{"id":"https://openalex.org/W7223375249","doi":"https://doi.org/10.1371/journal.pone.0361119","title":"Pharmacokinetic diversity of baloxavir marboxil across rare avian species","display_name":"Pharmacokinetic diversity of baloxavir marboxil across rare avian species","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223375249","doi":"https://doi.org/10.1371/journal.pone.0361119","pmid":"https://pubmed.ncbi.nlm.nih.gov/42912701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693923"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0361119","doi":"https://doi.org/10.1371/journal.pone.0361119","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361119","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361119&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361119&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113327137","display_name":"Yo Shimazu","orcid":"https://orcid.org/0009-0002-5668-8054","observed_orcids":["https://orcid.org/0009-0002-5668-8054"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yo Shimazu","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":"https://orcid.org/0009-0002-5668-8054","affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021286364","display_name":"Ryo Daniel Obara","orcid":"https://orcid.org/0000-0003-1022-3569","observed_orcids":["https://orcid.org/0000-0003-1022-3569"]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Daniel Obara","raw_affiliation_strings":["Shionogi and Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shionogi and Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159345994","display_name":"Mariko Miki","orcid":"https://orcid.org/0009-0000-6567-9825","observed_orcids":["https://orcid.org/0009-0000-6567-9825"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Miki","raw_affiliation_strings":["Hokkaido University","Shionogi and Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Shionogi and Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071568481","display_name":"Hiromi Osaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Osaki","raw_affiliation_strings":["Shionogi and Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shionogi and Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159364492","display_name":"Yuto Yoshimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuto Yoshimoto","raw_affiliation_strings":["Tokyo Sea Life Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Sea Life Park","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006645286","display_name":"Marina Hayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Hayashi","raw_affiliation_strings":["Tokyo Sea Life Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Sea Life Park","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159337920","display_name":"Kosuke Toyoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Toyoda","raw_affiliation_strings":["Adventure World"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adventure World","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159298932","display_name":"Miki Ozaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miki Ozaki","raw_affiliation_strings":["Adventure World"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adventure World","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035201803","display_name":"Ikumi HANADA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikumi Hanada","raw_affiliation_strings":["Adventure World"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adventure World","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688076","display_name":"Rei Matsumoto","orcid":"https://orcid.org/0000-0002-1146-9520","observed_orcids":["https://orcid.org/0000-0002-1146-9520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rei Matsumoto","raw_affiliation_strings":["Hyogo Park of the Oriental White Stork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hyogo Park of the Oriental White Stork","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159311834","display_name":"Kaori Ota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Ota","raw_affiliation_strings":["Tama Zoological Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tama Zoological Park","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049951192","display_name":"Ayumi Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayumi Yamaguchi","raw_affiliation_strings":["Tama Zoological Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tama Zoological Park","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159351357","display_name":"Kosuke Toda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Toda","raw_affiliation_strings":["Tama Zoological Park"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tama Zoological Park","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159344564","display_name":"Junko Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088800","display_name":"Tokyo Zoological Park Society","ror":"https://ror.org/002fj3m33","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210088800"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Ishii","raw_affiliation_strings":["Tokyo Zoological Park Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Zoological Park Society","institution_ids":["https://openalex.org/I4210088800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159368588","display_name":"Tsuneo Kizaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088800","display_name":"Tokyo Zoological Park Society","ror":"https://ror.org/002fj3m33","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210088800"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Kizaki","raw_affiliation_strings":["Tokyo Zoological Park Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Zoological Park Society","institution_ids":["https://openalex.org/I4210088800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048544435","display_name":"Yuzo Hirano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuzo Hirano","raw_affiliation_strings":["Ueno Zoological Gardens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ueno Zoological Gardens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159366046","display_name":"Yuma Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuma Sugimoto","raw_affiliation_strings":["Ueno Zoological Gardens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ueno Zoological Gardens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159342137","display_name":"Yukiko Watanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukiko Watanabe","raw_affiliation_strings":["Institute for Raptor Biomedicine Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Raptor Biomedicine Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023470018","display_name":"Keisuke Saito","orcid":"https://orcid.org/0000-0002-2293-9743","observed_orcids":["https://orcid.org/0000-0002-2293-9743","https://orcid.org/0000-0002-4805-8856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keisuke Saito","raw_affiliation_strings":["Institute for Raptor Biomedicine Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Raptor Biomedicine Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040661189","display_name":"Masato Kaku","orcid":"https://orcid.org/0000-0002-3878-749X","observed_orcids":["https://orcid.org/0000-0002-3878-749X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masato Kaku","raw_affiliation_strings":["Shikoku Aquarium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shikoku Aquarium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159369610","display_name":"Izumi Ide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Izumi Ide","raw_affiliation_strings":["Toyama Outdoor Nature Museum \u201cNei no Sato\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toyama Outdoor Nature Museum \u201cNei no Sato\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114708861","display_name":"Akihiro SADO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiro Sado","raw_affiliation_strings":["Sapporo Maruyama Zoo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapporo Maruyama Zoo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101328274","display_name":"Hidefumi Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidefumi Sakai","raw_affiliation_strings":["Sapporo Maruyama Zoo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapporo Maruyama Zoo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040252377","display_name":"Kyohei Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyohei Nishimura","raw_affiliation_strings":["Shionogi and Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shionogi and Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088502426","display_name":"Mayumi Endo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Endo","raw_affiliation_strings":["Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084229679","display_name":"Takahiro Hiono","orcid":"https://orcid.org/0000-0001-8897-3592","observed_orcids":["https://orcid.org/0000-0001-8897-3592"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405287186","display_name":"Institute for Vaccine Research and Development, Hokkaido University","ror":"https://ror.org/04bst9757","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"id":"https://openalex.org/I4405287359","display_name":"Hokkaido University International Institute for Zoonosis Control","ror":"https://ror.org/04z6qv748","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Hiono","raw_affiliation_strings":["Hokkaido University","Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","International Institute for Zoonosis Control, Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"raw_affiliation_string":"International Institute for Zoonosis Control, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073382805","display_name":"Norikazu Isoda","orcid":"https://orcid.org/0000-0003-3480-988X","observed_orcids":["https://orcid.org/0000-0003-3480-988X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405287186","display_name":"Institute for Vaccine Research and Development, Hokkaido University","ror":"https://ror.org/04bst9757","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"id":"https://openalex.org/I4405287359","display_name":"Hokkaido University International Institute for Zoonosis Control","ror":"https://ror.org/04z6qv748","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norikazu Isoda","raw_affiliation_strings":["Hokkaido University","Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","International Institute for Zoonosis Control, Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"raw_affiliation_string":"International Institute for Zoonosis Control, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062196470","display_name":"Takao Shishido","orcid":"https://orcid.org/0000-0002-2549-0945","observed_orcids":["https://orcid.org/0000-0002-2549-0945"]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Shishido","raw_affiliation_strings":["Shionogi and Co., Ltd"],"raw_orcid":"https://orcid.org/0000-0002-2549-0945","affiliations":[{"raw_affiliation_string":"Shionogi and Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003795677","display_name":"Yoshinori Ikenaka","orcid":"https://orcid.org/0000-0002-6633-6637","observed_orcids":["https://orcid.org/0000-0002-6633-6637"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I27765905","display_name":"North-West University","ror":"https://ror.org/010f1sq29","country_code":"ZA","type":"education","lineage":["https://openalex.org/I27765905"]}],"countries":["JP","ZA"],"is_corresponding":false,"raw_author_name":"Yoshinori Ikenaka","raw_affiliation_strings":["Hokkaido University","North-West University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"North-West University","institution_ids":["https://openalex.org/I27765905"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005821045","display_name":"Yoshihiro Sakoda","orcid":"https://orcid.org/0000-0001-7021-1688","observed_orcids":["https://orcid.org/0000-0001-7021-1688","https://orcid.org/0000-0002-1461-2548"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405287186","display_name":"Institute for Vaccine Research and Development, Hokkaido University","ror":"https://ror.org/04bst9757","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"id":"https://openalex.org/I4405287359","display_name":"Hokkaido University International Institute for Zoonosis Control","ror":"https://ror.org/04z6qv748","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihiro Sakoda","raw_affiliation_strings":["Hokkaido University","Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","International Institute for Zoonosis Control, Hokkaido University"],"raw_orcid":"https://orcid.org/0000-0001-7021-1688","affiliations":[{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287186"]},{"raw_affiliation_string":"International Institute for Zoonosis Control, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005821045"],"corresponding_institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287186","https://openalex.org/I4405287359"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8170166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0361119","last_page":"e0361119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baloxavir-marboxil","display_name":"baloxavir marboxil","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8399999737739563},{"id":"https://openalex.org/keywords/interspecies-variability","display_name":"interspecies variability","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dosing-regimen-optimization","display_name":"dosing regimen optimization","score":0.6980000138282776},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.7720000147819519},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6269999742507935},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8582000136375427},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7879999876022339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6711000204086304},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.6104000210762024},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.6031000018119812},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5996000170707703},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5733000040054321},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5615000128746033},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.48590001463890076},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.43709999322891235},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41679999232292175},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.38749998807907104},{"id":"https://openalex.org/C2993559633","wikidata":"https://www.wikidata.org/wiki/Q43987","display_name":"Avian influenza virus","level":4,"score":0.3605000078678131},{"id":"https://openalex.org/C3019819676","wikidata":"https://www.wikidata.org/wiki/Q43987","display_name":"Highly pathogenic","level":4,"score":0.3228999972343445},{"id":"https://openalex.org/C2993886244","wikidata":"https://www.wikidata.org/wiki/Q25367","display_name":"Absorption efficiency","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C2776997796","wikidata":"https://www.wikidata.org/wiki/Q1345259","display_name":"Entry inhibitor","level":5,"score":0.2854999899864197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003988","descriptor_name":"Dibenzothiepins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005585","descriptor_name":"Influenza in Birds","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005585","descriptor_name":"Influenza in Birds","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010078","descriptor_name":"Oxazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010078","descriptor_name":"Oxazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013846","descriptor_name":"Thiepins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013846","descriptor_name":"Thiepins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0361119","doi":"https://doi.org/10.1371/journal.pone.0361119","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361119","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361119&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693923","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693923/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693923/pdf/pone.0361119.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:42912701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42912701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e26bc9b173c34121a78ba42c642db01c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e26bc9b173c34121a78ba42c642db01c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 10, p e0361119 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0361119","doi":"https://doi.org/10.1371/journal.pone.0361119","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361119","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361119&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1188428243","display_name":null,"funder_award_id":"JPMEERF20254004","funder_id":"https://openalex.org/F4320315051","funder_display_name":"Environmental Restoration and Conservation Agency"},{"id":"https://openalex.org/G1885780102","display_name":null,"funder_award_id":"JPMJSP2119","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3501255619","display_name":null,"funder_award_id":"JP MJSP2119","funder_id":"https://openalex.org/F4320323533","funder_display_name":"Hokkaido University"},{"id":"https://openalex.org/G385053884","display_name":null,"funder_award_id":"JP20w m0125008","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G465657087","display_name":null,"funder_award_id":"JP223fa627005","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7427681983","display_name":null,"funder_award_id":"JPMJSP2119","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G9000922272","display_name":null,"funder_award_id":"JP253m0134005","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G9000922567","display_name":null,"funder_award_id":"JP263f0134005","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320315051","display_name":"Environmental Restoration and Conservation Agency","ror":"https://ror.org/01c9agy38"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320323533","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223375249.pdf","grobid_xml":"https://content.openalex.org/works/W7223375249.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1966206163","https://openalex.org/W1986729212","https://openalex.org/W2044600321","https://openalex.org/W2086358466","https://openalex.org/W2114584134","https://openalex.org/W2124218461","https://openalex.org/W2160428879","https://openalex.org/W2201228154","https://openalex.org/W2201447595","https://openalex.org/W2809190914","https://openalex.org/W2894555242","https://openalex.org/W2897317761","https://openalex.org/W2971996167","https://openalex.org/W2980289407","https://openalex.org/W3005804658","https://openalex.org/W3092363020","https://openalex.org/W3113131516","https://openalex.org/W4200311635","https://openalex.org/W4200494959","https://openalex.org/W4206000366","https://openalex.org/W4281993317","https://openalex.org/W4300089348","https://openalex.org/W4386378643","https://openalex.org/W4394823121","https://openalex.org/W4399605099","https://openalex.org/W4402135975","https://openalex.org/W4402206891","https://openalex.org/W4402927076","https://openalex.org/W4410974092","https://openalex.org/W4411494848","https://openalex.org/W7140143936","https://openalex.org/W7154456746"],"related_works":["https://openalex.org/W4415616920","https://openalex.org/W7154456746","https://openalex.org/W4399605099","https://openalex.org/W3113131516","https://openalex.org/W4206000366","https://openalex.org/W6886123975","https://openalex.org/W7140143936","https://openalex.org/W7165892336","https://openalex.org/W3206663314","https://openalex.org/W3035469718"],"abstract_inverted_index":{"High":[0],"pathogenicity":[1],"avian":[2,66,95,176,192],"influenza":[3,51],"virus":[4,52],"(HPAIV)":[5],"poses":[6],"a":[7,116,181],"serious":[8],"threat":[9],"to":[10,25,82,93,97,142,155,196,203],"captive":[11,30,205],"rare":[12,31,206],"birds.":[13],"Because":[14],"effective":[15],"countermeasures":[16],"are":[17],"limited,":[18],"the":[19,37,48,59,80,143,185,197],"use":[20,187],"of":[21,50,62,106,125,145,188,199],"human":[22,38],"antiviral":[23,39,60,201],"drugs":[24],"treat":[26],"HPAIV":[27],"infections":[28],"in":[29,54,64,138,168,190],"birds":[32,207],"has":[33],"been":[34],"considered.":[35],"Although":[36],"drug,":[40],"baloxavir":[41,131],"marboxil":[42],"(BXM),":[43],"is":[44],"not":[45],"approved":[46],"for":[47,101,149,184],"treatment":[49],"infection":[53],"birds,":[55],"previous":[56],"studies":[57,69],"demonstrated":[58,134],"efficacy":[61],"BXM":[63,77,90,107,126,189],"experimental":[65],"models.":[67],"Pharmacokinetic":[68,123],"have":[70],"also":[71],"revealed":[72,111],"substantial":[73],"interspecies":[74,136],"differences":[75,167],"following":[76],"administration,":[78],"suggesting":[79,164],"need":[81],"establish":[83],"species-specific":[84,166],"dosing":[85,99,147],"regimens.":[86],"In":[87],"this":[88],"study,":[89],"was":[91,157],"administered":[92],"14":[94],"species":[96],"optimize":[98],"regimens":[100,148],"each":[102,150],"species.":[103,151,177,193],"Oral":[104],"administration":[105],"using":[108],"different":[109],"methods":[110],"that":[112,165],"drug-food":[113],"interactions":[114],"had":[115],"limited":[117],"impact":[118],"on":[119],"systemic":[120,153],"drug":[121,139,161],"exposure.":[122],"analysis":[124],"and":[127],"its":[128],"active":[129],"metabolite,":[130],"acid":[132],"(BXA),":[133],"marked":[135],"variability":[137],"exposure,":[140],"contributing":[141],"development":[144,198],"optimized":[146],"Furthermore,":[152],"exposure":[154,174],"BXA":[156,173],"strongly":[158],"associated":[159],"with":[160],"absorption":[162,169],"indicators,":[163],"efficiency":[170],"largely":[171],"determine":[172],"among":[175],"This":[178],"study":[179],"provides":[180],"pharmacokinetic":[182],"basis":[183],"rational":[186],"diverse":[191],"It":[194],"contributes":[195],"practical":[200],"strategies":[202],"protect":[204],"against":[208],"HPAIVs.":[209]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-24T00:00:00"}
