{"id":"https://openalex.org/W7223340917","doi":"https://doi.org/10.1126/sciadv.adz0039","title":"An in situ forming immunomodulatory hydrogel reinvigorates exhausted CD8 + T cells via preserving their mitochondrial fitness","display_name":"An in situ forming immunomodulatory hydrogel reinvigorates exhausted CD8 + T cells via preserving their mitochondrial fitness","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223340917","doi":"https://doi.org/10.1126/sciadv.adz0039","pmid":"https://pubmed.ncbi.nlm.nih.gov/42913016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693686"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.adz0039","doi":"https://doi.org/10.1126/sciadv.adz0039","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz0039","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.adz0039","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009121661","display_name":"Yiming Qi","orcid":"https://orcid.org/0000-0002-0530-6661","observed_orcids":["https://orcid.org/0000-0002-0530-6661"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiming Qi","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0530-6661","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336971","display_name":"Jing Li","orcid":"https://orcid.org/0000-0002-6860-6135","observed_orcids":["https://orcid.org/0000-0002-6860-6135","https://orcid.org/0000-0002-8267-1275","https://orcid.org/0009-0000-0571-6022"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Pharmacy, Putuo People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200060, P.R. China"],"raw_orcid":"https://orcid.org/0009-0000-0571-6022","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Putuo People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200060, P.R. China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089991487","display_name":"Ziyan Chen","orcid":"https://orcid.org/0000-0003-4950-1036","observed_orcids":["https://orcid.org/0000-0003-4950-1036","https://orcid.org/0009-0006-8297-1258"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyan Chen","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0009-0006-8297-1258","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002392209","display_name":"Chenming Zou","orcid":"https://orcid.org/0000-0001-7400-5849","observed_orcids":["https://orcid.org/0000-0001-7400-5849"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenming Zou","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159373073","display_name":"Haichao Zhu","orcid":"https://orcid.org/0009-0004-4271-9918","observed_orcids":["https://orcid.org/0009-0004-4271-9918"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haichao Zhu","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0009-0004-4271-9918","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136165853","display_name":"Alice Shen Yi Shan","orcid":"https://orcid.org/0009-0007-7977-4453","observed_orcids":["https://orcid.org/0009-0007-7977-4453"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Alice Shen Yi Shan","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0009-0007-7977-4453","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114234313","display_name":"Yuli Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuli Fu","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159323553","display_name":"Jingwen Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Hou","raw_affiliation_strings":["Instrumental Analysis Centre, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instrumental Analysis Centre, Shanghai Jiao Tong University, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121371632","display_name":"Chaozhu Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119554","display_name":"Yancheng First People's Hospital","ror":"https://ror.org/02rbkz523","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119554"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaozhu Zheng","raw_affiliation_strings":["Rehabilitation Department, Yancheng No.1 People\u2019s Hospital, Affiliated Hospital of Medical School, Nanjing University, Yancheng 224000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rehabilitation Department, Yancheng No.1 People\u2019s Hospital, Affiliated Hospital of Medical School, Nanjing University, Yancheng 224000, P.R. China","institution_ids":["https://openalex.org/I4210119554","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042887647","display_name":"Qiongzhe Ren","orcid":"https://orcid.org/0000-0002-0904-3627","observed_orcids":["https://orcid.org/0000-0002-0904-3627"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiongzhe Ren","raw_affiliation_strings":["Biomedical Polymers Laboratory, College of Chemistry Chemical Engineering and Materials Science and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0904-3627","affiliations":[{"raw_affiliation_string":"Biomedical Polymers Laboratory, College of Chemistry Chemical Engineering and Materials Science and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P.R. China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101707994","display_name":"Yu Qiao","orcid":"https://orcid.org/0000-0001-5945-4734","observed_orcids":["https://orcid.org/0000-0001-5945-4734"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Qiao","raw_affiliation_strings":["Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University, Shanghai, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-5945-4734","affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101871215","display_name":"Jin Zhu","orcid":"https://orcid.org/0000-0001-6619-7705","observed_orcids":["https://orcid.org/0000-0001-6619-7705"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu Jin","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-6619-7705","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063084018","display_name":"Feihu Wang","orcid":"https://orcid.org/0000-0002-0358-967X","observed_orcids":["https://orcid.org/0000-0002-0358-967X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feihu Wang","raw_affiliation_strings":["School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0358-967X","affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064686579","display_name":"Shengrong Guo","orcid":"https://orcid.org/0000-0002-6897-2055","observed_orcids":["https://orcid.org/0000-0002-6897-2055"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengrong Guo","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-6897-2055","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Engineering for Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5009121661","https://openalex.org/A5063084018","https://openalex.org/A5064686579","https://openalex.org/A5100336971"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I183067930"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78471757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"43","first_page":"eadz0039","last_page":"eadz0039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/in-situ-forming-hydrogels","display_name":"in situ forming hydrogels","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tpgs","display_name":"TPGS","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tunneling-nanotubes","display_name":"tunneling nanotubes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nlg919","display_name":"NLG919","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.6549999713897705},{"id":"https://openalex.org/keywords/nanohybrids","display_name":"hybrid nanostructures","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7623000144958496},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6848999857902527},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5938000082969666},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5490999817848206},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5223000049591064},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5213000178337097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4505000114440918},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4449999928474426},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43529999256134033},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3734000027179718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3488999903202057},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34869998693466187},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.32679998874664307},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30469998717308044},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3043000102043152},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.2883000075817108},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2766000032424927},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C2778973524","wikidata":"https://www.wikidata.org/wiki/Q3910755","display_name":"Cross-presentation","level":5,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.adz0039","doi":"https://doi.org/10.1126/sciadv.adz0039","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz0039","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693686","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693686/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693686/pdf/sciadv.adz0039.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:42913016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42913016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.adz0039","doi":"https://doi.org/10.1126/sciadv.adz0039","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adz0039","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320330402","display_name":"Shanghai Technology Innovation Project","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223340917.pdf","grobid_xml":"https://content.openalex.org/works/W7223340917.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1677199798","https://openalex.org/W2024924871","https://openalex.org/W2025972601","https://openalex.org/W2038976751","https://openalex.org/W2043246560","https://openalex.org/W2055918848","https://openalex.org/W2103230459","https://openalex.org/W2120426523","https://openalex.org/W2135592618","https://openalex.org/W2149090315","https://openalex.org/W2168750058","https://openalex.org/W2397756710","https://openalex.org/W2518249323","https://openalex.org/W2552893209","https://openalex.org/W2561100838","https://openalex.org/W2768413943","https://openalex.org/W2773731465","https://openalex.org/W2786095824","https://openalex.org/W2791483720","https://openalex.org/W2797967795","https://openalex.org/W2804020683","https://openalex.org/W2887449433","https://openalex.org/W2905098668","https://openalex.org/W2907564726","https://openalex.org/W2940235725","https://openalex.org/W2964325900","https://openalex.org/W2980435746","https://openalex.org/W2997391673","https://openalex.org/W3000339487","https://openalex.org/W3006349318","https://openalex.org/W3009193015","https://openalex.org/W3020879277","https://openalex.org/W3047744552","https://openalex.org/W3109922543","https://openalex.org/W3127987319","https://openalex.org/W3129596738","https://openalex.org/W3134959125","https://openalex.org/W3155209389","https://openalex.org/W3168169234","https://openalex.org/W3212198885","https://openalex.org/W4200558611","https://openalex.org/W4210957446","https://openalex.org/W4281490788","https://openalex.org/W4293536468","https://openalex.org/W4309067272","https://openalex.org/W4310553113","https://openalex.org/W4315784610","https://openalex.org/W4320495502","https://openalex.org/W4322616926","https://openalex.org/W4324123712","https://openalex.org/W4365143025","https://openalex.org/W4382517285","https://openalex.org/W4391773766","https://openalex.org/W4393078422","https://openalex.org/W4402332263","https://openalex.org/W4403452817","https://openalex.org/W4406202048","https://openalex.org/W4406731670","https://openalex.org/W4414538004","https://openalex.org/W4416657264","https://openalex.org/W4416795338","https://openalex.org/W7116907712"],"related_works":["https://openalex.org/W4285732042","https://openalex.org/W4414479897","https://openalex.org/W4375855933","https://openalex.org/W4317567040","https://openalex.org/W3202228103","https://openalex.org/W4404929332","https://openalex.org/W4372334416","https://openalex.org/W4416958820","https://openalex.org/W7108478383","https://openalex.org/W7163152124"],"abstract_inverted_index":{"CD8":[0,40,109,131],"+":[1,41,110,132],"T":[2,42,111,126,133],"cell":[3,76,87,127],"exhaustion":[4,135],"driven":[5],"by":[6,44,114,129],"mitochondrial":[7,46,94,106],"dysfunction":[8],"remains":[9],"a":[10,49,67,156],"major":[11],"barrier":[12],"to":[13,65,78],"effective":[14],"cancer":[15,75,163],"immunotherapy.":[16],"Here,":[17],"we":[18],"report":[19],"an":[20],"in":[21,108],"situ":[22],"forming":[23],"d":[24],"-\u03b1-tocopheryl":[25],"polyethylene":[26],"glycol":[27],"succinate":[28],"(TPGS)\u2013based":[29],"hydrogel":[30,153],"[multifunctional":[31],"thermosensitive":[32],"composite":[33],"gel":[34],"(MTC":[35],"Gel)]":[36],"that":[37],"reinvigorates":[38],"exhausted":[39],"cells":[43,112,134],"preserving":[45],"fitness":[47],"through":[48],"two-pronged":[50],"strategy.":[51],"After":[52],"intratumoral":[53],"injection,":[54],"MTC":[55,102,123],"Gel":[56,103,124],"rapidly":[57],"undergoes":[58],"gelation":[59],"at":[60],"physiological":[61],"temperature":[62],"and":[63,90,139],"dissociates":[64],"generate":[66],"high":[68],"local":[69],"concentration":[70],"of":[71],"TPGS,":[72],"which":[73],"targets":[74],"mitochondria":[77],"trigger":[79],"prodeath":[80],"mitophagy.":[81],"This":[82],"process":[83],"induces":[84],"robust":[85],"immunogenic":[86],"death":[88],"(ICD)":[89],"blocks":[91],"tunneling":[92],"nanotube\u2013mediated":[93],"hijacking.":[95],"Meanwhile,":[96],"NLG919-loaded":[97],"hybrid":[98],"nanoparticles":[99],"released":[100],"from":[101],"synergistically":[104],"restore":[105],"biogenesis":[107],"suppressed":[113],"indoleamine":[115],"2,3-dioxygenase":[116],"1.":[117],"Across":[118],"multiple":[119],"murine":[120],"tumor":[121],"models,":[122],"reprograms":[125],"immunity":[128],"reducing":[130],"while":[136],"enhancing":[137],"effector":[138],"cytotoxic":[140],"functions,":[141],"thereby":[142],"eliciting":[143],"potent":[144],"tumoricidal":[145],"activity.":[146],"These":[147],"findings":[148],"highlight":[149],"this":[150],"rationally":[151],"designed":[152],"system":[154],"as":[155],"clinically":[157],"translatable":[158],"platform":[159],"for":[160],"next-generation":[161],"ICD-based":[162],"immunotherapies.":[164]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}
