{"id":"https://openalex.org/W7223346529","doi":"https://doi.org/10.3390/ijms27209359","title":"Sinapaldehyde Induces Mitochondrial Dysfunction and Modulates Autophagy/Mitophagy-Associated Signaling and Apoptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells","display_name":"Sinapaldehyde Induces Mitochondrial Dysfunction and Modulates Autophagy/Mitophagy-Associated Signaling and Apoptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223346529","doi":"https://doi.org/10.3390/ijms27209359","pmid":"https://pubmed.ncbi.nlm.nih.gov/42942124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13704905"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27209359","doi":"https://doi.org/10.3390/ijms27209359","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209359","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27209359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159342739","display_name":"Hiruni Sandunika Kumarasinghe","orcid":"https://orcid.org/0000-0003-3215-4226","observed_orcids":["https://orcid.org/0000-0003-3215-4226"]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hiruni Sandunika Kumarasinghe","raw_affiliation_strings":["Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3215-4226","affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121954550","display_name":"Ducdat Le","orcid":"https://orcid.org/0000-0002-5448-5651","observed_orcids":["https://orcid.org/0000-0002-5448-5651"]},"institutions":[{"id":"https://openalex.org/I199143407","display_name":"Sunchon National University","ror":"https://ror.org/043jqrs76","country_code":"KR","type":"education","lineage":["https://openalex.org/I199143407"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ducdat Le","raw_affiliation_strings":["AI Bio Autonomous Research Core Facility Center, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","Department of Natural Cosmetics Science and AI Digital Bioscience Research Institute, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AI Bio Autonomous Research Core Facility Center, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]},{"raw_affiliation_string":"College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]},{"raw_affiliation_string":"Department of Natural Cosmetics Science and AI Digital Bioscience Research Institute, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069934681","display_name":"Ji-Hyang Kim","orcid":"https://orcid.org/0000-0003-3532-3822","observed_orcids":["https://orcid.org/0000-0003-3532-3822"]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hyang Kim","raw_affiliation_strings":["Bio-Health Materials Core-Facility Center, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Health Materials Core-Facility Center, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058988581","display_name":"SU-LIM KIM","orcid":"https://orcid.org/0009-0009-2134-0171","observed_orcids":["https://orcid.org/0009-0009-2134-0171"]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Lim Kim","raw_affiliation_strings":["Graduate Program for Bio-Health/Innovative Drug Development Using Subtropical Bio-Resources, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-2134-0171","affiliations":[{"raw_affiliation_string":"Graduate Program for Bio-Health/Innovative Drug Development Using Subtropical Bio-Resources, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022180553","display_name":"Kyeoung Cheol Kim","orcid":"https://orcid.org/0000-0002-2485-636X","observed_orcids":["https://orcid.org/0000-0002-2485-636X"]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyeoung Cheol Kim","raw_affiliation_strings":["Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2485-636X","affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159316888","display_name":"Rambukka-na Maggonage Thiruni Dananjana Perera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rambukka-na Maggonage Thiruni Dananjana Perera","raw_affiliation_strings":["Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073838206","display_name":"Yaejun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yaejun Kim","raw_affiliation_strings":["Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100756496","display_name":"Mina Lee","orcid":"https://orcid.org/0000-0002-4187-3153","observed_orcids":["https://orcid.org/0000-0002-4187-3153"]},"institutions":[{"id":"https://openalex.org/I199143407","display_name":"Sunchon National University","ror":"https://ror.org/043jqrs76","country_code":"KR","type":"education","lineage":["https://openalex.org/I199143407"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mina Lee","raw_affiliation_strings":["AI Bio Autonomous Research Core Facility Center, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","Department of Natural Cosmetics Science and AI Digital Bioscience Research Institute, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4187-3153","affiliations":[{"raw_affiliation_string":"AI Bio Autonomous Research Core Facility Center, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]},{"raw_affiliation_string":"College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]},{"raw_affiliation_string":"Department of Natural Cosmetics Science and AI Digital Bioscience Research Institute, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea","institution_ids":["https://openalex.org/I199143407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008602238","display_name":"Dong\u2010Sun Lee","orcid":"https://orcid.org/0000-0001-7816-6471","observed_orcids":["https://orcid.org/0000-0001-7816-6471"]},"institutions":[{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dong-Sun Lee","raw_affiliation_strings":["Bio-Health Materials Core-Facility Center, Jeju National University, Jeju 63243, Republic of Korea","Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju 63243, Republic of Korea","Graduate Program for Bio-Health/Innovative Drug Development Using Subtropical Bio-Resources, Jeju National University, Jeju 63243, Republic of Korea","Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7816-6471","affiliations":[{"raw_affiliation_string":"Bio-Health Materials Core-Facility Center, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]},{"raw_affiliation_string":"Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]},{"raw_affiliation_string":"Graduate Program for Bio-Health/Innovative Drug Development Using Subtropical Bio-Resources, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]},{"raw_affiliation_string":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea","institution_ids":["https://openalex.org/I83202590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008602238","https://openalex.org/A5100756496"],"corresponding_institution_ids":["https://openalex.org/I199143407","https://openalex.org/I83202590"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71786338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"20","first_page":"9359","last_page":"9359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinapaldehyde","display_name":"sinapaldehyde","score":1.0},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ferritinophagy","display_name":"ferritinophagy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7839999794960022},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8790000081062317},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.4779999852180481},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.6941999793052673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6527000069618225},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6340000033378601},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5644999742507935},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5385000109672546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5314000248908997},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5289999842643738},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5055000185966492},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4392000138759613},{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.4375},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.3937999904155731},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30309998989105225},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.2962000072002411},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C2780670749","wikidata":"https://www.wikidata.org/wiki/Q14908239","display_name":"Annexin A5","level":4,"score":0.26429998874664307},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000092302","descriptor_name":"MDA-MB-231 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27209359","doi":"https://doi.org/10.3390/ijms27209359","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209359","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13704905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13704905/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13704905/pdf/ijms-27-09359.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42942124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42942124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27209359","doi":"https://doi.org/10.3390/ijms27209359","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209359","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000848240","display_name":null,"funder_award_id":"RS-2026-25533557","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322111","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223346529.pdf","grobid_xml":"https://content.openalex.org/works/W7223346529.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1997285537","https://openalex.org/W2080421381","https://openalex.org/W2101068876","https://openalex.org/W2557913761","https://openalex.org/W2577310139","https://openalex.org/W2803850072","https://openalex.org/W2920882938","https://openalex.org/W2990189593","https://openalex.org/W3033869790","https://openalex.org/W3083139201","https://openalex.org/W3168589640","https://openalex.org/W3214935442","https://openalex.org/W4211005384","https://openalex.org/W4307043564","https://openalex.org/W4311051500","https://openalex.org/W4318696266","https://openalex.org/W4362718584","https://openalex.org/W4367175251","https://openalex.org/W4385828734","https://openalex.org/W4386223335","https://openalex.org/W4386223396","https://openalex.org/W4388223020","https://openalex.org/W4388303538","https://openalex.org/W4391492467","https://openalex.org/W4392106647","https://openalex.org/W4396543840","https://openalex.org/W4396936983","https://openalex.org/W4401027998","https://openalex.org/W4407096057","https://openalex.org/W4407396207","https://openalex.org/W4407554946","https://openalex.org/W4409864235","https://openalex.org/W4411342504"],"related_works":["https://openalex.org/W4307248349","https://openalex.org/W2562942633","https://openalex.org/W4229375960","https://openalex.org/W3172144433","https://openalex.org/W2741791521","https://openalex.org/W2915165741","https://openalex.org/W4414602271","https://openalex.org/W2888915647","https://openalex.org/W7118602648","https://openalex.org/W3048596928"],"abstract_inverted_index":{"Triple-negative":[0],"breast":[1,157],"cancer":[2],"(TNBC)":[3],"is":[4,172],"highly":[5],"aggressive":[6],"and":[7,43,55,72,80,94,96,105,112,122,127,133,141,144,161,171,179,209,212,218],"lacks":[8],"targeted":[9],"therapies.":[10],"This":[11],"study":[12],"investigated":[13],"the":[14,90,192,213],"anti-cancer":[15],"mechanisms":[16],"of":[17,23,82,92,124,138,181],"sinapaldehyde":[18],"(SNAH).":[19],"The":[20],"biological":[21],"effects":[22],"SNAH":[24,86,129,167,196],"were":[25,46,115],"evaluated":[26],"in":[27,69,110,176,183,207],"vitro":[28],"using":[29],"MDA-MB-231":[30,184],"TNBC":[31,185],"cells.":[32,186],"Cellular":[33],"responses,":[34],"including":[35,100],"autophagy,":[36],"mitochondrial":[37,64,70,83,169],"function,":[38],"apoptosis,":[39],"cell-cycle":[40,150],"progression,":[41],"migration,":[42],"colony":[44,145],"formation":[45,146],"investigated.":[47],"In":[48,152],"silico":[49,153],"studies":[50,201],"explored":[51],"associated":[52,62,164,173],"regulatory":[53],"networks":[54],"binding":[56],"targets.":[57],"Sinapaldehyde":[58],"(SNAH)":[59],"treatment":[60,87],"was":[61],"with":[63,165,174],"dysfunction,":[65],"characterized":[66],"by":[67,117],"alterations":[68,175],"structural":[71],"functional":[73,200],"markers,":[74,99],"increased":[75,118],"reactive":[76],"oxygen":[77],"species(ROS)":[78],"production,":[79],"loss":[81],"membrane":[84],"potential.":[85],"also":[88,130],"altered":[89,131],"expression":[91],"PINK1":[93],"Parkin":[95],"modulated":[97],"autophagy-associated":[98],"LC3B,":[101],"p62,":[102],"LAMP1,":[103],"Beclin-1,":[104],"ATG":[106],"proteins.":[107],"Time-dependent":[108],"changes":[109,206],"autophagy-":[111],"apoptosis-associated":[113],"markers":[114],"accompanied":[116],"Annexin":[119],"V-positive":[120],"cells":[121],"activation":[123,180],"cleaved":[125],"caspase-9":[126],"caspase-3.":[128],"FTH1":[132],"NCOA4":[134],"expression,":[135],"suggesting":[136],"modulation":[137],"ferritinophagy-associated":[139],"processes,":[140],"inhibited":[142],"migration":[143],"while":[147,198],"inducing":[148],"G2/M":[149],"arrest.":[151],"analyses":[154],"identified":[155],"potential":[156],"cancer-related":[158],"molecular":[159],"targets":[160],"signaling":[162,178],"pathways":[163],"SNAH.":[166],"induces":[168],"dysfunction":[170],"autophagy/mitophagy-associated":[177],"apoptosis":[182],"These":[187],"findings":[188],"provide":[189],"insight":[190],"into":[191],"cellular":[193],"responses":[194],"to":[195,204],"treatment,":[197],"further":[199],"are":[202],"required":[203],"establish":[205],"mitophagic":[208],"ferritinophagic":[210],"flux":[211],"causal":[214],"relationship":[215],"between":[216],"autophagy":[217],"apoptosis.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}
