{"id":"https://openalex.org/W7223355133","doi":"https://doi.org/10.3389/fmed.2026.1992567","title":"Enteroendocrine signaling in irritable bowel syndrome: beyond cell counts toward stimulus-responsive physiological profiling","display_name":"Enteroendocrine signaling in irritable bowel syndrome: beyond cell counts toward stimulus-responsive physiological profiling","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223355133","doi":"https://doi.org/10.3389/fmed.2026.1992567"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1992567","doi":"https://doi.org/10.3389/fmed.2026.1992567","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1992567","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1992567/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1992567/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124988695","display_name":"Jiayi Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayi Han","raw_affiliation_strings":["College of Traditional Chinese Medicine, Changchun University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121004023","display_name":"Yixuan Lang","orcid":"https://orcid.org/0009-0004-1107-5005","observed_orcids":["https://orcid.org/0009-0004-1107-5005"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]},{"id":"https://openalex.org/I4210141161","display_name":"The Affiliated Hospital to Changchun University of Chinese Medicine","ror":"https://ror.org/03ksg3960","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141161"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Lang","raw_affiliation_strings":["The Affiliated Hospital of Changchun University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Changchun University of Chinese Medicine","institution_ids":["https://openalex.org/I4210128075","https://openalex.org/I4210141161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158749230","display_name":"Kangmeng Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kangmeng Yao","raw_affiliation_strings":["College of Traditional Chinese Medicine, Changchun University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Traditional Chinese Medicine, Changchun University of Chinese Medicine","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036216858","display_name":"Jia Mi","orcid":"https://orcid.org/0000-0002-1374-9809","observed_orcids":["https://orcid.org/0000-0002-1374-9809"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]},{"id":"https://openalex.org/I4210141161","display_name":"The Affiliated Hospital to Changchun University of Chinese Medicine","ror":"https://ror.org/03ksg3960","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141161"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jia Mi","raw_affiliation_strings":["The Affiliated Hospital of Changchun University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Changchun University of Chinese Medicine","institution_ids":["https://openalex.org/I4210128075","https://openalex.org/I4210141161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036216858"],"corresponding_institution_ids":["https://openalex.org/I4210128075","https://openalex.org/I4210141161"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81887928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enteroendocrine-cells","display_name":"enteroendocrine cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.46700000762939453},{"id":"https://openalex.org/keywords/postprandial-hormone-secretion","display_name":"postprandial hormone secretion","score":0.6970000267028809},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/peptide-yy","display_name":"peptide YY","score":0.9879999756813049},{"id":"https://openalex.org/keywords/motilin","display_name":"motilin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/visceral-sensitivity","display_name":"visceral sensitivity","score":0.527999997138977},{"id":"https://openalex.org/keywords/post-infectious-ibs","display_name":"post-infectious IBS","score":0.8050000071525574},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation","display_name":"irritable bowel syndrome with constipation","score":0.996999979019165},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.6790000200271606},{"id":"https://openalex.org/keywords/meal-challenge","display_name":"meal challenge","score":0.6000000238418579},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.5630000233650208},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.4059999883174896},{"id":"https://openalex.org/keywords/visceral-pain","display_name":"visceral pain","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.8475000262260437},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8398000001907349},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.6220999956130981},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5449000000953674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.534600019454956},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4480000138282776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44510000944137573},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4244000017642975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4124000072479248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4016000032424927},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.40059998631477356},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.39890000224113464},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3970000147819519},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C2781219945","wikidata":"https://www.wikidata.org/wiki/Q5572288","display_name":"Glucagon-like peptide-2","level":3,"score":0.3853999972343445},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3824999928474426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37770000100135803},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.35429999232292175},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.32910001277923584},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3255000114440918},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3068000078201294},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.296099990606308},{"id":"https://openalex.org/C2909240849","wikidata":"https://www.wikidata.org/wiki/Q2300099","display_name":"Intestinal Disorder","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C2777951760","wikidata":"https://www.wikidata.org/wiki/Q5526842","display_name":"Gastrointestinal hormone","level":4,"score":0.27619999647140503},{"id":"https://openalex.org/C142656374","wikidata":"https://www.wikidata.org/wiki/Q2706070","display_name":"Thermoreceptor","level":3,"score":0.2630999982357025}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmed.2026.1992567","doi":"https://doi.org/10.3389/fmed.2026.1992567","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1992567","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1992567/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:cb32361cf82348dd838f9da785ef45c5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cb32361cf82348dd838f9da785ef45c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1992567","doi":"https://doi.org/10.3389/fmed.2026.1992567","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1992567","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1992567/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223355133.pdf","grobid_xml":"https://content.openalex.org/works/W7223355133.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1783116048","https://openalex.org/W1823414671","https://openalex.org/W1964357386","https://openalex.org/W1970178265","https://openalex.org/W1971384756","https://openalex.org/W1992676701","https://openalex.org/W1998159103","https://openalex.org/W2028890830","https://openalex.org/W2035352122","https://openalex.org/W2046445528","https://openalex.org/W2052335898","https://openalex.org/W2055233572","https://openalex.org/W2097566770","https://openalex.org/W2098382176","https://openalex.org/W2100311096","https://openalex.org/W2128077096","https://openalex.org/W2132910924","https://openalex.org/W2140907934","https://openalex.org/W2146100858","https://openalex.org/W2167343594","https://openalex.org/W2657509782","https://openalex.org/W2914227154","https://openalex.org/W2922000510","https://openalex.org/W3016802365","https://openalex.org/W3027357281","https://openalex.org/W3034180794","https://openalex.org/W3120299325","https://openalex.org/W3198500586","https://openalex.org/W3204416586","https://openalex.org/W4211073917","https://openalex.org/W4214845002","https://openalex.org/W4225403862","https://openalex.org/W4225473705","https://openalex.org/W4283169178","https://openalex.org/W4380086625","https://openalex.org/W4388461974","https://openalex.org/W4398211177","https://openalex.org/W4400885503","https://openalex.org/W4401324222","https://openalex.org/W4403510815","https://openalex.org/W4405090866","https://openalex.org/W4408128787","https://openalex.org/W4408315924","https://openalex.org/W4412477975","https://openalex.org/W4413138106","https://openalex.org/W4413181229","https://openalex.org/W4413883400","https://openalex.org/W7168568590","https://openalex.org/W7201960839"],"related_works":["https://openalex.org/W2146100858","https://openalex.org/W3140698957","https://openalex.org/W4281563014","https://openalex.org/W2560257867","https://openalex.org/W2473491940","https://openalex.org/W2104999280","https://openalex.org/W2011221668","https://openalex.org/W2028754613","https://openalex.org/W2140907934","https://openalex.org/W7036462518"],"abstract_inverted_index":{"Meals":[0],"are":[1,186],"a":[2,93,139,166],"major":[3],"symptom":[4],"trigger":[5],"in":[6,44],"irritable":[7],"bowel":[8,24,119],"syndrome":[9],"(IBS),":[10],"yet":[11],"the":[12],"endocrine":[13,169],"steps":[14],"linking":[15],"luminal":[16,150],"nutrients":[17],"to":[18,175,189],"pain,":[19],"bloating,":[20],"urgency,":[21],"and":[22,56,58,81,112,121,127,137,156,182,192],"altered":[23,89],"habits":[25],"remain":[26,41],"poorly":[27],"defined.":[28],"Early":[29],"studies":[30,68,129],"relied":[31],"heavily":[32],"on":[33],"mucosal":[34,179],"enteroendocrine":[35],"cell":[36,59],"(EEC)":[37],"counts.":[38],"Those":[39],"observations":[40],"informative,":[42],"particularly":[43],"post-infectious":[45],"IBS,":[46],"but":[47],"findings":[48,148],"vary":[49,116],"with":[50,77,100,117],"intestinal":[51],"site,":[52],"bowel-habit":[53],"phenotype,":[54],"staining,":[55],"morphometry,":[57],"abundance":[60],"does":[61,163],"not":[62,164],"measure":[63],"secretory":[64],"function.":[65],"Human":[66],"meal-challenge":[67],"distinguish":[69],"circulating":[70],"concentrations":[71],"from":[72],"stimulus-evoked":[73,105],"responses.":[74],"In":[75],"IBS":[76,99,168],"diarrhea,":[78],"higher":[79],"fasting":[80],"fed":[82],"plasma":[83],"5-hydroxytryptamine":[84],"(serotonin,":[85],"5-HT)":[86],"may":[87],"reflect":[88],"handling":[90],"more":[91,187],"than":[92],"uniformly":[94],"exaggerated":[95],"postprandial":[96],"response,":[97],"whereas":[98],"constipation":[101],"can":[102],"show":[103],"impaired":[104],"release.":[106],"Cholecystokinin,":[107],"peptide":[108],"YY,":[109],"motilin,":[110],"ghrelin,":[111],"related":[113],"peptides":[114],"also":[115],"sex,":[118],"habit,":[120],"visceral":[122],"sensitivity.":[123],"Recent":[124],"human":[125],"organoid":[126],"transcriptomic":[128],"identify":[130],"distinct":[131],"nutrient-sensing":[132],"programs":[133],"among":[134],"EEC":[135],"subtypes":[136],"provide":[138],"cellular":[140],"framework":[141],"for":[142],"this":[143],"heterogeneity.":[144],"We":[145],"integrate":[146],"these":[147],"across":[149],"sensing,":[151],"secretion,":[152],"metabolism,":[153],"receptor":[154],"responsiveness,":[155],"motor":[157],"or":[158],"sensory":[159],"output.":[160],"The":[161],"evidence":[162],"support":[165],"single":[167],"signature.":[170],"Standardized":[171],"nutrient":[172],"challenges":[173],"linked":[174],"serial":[176],"hormone":[177],"measurements,":[178],"molecular":[180],"data,":[181],"objective":[183],"physiological":[184],"readouts":[185],"likely":[188],"yield":[190],"reproducible":[191],"clinically":[193],"testable":[194],"response":[195],"patterns.":[196]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-24T00:00:00"}
