{"id":"https://openalex.org/W7223433167","doi":"https://doi.org/10.1155/prm/8018460","title":"The Role of Cardiovascular Function in Endogenous Pain Modulation","display_name":"The Role of Cardiovascular Function in Endogenous Pain Modulation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7223433167","doi":"https://doi.org/10.1155/prm/8018460","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13737465"},"language":"en","primary_location":{"id":"doi:10.1155/prm/8018460","doi":"https://doi.org/10.1155/prm/8018460","is_oa":true,"landing_page_url":"https://doi.org/10.1155/prm/8018460","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/prm/8018460","source":{"id":"https://openalex.org/S170352678","display_name":"Pain Research and Management","issn_l":"1203-6765","issn":["1203-6765","1918-1523"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Research and Management","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/prm/8018460","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158906668","display_name":"Jo\u00eblle Katharina Metzger","orcid":"https://orcid.org/0009-0004-6778-5284","observed_orcids":["https://orcid.org/0009-0004-6778-5284"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jo\u00eblle Katharina Metzger","raw_affiliation_strings":["Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch"],"raw_orcid":"https://orcid.org/0009-0004-6778-5284","affiliations":[{"raw_affiliation_string":"Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]},{"raw_affiliation_string":"Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210124057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007878826","display_name":"Shane J. T. Balthazaar","orcid":"https://orcid.org/0000-0001-8860-2898","observed_orcids":["https://orcid.org/0000-0001-8860-2898"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]},{"id":"https://openalex.org/I4210128534","display_name":"International Collaboration On Repair Discoveries","ror":"https://ror.org/03ckrg061","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141945490","https://openalex.org/I4210128534"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["CA","CH","GB"],"is_corresponding":false,"raw_author_name":"Shane James Timothy Balthazaar","raw_affiliation_strings":["International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada  ubc.ca","Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK  birmingham.ac.uk","Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch"],"raw_orcid":"https://orcid.org/0000-0001-8860-2898","affiliations":[{"raw_affiliation_string":"International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada  ubc.ca","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210128534"]},{"raw_affiliation_string":"Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]},{"raw_affiliation_string":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK  birmingham.ac.uk","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210124057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126461702","display_name":"Sophie Sturzenegger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sophie Sturzenegger","raw_affiliation_strings":["Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210124057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123971049","display_name":"Tom E Nightingale","orcid":"https://orcid.org/0000-0003-2947-4931","observed_orcids":["https://orcid.org/0000-0003-2947-4931"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210128534","display_name":"International Collaboration On Repair Discoveries","ror":"https://ror.org/03ckrg061","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141945490","https://openalex.org/I4210128534"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Tom Edward Nightingale","raw_affiliation_strings":["International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada  ubc.ca","School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK  birmingham.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-2947-4931","affiliations":[{"raw_affiliation_string":"International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada  ubc.ca","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210128534"]},{"raw_affiliation_string":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK  birmingham.ac.uk","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012717312","display_name":"Mich\u00e8le Hubli","orcid":"https://orcid.org/0000-0001-6054-3283","observed_orcids":["https://orcid.org/0000-0001-6054-3283"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mich\u00e8le Hubli","raw_affiliation_strings":["Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch"],"raw_orcid":"https://orcid.org/0000-0001-6054-3283","affiliations":[{"raw_affiliation_string":"Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich  Zurich Switzerland  ethz.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]},{"raw_affiliation_string":"Spinal Cord Injury Center Balgrist University Hospital University of Zurich  Zurich Switzerland  balgrist.ch","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210124057"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5158906668"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4210124057"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80382677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-pain-modulation","display_name":"endogenous pain modulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/conditioned-pain-modulation","display_name":"conditioned pain modulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/offset-analgesia","display_name":"offset analgesia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/baroreflex-sensitivity","display_name":"baroreflex sensitivity","score":1.0},{"id":"https://openalex.org/keywords/blood-pressure-reactivity","display_name":"blood pressure reactivity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cold-pressor-test","display_name":"cold pressor test","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.7390000224113464},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6179999709129333},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6419000029563904},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4742000102996826},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.39559999108314514},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37779998779296875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.335999995470047},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.25760000944137573}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/prm/8018460","doi":"https://doi.org/10.1155/prm/8018460","is_oa":true,"landing_page_url":"https://doi.org/10.1155/prm/8018460","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/prm/8018460","source":{"id":"https://openalex.org/S170352678","display_name":"Pain Research and Management","issn_l":"1203-6765","issn":["1203-6765","1918-1523"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Research and Management","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13737465","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737465/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737465/pdf/PRM-2026-8018460.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Res Manag","raw_type":"Text"},{"id":"pmid:42985961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain research & management","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/583dd826-5fe5-45b6-9981-80a6176d413e","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/583dd826-5fe5-45b6-9981-80a6176d413e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metzger, J K, Balthazaar, S J T, Sturzenegger, S, Nightingale, T E & Hubli, M 2026, 'The Role of Cardiovascular Function in Endogenous Pain Modulation', Pain Research and Management.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1155/prm/8018460","doi":"https://doi.org/10.1155/prm/8018460","is_oa":true,"landing_page_url":"https://doi.org/10.1155/prm/8018460","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/prm/8018460","source":{"id":"https://openalex.org/S170352678","display_name":"Pain Research and Management","issn_l":"1203-6765","issn":["1203-6765","1918-1523"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Research and Management","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320921","display_name":"International Foundation for Research in Paraplegia","ror":"https://ror.org/04hhnrj18"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320336141","display_name":"Neuroscience Center Zurich, University of Zurich","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223433167.pdf","grobid_xml":"https://content.openalex.org/works/W7223433167.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1121556462","https://openalex.org/W1208606562","https://openalex.org/W1531145115","https://openalex.org/W1570752686","https://openalex.org/W1901422178","https://openalex.org/W1967840833","https://openalex.org/W1968259519","https://openalex.org/W1972408365","https://openalex.org/W1979695027","https://openalex.org/W1981291046","https://openalex.org/W1983395697","https://openalex.org/W1984642624","https://openalex.org/W1993480656","https://openalex.org/W2004607543","https://openalex.org/W2005396232","https://openalex.org/W2006274335","https://openalex.org/W2009381080","https://openalex.org/W2018407395","https://openalex.org/W2019326267","https://openalex.org/W2020142259","https://openalex.org/W2023126015","https://openalex.org/W2026200131","https://openalex.org/W2029543844","https://openalex.org/W2030849930","https://openalex.org/W2034397824","https://openalex.org/W2036395037","https://openalex.org/W2037994619","https://openalex.org/W2043737500","https://openalex.org/W2044229618","https://openalex.org/W2047688140","https://openalex.org/W2048203787","https://openalex.org/W2050876878","https://openalex.org/W2051275033","https://openalex.org/W2055847683","https://openalex.org/W2059590433","https://openalex.org/W2059951724","https://openalex.org/W2062645254","https://openalex.org/W2072471759","https://openalex.org/W2073913859","https://openalex.org/W2074619144","https://openalex.org/W2079542232","https://openalex.org/W2087199160","https://openalex.org/W2092666789","https://openalex.org/W2096954332","https://openalex.org/W2102423296","https://openalex.org/W2105390924","https://openalex.org/W2109841140","https://openalex.org/W2110509042","https://openalex.org/W2122464624","https://openalex.org/W2125634053","https://openalex.org/W2128902234","https://openalex.org/W2140104458","https://openalex.org/W2142850282","https://openalex.org/W2147788422","https://openalex.org/W2158316475","https://openalex.org/W2159722103","https://openalex.org/W2166281097","https://openalex.org/W2166630765","https://openalex.org/W2167125051","https://openalex.org/W2176975324","https://openalex.org/W2286899982","https://openalex.org/W2295416986","https://openalex.org/W2319720537","https://openalex.org/W2325750073","https://openalex.org/W2399492758","https://openalex.org/W2474598566","https://openalex.org/W2520603488","https://openalex.org/W2522045921","https://openalex.org/W2552904306","https://openalex.org/W2585933955","https://openalex.org/W2739306046","https://openalex.org/W2759190050","https://openalex.org/W2900199470","https://openalex.org/W2912246816","https://openalex.org/W2966127300","https://openalex.org/W2991704716","https://openalex.org/W3094086029","https://openalex.org/W3110481487","https://openalex.org/W3119436632","https://openalex.org/W3128588670","https://openalex.org/W3134393167","https://openalex.org/W3146473323","https://openalex.org/W3183806239","https://openalex.org/W3206427107","https://openalex.org/W3217697925","https://openalex.org/W4210392360","https://openalex.org/W4293214708","https://openalex.org/W4361004411","https://openalex.org/W4382877091","https://openalex.org/W4384201600","https://openalex.org/W4385231004","https://openalex.org/W4403276081","https://openalex.org/W4403302372","https://openalex.org/W4404637014","https://openalex.org/W4414392639","https://openalex.org/W4416439243","https://openalex.org/W7133889826","https://openalex.org/W7167674603","https://openalex.org/W7170810494"],"related_works":["https://openalex.org/W4254280442","https://openalex.org/W2074785085","https://openalex.org/W7115261136","https://openalex.org/W7073560710","https://openalex.org/W7115300230","https://openalex.org/W2600747450","https://openalex.org/W4251942656","https://openalex.org/W2734528164","https://openalex.org/W7130684139","https://openalex.org/W2419164377"],"abstract_inverted_index":{"Structural":[0],"and":[1,7,48,67,79,93,106,129,137,166,186,215,254,287],"functional":[2,248],"overlap":[3],"between":[4,44,122,132,250],"the":[5,42,114,119,127,261],"nociceptive":[6],"cardiovascular":[8,49,138,255,264],"systems":[9],"establish":[10],"a":[11,80,241,247],"bidirectional":[12],"coupling":[13,24,249,274],"that":[14],"supports":[15],"dynamic":[16],"regulation":[17,256],"across":[18],"both":[19,207],"systems.":[20],"Disruption":[21],"of":[22,58,103,263],"this":[23,37,148,272],"could":[25],"contribute":[26],"to":[27,40,177,229],"impaired":[28],"endogenous":[29,45,251,281],"pain":[30,34,46,59,69,74,133,157,252,268,282,296],"modulation":[31,47,70,134,253,283],"in":[32,51,206,257,266,280,284,294],"chronic":[33,295],"conditions.":[35,297],"Thus,":[36],"study":[38],"aimed":[39],"investigate":[41],"relationship":[43],"function":[50,139],"healthy":[52,149,258,285],"participants.":[53],"Thirty":[54],"participants":[55,154],"underwent":[56],"assessment":[57],"modulatory":[60],"capacity":[61,188,198,226],"using":[62],"offset":[63],"analgesia":[64],"(OA;":[65],"47-48\u00b0C-47\u00b0C)":[66],"conditioned":[68],"(CPM),":[71],"with":[72,160,201],"pressure":[73,111,125,143,204],"thresholds":[75],"as":[76,85,118],"test":[77,83],"stimuli":[78],"cold":[81],"pressor":[82],"(CPT)":[84],"conditioning":[86],"stimulus.":[87],"Resting":[88],"heart":[89],"rate":[90],"variability":[91,279],"(HRV)":[92],"baroreflex":[94],"sensitivity":[95],"(BRS)":[96],"were":[97,145],"derived":[98],"from":[99],"5-min":[100],"baseline":[101],"recordings":[102],"continuous":[104],"electrocardiography":[105],"beat-to-beat":[107],"blood":[108,124,142,203],"pressure.":[109],"Blood":[110],"reactivity":[112],"during":[113,126],"CPT":[115,128],"was":[116,175,199,227],"calculated":[117],"relative":[120],"difference":[121],"peak":[123],"baseline.":[130],"Associations":[131],"(OA,":[135],"CPM)":[136],"(HRV,":[140],"BRS,":[141],"reactivity)":[144],"examined.":[146],"In":[147],"cohort":[150],"(N":[151],"=":[152,181,184,190,193,210,213,219,222,233,236],"30),":[153],"exhibited":[155],"pronounced":[156],"inhibitory":[158,269],"capacity,":[159],"OA":[161,179,225],"at":[162,168,238],"-85.7%":[163],"\u00b1":[164,170],"21.8%":[165],"CPM":[167,187,197],"-19.0%":[169],"14.7%.":[171],"Higher":[172],"resting":[173],"BRS":[174],"related":[176],"higher":[178,196,230],"(rho":[180,189,209,218,232],"-0.48,":[182,211],"p":[183,192,212,221,235],"0.030)":[185,237],"-0.52,":[191],"0.021).":[194],"Moreover,":[195],"associated":[200],"larger":[202],"responses":[205],"parallel":[208],"0.021)":[214],"sequential":[216],"designs":[217],"-0.49,":[220],"0.033).":[223],"Increased":[224],"linked":[228],"HRV":[231],"-0.50,":[234],"rest.":[239],"Using":[240],"multimodal":[242],"approach,":[243],"these":[244],"findings":[245],"support":[246],"individuals,":[259],"emphasizing":[260],"role":[262],"adaptability":[265],"shaping":[267],"processes.":[270],"Understanding":[271],"pain-cardiovascular":[273],"may":[275],"help":[276],"explain":[277],"interindividual":[278],"individuals":[286],"might":[288],"offer":[289],"insight":[290],"into":[291],"its":[292],"disruption":[293],"Trial":[298],"Registration:":[299],"ClinicalTrials.gov":[300],"identifier:":[301],"NCT06443281.":[302]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-24T00:00:00"}