{"id":"https://openalex.org/W7223346048","doi":"https://doi.org/10.2147/ijgm.s632408","title":"Association Between Neutrophil Percentage-to-Albumin Ratio and Prolonged Length of Hospital Stay in Older Patients with Acute Exacerbation of COPD: A Retrospective Analysis","display_name":"Association Between Neutrophil Percentage-to-Albumin Ratio and Prolonged Length of Hospital Stay in Older Patients with Acute Exacerbation of COPD: A Retrospective Analysis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223346048","doi":"https://doi.org/10.2147/ijgm.s632408","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13712224"},"language":"en","primary_location":{"id":"doi:10.2147/ijgm.s632408","doi":"https://doi.org/10.2147/ijgm.s632408","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s632408","pdf_url":"https://www.dovepress.com/article/download/121284","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113424369","display_name":"Yan Lu","orcid":"https://orcid.org/0009-0005-8291-2744","observed_orcids":["https://orcid.org/0009-0005-8291-2744"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0005-8291-2744","affiliations":[{"raw_affiliation_string":"Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683704","display_name":"Yuan Li","orcid":"https://orcid.org/0009-0006-0088-1567","observed_orcids":["https://orcid.org/0009-0006-0088-1567"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":["Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043507157","display_name":"Jianjie Lou","orcid":"https://orcid.org/0009-0005-4194-1434","observed_orcids":["https://orcid.org/0009-0005-4194-1434"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjie Lou","raw_affiliation_strings":["Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0005-4194-1434","affiliations":[{"raw_affiliation_string":"Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013937502","display_name":"Sizhe Hu","orcid":"https://orcid.org/0000-0003-1700-1571","observed_orcids":["https://orcid.org/0000-0003-1700-1571"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sizhe Hu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, People's Republic of China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013937502","https://openalex.org/A5113424369"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83317715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.13650000095367432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-percentage-to-albumin-ratio","display_name":"neutrophil percentage-to-albumin ratio","score":0.996999979019165},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9869999885559082},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8370000123977661},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.9909999966621399},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.796999990940094},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9717000126838684},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6812000274658203},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.619700014591217},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.605400025844574},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.555899977684021},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5016000270843506},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.43059998750686646},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4041000008583069},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.38199999928474426},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3370000123977661},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2780861865","wikidata":"https://www.wikidata.org/wiki/Q4677923","display_name":"Acute exacerbation of chronic obstructive pulmonary disease","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C3019871722","wikidata":"https://www.wikidata.org/wiki/Q718944","display_name":"Hospital admission","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29269999265670776},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2806999981403351},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C207386681","wikidata":"https://www.wikidata.org/wiki/Q451323","display_name":"Derivation","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C2910217193","wikidata":"https://www.wikidata.org/wiki/Q4677923","display_name":"Copd exacerbation","level":4,"score":0.2540999948978424},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ijgm.s632408","doi":"https://doi.org/10.2147/ijgm.s632408","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s632408","pdf_url":"https://www.dovepress.com/article/download/121284","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13712224","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712224/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712224/pdf/IJGM-19-632408.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Gen Med","raw_type":"Text"},{"id":"pmid:42948320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of general medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3613a3829e8d4e3990c86ec43f14a51d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3613a3829e8d4e3990c86ec43f14a51d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Journal of General Medicine, Vol Volume 19, Iss Issue 1, Pp 1-13 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121284","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/association-between-neutrophil-percentage-to-albumin-ratio-and-prolong-peer-reviewed-fulltext-article-IJGM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijgm.s632408","doi":"https://doi.org/10.2147/ijgm.s632408","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s632408","pdf_url":"https://www.dovepress.com/article/download/121284","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324867","display_name":"Jinhua Science and Technology Bureau","ror":"https://ror.org/0347g4065"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223346048.pdf","grobid_xml":"https://content.openalex.org/works/W7223346048.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W2005117940","https://openalex.org/W2063881829","https://openalex.org/W2145466675","https://openalex.org/W2580357067","https://openalex.org/W2773432295","https://openalex.org/W2907687349","https://openalex.org/W2908494569","https://openalex.org/W2986343434","https://openalex.org/W3120395915","https://openalex.org/W4221110952","https://openalex.org/W4367293848","https://openalex.org/W4386289978","https://openalex.org/W4390611922","https://openalex.org/W4392081744","https://openalex.org/W4393858312","https://openalex.org/W4400111555","https://openalex.org/W4405763274","https://openalex.org/W4407752674","https://openalex.org/W4408863980","https://openalex.org/W4409168363","https://openalex.org/W4409180625","https://openalex.org/W4409807970","https://openalex.org/W4411156544","https://openalex.org/W4413660250","https://openalex.org/W4416851174","https://openalex.org/W7152999211"],"related_works":["https://openalex.org/W4411156544","https://openalex.org/W3096563213","https://openalex.org/W6906266477","https://openalex.org/W7008153196","https://openalex.org/W7052226331","https://openalex.org/W2980636963","https://openalex.org/W4411101745","https://openalex.org/W2779882932","https://openalex.org/W4400744644","https://openalex.org/W3198457951"],"abstract_inverted_index":{"Purpose:":[0],"The":[1,215],"neutrophil":[2],"percentage-to-albumin":[3],"ratio":[4],"(NPAR)":[5],"is":[6,261],"a":[7,163,206,245],"novel":[8],"integrated":[9,154],"biomarker":[10,275],"that":[11],"reflects":[12],"systemic":[13],"inflammation":[14],"and":[15,34,76,93,113,140,153,162,221,238,251],"nutritional":[16],"status.":[17],"In":[18],"this":[19,273],"study,":[20],"we":[21],"investigated":[22],"the":[23,28,80,108,122,130,133,141,172,283],"early":[24,284],"risk-stratifying":[25],"potential":[26],"of":[27,36,46,84,192,228,286],"independent":[29,109],"association":[30,110],"between":[31,73,111],"admission":[32,259],"NPAR":[33,90,112,185,260],"length":[35],"hospital":[37],"stay":[38],"(LOHS)":[39],"in":[40,234,267,282],"older":[41,64,268],"patients":[42,65,253,269],"with":[43,68,116,159,189,205,244,264,270],"acute":[44],"exacerbation":[45],"chronic":[47],"obstructive":[48],"pulmonary":[49],"disease":[50],"(AECOPD).":[51],"Methods:":[52],"A":[53],"retrospective":[54],"cohort":[55],"analysis":[56,166,237],"was":[57,91,96,104,127,147,186,218],"performed":[58],"using":[59,129],"clinical":[60,278],"data":[61],"from":[62],"6137":[63,173],"(\u226560":[66],"years)":[67],"AECOPD,":[69],"who":[70],"were":[71,167,239],"hospitalized":[72],"January":[74],"2010":[75],"March":[77],"2024":[78],"at":[79,225],"Affiliated":[81],"Dongyang":[82],"Hospital":[83],"Wenzhou":[85],"Medical":[86],"University,":[87],"China.":[88],"Admission":[89],"calculated,":[92],"prolonged":[94,114,179,193,265],"LOHS":[95,194,266],"defined":[97],"as":[98],">7":[99],"days.":[100],"Multivariable":[101],"logistic":[102],"regression":[103],"used":[105],"to":[106,120],"assess":[107],"LOHS,":[115],"restricted":[117],"cubic":[118],"splines":[119],"characterize":[121],"dose-response":[123,208],"relationship.":[124],"Model":[125],"performance":[126],"evaluated":[128],"area":[131],"under":[132],"receiver":[134],"operating":[135],"characteristic":[136],"curve,":[137],"calibration":[138],"plots,":[139],"Hosmer-Lemeshow":[142],"test.":[143],"Incremental":[144],"predictive":[145],"value":[146],"quantified":[148],"via":[149],"net":[150,223],"reclassification":[151],"improvement":[152],"discrimination":[155],"improvement.":[156],"Subgroup":[157],"analyses":[158],"Bonferroni":[160],"correction":[161],"complete-case":[164,235],"sensitivity":[165,236],"also":[168],"performed.":[169],"Results:":[170],"Of":[171],"eligible":[174],"patients,":[175],"2923":[176],"(47.6%)":[177],"experienced":[178],"LOHS.":[180],"After":[181],"full":[182],"adjustment,":[183],"higher":[184],"independently":[187,262],"associated":[188,263],"increased":[190],"risk":[191],"(odds":[195],"ratio:":[196],"2.405;":[197],"95%":[198],"confidence":[199],"interval:":[200],"1.904-3.046;":[201],"P":[202],"<":[203],"0.001),":[204],"linear":[207],"relationship":[209],"(P":[210],"for":[211,249,252],"nonlinearity":[212],"=":[213],"0.590).":[214],"NPAR-integrated":[216],"model":[217],"well":[219],"calibrated":[220],"showed":[222],"benefit":[224],"threshold":[226],"probabilities":[227],"15%-77%.":[229],"These":[230],"findings":[231],"remained":[232],"robust":[233],"consistent":[240],"across":[241],"most":[242],"subgroups,":[243],"stronger":[246],"effect":[247],"observed":[248],"males":[250],"aged":[254],"\u226475":[255],"years.":[256],"Conclusion:":[257],"Higher":[258],"AECOPD.":[271],"Incorporating":[272],"accessible":[274],"into":[276],"initial":[277],"assessment":[279],"may":[280],"aid":[281],"identification":[285],"high-risk":[287],"patients.":[288]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}