{"id":"https://openalex.org/W7223440343","doi":"https://doi.org/10.1186/s13014-026-02950-6","title":"Prognostic value of body composition combined with Epstein-Barr virus DNA and platelet-to-lymphocyte ratio in locally advanced nasopharyngeal carcinoma","display_name":"Prognostic value of body composition combined with Epstein-Barr virus DNA and platelet-to-lymphocyte ratio in locally advanced nasopharyngeal carcinoma","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7223440343","doi":"https://doi.org/10.1186/s13014-026-02950-6"},"language":"en","primary_location":{"id":"doi:10.1186/s13014-026-02950-6","doi":"https://doi.org/10.1186/s13014-026-02950-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13014-026-02950-6","pdf_url":null,"source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13014-026-02950-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159383167","display_name":"Huan Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Dong","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","School of Basic Medical Sciences, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"School of Basic Medical Sciences, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004104104","display_name":"\u9ec4\u6cb3\u6e05","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heqing Huang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036133262","display_name":"Yating Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yating Qin","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159463533","display_name":"Zhen Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Meng","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159468386","display_name":"Ding Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ding Liang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113244672","display_name":"Huisi Zhang","orcid":"https://orcid.org/0009-0009-7731-0780","observed_orcids":["https://orcid.org/0009-0009-7731-0780"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huisi Zhang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129883742","display_name":"Guangyao He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangyao He","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159381766","display_name":"Min Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Kang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":[]},{"raw_affiliation_string":"Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, No. 22 Shuangyong Road, Nanning, Guangxi, 530021, People\u2019s Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5129883742","https://openalex.org/A5159381766"],"corresponding_institution_ids":["https://openalex.org/I4210126060"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/locally-advanced-nasopharyngeal-carcinoma","display_name":"locally advanced nasopharyngeal carcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/epstein-barr-virus-dna","display_name":"Epstein-Barr virus DNA","score":0.8970000147819519},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.9750000238418579},{"id":"https://openalex.org/keywords/phase-angle","display_name":"phase angle","score":0.9959999918937683},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8389999866485596},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.9192000031471252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8963000178337097},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.6500999927520752},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5687999725341797},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5285999774932861},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4887999892234802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4262000024318695},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.4068000018596649},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3930000066757202},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3865000009536743},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3862999975681305},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3492000102996826},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13014-026-02950-6","doi":"https://doi.org/10.1186/s13014-026-02950-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13014-026-02950-6","pdf_url":null,"source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13014-026-02950-6","doi":"https://doi.org/10.1186/s13014-026-02950-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13014-026-02950-6","pdf_url":null,"source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389508448","https://openalex.org/W4403378832","https://openalex.org/W7207549224","https://openalex.org/W3030828872","https://openalex.org/W7011740268","https://openalex.org/W4384663206","https://openalex.org/W4283079995","https://openalex.org/W333304685","https://openalex.org/W4389286598","https://openalex.org/W7125408010"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,34,43,47,59,89,94,134,140,196],"prognostic":[3,176],"value":[4],"of":[5,36,64,121,157,161,166,198],"body":[6,53,82],"composition":[7,22,54,83],"parameters":[8,23,55,84],"combined":[9],"with":[10,15,28,126,154,169,200],"clinical":[11,173],"factors":[12],"in":[13,26,81,88,93,124],"patients":[14,27,39,125,199],"locally":[16],"advanced":[17],"nasopharyngeal":[18],"carcinoma":[19],"(LA-NPC).":[20],"Body":[21],"were":[24,40,56,68,85,118],"assessed":[25],"LA-NPC":[29],"during":[30],"radiotherapy.":[31],"Based":[32],"on":[33],"occurrence":[35],"disease":[37],"progression,":[38],"divided":[41],"into":[42],"non-recurrence/metastasis":[44,95],"group":[45,91,96],"and":[46,52,70,76,115,163,172,190],"recurrence/metastasis":[48,90],"group.":[49],"Clinical":[50],"characteristics":[51],"compared":[57],"between":[58],"two":[60],"groups.":[61],"Independent":[62],"predictors":[63,120,149],"progression-free":[65],"survival":[66],"(PFS)":[67],"identified,":[69],"a":[71,159,164],"predictive":[72,136,152],"model":[73,177],"was":[74],"constructed":[75],"validated.":[77],"After":[78],"radiotherapy,":[79],"reductions":[80],"significantly":[86],"greater":[87],"than":[92],"(":[97],"P":[98],"<":[99],"0.05).":[100],"Immunotherapy,":[101],"pre-radiotherapy":[102,108,181,185],"Epstein-Barr":[103],"virus":[104],"(EBV)":[105],"DNA":[106,183],"level,":[107,184],"platelet-to-lymphocyte":[109],"ratio":[110],"(PLR),":[111],"skeletal":[112,130,187],"muscle":[113,131,188],"mass,":[114,189],"phase":[116,191],"angle":[117,192],"independent":[119],"3-year":[122],"PFS":[123],"LA-NPC.":[127,201],"Among":[128],"these,":[129],"mass":[132],"exhibited":[133],"highest":[135],"performance":[137],"(area":[138],"under":[139],"curve":[141],"[AUC]":[142],"=":[143],"0.952).":[144],"The":[145],"nomogram":[146],"incorporating":[147,178],"all":[148],"had":[150],"higher":[151],"efficacy,":[153],"an":[155],"AUC":[156],"0.987,":[158],"sensitivity":[160],"1.00,":[162],"specificity":[165],"0.92,":[167],"along":[168],"good":[170],"calibration":[171],"utility.":[174],"A":[175],"immunotherapy":[179],"status,":[180],"EBV":[182],"PLR,":[186],"can":[193],"effectively":[194],"predict":[195],"prognosis":[197],"Not":[202],"applicable":[203]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-25T00:00:00"}