{"id":"https://openalex.org/W7223348673","doi":"https://doi.org/10.2147/ndt.s649205","title":"Advances in Multi-Omics Research on Post-Stroke Depression: From Molecular Mechanisms to Therapeutic Strategies","display_name":"Advances in Multi-Omics Research on Post-Stroke Depression: From Molecular Mechanisms to Therapeutic Strategies","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223348673","doi":"https://doi.org/10.2147/ndt.s649205","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13715653"},"language":"en","primary_location":{"id":"doi:10.2147/ndt.s649205","doi":"https://doi.org/10.2147/ndt.s649205","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s649205","pdf_url":"https://www.dovepress.com/article/download/121308","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121308","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159333465","display_name":"Guoxun Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoxun Feng","raw_affiliation_strings":["Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102361218","display_name":"Lei Gao","orcid":"https://orcid.org/0000-0002-0081-0172","observed_orcids":["https://orcid.org/0000-0002-0081-0172"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Gao","raw_affiliation_strings":["Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022803130","display_name":"Yuanzhi Zhao","orcid":"https://orcid.org/0000-0001-9108-2256","observed_orcids":["https://orcid.org/0000-0001-9108-2256"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I4210115287","display_name":"Ningbo Kangning Hospital","ror":"https://ror.org/021nfay74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115287"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanzhi Zhao","raw_affiliation_strings":["Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-9108-2256","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558","https://openalex.org/I4210115287"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159357923","display_name":"Zhaoying Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoying Yu","raw_affiliation_strings":["Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126771810","display_name":"Mei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I4210115287","display_name":"Ningbo Kangning Hospital","ror":"https://ror.org/021nfay74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115287"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Yang","raw_affiliation_strings":["Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558","https://openalex.org/I4210115287"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159305885","display_name":"Yaping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaping Chen","raw_affiliation_strings":["Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100696660","display_name":"Xing Xu","orcid":"https://orcid.org/0000-0003-1346-5854","observed_orcids":["https://orcid.org/0000-0003-1346-5854"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Xu","raw_affiliation_strings":["Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","Health Science Center, Ningbo University, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Affiliated Minkang Hospital of Ningbo University (Ningbo Psychiatric Hospital), Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Health Science Center, Ningbo University, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I109935558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100696660"],"corresponding_institution_ids":["https://openalex.org/I109935558"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67822967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 22","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-stroke-depression","display_name":"post-stroke depression","score":1.0},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.968999981880188},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/microbiota-gut-brain-axis","display_name":"microbiota-gut-brain axis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/psychosocial-factors","display_name":"psychosocial factors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8130000233650208},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135000109672546},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.428600013256073},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3756999969482422},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2802000045776367},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2754000127315521},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2264000028371811},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.2071000039577484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2069000005722046}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ndt.s649205","doi":"https://doi.org/10.2147/ndt.s649205","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s649205","pdf_url":"https://www.dovepress.com/article/download/121308","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13715653","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715653/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715653/pdf/NDT-22-649205.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},{"id":"pmid:42953433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric disease and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:efb688f51a474c7aa985df2587bac24e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/efb688f51a474c7aa985df2587bac24e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropsychiatric Disease and Treatment, Vol Volume 22, Iss Issue 1, Pp 1-16 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121308","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/advances-in-multi-omics-research-on-post-stroke-depression-from-molecu-peer-reviewed-fulltext-article-NDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ndt.s649205","doi":"https://doi.org/10.2147/ndt.s649205","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s649205","pdf_url":"https://www.dovepress.com/article/download/121308","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223348673.pdf","grobid_xml":"https://content.openalex.org/works/W7223348673.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W2462454946","https://openalex.org/W2483400001","https://openalex.org/W2553248347","https://openalex.org/W3130187613","https://openalex.org/W3140861702","https://openalex.org/W3198753852","https://openalex.org/W3200779911","https://openalex.org/W3210696970","https://openalex.org/W3214449456","https://openalex.org/W3216929906","https://openalex.org/W4200041757","https://openalex.org/W4200340768","https://openalex.org/W4200534257","https://openalex.org/W4205442010","https://openalex.org/W4220752601","https://openalex.org/W4223912756","https://openalex.org/W4224291771","https://openalex.org/W4226356669","https://openalex.org/W4280528197","https://openalex.org/W4281565098","https://openalex.org/W4285505815","https://openalex.org/W4297243409","https://openalex.org/W4303648231","https://openalex.org/W4306167779","https://openalex.org/W4308144309","https://openalex.org/W4309815448","https://openalex.org/W4311616532","https://openalex.org/W4321789032","https://openalex.org/W4323566977","https://openalex.org/W4361215288","https://openalex.org/W4362592557","https://openalex.org/W4364351465","https://openalex.org/W4376611458","https://openalex.org/W4376638628","https://openalex.org/W4377030612","https://openalex.org/W4383711036","https://openalex.org/W4384498158","https://openalex.org/W4385406641","https://openalex.org/W4385623702","https://openalex.org/W4385945377","https://openalex.org/W4391758128","https://openalex.org/W4392203386","https://openalex.org/W4392251192","https://openalex.org/W4393168173","https://openalex.org/W4393987377","https://openalex.org/W4399244716","https://openalex.org/W4401378600","https://openalex.org/W4403379267","https://openalex.org/W4404432119","https://openalex.org/W4405221449","https://openalex.org/W4407115716","https://openalex.org/W4407366024","https://openalex.org/W4407578971","https://openalex.org/W4408131699","https://openalex.org/W4409196367","https://openalex.org/W4409343798","https://openalex.org/W4410120351","https://openalex.org/W4410406327","https://openalex.org/W4412134703","https://openalex.org/W4412707088","https://openalex.org/W4412862903","https://openalex.org/W4413099405","https://openalex.org/W4413847532","https://openalex.org/W4414263681","https://openalex.org/W4414346009","https://openalex.org/W4415195149","https://openalex.org/W4415972778","https://openalex.org/W4417321959","https://openalex.org/W7117744165","https://openalex.org/W7117757155","https://openalex.org/W7126100693","https://openalex.org/W7127900678","https://openalex.org/W7128742742","https://openalex.org/W7131351901","https://openalex.org/W7133982809","https://openalex.org/W7136476534","https://openalex.org/W7138946808","https://openalex.org/W7139953494","https://openalex.org/W7151963310","https://openalex.org/W7154481540","https://openalex.org/W7154701068","https://openalex.org/W7156217878","https://openalex.org/W7160193639","https://openalex.org/W7161270555","https://openalex.org/W7162443116","https://openalex.org/W7162776839","https://openalex.org/W7164969051","https://openalex.org/W7165568978","https://openalex.org/W7165762703","https://openalex.org/W7170511793"],"related_works":["https://openalex.org/W7165762703","https://openalex.org/W4417321959","https://openalex.org/W2280573350","https://openalex.org/W7162596263","https://openalex.org/W4414938138","https://openalex.org/W7155519564","https://openalex.org/W3164285767","https://openalex.org/W4411006428","https://openalex.org/W7213075187","https://openalex.org/W3114293409"],"abstract_inverted_index":{"Post-stroke":[0],"depression":[1],"(PSD)":[2],"is":[3,70,167],"a":[4,12,74],"common":[5],"neuropsychiatric":[6],"complication":[7],"after":[8],"stroke":[9],"and":[10,21,32,50,57,95,103,149,164,188,195,208],"has":[11,114],"substantial":[13],"impact":[14],"on":[15,47,141],"functional":[16],"recovery,":[17],"quality":[18],"of":[19,42,68,88,99,111,134,155,172,186,192],"life,":[20],"long-term":[22],"outcomes.":[23],"Because":[24],"stroke-related":[25],"manifestations,":[26],"including":[27,82],"aphasia,":[28],"cognitive":[29],"impairment,":[30],"fatigue,":[31],"somatic":[33],"symptoms,":[34,38],"overlap":[35],"with":[36],"depressive":[37],"the":[39,66,89,100,120,132,153,156,170,183,190],"clinical":[40,51,200],"identification":[41,191],"PSD":[43,69,138,165,187],"still":[44],"largely":[45],"relies":[46],"symptom":[48],"assessment":[49],"interviews,":[52],"resulting":[53],"in":[54,59,93,131,137,160],"delayed":[55],"diagnosis":[56],"intervention":[58],"some":[60],"patients.":[61],"Recent":[62],"studies":[63,177],"indicate":[64],"that":[65],"development":[67,166],"not":[71],"driven":[72],"by":[73],"single":[75],"pathological":[76],"process":[77],"but":[78],"involves":[79],"multiple":[80],"mechanisms,":[81],"neuroinflammation,":[83],"neural":[84],"network":[85],"alterations,":[86],"dysfunction":[87],"neurovascular":[90],"unit,":[91],"disturbances":[92],"energy":[94],"lipid":[96],"metabolism,":[97],"imbalance":[98],"microbiota-gut-brain":[101],"axis,":[102],"psychosocial":[104],"factors":[105],"following":[106],"brain":[107],"injury.":[108],"The":[109],"advancement":[110],"multi-omics":[112,135,176],"technologies":[113],"provided":[115,179],"new":[116,180],"approaches":[117,136],"for":[118],"investigating":[119],"biological":[121],"mechanisms":[122],"underlying":[123],"PSD.":[124],"This":[125],"review":[126],"systematically":[127],"summarizes":[128],"recent":[129],"progress":[130],"application":[133],"research,":[139],"focusing":[140],"molecular":[142,184],"alterations":[143],"identified":[144],"across":[145],"different":[146],"omics":[147],"platforms":[148],"potential":[150,193],"biomarkers.":[151],"Furthermore,":[152],"role":[154],"hypothalamic-pituitary-adrenal":[157],"(HPA)":[158],"axis":[159],"stress":[161],"response":[162],"regulation":[163],"discussed":[168],"within":[169],"context":[171],"neuro-immune-metabolic":[173],"interactions.":[174],"Overall,":[175],"have":[178],"insights":[181],"into":[182],"basis":[185],"facilitated":[189],"biomarkers":[194],"therapeutic":[196],"targets.":[197],"However,":[198],"their":[199],"utility":[201],"requires":[202],"further":[203],"evaluation":[204],"through":[205],"standardized":[206],"cohorts":[207],"validation":[209],"studies.":[210]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}