{"id":"https://openalex.org/W7223375985","doi":"https://doi.org/10.64898/2026.10.19.760044","title":"Recurrent leukaemia stem cell states define the antigenic landscape of paediatric Acute Myeloid Leukaemia","display_name":"Recurrent leukaemia stem cell states define the antigenic landscape of paediatric Acute Myeloid Leukaemia","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223375985","doi":"https://doi.org/10.64898/2026.10.19.760044"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.19.760044","doi":"https://doi.org/10.64898/2026.10.19.760044","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760044","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115006307","display_name":"Sina Kanannejad","orcid":"https://orcid.org/0009-0002-1647-2873","observed_orcids":["https://orcid.org/0009-0002-1647-2873"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sina Kanannejad","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004258016","display_name":"Macarena Oporto Espuelas","orcid":"https://orcid.org/0000-0002-4542-2712","observed_orcids":["https://orcid.org/0000-0002-4542-2712"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Macarena Oporto Espuelas","raw_affiliation_strings":["Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006226092","display_name":"Claudia D\u2019Oria","orcid":"https://orcid.org/0000-0002-1016-4100","observed_orcids":["https://orcid.org/0000-0002-1016-4100"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia D\u2019Oria","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002369059","display_name":"Filippo Martignano","orcid":"https://orcid.org/0000-0001-7564-9224","observed_orcids":["https://orcid.org/0000-0001-7564-9224"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Martignano","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067119324","display_name":"Ilaria Marina Michelozzi","orcid":"https://orcid.org/0000-0002-3550-2129","observed_orcids":["https://orcid.org/0000-0002-3550-2129"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ilaria Marina Michelozzi","raw_affiliation_strings":["Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067703063","display_name":"Soumick Chatterjee","orcid":"https://orcid.org/0000-0001-7594-1188","observed_orcids":["https://orcid.org/0000-0001-7594-1188"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE","IT"],"is_corresponding":false,"raw_author_name":"Soumick Chatterjee","raw_affiliation_strings":["Faculty of Computer Science, Otto von Guericke University Magdeburg, Magdeburg, Germany","Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Computer Science, Otto von Guericke University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091819421","display_name":"Edoardo Giacopuzzi","orcid":"https://orcid.org/0000-0002-5692-366X","observed_orcids":["https://orcid.org/0000-0002-5692-366X"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Giacopuzzi","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159371989","display_name":"Eduardo Gomez Castaneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eduardo Gomez Castaneda","raw_affiliation_strings":["Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120529195","display_name":"Aurora Casiraghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aurora Casiraghi","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137954998","display_name":"Theodoros Xenakis","orcid":"https://orcid.org/0000-0003-3682-8873","observed_orcids":["https://orcid.org/0000-0003-3682-8873"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Theodoros Xenakis","raw_affiliation_strings":["Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006934145","display_name":"George T. Hall","orcid":"https://orcid.org/0000-0002-4828-0668","observed_orcids":["https://orcid.org/0000-0002-4828-0668"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George T. Hall","raw_affiliation_strings":["Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047511373","display_name":"Efstratios Kirtsios","orcid":"https://orcid.org/0000-0003-3368-7331","observed_orcids":["https://orcid.org/0000-0003-3368-7331"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Efstratios Kirtsios","raw_affiliation_strings":["Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077898802","display_name":"Cecilia Reyneri","orcid":"https://orcid.org/0000-0002-9950-5468","observed_orcids":["https://orcid.org/0000-0002-9950-5468"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Reyneri","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064844758","display_name":"Hannah L. Macpherson","orcid":"https://orcid.org/0000-0002-9535-4025","observed_orcids":["https://orcid.org/0000-0002-9535-4025"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Macpherson","raw_affiliation_strings":["Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013867832","display_name":"Jack Luke Bartram","orcid":"https://orcid.org/0000-0003-1573-2506","observed_orcids":["https://orcid.org/0000-0003-1573-2506"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jack Bartram","raw_affiliation_strings":["Great Ormond Street Hospital for Children, London, United Kingdom","North Thames Genomic Laboratory Hub, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Great Ormond Street Hospital for Children, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641"]},{"raw_affiliation_string":"North Thames Genomic Laboratory Hub, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022518344","display_name":"Rebecca Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Thomas","raw_affiliation_strings":["Department of Haematology, Great Ormond Street Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Great Ormond Street Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158671744","display_name":"Sergi Castellano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sergi Castellano","raw_affiliation_strings":["Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073776230","display_name":"Persis Jal Amrolia","orcid":"https://orcid.org/0000-0003-0480-3911","observed_orcids":["https://orcid.org/0000-0003-0480-3911"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Persis J. Amrolia","raw_affiliation_strings":["Bone Marrow Transplant Department, Great Ormond Street Hospital, London, United Kingdom","Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplant Department, Great Ormond Street Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091403632","display_name":"Alice Giustacchini","orcid":"https://orcid.org/0000-0002-8733-8594","observed_orcids":["https://orcid.org/0000-0002-8733-8594"]},"institutions":[{"id":"https://openalex.org/I4210115812","display_name":"Human Technopole","ror":"https://ror.org/029gmnc79","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115812"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"Alice Giustacchini","raw_affiliation_strings":["Genomics Research Centre, Human Technopole, Milan, Italy","Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8733-8594","affiliations":[{"raw_affiliation_string":"Genomics Research Centre, Human Technopole, Milan, Italy","institution_ids":["https://openalex.org/I4210115812"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091403632"],"corresponding_institution_ids":["https://openalex.org/I4210115812","https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-acute-myeloid-leukemia","display_name":"pediatric acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/clec12a","display_name":"CLEC12A","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cd84","display_name":"CD84","score":1.0},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.6110000014305115},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.5509999990463257},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6262000203132629},{"id":"https://openalex.org/C2993296363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukaemia","level":2,"score":0.597100019454956},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.551800012588501},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5264999866485596},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4706000089645386},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.435699999332428},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42910000681877136},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4269999861717224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4074999988079071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40290001034736633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837999999523163},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.31859999895095825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C3019217517","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor associated antigen","level":4,"score":0.2946999967098236},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2653000056743622},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.19.760044","doi":"https://doi.org/10.64898/2026.10.19.760044","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760044","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1967358345","https://openalex.org/W2002213310","https://openalex.org/W2012034410","https://openalex.org/W2108747515","https://openalex.org/W2156439133","https://openalex.org/W2560012305","https://openalex.org/W2617342763","https://openalex.org/W2761903029","https://openalex.org/W2773514102","https://openalex.org/W2817838603","https://openalex.org/W2958554910","https://openalex.org/W2974775294","https://openalex.org/W2981878588","https://openalex.org/W2981952148","https://openalex.org/W2984472267","https://openalex.org/W3006262357","https://openalex.org/W3196650609","https://openalex.org/W3203654614","https://openalex.org/W4214876469","https://openalex.org/W4281569605","https://openalex.org/W4283271244","https://openalex.org/W4283716970","https://openalex.org/W4284704036","https://openalex.org/W4284961870","https://openalex.org/W4296827904","https://openalex.org/W4321079297","https://openalex.org/W4324044837","https://openalex.org/W4362729058","https://openalex.org/W4377263775","https://openalex.org/W4380870546","https://openalex.org/W4382010567","https://openalex.org/W4385638791","https://openalex.org/W4386331814","https://openalex.org/W4387371226","https://openalex.org/W4387378062","https://openalex.org/W4388722346","https://openalex.org/W4390750643","https://openalex.org/W4393043550","https://openalex.org/W4402926235","https://openalex.org/W4403920876","https://openalex.org/W4404995922","https://openalex.org/W4409247188","https://openalex.org/W4409285581","https://openalex.org/W4409872473","https://openalex.org/W4413025252","https://openalex.org/W4413754435","https://openalex.org/W4414091902","https://openalex.org/W4415913415","https://openalex.org/W7160497059"],"related_works":["https://openalex.org/W4405040503","https://openalex.org/W7046221797","https://openalex.org/W3094433457","https://openalex.org/W4400486256","https://openalex.org/W4220748641","https://openalex.org/W4389454361","https://openalex.org/W1514209667","https://openalex.org/W4389483350","https://openalex.org/W3093070298","https://openalex.org/W2970554736"],"abstract_inverted_index":{"Abstract":[0],"Paediatric":[1],"acute":[2],"myeloid":[3],"leukaemia":[4,58],"(pAML)":[5],"remains":[6],"a":[7,18,180,191,201],"leading":[8],"cause":[9],"of":[10,146,174,207],"childhood":[11],"cancer":[12],"mortality,":[13],"with":[14,84],"disease":[15],"heterogeneity":[16],"representing":[17],"major":[19],"obstacle":[20],"to":[21],"effective":[22],"immunotherapy.":[23],"To":[24],"enable":[25],"rational":[26,205],"immunotherapy":[27],"design":[28,206],"accounting":[29],"for":[30,45,183,203],"such":[31],"heterogeneity,":[32],"we":[33,54],"combined":[34],"single-cell":[35,167],"transcriptomics":[36],"and":[37,49,67,79,87,114,131,134,148,168,199],"surface":[38,91],"proteomics":[39],"(CITE-seq).":[40],"Using":[41],"an":[42,104],"integrated":[43],"framework":[44,182],"malignant":[46],"cell":[47,60],"identification":[48],"unbiased":[50],"gene":[51],"program":[52],"identification,":[53],"resolved":[55],"three":[56,155],"conserved":[57],"stem":[59,162],"(LSC)":[61],"subtypes,":[62,157],"primitive":[63],"(P-LSC),":[64],"monocytic":[65],"(M-LSC),":[66],"erythroid-like":[68],"(E-LSC),":[69],"that":[70,95],"frequently":[71],"coexist":[72],"within":[73],"individual":[74],"patients":[75],"in":[76,128,140,186],"varying":[77],"proportions":[78],"represent":[80],"distinct":[81],"stem-cell":[82],"states":[83],"characteristic":[85],"immunophenotypes":[86],"transcriptional":[88],"programmes.":[89],"Quantitative":[90],"antigen":[92,105,184],"profiling":[93],"revealed":[94],"no":[96],"single":[97],"target":[98,139],"achieved":[99],"full":[100],"LSC":[101,156,197],"coverage.":[102],"CLEC12A,":[103],"currently":[106],"being":[107],"evaluated":[108],"clinically,":[109],"was":[110,117],"expressed":[111],"across":[112,153,165,195],"P-LSC":[113],"M-LSC":[115],"but":[116],"largely":[118],"absent":[119],"from":[120],"E-LSC.":[121],"In":[122],"contrast,":[123],"CD84":[124,149],"provided":[125,150],"complementary":[126],"coverage":[127,152],"the":[129,137,141,172,204],"P":[130],"M":[132],"groups":[133],"served":[135],"as":[136,190],"primary":[138],"E-LSC":[142],"population.":[143],"The":[144],"combination":[145],"CLEC12A":[147],"broad":[151],"all":[154],"while":[158],"sparing":[159],"healthy":[160],"haematopoietic":[161],"cells.":[163],"Validation":[164],"independent":[166],"bulk":[169],"cohorts":[170],"confirmed":[171],"robustness":[173],"this":[175],"combination.":[176],"These":[177],"findings":[178],"establish":[179],"paediatric-specific":[181],"prioritisation":[185],"AML,":[187],"identify":[188],"CLEC12A/CD84":[189],"robust":[192],"dual-targeting":[193],"strategy":[194],"heterogeneous":[196],"states,":[198],"provide":[200],"blueprint":[202],"next-generation":[208],"CAR":[209],"T-cell":[210],"combinations.":[211]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-24T00:00:00"}