{"id":"https://openalex.org/W7223552009","doi":"https://doi.org/10.64898/2026.10.21.760722","title":"Erythrocyte extravasation drives ferroptosis and inflammatory amplification in eccentric contraction\u2013induced skeletal muscle injury via the heme\u2013HO-1\u2013iron axis","display_name":"Erythrocyte extravasation drives ferroptosis and inflammatory amplification in eccentric contraction\u2013induced skeletal muscle injury via the heme\u2013HO-1\u2013iron axis","publication_year":2026,"publication_date":"2026-10-25","ids":{"openalex":"https://openalex.org/W7223552009","doi":"https://doi.org/10.64898/2026.10.21.760722"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.21.760722","doi":"https://doi.org/10.64898/2026.10.21.760722","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.760722","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.21.760722.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.21.760722.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159551494","display_name":"Menghua Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghua Liu","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159551957","display_name":"Xiaoyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Wang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159481310","display_name":"Zhengwei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwei Liu","raw_affiliation_strings":["School of Physical Education, Xinyang Normal University, Xinyang, Henan 464000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physical Education, Xinyang Normal University, Xinyang, Henan 464000, China","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157847190","display_name":"Fengming You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengming You","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159497089","display_name":"Qi Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Shen","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159551583","display_name":"Miao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Zhang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122899610","display_name":"Shumin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261629","display_name":"Institute of Basic Theory for Chinese Medicine","ror":"https://ror.org/05kf82e36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shumin Chen","raw_affiliation_strings":["Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4405261629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112813155","display_name":"Yeteng Jing","orcid":"https://orcid.org/0009-0005-3694-9327","observed_orcids":["https://orcid.org/0009-0005-3694-9327"]},"institutions":[{"id":"https://openalex.org/I4405261629","display_name":"Institute of Basic Theory for Chinese Medicine","ror":"https://ror.org/05kf82e36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yeteng Jing","raw_affiliation_strings":["Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4405261629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159518630","display_name":"Jinsheng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261629","display_name":"Institute of Basic Theory for Chinese Medicine","ror":"https://ror.org/05kf82e36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4405261629"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinsheng Yang","raw_affiliation_strings":["Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4405261629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159483122","display_name":"Yingying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingying Wang","raw_affiliation_strings":["Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China","institution_ids":["https://openalex.org/I4210141683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5159483122"],"corresponding_institution_ids":["https://openalex.org/I4210141683"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eccentric-contraction","display_name":"eccentric contraction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/skeletal-muscle-injury","display_name":"skeletal muscle injury","score":0.972000002861023},{"id":"https://openalex.org/keywords/erythrocyte-extravasation","display_name":"erythrocyte extravasation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.6320000290870667},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7599999904632568},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.675000011920929},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7218000292778015},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.5764999985694885},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.5641000270843506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4447999894618988},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4244999885559082},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.40059998631477356},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.39879998564720154},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37299999594688416},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3718000054359436},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.35839998722076416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33820000290870667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3366999924182892},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C2993864201","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen transport","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.27549999952316284},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.26350000500679016},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.21.760722","doi":"https://doi.org/10.64898/2026.10.21.760722","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.760722","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.21.760722.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.21.760722","doi":"https://doi.org/10.64898/2026.10.21.760722","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.760722","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.21.760722.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4263121440","display_name":null,"funder_award_id":"CI2025C001","funder_id":"https://openalex.org/F4320323485","funder_display_name":"China Academy of Chinese Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323485","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223552009.pdf","grobid_xml":"https://content.openalex.org/works/W7223552009.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1975916082","https://openalex.org/W1982374396","https://openalex.org/W2041531695","https://openalex.org/W2057070304","https://openalex.org/W2063193002","https://openalex.org/W2112039060","https://openalex.org/W2183123070","https://openalex.org/W2587398364","https://openalex.org/W2604429438","https://openalex.org/W2799503713","https://openalex.org/W2886212667","https://openalex.org/W2913973491","https://openalex.org/W2982991142","https://openalex.org/W3022014008","https://openalex.org/W3096733279","https://openalex.org/W3113059059","https://openalex.org/W3159432564","https://openalex.org/W3211854257","https://openalex.org/W4214511313","https://openalex.org/W4225300700","https://openalex.org/W4285005408","https://openalex.org/W4288058403","https://openalex.org/W4296887805","https://openalex.org/W4308105849","https://openalex.org/W4309937987","https://openalex.org/W4312205611","https://openalex.org/W4318065221","https://openalex.org/W4362719700","https://openalex.org/W4386910961","https://openalex.org/W4391878282","https://openalex.org/W4394594723","https://openalex.org/W4394709659","https://openalex.org/W4403605263","https://openalex.org/W4404536132","https://openalex.org/W4407927815","https://openalex.org/W4408744969","https://openalex.org/W4409484028","https://openalex.org/W4413684090","https://openalex.org/W4413847799","https://openalex.org/W4416267998","https://openalex.org/W4416772213","https://openalex.org/W7150123330","https://openalex.org/W7160331891","https://openalex.org/W7163320570"],"related_works":["https://openalex.org/W4401314017","https://openalex.org/W7162013129","https://openalex.org/W2770679908","https://openalex.org/W4403605263","https://openalex.org/W7130394411","https://openalex.org/W2129172944","https://openalex.org/W7133310957","https://openalex.org/W4400974394","https://openalex.org/W2147837427","https://openalex.org/W4406178417"],"abstract_inverted_index":{"Abstract":[0],"Eccentric":[1],"contraction-induced":[2],"skeletal":[3],"muscle":[4,15,39,77,161,187],"injury":[5,78],"is":[6],"a":[7,87,180,190],"common":[8],"sports-related":[9],"condition":[10],"characterized":[11],"by":[12,153],"pain,":[13],"impaired":[14],"function,":[16],"slow":[17],"recovery,":[18],"and":[19,26,34,53,65,116,128,146,165,170,174,195],"frequent":[20],"recurrence,":[21],"yet":[22],"treatment":[23],"remains":[24,79],"symptomatic":[25],"mechanism-based":[27],"targets":[28],"are":[29],"lacking.":[30],"Although":[31],"microvascular":[32],"disruption":[33],"erythrocyte":[35,142],"extravasation":[36],"characterize":[37],"severe":[38],"strain,":[40],"the":[41,93],"metabolic":[42],"fate":[43],"of":[44],"extravasated":[45],"erythrocytes":[46],"has":[47],"received":[48],"little":[49],"attention.":[50],"In":[51],"hemorrhagic":[52],"hemolytic":[54],"conditions,":[55],"erythrocyte-derived":[56],"heme":[57,60],"can":[58],"activate":[59],"oxygenase-1":[61],"(HO-1)-mediated":[62],"iron":[63,162],"release":[64],"ferroptosis,":[66],"potentially":[67],"amplifying":[68],"inflammation;":[69],"however,":[70],"whether":[71],"this":[72,83],"pathway":[73],"contributes":[74],"to":[75],"eccentric":[76,101,186],"unknown.":[80],"To":[81],"address":[82],"gap,":[84],"we":[85],"established":[86],"parameter-controlled":[88],"rat":[89],"model":[90],"in":[91,156,185],"which":[92],"gastrocnemius":[94],"underwent":[95],"0,":[96],"50,":[97],"100,":[98],"or":[99],"150":[100],"stretch":[102],"repetitions.":[103],"Muscle":[104],"torque,":[105],"gait,":[106],"weight-bearing,":[107],"endurance,":[108],"pain":[109],"threshold,":[110],"histopathology,":[111],"microcirculatory":[112,147],"perfusion,":[113],"macrophage":[114,173],"polarization,":[115],"heme,":[117],"ferrous":[118],"iron,":[119],"glutathione":[120,124],"(GSH),":[121],"malondialdehyde":[122],"(MDA),":[123],"peroxidase":[125],"4":[126],"(GPX4),":[127],"pro-inflammatory":[129],"cytokine":[130,175],"levels":[131],"were":[132],"assessed.":[133],"Increasing":[134],"repetitions":[135],"produced":[136],"graded":[137],"functional":[138],"impairment,":[139],"myofiber":[140],"damage,":[141],"extravasation,":[143],"inflammatory":[144,183],"infiltration,":[145],"disturbance.":[148],"Heme":[149],"accumulation":[150],"was":[151],"accompanied":[152],"HO-1":[154],"upregulation":[155],"perivascular":[157],"CD68-positive":[158],"(CD68\u25a1)":[159],"macrophages,":[160],"accumulation,":[163],"GSH":[164],"GPX4":[166],"depletion,":[167],"elevated":[168],"MDA,":[169],"increased":[171],"M1":[172],"levels.":[176],"These":[177],"findings":[178],"suggest":[179],"potential":[181],"heme\u2013HO-1\u2013iron\u2013ferroptosis-associated":[182],"mechanism":[184],"injury,":[188],"providing":[189],"rationale":[191],"for":[192],"mechanistic":[193],"validation":[194],"targeted":[196],"therapeutic":[197],"development.":[198]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-26T00:00:00"}