{"id":"https://openalex.org/W7223561897","doi":"https://doi.org/10.1002/brb3.71789","title":"Childhood Trauma Exposure Associated With a More Severe Course of Metabolic Disturbances in Bipolar Disorder: A 36\u2010Month Longitudinal Prospective Cohort Study","display_name":"Childhood Trauma Exposure Associated With a More Severe Course of Metabolic Disturbances in Bipolar Disorder: A 36\u2010Month Longitudinal Prospective Cohort Study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223561897","doi":"https://doi.org/10.1002/brb3.71789","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926321","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13695791"},"language":"en","primary_location":{"id":"doi:10.1002/brb3.71789","doi":"https://doi.org/10.1002/brb3.71789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.71789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.71789","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.71789","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020900505","display_name":"Juan Francisco Galvez-Florez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan F. Galvez\u2010Florez","raw_affiliation_strings":["Cl\u00ednica De Nuestra Se\u00f1ora De La Paz Orden Hospitalaria de San Juan De Dios, Center for Clinical and Translational Research  Bogot\u00e1 D.C. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica De Nuestra Se\u00f1ora De La Paz Orden Hospitalaria de San Juan De Dios, Center for Clinical and Translational Research  Bogot\u00e1 D.C. Colombia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062720491","display_name":"Hernan Felipe Guillen-Burgos","orcid":"https://orcid.org/0000-0003-1835-431X","observed_orcids":["https://orcid.org/0000-0003-1835-431X","https://orcid.org/0000-0002-6961-4022"]},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]},{"id":"https://openalex.org/I4210132036","display_name":"Universidad Sim\u00f3n Bol\u00edvar","ror":"https://ror.org/02njbw696","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210132036"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Hern\u00e1n F. Guillen\u2010Burgos","raw_affiliation_strings":["Center For Clinical and Translational Research Universidad Sim\u00f3n Bol\u00edvar  Barranquilla Colombia","Cl\u00ednica De Nuestra Se\u00f1ora De La Paz Orden Hospitalaria de San Juan De Dios, Center for Clinical and Translational Research  Bogot\u00e1 D.C. Colombia","Department of Psychiatry and Mental Health Pontificia Universidad Javeriana  Bogot\u00e1 D.C. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center For Clinical and Translational Research Universidad Sim\u00f3n Bol\u00edvar  Barranquilla Colombia","institution_ids":["https://openalex.org/I4210132036"]},{"raw_affiliation_string":"Cl\u00ednica De Nuestra Se\u00f1ora De La Paz Orden Hospitalaria de San Juan De Dios, Center for Clinical and Translational Research  Bogot\u00e1 D.C. Colombia","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry and Mental Health Pontificia Universidad Javeriana  Bogot\u00e1 D.C. Colombia","institution_ids":["https://openalex.org/I233745408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050514958","display_name":"Sergio Moreno","orcid":"https://orcid.org/0000-0002-3043-0963","observed_orcids":["https://orcid.org/0000-0002-3043-0963"]},"institutions":[{"id":"https://openalex.org/I162096671","display_name":"Universidad de Los Andes","ror":"https://ror.org/02mhbdp94","country_code":"CO","type":"education","lineage":["https://openalex.org/I162096671"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Sergio Moreno\u2010L\u00f3pez","raw_affiliation_strings":["School of Medicine Universidad De Los Andes  Bogot\u00e1 D.C. Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Universidad De Los Andes  Bogot\u00e1 D.C. Colombia","institution_ids":["https://openalex.org/I162096671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021854570","display_name":"Mariana Ram\u00edrez\u2010Posada","orcid":"https://orcid.org/0009-0008-9628-3610","observed_orcids":["https://orcid.org/0009-0008-9628-3610"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana Ram\u00edrez\u2010Posada","raw_affiliation_strings":["Department of Dermatology Stanford University  Palo Alto California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology Stanford University  Palo Alto California USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051051572","display_name":"Juan\u2010Manuel Anaya","orcid":"https://orcid.org/0000-0002-6444-1249","observed_orcids":["https://orcid.org/0000-0002-6444-1249"]},"institutions":[{"id":"https://openalex.org/I4210112678","display_name":"Universidad de la Costa","ror":"https://ror.org/01v5nhr20","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210112678"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Juan\u2010Manuel Anaya","raw_affiliation_strings":["Healthy Longevity Center Universidad de la Costa  Barranquilla Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Healthy Longevity Center Universidad de la Costa  Barranquilla Colombia","institution_ids":["https://openalex.org/I4210112678"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068850044","display_name":"Roger S. McIntyre","orcid":"https://orcid.org/0000-0003-4733-2523","observed_orcids":["https://orcid.org/0000-0003-4733-2523"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Roger S. McIntyre","raw_affiliation_strings":["Department of Psychiatry University of Toronto  Toronto Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Toronto  Toronto Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5062720491","https://openalex.org/A5068850044"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I233745408","https://openalex.org/I4210132036"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8289966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-trauma","display_name":"childhood trauma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.527999997138977},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.7059999704360962},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7649999856948853},{"id":"https://openalex.org/keywords/trauma-informed-care","display_name":"trauma-informed care","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7663000226020813},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.7268000245094299},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7214999794960022},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5759000182151794},{"id":"https://openalex.org/C2779915747","wikidata":"https://www.wikidata.org/wiki/Q17058619","display_name":"Inverse probability weighting","level":3,"score":0.5275999903678894},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.49970000982284546},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38769999146461487},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C26831200","wikidata":"https://www.wikidata.org/wiki/Q16963953","display_name":"Marginal structural model","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3601999878883362},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.35089999437332153},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3068999946117401},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C187155963","wikidata":"https://www.wikidata.org/wiki/Q629029","display_name":"Occupational safety and health","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C2777082460","wikidata":"https://www.wikidata.org/wiki/Q3377398","display_name":"Early childhood","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2777914111","wikidata":"https://www.wikidata.org/wiki/Q1064904","display_name":"Major trauma","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2793000042438507},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2784000039100647},{"id":"https://openalex.org/C190512316","wikidata":"https://www.wikidata.org/wiki/Q1924756","display_name":"Metabolic equivalent","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.25220000743865967}],"mesh":[{"descriptor_ui":"D000076783","descriptor_name":"Adverse Childhood Experiences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/brb3.71789","doi":"https://doi.org/10.1002/brb3.71789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.71789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.71789","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13695791","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695791/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695791/pdf/BRB3-16-e71789.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Behav","raw_type":"Text"},{"id":"pmid:42926321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and behavior","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8ffdd2a53b0e455dbfeb3fe3d5d1d790","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8ffdd2a53b0e455dbfeb3fe3d5d1d790","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain and Behavior, Vol 16, Iss 10, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/brb3.71789","doi":"https://doi.org/10.1002/brb3.71789","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.71789","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.71789","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325054","display_name":"Universidad Sim\u00f3n Bol\u00edvar","ror":"https://ror.org/01ak5cj98"},{"id":"https://openalex.org/F4320325859","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28"},{"id":"https://openalex.org/F4320332941","display_name":"Center for Clinical and Translational Research","ror":"https://ror.org/01njes783"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223561897.pdf","grobid_xml":"https://content.openalex.org/works/W7223561897.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1962454315","https://openalex.org/W1983200719","https://openalex.org/W2015594426","https://openalex.org/W2040738795","https://openalex.org/W2079989528","https://openalex.org/W2080074328","https://openalex.org/W2089155812","https://openalex.org/W2099254465","https://openalex.org/W2116763520","https://openalex.org/W2129097348","https://openalex.org/W2137839156","https://openalex.org/W2139276071","https://openalex.org/W2144001592","https://openalex.org/W2158083741","https://openalex.org/W2517180665","https://openalex.org/W2542999051","https://openalex.org/W2570594186","https://openalex.org/W2780924575","https://openalex.org/W2944446355","https://openalex.org/W2966857659","https://openalex.org/W3014295004","https://openalex.org/W3017192965","https://openalex.org/W3025500123","https://openalex.org/W3027268342","https://openalex.org/W3171850614","https://openalex.org/W3172216446","https://openalex.org/W3204839307","https://openalex.org/W4200507756","https://openalex.org/W4210998119","https://openalex.org/W4224313858","https://openalex.org/W4283366814","https://openalex.org/W4294953492","https://openalex.org/W4306292138","https://openalex.org/W4307405284","https://openalex.org/W4319812906","https://openalex.org/W4368351403","https://openalex.org/W4393529919","https://openalex.org/W4401891247","https://openalex.org/W4403514025","https://openalex.org/W4405794206"],"related_works":["https://openalex.org/W7140206364","https://openalex.org/W3110682266","https://openalex.org/W3172216446","https://openalex.org/W2937141807","https://openalex.org/W4385669175","https://openalex.org/W4405794206","https://openalex.org/W4229069286","https://openalex.org/W4388830260","https://openalex.org/W2614280155","https://openalex.org/W4366780946"],"abstract_inverted_index":{"BACKGROUND:":[0],"Childhood":[1,95],"trauma":[2],"(CT)":[3],"is":[4,197],"a":[5,127],"recognized":[6],"risk":[7,208,265],"factor":[8],"for":[9,164,190],"adverse":[10],"psychiatric":[11,240],"and":[12,50,76,111,122,135,199,203,233,241,252,258],"physical":[13,242],"health":[14,243],"outcomes":[15,101],"in":[16,38,59,146,184,244,266],"individuals":[17,185],"with":[18,61,72,115,143,177,186],"bipolar":[19],"disorder":[20],"(BD).":[21],"However,":[22],"few":[23],"prospective":[24,66],"studies":[25],"have":[26],"examined":[27],"how":[28],"CT":[29,48,91,173],"relates":[30],"to":[31,43,90,261],"the":[32,45,51,94,147,195,227],"longitudinal":[33],"course":[34],"of":[35,53,118,181,206,229,234],"metabolic":[36,54,182,207],"dysregulation":[37],"BD.":[39,62,245],"This":[40],"study":[41],"aimed":[42],"describe":[44],"association":[46],"between":[47],"exposure":[49,92,174],"progression":[52],"disturbances":[55],"over":[56,83],"36":[57,84],"months":[58],"adults":[60,70],"METHODS:":[63],"In":[64,169],"this":[65,170,267],"cohort":[67],"study,":[68],"305":[69],"diagnosed":[71],"BD":[73,187],"(Types":[74],"I":[75],"II)":[77],"were":[78,87,113,152,209],"followed":[79],"across":[80],"13":[81],"visits":[82],"months.":[85],"Participants":[86],"stratified":[88],"according":[89],"using":[93],"Trauma":[96],"Questionnaire-Short":[97],"Form":[98],"(CTQ-SF).":[99],"Metabolic":[100],"(HbA1c,":[102],"BMI,":[103],"total":[104],"cholesterol,":[105,107,109],"HDL":[106],"LDL":[108],"triglycerides,":[110],"hs-CRP)":[112],"analyzed":[114],"inverse":[116],"probability":[117],"treatment":[119],"weighting":[120,163,189],"(IPTW)":[121],"linear":[123],"mixed-effects":[124],"models":[125],"incorporating":[126],"group-by-time":[128],"interaction.":[129],"RESULTS:":[130],",":[131],"95%":[132,139],"CI":[133,140],"3.90-5.03),":[134],"hs-CRP":[136],"(2.68":[137],"mg/L,":[138],"2.52-2.84),":[141],"together":[142],"unfavorable":[144],"changes":[145],"lipid":[148],"profile.":[149],"Effect":[150],"sizes":[151],"large":[153],"(Cohen's":[154],"d":[155],">":[156],"0.8).":[157],"These":[158],"associations":[159,218],"persisted":[160],"after":[161,188],"IPTW":[162],"measured":[165,191],"baseline":[166,192],"covariates.":[167],"CONCLUSIONS:":[168],"observational":[171,198],"cohort,":[172],"was":[175],"associated":[176],"an":[178],"accelerated":[179],"trajectory":[180],"deterioration":[183],"characteristics.":[193],"Because":[194],"design":[196],"several":[200],"behavioral,":[201],"socioeconomic,":[202],"illness-course":[204],"determinants":[205],"not":[210],"measured,":[211],"these":[212],"findings":[213],"should":[214,248],"be":[215],"interpreted":[216],"as":[217,221],"rather":[219],"than":[220],"causal":[222],"effects.":[223],"They":[224],"nonetheless":[225],"support":[226],"value":[228],"early":[230],"trauma-informed":[231],"assessment":[232],"integrated":[235],"care":[236],"strategies":[237],"addressing":[238],"both":[239],"Future":[246],"research":[247],"incorporate":[249],"detailed":[250],"lifestyle":[251],"treatment-exposure":[253],"data,":[254],"additional":[255],"inflammatory":[256],"biomarkers,":[257],"preventive":[259],"interventions":[260],"mitigate":[262],"long-term":[263],"cardiometabolic":[264],"vulnerable":[268],"population.":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-26T00:00:00"}