{"id":"https://openalex.org/W7223404969","doi":"https://doi.org/10.3389/fimmu.2026.1937624","title":"PPAR\u03b3: a transfactor for Th-cell subsets","display_name":"PPAR\u03b3: a transfactor for Th-cell subsets","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223404969","doi":"https://doi.org/10.3389/fimmu.2026.1937624"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1937624","doi":"https://doi.org/10.3389/fimmu.2026.1937624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937624/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159363550","display_name":"Sihang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Sihang Chen","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center","Division of Life Sciences, Faculty of Science, The Chinese University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Division of Life Sciences, Faculty of Science, The Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016736075","display_name":"Ming Chu","orcid":"https://orcid.org/0000-0002-0507-9569","observed_orcids":["https://orcid.org/0000-0002-0507-9569"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Chu","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016736075"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68935886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-helper-cell-differentiation","display_name":"T helper cell differentiation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.875},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/th9-cells","display_name":"Th9 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6890000104904175},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.996999979019165},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bcl6","display_name":"BCL6","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6499999761581421},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.8223999738693237},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6241999864578247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5835999846458435},{"id":"https://openalex.org/C2779161069","wikidata":"https://www.wikidata.org/wiki/Q2496179","display_name":"Orphan receptor","level":4,"score":0.5825999975204468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5737000107765198},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.48890000581741333},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45179998874664307},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4415999948978424},{"id":"https://openalex.org/C2908554999","wikidata":"https://www.wikidata.org/wiki/Q905506","display_name":"Forkhead Transcription Factors","level":4,"score":0.4352000057697296},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.4034999907016754},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3840999901294708},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.35839998722076416},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.3192000091075897},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3174999952316284},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.31610000133514404},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.2994999885559082},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C191163429","wikidata":"https://www.wikidata.org/wiki/Q20970205","display_name":"Sp3 transcription factor","level":5,"score":0.288100004196167},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C77179829","wikidata":"https://www.wikidata.org/wiki/Q4677459","display_name":"Activating transcription factor","level":4,"score":0.27300000190734863},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.258899986743927}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1937624","doi":"https://doi.org/10.3389/fimmu.2026.1937624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c11787b170bd4e45adb6ee6d57f9fcf9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c11787b170bd4e45adb6ee6d57f9fcf9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1937624","doi":"https://doi.org/10.3389/fimmu.2026.1937624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223404969.pdf","grobid_xml":"https://content.openalex.org/works/W7223404969.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W1756692753","https://openalex.org/W1967261754","https://openalex.org/W1967640260","https://openalex.org/W1976209276","https://openalex.org/W1980237439","https://openalex.org/W1990055069","https://openalex.org/W2005674716","https://openalex.org/W2007176522","https://openalex.org/W2015721847","https://openalex.org/W2016868307","https://openalex.org/W2023729916","https://openalex.org/W2028769116","https://openalex.org/W2029383851","https://openalex.org/W2041544510","https://openalex.org/W2045146412","https://openalex.org/W2047852384","https://openalex.org/W2052998574","https://openalex.org/W2054172604","https://openalex.org/W2056409304","https://openalex.org/W2060658973","https://openalex.org/W2075503219","https://openalex.org/W2076076541","https://openalex.org/W2076543085","https://openalex.org/W2076604793","https://openalex.org/W2087701253","https://openalex.org/W2089929836","https://openalex.org/W2090858036","https://openalex.org/W2102545802","https://openalex.org/W2111953454","https://openalex.org/W2112866067","https://openalex.org/W2126538938","https://openalex.org/W2127633278","https://openalex.org/W2134717682","https://openalex.org/W2152014155","https://openalex.org/W2157655920","https://openalex.org/W2167691893","https://openalex.org/W2170644000","https://openalex.org/W2254672185","https://openalex.org/W2474811637","https://openalex.org/W2513413220","https://openalex.org/W2552866350","https://openalex.org/W2586061771","https://openalex.org/W2593337891","https://openalex.org/W2593593231","https://openalex.org/W2603846877","https://openalex.org/W2619691134","https://openalex.org/W2623907055","https://openalex.org/W2625891699","https://openalex.org/W2742795003","https://openalex.org/W2763664029","https://openalex.org/W2765767647","https://openalex.org/W2772222670","https://openalex.org/W2807900389","https://openalex.org/W2886801533","https://openalex.org/W2899394453","https://openalex.org/W2908777491","https://openalex.org/W2909798657","https://openalex.org/W2924408078","https://openalex.org/W2947844033","https://openalex.org/W2971517201","https://openalex.org/W2975912975","https://openalex.org/W3002407564","https://openalex.org/W3015145199","https://openalex.org/W3038374791","https://openalex.org/W3128325031","https://openalex.org/W3133116384","https://openalex.org/W3133792239","https://openalex.org/W3138180770","https://openalex.org/W3154649093","https://openalex.org/W3165120770","https://openalex.org/W3165473621","https://openalex.org/W3182510947","https://openalex.org/W3202018645","https://openalex.org/W3204654219","https://openalex.org/W3208683580","https://openalex.org/W3216941127","https://openalex.org/W4220824598","https://openalex.org/W4223417639","https://openalex.org/W4224020909","https://openalex.org/W4224218821","https://openalex.org/W4281705820","https://openalex.org/W4283720053","https://openalex.org/W4283772529","https://openalex.org/W4284886918","https://openalex.org/W4296323692","https://openalex.org/W4297537346","https://openalex.org/W4306149677","https://openalex.org/W4313353106","https://openalex.org/W4313410109","https://openalex.org/W4317708645","https://openalex.org/W4321097759","https://openalex.org/W4366817671","https://openalex.org/W4367368645","https://openalex.org/W4375851406","https://openalex.org/W4378783417","https://openalex.org/W4382515756","https://openalex.org/W4387868905","https://openalex.org/W4389444743","https://openalex.org/W4391540827","https://openalex.org/W4392859368","https://openalex.org/W4395669949","https://openalex.org/W4396917787","https://openalex.org/W4399718338","https://openalex.org/W4403537386","https://openalex.org/W4403916083","https://openalex.org/W4403981373","https://openalex.org/W4404016612","https://openalex.org/W4404258088","https://openalex.org/W4404320010","https://openalex.org/W4405728059","https://openalex.org/W4405739189","https://openalex.org/W4406774696","https://openalex.org/W4408029612","https://openalex.org/W4408853298","https://openalex.org/W4409095542","https://openalex.org/W4410113861","https://openalex.org/W4410160773","https://openalex.org/W4411146541","https://openalex.org/W4411163585","https://openalex.org/W4411872976","https://openalex.org/W4412066663","https://openalex.org/W4413100126","https://openalex.org/W4413514900","https://openalex.org/W4413930130","https://openalex.org/W4414190156","https://openalex.org/W4414997368","https://openalex.org/W4415172561","https://openalex.org/W4415607321","https://openalex.org/W4416224817","https://openalex.org/W4416411708","https://openalex.org/W4416677982","https://openalex.org/W4416771408","https://openalex.org/W4416966346","https://openalex.org/W4417098071","https://openalex.org/W4417349880","https://openalex.org/W7117130201","https://openalex.org/W7125370436","https://openalex.org/W7133350499","https://openalex.org/W7133624117","https://openalex.org/W7135196908","https://openalex.org/W7154488134"],"related_works":["https://openalex.org/W3030661402","https://openalex.org/W4313353106","https://openalex.org/W1511195742","https://openalex.org/W2908777491","https://openalex.org/W2800858578","https://openalex.org/W2971888745","https://openalex.org/W2126538938","https://openalex.org/W7223430342","https://openalex.org/W4309479217","https://openalex.org/W4313349544"],"abstract_inverted_index":{"Peroxisome":[0],"proliferator-activated":[1],"receptor":[2,64],"\u03b3":[3],"(PPAR\u03b3)":[4],"is":[5],"a":[6,149,173],"ligand-activated":[7],"nuclear":[8],"transcription":[9,69,94,151],"factor":[10,152],"that":[11],"governs":[12],"helper":[13],"T":[14],"cell":[15,84,121],"(Th)":[16],"immunometabolism":[17],"and":[18,27,49,70,95,131,141,156],"functional":[19],"differentiation":[20,85],"by":[21,86,137],"regulating":[22],"gene":[23],"transcription,":[24],"cellular":[25,55],"metabolism,":[26],"cytokine":[28],"microenvironment.":[29],"In":[30,57,79,99],"Th1":[31],"cells,":[32,41,59,101,110],"PPAR\u03b3":[33,81,102,114,129,147],"primarily":[34],"regulates":[35],"interferon-\u03b3":[36],"(IFN-\u03b3)":[37],"secretion.":[38],"Within":[39,108],"Th2":[40],"it":[42,60,171],"influences":[43],"GATA-binding":[44],"protein":[45],"3":[46],"(GATA3)":[47],"expression":[48],"provides":[50],"metabolic":[51,97,140],"support":[52],"for":[53,175],"normal":[54],"functions.":[56],"Th17":[58],"inhibits":[61],"RAR-related":[62],"orphan":[63],"\u03b3t":[65],"(":[66,91,124],"ROR\u03b3t":[67],")":[68,93,126],"suppresses":[71],"inflammatory":[72,77],"signals,":[73],"thereby":[74],"alleviating":[75],"Th17-mediated":[76],"responses.":[78],"Tregs,":[80],"aids":[82],"in":[83,119],"activating":[87],"forkhead":[88],"box":[89],"P3":[90],"Foxp3":[92],"inducing":[96],"reprogramming.":[98],"Th9":[100],"promotes":[103],"the":[104,111,164],"secretion":[105],"of":[106,113,178],"IL-9.":[107],"Tfh":[109],"deficiency":[112],"leads":[115],"to":[116],"an":[117],"increase":[118],"B":[120],"leukemia/lymphoma":[122],"6":[123],"Bcl-6":[125],"expression.":[127],"Notably,":[128],"agonists":[130],"antagonists":[132],"effectively":[133],"preserve":[134],"Th-cell":[135,154],"homeostasis":[136],"targeting":[138],"PPAR\u03b3-mediated":[139],"signaling":[142],"pathways.":[143],"This":[144],"review":[145],"summarizes":[146],"as":[148],"crucial":[150],"governing":[153],"responses":[155],"elucidates":[157],"its":[158],"underlying":[159],"molecular":[160],"mechanisms.":[161],"Based":[162],"on":[163],"evidence":[165],"predominantly":[166],"derived":[167],"from":[168],"animal":[169],"models,":[170],"lays":[172],"foundation":[174],"translational":[176],"research":[177],"PPAR\u03b3-targeted":[179],"immunotherapy.":[180]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-24T00:00:00"}