{"id":"https://openalex.org/W7223468041","doi":"https://doi.org/10.64898/2026.10.22.761060","title":"Cisplatin Exposure Alters the Effects of Honokiol on Genes Involved in Outer Hair Cell Physiological Function","display_name":"Cisplatin Exposure Alters the Effects of Honokiol on Genes Involved in Outer Hair Cell Physiological Function","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7223468041","doi":"https://doi.org/10.64898/2026.10.22.761060","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13738744"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.22.761060","doi":"https://doi.org/10.64898/2026.10.22.761060","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.761060","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.761060.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.761060.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002513150","display_name":"Chail Koo","orcid":"https://orcid.org/0000-0002-4556-1755","observed_orcids":["https://orcid.org/0000-0002-4556-1755"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chail Koo","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"],"raw_orcid":"https://orcid.org/0000-0002-4556-1755","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034598874","display_name":"Xiaodong Tan","orcid":"https://orcid.org/0000-0003-0251-2774","observed_orcids":["https://orcid.org/0000-0003-0251-2774"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaodong Tan","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA"],"raw_orcid":"https://orcid.org/0000-0003-0251-2774","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034598874"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/honokiol","display_name":"honokiol","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cisplatin-induced-hearing-loss","display_name":"cisplatin-induced hearing loss","score":0.9829999804496765},{"id":"https://openalex.org/keywords/outer-hair-cells","display_name":"outer hair cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4620000123977661},{"id":"https://openalex.org/keywords/tmc-1","display_name":"TMC-1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cib2","display_name":"CIB2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ion-homeostasis","display_name":"ion homeostasis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cisplatin-uptake","display_name":"cisplatin uptake","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2781334404","wikidata":"https://www.wikidata.org/wiki/Q5896650","display_name":"Honokiol","level":2,"score":0.8873999714851379},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7002999782562256},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.6955000162124634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6445000171661377},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6399000287055969},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5921000242233276},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5478000044822693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4553000032901764},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3926999866962433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.375},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C2776360568","wikidata":"https://www.wikidata.org/wiki/Q2697787","display_name":"Hair loss","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C11658465","wikidata":"https://www.wikidata.org/wiki/Q6414172","display_name":"Kinocilium","level":4,"score":0.2662999927997589},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.22.761060","doi":"https://doi.org/10.64898/2026.10.22.761060","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.761060","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.761060.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738744","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738744/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738744/pdf/nihpp-2026.10.22.761060v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42996040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.22.761060","doi":"https://doi.org/10.64898/2026.10.22.761060","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.761060","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.761060.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000860871","display_name":"Hearing Protection in Cisplatin Chemotherapy","funder_award_id":"R01DC019434","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223468041.pdf","grobid_xml":"https://content.openalex.org/works/W7223468041.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W15464296","https://openalex.org/W1992088747","https://openalex.org/W2017614800","https://openalex.org/W2026889343","https://openalex.org/W2038717281","https://openalex.org/W2768737575","https://openalex.org/W2901044552","https://openalex.org/W2965927230","https://openalex.org/W3136807286","https://openalex.org/W3202587827","https://openalex.org/W4211053956","https://openalex.org/W4283021724","https://openalex.org/W7203750400"],"related_works":["https://openalex.org/W7203750400","https://openalex.org/W7220912341","https://openalex.org/W3018547828","https://openalex.org/W3121087799","https://openalex.org/W4396521011","https://openalex.org/W4211053956","https://openalex.org/W7057716092","https://openalex.org/W3209711501","https://openalex.org/W7056837262","https://openalex.org/W4392872934"],"abstract_inverted_index":{"Abstract":[0],"Outer":[1],"hair":[2,54,120],"cell":[3],"(OHC)":[4],"loss":[5,10],"occurs":[6],"in":[7,25,40,51,88,116],"cisplatin-induced":[8,22],"hearing":[9],"(CIHL).":[11],"We":[12],"previously":[13],"reported":[14],"that":[15,127],"honokiol":[16,35,93],"protects":[17],"against":[18,136],"CIHL":[19],"and":[20,53,59,63,107],"mitigates":[21],"transcriptomic":[23],"changes":[24,123,141],"OHCs.":[26],"Here,":[27],"we":[28],"re-analyzed":[29],"OHC":[30,41],"RNA-seq":[31],"to":[32,133,146],"determine":[33],"whether":[34,139],"differentially":[36],"affects":[37],"genes":[38,49,70,96],"involved":[39,50],"physiological":[42],"function":[43],"depending":[44],"on":[45],"cisplatin":[46,143],"exposure.":[47],"Twenty-two":[48],"mechanotransduction":[52,99],"bundle":[55],"function,":[56],"membrane":[57],"potential":[58],"ion":[60],"homeostasis,":[61],"electromotility,":[62],"efferent":[64],"regulation":[65],"were":[66,85],"selected.":[67],"Among":[68],"20":[69],"with":[71,98],"available":[72],"interaction":[73],"statistics,":[74],"16":[75],"showed":[76],"significant":[77],"Honokiol":[78],"\u00d7":[79],"Cisplatin":[80],"interactions,":[81],"of":[82,91],"which":[83],"15":[84],"negative.":[86],"Notably,":[87],"the":[89,125],"presence":[90],"cisplatin,":[92],"downregulated":[94],"several":[95],"associated":[97],"(MET)":[100],"machinery,":[101],"including":[102],"Lhfpl5,":[103],"Tmc1,":[104],"Cib2":[105],",":[106],"Tomt":[108],".":[109],"Because":[110],"MET":[111,129],"channels":[112],"have":[113],"been":[114],"implicated":[115],"cisplatin\u2019s":[117],"entry":[118],"into":[119],"cells,":[121],"these":[122,140],"raise":[124],"possibility":[126],"altered":[128],"machinery":[130],"may":[131],"contribute":[132],"honokiol-mediated":[134],"protection":[135],"CIHL.":[137],"However,":[138],"decrease":[142],"uptake":[144],"remains":[145],"be":[147],"determined.":[148]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-25T00:00:00"}
