{"id":"https://openalex.org/W7223474033","doi":"https://doi.org/10.64898/2026.10.22.760784","title":"Identification of cis -regulatory modules responding to positional cues regulating the patterned expression of the Drosophila follicle cell fate determinants mid and mirr","display_name":"Identification of cis -regulatory modules responding to positional cues regulating the patterned expression of the Drosophila follicle cell fate determinants mid and mirr","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7223474033","doi":"https://doi.org/10.64898/2026.10.22.760784"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.22.760784","doi":"https://doi.org/10.64898/2026.10.22.760784","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760784","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760784.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760784.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112207504","display_name":"Scott De Vito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. De Vito","raw_affiliation_strings":["Department of Biology, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106005712","display_name":"Kelvin Ip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. Ip","raw_affiliation_strings":["Department of Biology, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092654251","display_name":"Baptiste Rafanel","orcid":"https://orcid.org/0009-0000-4367-0504","observed_orcids":["https://orcid.org/0009-0000-4367-0504"]},"institutions":[{"id":"https://openalex.org/I125523173","display_name":"Institute of Molecular Biotechnology","ror":"https://ror.org/01zqrxf85","country_code":"AT","type":"facility","lineage":["https://openalex.org/I125523173","https://openalex.org/I138211613"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210142901","display_name":"Vienna Biocenter","ror":"https://ror.org/04khwmr87","country_code":"AT","type":"other","lineage":["https://openalex.org/I4210142901"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["AT","CA"],"is_corresponding":false,"raw_author_name":"B. Rafanel","raw_affiliation_strings":["Department of Biology, McGill University","Vienna BioCenter PhD Program, Institute of Molecular Biotechnology of the Austrian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, McGill University","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Vienna BioCenter PhD Program, Institute of Molecular Biotechnology of the Austrian Academy of Sciences","institution_ids":["https://openalex.org/I125523173","https://openalex.org/I138211613","https://openalex.org/I4210142901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159446989","display_name":"Mariana Fregoso Lomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161737","display_name":"Novartis (Canada)","ror":"https://ror.org/05afs3z13","country_code":"CA","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210161737"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Fregoso Lomas","raw_affiliation_strings":["Department of Biology, McGill University","Novartis Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, McGill University","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Novartis Canada","institution_ids":["https://openalex.org/I4210161737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022933048","display_name":"Laura A. Nilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"L.A. Nilson","raw_affiliation_strings":["Department of Biology, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, McGill University","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022933048"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cis-regulatory-modules","display_name":"cis-regulatory modules","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mid","display_name":"MID","score":0.492000013589859},{"id":"https://openalex.org/keywords/gurken","display_name":"Gurken","score":0.6209999918937683},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7509999871253967},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dpp","display_name":"DPP","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mutual-repression","display_name":"mutual repression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/drosophila-ovary","display_name":"Drosophila ovary","score":0.781000018119812},{"id":"https://openalex.org/keywords/positional-cues","display_name":"positional cues","score":0.628000020980835},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8119000196456909},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.7062000036239624},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6583999991416931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.534500002861023},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.5315999984741211},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.507099986076355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5037000179290771},{"id":"https://openalex.org/C50729890","wikidata":"https://www.wikidata.org/wiki/Q10364247","display_name":"Rhomboid","level":4,"score":0.4884999990463257},{"id":"https://openalex.org/C64632358","wikidata":"https://www.wikidata.org/wiki/Q95351881","display_name":"engrailed","level":5,"score":0.4507000148296356},{"id":"https://openalex.org/C91986751","wikidata":"https://www.wikidata.org/wiki/Q996011","display_name":"Imaginal disc","level":4,"score":0.4375999867916107},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.39250001311302185},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3612000048160553},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.34119999408721924},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.32839998602867126},{"id":"https://openalex.org/C2781435330","wikidata":"https://www.wikidata.org/wiki/Q6440544","display_name":"Kr\u00fcppel","level":4,"score":0.31929999589920044},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.3188000023365021},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.2904999852180481},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C142455686","wikidata":"https://www.wikidata.org/wiki/Q59250989","display_name":"GATA transcription factor","level":5,"score":0.2815000116825104},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2766999900341034},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C184937244","wikidata":"https://www.wikidata.org/wiki/Q410820","display_name":"Gap gene","level":4,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.22.760784","doi":"https://doi.org/10.64898/2026.10.22.760784","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760784","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760784.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.22.760784","doi":"https://doi.org/10.64898/2026.10.22.760784","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760784","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760784.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000095838","display_name":null,"funder_award_id":"NIH-P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223474033.pdf","grobid_xml":"https://content.openalex.org/works/W7223474033.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005438342","https://openalex.org/W7161985572","https://openalex.org/W2510038514","https://openalex.org/W7028386370","https://openalex.org/W7018354658","https://openalex.org/W7043462093","https://openalex.org/W6940311994","https://openalex.org/W6957989432","https://openalex.org/W1641850409","https://openalex.org/W1970914997"],"abstract_inverted_index":{"Abstract":[0],"Using":[1],"the":[2,5,9,39,49,56,66,71,74,80,89,92,95,102,147,163,172],"patterning":[3],"of":[4,8,32,73,94,126,162,181,206,224,232],"follicular":[6,58],"epithelium":[7],"Drosophila":[10,210],"ovary":[11],"as":[12],"a":[13,190],"model,":[14],"we":[15,142],"study":[16],"how":[17,23,136,195],"cells":[18],"perceive":[19],"spatial":[20,201],"cues":[21,139],"and":[22,86,121,123,130,150,174,185,228],"this":[24],"information":[25],"is":[26,63,114],"interpreted":[27],"by":[28,116,124,128,132],"cis":[29,216],"-regulatory":[30,217],"regions":[31,145,169],"their":[33,182,233],"downstream":[34],"target":[35],"genes.":[36,165],"During":[37],"oogenesis,":[38],"oocyte":[40],"secretes":[41],"an":[42],"inductive":[43],"signal,":[44],"Gurken":[45],"(Grk),":[46],"that":[47,155,161,219],"activates":[48],"epidermal":[50],"growth":[51],"factor":[52],"receptor":[53],"(EGFR)":[54],"within":[55],"overlying":[57],"epithelium.":[59],"Grk/EGFR":[60],"signaling":[61],"outcome":[62],"context-dependent.":[64],"At":[65,88],"posterior,":[67],"Grk":[68,100],"signals":[69],"in":[70,91,158],"presence":[72,93],"JAK/STAT":[75],"pathway":[76,97],"ligand":[77,98],"Unpaired,":[78],"inducing":[79],"posterior":[81],"fate":[82,213],"determinants":[83],"midline":[84],"(mid)":[85],"H15.":[87],"anterior,":[90],"BMP":[96],"Dpp,":[99],"induces":[101],"dorsal":[103],"anterior":[104],"determinant":[105],"mirror":[106],"(mirr)":[107],".":[108],"The":[109],"choice":[110],"between":[111,119],"these":[112,137,196],"targets":[113],"reinforced":[115],"mutual":[117],"repression":[118,125],"Mid/H15":[120],"Mirr,":[122],"mirr":[127,151,175],"Upd":[129],"mid/H15":[131],"Dpp.":[133],"To":[134],"ask":[135],"positional":[138],"are":[140],"interpreted,":[141],"screened":[143],"non-coding":[144,207],"from":[146,171],"H15,":[148],"mid":[149,173],"loci":[152],"for":[153,193],"CRMs":[154],"drive":[156],"expression":[157,184,234],"patterns":[159],"resembling":[160],"endogenous":[164,183],"We":[166],"identify":[167],"two":[168],"each":[170,177],"loci,":[176],"reproducing":[178],"distinct":[179],"aspects":[180,231],"regulation.":[186],"These":[187],"data":[188],"provide":[189],"simplified":[191],"system":[192],"asking":[194],"sequences":[197,208],"respond":[198,220],"to":[199,221],"upstream":[200],"cues.":[202],"Summary":[203],"statement":[204],"Screening":[205],"near":[209],"follicle":[211],"cell":[212],"genes":[214],"identified":[215],"modules":[218],"different":[222,230],"subsets":[223],"known":[225],"regulatory":[226],"inputs":[227],"reproduce":[229],"patterns.":[235]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-25T00:00:00"}
