{"id":"https://openalex.org/W7223442200","doi":"https://doi.org/10.64898/2026.10.22.760485","title":"Engineered T cells controlled by granulocyte colony-stimulating factor eradicate murine melanoma without lymphodepletion or interleukin-2","display_name":"Engineered T cells controlled by granulocyte colony-stimulating factor eradicate murine melanoma without lymphodepletion or interleukin-2","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7223442200","doi":"https://doi.org/10.64898/2026.10.22.760485"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.22.760485","doi":"https://doi.org/10.64898/2026.10.22.760485","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760485","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760485.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760485.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159437286","display_name":"Sam C Preshaw","orcid":"https://orcid.org/0009-0002-0683-9133","observed_orcids":["https://orcid.org/0009-0002-0683-9133"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sam C. Preshaw","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0009-0002-0683-9133","affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035065113","display_name":"Megan Fuller","orcid":"https://orcid.org/0000-0002-8752-8312","observed_orcids":["https://orcid.org/0000-0002-8752-8312"]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Megan E. Fuller","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8752-8312","affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052450695","display_name":"Cameron J. Powell","orcid":"https://orcid.org/0000-0002-5889-8963","observed_orcids":["https://orcid.org/0000-0002-5889-8963"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cameron J. Powell","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5889-8963","affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066165449","display_name":"Katy Milne","orcid":"https://orcid.org/0000-0001-5616-1821","observed_orcids":["https://orcid.org/0000-0001-5616-1821"]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katy Milne","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143245290","display_name":"Kassandra Sewell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kassandra Sewell","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102970376","display_name":"Mitchell Brady Adamson","orcid":"https://orcid.org/0000-0003-4386-6130","observed_orcids":["https://orcid.org/0000-0003-4386-6130"]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mitchell B. Adamson","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4386-6130","affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085440666","display_name":"Alexi S. Pearson-Lund","orcid":"https://orcid.org/0009-0008-8330-2181","observed_orcids":["https://orcid.org/0009-0008-8330-2181"]},"institutions":[{"id":"https://openalex.org/I34403800","display_name":"GEOMAR Helmholtz Centre for Ocean Research Kiel","ror":"https://ror.org/02h2x0161","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I34403800"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA","DE"],"is_corresponding":false,"raw_author_name":"Alexi Pearson-Lund","raw_affiliation_strings":["Research Unit Marine Symbioses, GEOMAR Helmholtz Centre for Ocean Research; Kiel, Germany","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0009-0008-8330-2181","affiliations":[{"raw_affiliation_string":"Research Unit Marine Symbioses, GEOMAR Helmholtz Centre for Ocean Research; Kiel, Germany","institution_ids":["https://openalex.org/I34403800"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159419859","display_name":"Marco Joly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marco Joly","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036334955","display_name":"Sydney Goodwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sydney Goodwin","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159390001","display_name":"Niloufar Shakerian","orcid":"https://orcid.org/0009-0000-8181-525X","observed_orcids":["https://orcid.org/0009-0000-8181-525X"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Niloufar Shakerian","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0009-0000-8181-525X","affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159377188","display_name":"Natalie J.S. Taylor","orcid":"https://orcid.org/0009-0005-1834-3970","observed_orcids":["https://orcid.org/0009-0005-1834-3970"]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Natalie J.S. Taylor","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0009-0005-1834-3970","affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152103962","display_name":"Ming Zi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ming Zi Xu","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159454983","display_name":"Danielle Klassen","orcid":"https://orcid.org/0009-0008-1442-9111","observed_orcids":["https://orcid.org/0009-0008-1442-9111"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle Klassen","raw_affiliation_strings":["Department of Biology, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0009-0008-1442-9111","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159456415","display_name":"Taise Bryce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Taise Bryce","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159459302","display_name":"Julian C Smazynski","orcid":"https://orcid.org/0000-0001-7922-3757","observed_orcids":["https://orcid.org/0000-0001-7922-3757"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julian Smazynski","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0001-7922-3757","affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009676326","display_name":"Martin J. Boulanger","orcid":"https://orcid.org/0000-0001-6835-9309","observed_orcids":["https://orcid.org/0000-0001-6835-9309"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin J. Boulanger","raw_affiliation_strings":["School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6835-9309","affiliations":[{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058837420","display_name":"Brad H. Nelson","orcid":"https://orcid.org/0000-0002-4445-5539","observed_orcids":["https://orcid.org/0000-0002-4445-5539"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]},{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Brad H. Nelson","raw_affiliation_strings":["Department of Medical Genetics, University of British Columbia; Vancouver, British Columbia, Canada","School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4445-5539","affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of British Columbia; Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"School of Molecular Life Sciences, University of Victoria; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, BC Cancer; Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058837420"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I212119943","https://openalex.org/I4405286984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6890000104904175},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chimeric-receptors","display_name":"chimeric receptors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5899999737739563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5503000020980835},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5317000150680542},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5188999772071838},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5101000070571899},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49219998717308044},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4724999964237213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.453000009059906},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3937999904155731},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.35659998655319214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34599998593330383},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.33730000257492065},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.2976999878883362},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2721000015735626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.2531999945640564},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.22.760485","doi":"https://doi.org/10.64898/2026.10.22.760485","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760485","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760485.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.22.760485","doi":"https://doi.org/10.64898/2026.10.22.760485","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760485","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/24/2026.10.22.760485.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223442200.pdf","grobid_xml":"https://content.openalex.org/works/W7223442200.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7204146972"],"related_works":["https://openalex.org/W2320324984","https://openalex.org/W2038972196","https://openalex.org/W2097000480","https://openalex.org/W2156932621","https://openalex.org/W2122330550","https://openalex.org/W2243949585","https://openalex.org/W1662416542","https://openalex.org/W1999971876","https://openalex.org/W7209835930","https://openalex.org/W2021008437"],"abstract_inverted_index":{"Abstract":[0],"Tumour-infiltrating":[1],"lymphocyte":[2],"(TIL)":[3],"therapy":[4],"can":[5,25,179],"be":[6,166,180],"effective":[7],"against":[8],"metastatic":[9],"melanoma,":[10,97],"including":[11],"immune":[12],"checkpoint-resistant":[13],"disease,":[14],"but":[15,150],"current":[16],"protocols":[17],"require":[18],"lymphodepletion":[19],"and":[20,78,87,164,193],"high-dose":[21],"interleukin-2":[22],"(IL-2),":[23],"which":[24],"cause":[26],"substantial":[27],"toxicity.":[28],"To":[29],"overcome":[30],"this":[31],"limitation,":[32],"we":[33],"engineered":[34],"a":[35,52],"chimeric":[36],"receptor,":[37],"G2R,":[38],"that":[39,197],"generates":[40],"an":[41,195],"IL-2-like":[42],"proliferative":[43],"signal":[44],"in":[45,57,65,67,71,125,147,153],"response":[46,68],"to":[47,69,182,201],"granulocyte":[48],"colony-stimulating":[49],"factor":[50],"(G-CSF),":[51],"well-tolerated":[53],"cytokine":[54,88],"widely":[55],"used":[56],"oncology.":[58],"Human":[59],"T":[60,105,114,160,186],"cells":[61,106,161],"expressing":[62],"G2R":[63],"expanded":[64],"vitro":[66],"G-CSF":[70,110,141,169,178],"place":[72],"of":[73,100,128,173,189],"IL-2":[74,136],"or":[75,137,156],"interleukin-15":[76],"(IL-15),":[77],"the":[79,131],"three":[80],"cytokines":[81],"induced":[82,112,143],"broadly":[83],"similar":[84],"intracellular":[85],"signalling":[86],"secretion":[89],"profiles.":[90],"In":[91],"immune-competent":[92],"mice":[93],"bearing":[94],"established":[95],"B16-F10":[96],"adoptive":[98],"transfer":[99],"G2R-expressing,":[101],"tumour-reactive":[102],"CD8":[103],"+":[104],"followed":[107],"by":[108,120],"systemic":[109],"treatment":[111,142],"profound":[113,190],"cell":[115,187],"expansion.":[116],"This":[117],"was":[118],"accompanied":[119],"complete,":[121],"durable":[122],"tumour":[123,175],"regression":[124],"over":[126],"75%":[127],"animals":[129],"without":[130],"need":[132],"for":[133],"lymphodepletion,":[134],"exogenous":[135],"any":[138],"other":[139],"therapy.":[140],"transient":[144],"neutrophil":[145],"expansion":[146],"peripheral":[148],"blood":[149],"no":[151],"increase":[152],"intratumoural":[154],"neutrophils":[155],"macrophages.":[157],"G2R-expressing":[158],"memory":[159],"persisted":[162],"long-term":[163],"could":[165],"re-expanded":[167],"upon":[168],"re-treatment,":[170],"enabling":[171],"rejection":[172],"second":[174],"challenges.":[176],"Thus,":[177],"repurposed":[181],"enable":[183],"clinician-controlled":[184],"anti-tumour":[185],"responses":[188],"magnitude,":[191],"efficacy":[192],"durability,":[194],"approach":[196],"is":[198],"readily":[199],"translatable":[200],"humans.":[202]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-25T00:00:00"}
