{"id":"https://openalex.org/W7223405172","doi":"https://doi.org/10.1080/17568919.2026.2748650","title":"Investigating the effect of glucosamine conjugation on the inhibitory activity of 2,3-dihydro-1H-perimidine derivatives against protein tyrosine phosphatases","display_name":"Investigating the effect of glucosamine conjugation on the inhibitory activity of 2,3-dihydro-1H-perimidine derivatives against protein tyrosine phosphatases","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223405172","doi":"https://doi.org/10.1080/17568919.2026.2748650","pmid":"https://pubmed.ncbi.nlm.nih.gov/42921894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733570"},"language":"en","primary_location":{"id":"doi:10.1080/17568919.2026.2748650","doi":"https://doi.org/10.1080/17568919.2026.2748650","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17568919.2026.2748650","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42921894/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035607719","display_name":"Slieman Milaneh","orcid":"https://orcid.org/0009-0004-2559-3102","observed_orcids":["https://orcid.org/0009-0004-2559-3102"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Slieman Milaneh","raw_affiliation_strings":["Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159365445","display_name":"Miao Miao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Miao Wang","raw_affiliation_strings":["Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124337959","display_name":"Zehao Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zehao Ye","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147290700","display_name":"Li-Xing Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Xing Gao","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese \u200eAcademy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese \u200eAcademy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159329612","display_name":"Jia Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159356180","display_name":"Yu-Bo Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Bo Zhou","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese \u200eAcademy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese \u200eAcademy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159350089","display_name":"Lei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159304472","display_name":"Wenlong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenlong Wang","raw_affiliation_strings":["Jiangnan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangnan University","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5159304472"],"corresponding_institution_ids":["https://openalex.org/I111599522"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68936931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"3033","last_page":"3046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase-inhibitors","display_name":"protein tyrosine phosphatase inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tcptp","display_name":"TCPTP","score":0.7580000162124634},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.972000002861023},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6899999976158142},{"id":"https://openalex.org/keywords/enzyme-ligand-complex","display_name":"enzyme-ligand complex","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.6579999923706055},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.8610000014305115},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7861999869346619},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5812000036239624},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5663999915122986},{"id":"https://openalex.org/C2778125326","wikidata":"https://www.wikidata.org/wiki/Q327506","display_name":"Glucosamine","level":2,"score":0.5284000039100647},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.40130001306533813},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.38609999418258667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.37439998984336853},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3617999851703644},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35179999470710754},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2906000018119812},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C3017707949","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Negative regulator","level":3,"score":0.25429999828338623},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/17568919.2026.2748650","doi":"https://doi.org/10.1080/17568919.2026.2748650","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17568919.2026.2748650","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:42921894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42921894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733570","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42921894/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13733570","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42921894/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Med Chem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1036181247","https://openalex.org/W1985671883","https://openalex.org/W2033495141","https://openalex.org/W2040328392","https://openalex.org/W2089330181","https://openalex.org/W2105649494","https://openalex.org/W2109473478","https://openalex.org/W2125393146","https://openalex.org/W2130062208","https://openalex.org/W2146538702","https://openalex.org/W2154700713","https://openalex.org/W2162445476","https://openalex.org/W2165304197","https://openalex.org/W2308169993","https://openalex.org/W2407248256","https://openalex.org/W2468923062","https://openalex.org/W2590560529","https://openalex.org/W2606059677","https://openalex.org/W2607033358","https://openalex.org/W2766238077","https://openalex.org/W2888848851","https://openalex.org/W2905830510","https://openalex.org/W2968639857","https://openalex.org/W3000253725","https://openalex.org/W3015038907","https://openalex.org/W3037427595","https://openalex.org/W3085717162","https://openalex.org/W3158037998","https://openalex.org/W3196817482","https://openalex.org/W3217434924","https://openalex.org/W4200037706","https://openalex.org/W4234825578","https://openalex.org/W4248107770","https://openalex.org/W4307180832","https://openalex.org/W4308125379","https://openalex.org/W4311460169","https://openalex.org/W4318542513","https://openalex.org/W4361002016","https://openalex.org/W4389503062","https://openalex.org/W4400233963","https://openalex.org/W4407667511","https://openalex.org/W4410635244","https://openalex.org/W4417238920"],"related_works":["https://openalex.org/W2109473478","https://openalex.org/W2035353423","https://openalex.org/W2162445476","https://openalex.org/W1558053878","https://openalex.org/W1978262600","https://openalex.org/W7203985523","https://openalex.org/W2057917289","https://openalex.org/W7098854525","https://openalex.org/W3043794648","https://openalex.org/W2054160647"],"abstract_inverted_index":{"This":[0],"research":[1],"investigates":[2],"the":[3,15,68,91,105,122,139,143,190],"impact":[4],"of":[5,17,24,46,74,99,125,152,174,192],"attaching":[6],"glucosamine":[7,175],"(GlcN)":[8],"derivatives":[9],"to":[10,48,62,67,76,161],"a":[11,41,77,182],"2,3-dihydro-1H-perimidine":[12],"core":[13],"on":[14],"inhibition":[16],"protein":[18],"tyrosine":[19],"phosphatases":[20],"(PTPs).":[21],"A":[22],"total":[23],"twelve":[25],"novel":[26],"hybrid":[27],"compounds":[28],"(1\u201312)":[29],"were":[30],"synthesized":[31],"and":[32,85,108,115,134,194],"evaluated":[33],"against":[34,104,155],"various":[35],"PTP":[36,178],"isoforms.":[37],"The":[38],"findings":[39,170],"reveal":[40],"scaffold-dependent":[42],"steric-activity":[43],"relationship:":[44],"conjugation":[45,173],"GlcN":[47,75,126],"compound":[49,80,153],"C1,":[50],"which":[51],"exhibits":[52],"high":[53],"inhibitory":[54,179],"activity,":[55,180],"resulted":[56],"in":[57],"diminished":[58],"efficacy,":[59],"likely":[60],"due":[61],"steric":[63],"hindrance":[64],"impeding":[65],"access":[66],"catalytic":[69,144],"site.":[70],"In":[71],"contrast,":[72],"attachment":[73],"less":[78],"active":[79],"C2":[81],"significantly":[82],"enhanced":[83],"potency":[84],"selectivity.":[86],"Compound":[87],"9":[88,154],"emerged":[89],"as":[90],"most":[92],"potent":[93],"candidate,":[94],"with":[95,131],"an":[96],"IC50":[97],"value":[98],"7.65":[100],"\u00b1":[101],"0.67":[102],"\u03bcM":[103],"SHP2-E76K":[106],"mutant":[107],"modest":[109],"selectivity":[110],"over":[111],"PTP1B,":[112],"TCPTP,":[113],"SHP1,":[114],"SHP2.":[116],"Molecular":[117],"docking":[118],"studies":[119],"suggested":[120],"that":[121,165,172],"deacetylated":[123],"form":[124,128],"may":[127],"hydrogen":[129],"bonds":[130],"Glu":[132],"A:200":[133],"Lys":[135],"A:279,":[136],"thereby":[137],"stabilizing":[138],"enzyme-ligand":[140],"complex":[141],"within":[142],"pocket.":[145],"Cellular":[146],"assays":[147],"demonstrated":[148],"limited":[149],"antiproliferative":[150],"activity":[151],"U2OS":[156],"osteosarcoma":[157],"cells,":[158],"possibly":[159],"attributable":[160],"poor":[162],"membrane":[163],"permeability":[164],"hampers":[166],"intracellular":[167],"delivery.":[168],"These":[169],"imply":[171],"can":[176],"enhance":[177],"providing":[181],"foundational":[183],"basis":[184],"for":[185],"structure-based":[186],"optimization":[187],"aimed":[188],"at":[189],"treatment":[191],"cancer":[193],"metabolic":[195],"diseases.":[196]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}