{"id":"https://openalex.org/W7223453755","doi":"https://doi.org/10.64898/2026.10.21.26366177","title":"Nasal CPAP is associated with increased midfacial retrusion in children with FGFR -related craniosynostoses: risk factors and biomechanical determinants","display_name":"Nasal CPAP is associated with increased midfacial retrusion in children with FGFR -related craniosynostoses: risk factors and biomechanical determinants","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7223453755","doi":"https://doi.org/10.64898/2026.10.21.26366177"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.21.26366177","doi":"https://doi.org/10.64898/2026.10.21.26366177","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.26366177","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/24/2026.10.21.26366177.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/24/2026.10.21.26366177.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024125034","display_name":"M.A.M. Taverne","orcid":"https://orcid.org/0000-0003-3355-6200","observed_orcids":["https://orcid.org/0000-0003-3355-6200"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxime Taverne","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-3355-6200","affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159377960","display_name":"Margaux Ntirubuza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Margaux Ntirubuza","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019484523","display_name":"Yehong Zhong","orcid":"https://orcid.org/0000-0003-4497-1821","observed_orcids":["https://orcid.org/0000-0003-4497-1821"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210092004","display_name":"Plastic Surgery Hospital","ror":"https://ror.org/00fk0yb75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yehong Zhong","raw_affiliation_strings":["Department of Craniomaxillofacial Surgery and Digital Technology Center, Plastic Surgery Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniomaxillofacial Surgery and Digital Technology Center, Plastic Surgery Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210092004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159435227","display_name":"Alois Roussel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alo\u00efs Roussel","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159442812","display_name":"Suzann Beukes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Suzann Beukes","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012810800","display_name":"Ombline Delassus","orcid":"https://orcid.org/0000-0003-1225-6065","observed_orcids":["https://orcid.org/0000-0003-1225-6065"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ombline Delassus","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075330454","display_name":"Lucie Griffon","orcid":"https://orcid.org/0009-0008-1942-4627","observed_orcids":["https://orcid.org/0009-0008-1942-4627"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucie Griffon","raw_affiliation_strings":["Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","VIFASOM UMR 7330, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"VIFASOM UMR 7330, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012181087","display_name":"Mehran Moazen","orcid":"https://orcid.org/0000-0002-9951-2975","observed_orcids":["https://orcid.org/0000-0002-9951-2975"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mehran Moazen","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113909666","display_name":"S. Laporte","orcid":"https://orcid.org/0000-0001-5104-7499","observed_orcids":["https://orcid.org/0000-0001-5104-7499"]},"institutions":[{"id":"https://openalex.org/I190861549","display_name":"Arts et M\u00e9tiers","ror":"https://ror.org/018pp1107","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210153840","display_name":"Institut de Biom\u00e9canique Humaine Georges Charpak","ror":"https://ror.org/053gdvc84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210091279","https://openalex.org/I4210134562","https://openalex.org/I4210153840"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Laporte","raw_affiliation_strings":["Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France","institution_ids":["https://openalex.org/I190861549","https://openalex.org/I4210153840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087979588","display_name":"Christophe Muth-Seng","orcid":"https://orcid.org/0000-0002-7467-7722","observed_orcids":["https://orcid.org/0000-0002-7467-7722"]},"institutions":[{"id":"https://openalex.org/I190861549","display_name":"Arts et M\u00e9tiers","ror":"https://ror.org/018pp1107","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210153840","display_name":"Institut de Biom\u00e9canique Humaine Georges Charpak","ror":"https://ror.org/053gdvc84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210091279","https://openalex.org/I4210134562","https://openalex.org/I4210153840"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Muth-Seng","raw_affiliation_strings":["Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France","institution_ids":["https://openalex.org/I190861549","https://openalex.org/I4210153840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051583715","display_name":"Philippe Rouch","orcid":"https://orcid.org/0000-0001-8827-0547","observed_orcids":["https://orcid.org/0000-0001-8827-0547"]},"institutions":[{"id":"https://openalex.org/I190861549","display_name":"Arts et M\u00e9tiers","ror":"https://ror.org/018pp1107","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210153840","display_name":"Institut de Biom\u00e9canique Humaine Georges Charpak","ror":"https://ror.org/053gdvc84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I190861549","https://openalex.org/I4210091279","https://openalex.org/I4210134562","https://openalex.org/I4210153840"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Rouch","raw_affiliation_strings":["Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biom\u00e9canique Humaine Georges Charpak (I-Biomec), Arts et M\u00e9tiers ParisTech, Paris, France","institution_ids":["https://openalex.org/I190861549","https://openalex.org/I4210153840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029299581","display_name":"Giovanna Paternoster","orcid":"https://orcid.org/0000-0002-2970-0858","observed_orcids":["https://orcid.org/0000-0002-2970-0858"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Giovanna Paternoster","raw_affiliation_strings":["Department of Pediatric Neurosurgery, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurosurgery, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040910222","display_name":"\u00c9ric Arnaud","orcid":"https://orcid.org/0000-0002-4981-3366","observed_orcids":["https://orcid.org/0000-0002-4981-3366"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Arnaud","raw_affiliation_strings":["Clinique Marcel Sembat, Ramsay G\u00e9n\u00e9rale de Sant\u00e9, Boulogne-Billancourt, France","Department of Pediatric Neurosurgery, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique Marcel Sembat, Ramsay G\u00e9n\u00e9rale de Sant\u00e9, Boulogne-Billancourt, France","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Neurosurgery, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026614086","display_name":"Corinne Collet","orcid":"https://orcid.org/0000-0001-6990-863X","observed_orcids":["https://orcid.org/0000-0001-6990-863X"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Collet","raw_affiliation_strings":["Service de m\u00e9decine g\u00e9nomique des maladies rares, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de m\u00e9decine g\u00e9nomique des maladies rares, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079983453","display_name":"Brigitte Fauroux","orcid":"https://orcid.org/0000-0001-6092-2662","observed_orcids":["https://orcid.org/0000-0001-6092-2662"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte Fauroux","raw_affiliation_strings":["Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019429737","display_name":"Sonia Khirani","orcid":"https://orcid.org/0000-0003-4163-5021","observed_orcids":["https://orcid.org/0000-0003-4163-5021"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sonia Khirani","raw_affiliation_strings":["ASV Sant\u00e9, Gennevilliers, France","Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","VIFASOM UMR 7330, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ASV Sant\u00e9, Gennevilliers, France","institution_ids":[]},{"raw_affiliation_string":"Pediatric Noninvasive Ventilation and Sleep Unit, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"VIFASOM UMR 7330, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100755843","display_name":"Roman Hossein Khonsari","orcid":"https://orcid.org/0000-0002-0649-1432","observed_orcids":["https://orcid.org/0000-0002-0649-1432","https://orcid.org/0000-0002-6745-2701"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Roman H. Khonsari","raw_affiliation_strings":["Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","Service de chirurgie maxillofaciale et chirurgie plastique, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-0649-1432","affiliations":[{"raw_affiliation_string":"Craniofacial Growth and Form Laboratory, Imagine Institute, INSERM UMR1163, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]},{"raw_affiliation_string":"Service de chirurgie maxillofaciale et chirurgie plastique, H\u00f4pital Necker \u2013 Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5100755843"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210165077"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasal-cpap","display_name":"nasal continuous positive airway pressure","score":0.722000002861023},{"id":"https://openalex.org/keywords/craniofacial-growth","display_name":"craniofacial growth","score":0.8880000114440918},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mask-fit","display_name":"mask fit","score":0.5189999938011169},{"id":"https://openalex.org/keywords/craniofacial-morphology","display_name":"craniofacial morphology","score":0.7689999938011169},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.8454999923706055},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.7827000021934509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7175999879837036},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.5241000056266785},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.45329999923706055},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4375999867916107},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.4359000027179718},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4099000096321106},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.3962000012397766},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.353300005197525},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2777081826","wikidata":"https://www.wikidata.org/wiki/Q2418904","display_name":"Cephalometry","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2778043341","wikidata":"https://www.wikidata.org/wiki/Q5182142","display_name":"Craniofacial surgery","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2775867611","wikidata":"https://www.wikidata.org/wiki/Q1024207","display_name":"Positive airway pressure","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C2911059045","wikidata":"https://www.wikidata.org/wiki/Q378183","display_name":"Craniosynostoses","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2778951934","wikidata":"https://www.wikidata.org/wiki/Q5182137","display_name":"Craniofacial abnormality","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.21.26366177","doi":"https://doi.org/10.64898/2026.10.21.26366177","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.26366177","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/24/2026.10.21.26366177.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.21.26366177","doi":"https://doi.org/10.64898/2026.10.21.26366177","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.21.26366177","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/24/2026.10.21.26366177.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223453755.pdf","grobid_xml":"https://content.openalex.org/works/W7223453755.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2615486937","https://openalex.org/W2900276053","https://openalex.org/W4280645913","https://openalex.org/W4412108551","https://openalex.org/W4415216113"],"related_works":["https://openalex.org/W2045409031","https://openalex.org/W2200679335","https://openalex.org/W2139087874","https://openalex.org/W3034995505","https://openalex.org/W2799948387","https://openalex.org/W7037447449","https://openalex.org/W2099236813","https://openalex.org/W2009768280","https://openalex.org/W3201520022","https://openalex.org/W7161562064"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Children":[2],"with":[3,66,70,85,127,206,213,217],"FGFR":[4,67,214],"-related":[5,68,215],"craniosynostoses":[6,69],"frequently":[7],"require":[8],"prolonged":[9,238],"nasal":[10],"continuous":[11],"positive":[12],"airway":[13],"pressure":[14,77,170],"(CPAP)":[15],"for":[16],"severe":[17],"obstructive":[18],"sleep":[19],"apnea":[20],"while":[21],"definitive":[22],"craniofacial":[23,59,234,250],"procedures":[24],"are":[25],"delayed.":[26],"We":[27],"investigated":[28],"whether":[29],"sustained":[30],"CPAP":[31,109,180,203,239],"use":[32,132],"alters":[33],"midfacial":[34,122,208],"growth":[35,90,117,174,209,235],"and":[36,40,63,76,92,108,158,169,172,196,226,240,245],"identified":[37],"the":[38,98,143,148,164],"morphological":[39,177],"biomechanical":[41],"determinants":[42],"of":[43,58,73,100,136,167,173,242],"this":[44,48],"effect.":[45],"Methods":[46],"In":[47],"retrospective":[49],"observational":[50],"study,":[51],"we":[52],"combined":[53],"longitudinal":[54,249],"3D":[55],"morphometric":[56],"analyses":[57,88],"shape":[60],"in":[61,211],"CPAP-treated":[62,112],"untreated":[64,125],"children":[65,212],"experimental":[71],"measurements":[72],"mask-induced":[74],"forces":[75],"distribution":[78],"using":[79],"3D-printed":[80],"patient-specific":[81],"facial":[82],"models":[83],"instrumented":[84],"sensors.":[86],"Multivariate":[87],"characterized":[89,119],"trajectories,":[91],"structural":[93],"equation":[94],"modeling":[95],"(SEM)":[96],"disentangled":[97],"effects":[99],"three":[101],"major":[102],"risk":[103,178],"factors:":[104],"age,":[105],"initial":[106],"morphology,":[107,193,223],"duration.":[110],"Results":[111],"patients":[113,126],"exhibited":[114],"a":[115],"distinct":[116],"trajectory":[118],"by":[120],"greater":[121],"retrusion":[123],"than":[124],"similar":[128],"baseline":[129,222],"morphology.":[130],"Mask":[131],"generated":[133],"mechanical":[134,194],"loads":[135],"6\u201310":[137],"N.":[138],"Intentional":[139],"overtightening":[140],"markedly":[141],"increased":[142],"total":[144],"force":[145,168],"applied":[146],"to":[147],"face,":[149],"but":[150],"no":[151],"notable":[152],"difference":[153],"was":[154,163],"observed":[155],"between":[156,192],"expert":[157],"non-expert":[159],"operators.":[160],"Craniofacial":[161],"morphology":[162],"main":[165],"determinant":[166],"distributions":[171],"response,":[175],"identifying":[176],"factors.":[179],"duration":[181],"exaggerated":[182],"these":[183],"effects,":[184],"particularly":[185],"at":[186,228],"younger":[187],"ages.":[188],"SEM":[189],"supported":[190],"links":[191],"loading,":[195],"deviation":[197,210],"from":[198],"expected":[199],"growth.":[200],"Conclusions":[201],"Nasal":[202],"is":[204],"associated":[205],"additional":[207],"craniosynostoses,":[216],"susceptibility":[218],"strongly":[219],"dependent":[220],"on":[221],"treatment":[224,251],"duration,":[225],"age":[227],"initiation.":[229],"These":[230],"findings":[231],"support":[232],"systematic":[233],"monitoring":[236],"during":[237],"consideration":[241],"respiratory":[243],"management":[244],"interface":[246],"fit":[247],"within":[248],"planning.":[252]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-25T00:00:00"}
