{"id":"https://openalex.org/W7223550776","doi":"https://doi.org/10.1093/eurheartj/ehag785.2658","title":"Impact of smoking on premature vascular aging in a cohort of healthy men with erectile dysfunction","display_name":"Impact of smoking on premature vascular aging in a cohort of healthy men with erectile dysfunction","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223550776","doi":"https://doi.org/10.1093/eurheartj/ehag785.2658"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehag785.2658","doi":"https://doi.org/10.1093/eurheartj/ehag785.2658","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.2658","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.2658/72496798/ehag785.2658.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.2658/72496798/ehag785.2658.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159530338","display_name":"E Georgousi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E Georgousi","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028956052","display_name":"N. Ioakeimidis","orcid":"https://orcid.org/0000-0001-7344-2828","observed_orcids":["https://orcid.org/0000-0001-7344-2828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Ioakeimidis","raw_affiliation_strings":["Spiliopoulio Hospital \"Agia Eleni\", Cardiology Department , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spiliopoulio Hospital \"Agia Eleni\", Cardiology Department , Athens ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031983325","display_name":"Dimitrios G. Terentes-Printzios","orcid":"https://orcid.org/0000-0003-4039-8263","observed_orcids":["https://orcid.org/0000-0003-4039-8263"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D Terentes-Printzios","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159504423","display_name":"I Dima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I Dima","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117637639","display_name":"Maria Eleni Koilakou","orcid":"https://orcid.org/0009-0001-4589-7822","observed_orcids":["https://orcid.org/0009-0001-4589-7822"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M E Koilakou","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159513133","display_name":"P Alexiou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P Alexiou","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159530886","display_name":"D Kalfoutzos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Kalfoutzos","raw_affiliation_strings":["Spiliopoulio Hospital \"Agia Eleni\", Cardiology Department , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spiliopoulio Hospital \"Agia Eleni\", Cardiology Department , Athens ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111509805","display_name":"Costas Tsioufis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C Tsioufis","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111981472","display_name":"C Vlachopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C Vlachopoulos","raw_affiliation_strings":["National & Kapodistrian University of Athens , Athens ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National & Kapodistrian University of Athens , Athens ,","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8569999933242798},{"id":"https://openalex.org/keywords/vasculogenic-erectile-dysfunction","display_name":"vasculogenic erectile dysfunction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9980000257492065},{"id":"https://openalex.org/keywords/subclinical-atherosclerosis","display_name":"subclinical atherosclerosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/pack-years","display_name":"pack-years","score":0.7269999980926514},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.4020000100135803},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.38499999046325684},{"id":"https://openalex.org/keywords/carotid-femoral-pwv","display_name":"carotid-femoral PWV","score":0.6990000009536743},{"id":"https://openalex.org/keywords/brachials","display_name":"brachials","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9652000069618225},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.7465999722480774},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7225000262260437},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7099999785423279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7067999839782715},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.6879000067710876},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.6808000206947327},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6571000218391418},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6448000073432922},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.4936999976634979},{"id":"https://openalex.org/C2779339615","wikidata":"https://www.wikidata.org/wiki/Q2698596","display_name":"Intima-media thickness","level":3,"score":0.48190000653266907},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C3019085024","wikidata":"https://www.wikidata.org/wiki/Q7212330","display_name":"Cigarette smoking","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehag785.2658","doi":"https://doi.org/10.1093/eurheartj/ehag785.2658","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.2658","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.2658/72496798/ehag785.2658.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehag785.2658","doi":"https://doi.org/10.1093/eurheartj/ehag785.2658","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag785.2658","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/47/Supplement_1/ehag785.2658/72496798/ehag785.2658.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7223550776.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W57951851","https://openalex.org/W4300827228","https://openalex.org/W2002269004","https://openalex.org/W2067805683","https://openalex.org/W2028974515","https://openalex.org/W4306254463","https://openalex.org/W2048967566","https://openalex.org/W2067489807","https://openalex.org/W2973715068","https://openalex.org/W2114280011"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Vascular":[2,294],"aging":[3],"in":[4,296,309,332,376,402],"smokers":[5,74,163,169,209,297],"is":[6,25,319,379],"a":[7,91,223,238,264,301,320,395],"multi-factorial":[8],"process,":[9],"driven":[10],"by":[11],"traditional":[12],"cardiovascular":[13,88,374],"risk":[14],"factors":[15],"that":[16,51,222,346],"mostly":[17],"rely":[18],"on":[19,137,349],"cumulative":[20],"tobacco":[21,385],"exposure.":[22],"While":[23,317],"this":[24],"standard":[26],"clinical":[27],"practice,":[28],"it":[29],"may":[30,355],"fail":[31],"to":[32,44,102,124,162,251,299,369,393,410],"identify":[33],"early":[34,357],"subclinical":[35],"signs":[36],"suggesting":[37,221],"early-onset":[38],"vascular":[39,54,93,176,314,324,399],"decay.":[40],"This":[41],"study":[42],"aimed":[43],"evaluate":[45,103],"premature":[46,396],"functional":[47,333,358,366],"and":[48,118,151,192,235,248,283,327,414],"structural":[49,64,104,229,353],"markers":[50],"can":[52,306,329],"predict":[53],"dysregulation":[55],"at":[56,389],"earlier":[57,310],"stages":[58,311],"than":[59],"classic":[60],"risk-factor":[61],"assessment,":[62,94],"before":[63,339],"remodeling":[65],"appears.":[66],"Methods":[67],"A":[68],"total":[69,373],"of":[70,115,219,323,335,360,398],"386":[71],"active":[72],"healthy":[73],"(mean":[75,217],"age:":[76],"52\u00b114":[77],"years)":[78],"with":[79,164,170,210,257],"ultrasonographically":[80],"documented":[81],"vasculogenic":[82],"erectile":[83],"dysfunction":[84],"(ED),":[85],"without":[86],"known":[87],"disease":[89],"underwent":[90],"multi-modal":[92],"which":[95],"included":[96],"carotid":[97,138,166,212,403],"Intima-Media":[98],"Thickness":[99],"(IMT)":[100],"measurements":[101],"remodeling,":[105,325],"carotid-femoral":[106],"Pulse":[107],"Wave":[108],"Velocity":[109],"(PWV)":[110],"values":[111],"as":[112],"an":[113],"indicator":[114,322],"arterial":[116,194,285],"stiffness,":[117],"brachial":[119],"Flow-Mediated":[120],"Dilation":[121],"(FMD)":[122],"metrics":[123],"estimate":[125],"endothelial":[126,180,225],"dysfunction.":[127],"Results":[128],"Participants":[129],"were":[130],"further":[131],"subdivided":[132],"into":[133],"two":[134],"groups":[135],"based":[136],"IMT":[139,153,172,213,318,404],"values:":[140],"Normal":[141],"wall":[142,167],"thickness":[143],"(IMT":[144,154],"\u2264":[145],"0.9":[146,156],"mm,":[147,157],"N":[148,158],"=":[149,159,243,288],"224)":[150],"increased":[152,171],">":[155],"162).":[160],"Compared":[161],"normal":[165,211],"thickness,":[168],"exhibited":[173,214],"substantially":[174],"worse":[175],"profiles,":[177],"regarding":[178],"impaired":[179,215],"function":[181,315],"(2.44":[182],"\u00b1":[183,187,197,201],"1.29%":[184],"vs.":[185,199],"3.41":[186],"1.58%,":[188],"p":[189,204,245,290],"<":[190,205,246,291],".001)":[191],"higher":[193],"stiffness":[195],"(9.53":[196],"1.47":[198],"8.54":[200],"1.44":[202],"m/s,":[203],".001).":[206,292],"Notably,":[207],"even":[208],"FMD":[216,234,258,326],"value":[218],"3.41%),":[220],"significant":[224,239,273],"impairment":[226,359],"precedes":[227],"overt":[228],"atherosclerosis.":[230],"In":[231],"correlation":[232,241,401],"analysis,":[233],"PWV":[236,260,328],"demonstrated":[237],"inverse":[240],"(r":[242],"-0.261,":[244],".001),":[247],"when":[249],"tailored":[250],"pack-years,":[252],"no":[253],"apparent":[254],"linear":[255],"relationship":[256],"or":[259,352],"was":[261],"observed,":[262],"indicating":[263],"dose-independent":[265],"outcome":[266],"(figure).":[267],"The":[268],"above-mentioned":[269],"associations":[270],"remained":[271],"statistically":[272],"after":[274],"adjusting":[275],"for":[276],"age,":[277],"body":[278],"mass":[279],"index,":[280],"lipid":[281],"profile":[282],"mean":[284],"pressure":[286],"(aR2":[287],"0.237,":[289],"Conclusion":[293],"decay":[295],"appears":[298],"follow":[300],"worsening":[302],"trajectory":[303],"that,":[304,382],"however,":[305],"be":[307],"identified":[308],"using":[312],"the":[313,361,372,411],"biomarkers.":[316],"later-stage":[321],"detect":[330],"changes":[331,341],"properties":[334],"normally":[336],"structured":[337],"arteries":[338],"macroscopic":[340],"emerge.":[342],"These":[343],"findings":[344],"suggest":[345],"relying":[347],"solely":[348],"smoking":[350],"history":[351],"imaging":[354],"underestimate":[356],"vasculature.":[362],"Clinicians":[363],"should":[364],"consider":[365],"assessments":[367],"(FMD/PWV)":[368],"better":[370],"capture":[371],"burden":[375],"smokers.":[377],"It":[378],"also":[380],"evident":[381],"despite":[383],"accumulated":[384],"exposure,":[386],"cigarette":[387],"smoking\u2014even":[388],"any":[390],"extent\u2014is":[391],"sufficient":[392],"initiate":[394],"process":[397],"aging.PWV-FMD":[400],"subgroupsFor":[405],"image":[406],"description,":[407],"please":[408],"refer":[409],"figure":[412],"legend":[413],"surrounding":[415],"text.":[416]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-26T00:00:00"}