[155],"events":[158],"(MACE:":[159],"all-cause":[160],"mortality,":[161],"acute":[162,170,266,353],"myocardial":[163],"infarction,":[164],"ischaemic":[165],"stroke).":[166],"Secondary":[167],"failure":[172,268,355],"hospitalisation":[173,269],"arrhythmias":[175,297],"(atrial":[176],"fibrillation/flutter,":[177],"ventricular":[178,180],"fibrillation,":[179],"tachycardia).":[181],"Baseline":[182],"characteristics":[183],"shown":[187],"Figure":[189],"1a.":[190],"Before":[191],"matching,":[192,205],"sizes":[194],"4,962":[196],"RA)":[198],"36,249":[200],"(no":[201],"RA);":[203],"4,930":[206],"patients":[207,216],"included":[209],"each":[211],"cohort.":[212],"For":[213,265,296],"MACE":[214,244,340],"(excluding":[215,270,298],"a":[218],"estimates),":[223],"cumulative":[224,274,301],"10.0%":[227],"vs":[228,263,278,305],"15.4%":[229],"(odds":[230,280],"ratio":[231,246,281],"0.61;":[232],"absolute":[233],"difference":[235,349],"\u22125.4%;":[236],"p<0.0001).":[237],"In":[238,320],"time-to-event":[239],"analysis":[240],"(Figure":[241],"1b),":[242],"hazard":[245],"(HR)":[247],"0.64":[249],"(95%":[250,291,315],"CI":[251,292,316],"0.59\u20130.71;":[252],"log-rank":[253,294,318],"p<0.0001),":[254],"MACE-free":[256,344],"survival":[257],"at":[258],"of":[261,325,339],"54.3%":[262],"31.7%.":[264],"such":[272],"events),":[273,300],"4.7%":[277],"5.1%":[279],"OR":[283],"0.92;":[284],"p=0.40);":[285],"Cox":[286,310],"proportional":[287,311],"HR":[288,312],"0.84":[290],"0.70\u20131.02;":[293],"p=0.08).":[295],"12.8%":[304],"11.2%":[306],"(OR":[307],"1.16;":[308],"p=0.04);":[309],"1.07":[314],"0.93\u20131.23;":[317],"p=0.38).":[319],"this":[321],"large":[322],"real-world":[323],"OSA,":[330],"associated":[335],"lower":[337],"odds":[338],"improved":[342],"survival.":[345],"No":[346],"statistically":[347],"significant":[348],"observed":[351],"hospitalisations.":[356],"Prospective":[357],"studies":[358],"warranted":[360],"confirm":[362],"these":[363],"associations.Figure":[364]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-26T00:00:00"}