{"id":"https://openalex.org/W7223353974","doi":"https://doi.org/10.1371/journal.pone.0361484","title":"Multienzyme cascade biotransformation of L-Tyrosine to Danshensu by engineered Escherichia coli","display_name":"Multienzyme cascade biotransformation of L-Tyrosine to Danshensu by engineered Escherichia coli","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223353974","doi":"https://doi.org/10.1371/journal.pone.0361484","pmid":"https://pubmed.ncbi.nlm.nih.gov/42912794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693876"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0361484","doi":"https://doi.org/10.1371/journal.pone.0361484","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361484","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361484&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361484&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005991799","display_name":"Tianzhen Xiong","orcid":"https://orcid.org/0000-0001-6868-1269","observed_orcids":["https://orcid.org/0000-0001-6868-1269"]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianzhen Xiong","raw_affiliation_strings":["Dabie Mountain Laboratory","Xinyang Normal University"],"raw_orcid":"https://orcid.org/0000-0001-6868-1269","affiliations":[{"raw_affiliation_string":"Dabie Mountain Laboratory","institution_ids":[]},{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159312089","display_name":"Shuqing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqing Li","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123857742","display_name":"Xiaoya Li","orcid":"https://orcid.org/0009-0008-9643-794X","observed_orcids":["https://orcid.org/0009-0008-9643-794X"]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoya Li","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025349009","display_name":"Xinmeng Li","orcid":"https://orcid.org/0000-0002-6863-6078","observed_orcids":["https://orcid.org/0000-0002-6863-6078","https://orcid.org/0009-0004-1379-0010"]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinmeng Li","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017272190","display_name":"Mengdan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengdan Wu","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159369444","display_name":"Jinru Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinru Liu","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159340039","display_name":"Jinxiu Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxiu Guo","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100601315","display_name":"Xinrui Li","orcid":"https://orcid.org/0000-0001-6677-5683","observed_orcids":["https://orcid.org/0000-0001-6677-5683"]},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinrui Li","raw_affiliation_strings":["Xinyang Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyang Normal University","institution_ids":["https://openalex.org/I130750295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005991799"],"corresponding_institution_ids":["https://openalex.org/I130750295"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72187404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0361484","last_page":"e0361484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14150","display_name":"Biochemical and biochemical processes","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/danshensu","display_name":"danshensu","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tyrosine","display_name":"tyrosine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/multi-enzyme-cascade","display_name":"multi-enzyme cascade","score":0.9570000171661377},{"id":"https://openalex.org/keywords/whole-cell-biocatalysis","display_name":"whole-cell biocatalysis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/engineered-escherichia-coli","display_name":"engineered Escherichia coli","score":0.9319999814033508},{"id":"https://openalex.org/keywords/l-amino-acid-deaminase","display_name":"L-amino acid deaminase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glucose-dehydrogenase","display_name":"glucose dehydrogenase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/d-lactate-dehydrogenase","display_name":"D-lactate dehydrogenase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/bioreactor-production","display_name":"bioreactor production","score":0.6800000071525574},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.9157999753952026},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8669000267982483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5974000096321106},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.5529000163078308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.54339998960495},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.4440999925136566},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.4417000114917755},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4390999972820282},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.3905999958515167},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.36399999260902405},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29429998993873596},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2567000091075897}],"mesh":[{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0361484","doi":"https://doi.org/10.1371/journal.pone.0361484","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361484","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361484&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693876","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693876/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693876/pdf/pone.0361484.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:42912794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42912794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1b9c469948f14f95bda64a1f47557cf5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1b9c469948f14f95bda64a1f47557cf5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 10, p e0361484 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0361484","doi":"https://doi.org/10.1371/journal.pone.0361484","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0361484","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0361484&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335834","display_name":"Nanhu Scholars Program for Young Scholars of Xinyang Normal University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223353974.pdf","grobid_xml":"https://content.openalex.org/works/W7223353974.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W2006430655","https://openalex.org/W2031037185","https://openalex.org/W2042795586","https://openalex.org/W2052814829","https://openalex.org/W2158701760","https://openalex.org/W2315633551","https://openalex.org/W2614378327","https://openalex.org/W2735860179","https://openalex.org/W2764113848","https://openalex.org/W2808957042","https://openalex.org/W2846428146","https://openalex.org/W2888574882","https://openalex.org/W2906209358","https://openalex.org/W2916341658","https://openalex.org/W2944355965","https://openalex.org/W2945557191","https://openalex.org/W2949111546","https://openalex.org/W2949846615","https://openalex.org/W2982244810","https://openalex.org/W3012604428","https://openalex.org/W3177526849","https://openalex.org/W4292148561","https://openalex.org/W4297874831","https://openalex.org/W4309661438","https://openalex.org/W4367627300","https://openalex.org/W4388750722","https://openalex.org/W4405740189","https://openalex.org/W4406015276","https://openalex.org/W4406107099","https://openalex.org/W4407032511","https://openalex.org/W4408364643","https://openalex.org/W4410540213","https://openalex.org/W4411162953","https://openalex.org/W4411343351","https://openalex.org/W7117469234","https://openalex.org/W7160248545","https://openalex.org/W7162487282"],"related_works":["https://openalex.org/W2945557191","https://openalex.org/W4309661438","https://openalex.org/W2949111546","https://openalex.org/W2981075294","https://openalex.org/W4285807361","https://openalex.org/W2980581493","https://openalex.org/W3037959087","https://openalex.org/W4296465886","https://openalex.org/W4406015276","https://openalex.org/W2949846615"],"abstract_inverted_index":{"Danshensu":[0],"(DSS),":[1],"a":[2,27],"water-soluble":[3],"bioactive":[4],"compound":[5,116],"with":[6],"significant":[7],"antioxidant,":[8],"anti-inflammatory,":[9],"cardioprotective":[10],"and":[11,19,54],"neuroprotective":[12],"properties,":[13],"is":[14],"widely":[15],"utilized":[16],"in":[17,31,96],"cardiovascular":[18],"cerebrovascular":[20],"disease.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"established":[26],"multi-enzyme":[28],"cascade":[29],"system":[30],"engineered":[32],"Escherichia":[33],"coli":[34],"to":[35,67],"synthesize":[36],"DSS":[37,65,82,101,118],"from":[38,86,119],"L-Tyrosine.":[39,124],"The":[40,62],"initial":[41],"co-expression":[42],"of":[43,64,81,113,117,123],"4-hydroxyphenylacetate":[44],"3-monooxygenase":[45],"(HpaBC),":[46],"L-amino":[47],"acid":[48],"deaminase":[49],"(aadL),":[50],"glucose":[51],"dehydrogenase":[52,56],"(gdh)":[53],"D-lactate":[55],"(ldhD)":[57],"yielded":[58,98],"5.1":[59],"mM":[60,69,85,100],"DSS.":[61],"production":[63],"increased":[66],"6.53":[68],"through":[70],"optimizing":[71,76],"plasmid":[72],"copy":[73],"number.":[74],"After":[75],"the":[77,79,110],"conditions,":[78],"yield":[80],"reached":[83],"8.66":[84],"strain":[87,94],"6.":[88],"Finally,":[89],"whole":[90],"cell":[91],"biotransformation":[92],"using":[93],"6":[95],"bioreactor":[97],"19.47":[99],"within":[102],"32h.":[103],"These":[104],"findings":[105],"provide":[106],"valuable":[107],"insights":[108],"for":[109],"scalable":[111],"biosynthesis":[112],"pharmaceutically":[114],"important":[115],"naturally":[120],"available":[121],"substrates":[122]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}
