{"id":"https://openalex.org/W7223339670","doi":"https://doi.org/10.3389/fimmu.2026.1902009","title":"SPOCK2-mediated phenotype switch of vascular smooth muscle cells contributes to aortic aneurysm in Kawasaki disease","display_name":"SPOCK2-mediated phenotype switch of vascular smooth muscle cells contributes to aortic aneurysm in Kawasaki disease","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223339670","doi":"https://doi.org/10.3389/fimmu.2026.1902009","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13739779"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1902009","doi":"https://doi.org/10.3389/fimmu.2026.1902009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1902009","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1902009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1902009/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110085664","display_name":"Xiao Xu","orcid":"https://orcid.org/0000-0002-2742-6023","observed_orcids":["https://orcid.org/0000-0002-2742-6023"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xu","raw_affiliation_strings":["Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159310725","display_name":"Yucong Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yucong Wei","raw_affiliation_strings":["Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159334920","display_name":"Min Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102923572","display_name":"Jiahui Liu","orcid":"https://orcid.org/0000-0002-4099-5079","observed_orcids":["https://orcid.org/0000-0002-4099-5079"]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Liu","raw_affiliation_strings":["Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125532482","display_name":"Ting Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhao","raw_affiliation_strings":["Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159305585","display_name":"Xian Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian Ma","raw_affiliation_strings":["Department of Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066227053","display_name":"Tielong Chen","orcid":"https://orcid.org/0000-0003-1177-2404","observed_orcids":["https://orcid.org/0000-0003-1177-2404"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tielong Chen","raw_affiliation_strings":["Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078398693","display_name":"Buddhadeb Dawn","orcid":"https://orcid.org/0000-0001-5890-115X","observed_orcids":["https://orcid.org/0000-0001-5890-115X"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buddhadeb Dawn","raw_affiliation_strings":["Department of Internal Medicine, Kirk Kerkorian School of Medicine at the University of Nevada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Kirk Kerkorian School of Medicine at the University of Nevada","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110406627","display_name":"Fangqi Gong","orcid":"https://orcid.org/0000-0001-8925-5904","observed_orcids":["https://orcid.org/0000-0001-8925-5904","https://orcid.org/0000-0003-2081-096X","https://orcid.org/0009-0004-1386-477X"]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fangqi Gong","raw_affiliation_strings":["Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001371863","display_name":"Lin Zhao","orcid":"https://orcid.org/0000-0002-9326-3349","observed_orcids":["https://orcid.org/0000-0002-9326-3349"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Zhao","raw_affiliation_strings":["Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001371863","https://openalex.org/A5110406627"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210113495","https://openalex.org/I76130692"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84683108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1902009","last_page":"1902009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kawasaki-disease","display_name":"Kawasaki disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/spock2","display_name":"SPOCK2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/aortic-aneurysm","display_name":"aortic aneurysm","score":0.9559999704360962},{"id":"https://openalex.org/keywords/coronary-artery-aneurysm","display_name":"coronary artery aneurysm","score":0.9620000123977661},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vasculitis","display_name":"vasculitis","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2781423770","wikidata":"https://www.wikidata.org/wiki/Q265936","display_name":"Kawasaki disease","level":3,"score":0.7829999923706055},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6863999962806702},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.6205999851226807},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.5253000259399414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4970000088214874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48890000581741333},{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.47360000014305115},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4569000005722046},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.44589999318122864},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44510000944137573},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4449999928474426},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4429999887943268},{"id":"https://openalex.org/C2777374719","wikidata":"https://www.wikidata.org/wiki/Q7663822","display_name":"Systemic vasculitis","level":4,"score":0.41280001401901245},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3853999972343445},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C99322962","wikidata":"https://www.wikidata.org/wiki/Q17165464","display_name":"Vascular remodelling in the embryo","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.352400004863739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3506999909877777},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3041999936103821},{"id":"https://openalex.org/C166397571","wikidata":"https://www.wikidata.org/wiki/Q968604","display_name":"Vascular tissue","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2667999863624573},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.25940001010894775}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066253","descriptor_name":"Vascular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1902009","doi":"https://doi.org/10.3389/fimmu.2026.1902009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1902009","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1902009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42996707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13739779","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13739779/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3586d8ec3cb649a0bd79b30bfb52877c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3586d8ec3cb649a0bd79b30bfb52877c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1902009","doi":"https://doi.org/10.3389/fimmu.2026.1902009","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1902009","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1902009/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223339670.pdf","grobid_xml":"https://content.openalex.org/works/W7223339670.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1987394367","https://openalex.org/W2031224113","https://openalex.org/W2034264001","https://openalex.org/W2116014852","https://openalex.org/W2120648712","https://openalex.org/W2511327972","https://openalex.org/W2620868536","https://openalex.org/W2767198624","https://openalex.org/W2799653627","https://openalex.org/W2956246587","https://openalex.org/W2971638175","https://openalex.org/W2984323265","https://openalex.org/W3007753607","https://openalex.org/W3032564210","https://openalex.org/W3037210668","https://openalex.org/W3045480960","https://openalex.org/W3134877558","https://openalex.org/W3153473403","https://openalex.org/W3198290615","https://openalex.org/W3201531511","https://openalex.org/W3208169447","https://openalex.org/W4211009017","https://openalex.org/W4211257262","https://openalex.org/W4293030847","https://openalex.org/W4295796037","https://openalex.org/W4318617162","https://openalex.org/W4376641784","https://openalex.org/W4386852444","https://openalex.org/W4392079420","https://openalex.org/W4399388258","https://openalex.org/W4402390392","https://openalex.org/W4402735704","https://openalex.org/W4403219765","https://openalex.org/W4404332640","https://openalex.org/W4407157946","https://openalex.org/W4410953868","https://openalex.org/W7154082539"],"related_works":["https://openalex.org/W3037210668","https://openalex.org/W2087136800","https://openalex.org/W1987675528","https://openalex.org/W2076588038","https://openalex.org/W2148163936","https://openalex.org/W2090231969","https://openalex.org/W7164642179","https://openalex.org/W2956246587","https://openalex.org/W4401567770","https://openalex.org/W2009448247"],"abstract_inverted_index":{"Background:":[0],"Coronary":[1],"artery":[2],"aneurysm":[3,180,203],"is":[4,147],"a":[5,23,82,209,259,268],"major":[6],"cardiovascular":[7],"complication":[8],"of":[9,16,57,80,110,154,186,213,230,235,251],"Kawasaki":[10,281],"disease":[11],"(KD).":[12],"The":[13],"phenotype":[14],"switch":[15],"vascular":[17,28,53,87,118,177,264,275],"smooth":[18],"muscle":[19],"cells":[20],"(VSMCs)":[21],"plays":[22],"crucial":[24],"role":[25,56,79],"in":[26,31,51,62,86,107,112,150,167,183,263,280],"pathological":[27,233],"wall":[29,88,265],"remodeling":[30,276],"KD;":[32],"however,":[33],"the":[34,44,55,75,151,155,192,227,232],"molecular":[35],"mechanisms":[36],"driving":[37],"this":[38],"process":[39],"remain":[40],"incompletely":[41],"understood.":[42],"Although":[43],"SPARC":[45,59,83],"protein":[46],"family":[47,60,84],"has":[48],"been":[49],"implicated":[50],"various":[52],"diseases,":[54],"specific":[58,210],"members":[61],"mediating":[63],"VSMC":[64,115,194],"phenotypic":[65,116],"transition":[66,250],"during":[67],"KD-associated":[68],"vasculitis":[69,160,198,279],"remains":[70],"unknown.":[71],"Here,":[72],"we":[73],"investigated":[74],"function":[76],"and":[77,124,136,143,171,179,199,247,267,277],"mechanistic":[78],"SPOCK2,":[81],"member,":[85],"homeostasis":[89,266],"under":[90],"KD-induced":[91],"inflammatory":[92,228],"stress.":[93],"Methods:":[94],"water-soluble":[95],"fraction":[96],"(CAWS).":[97],"Adeno-associated":[98],"virus":[99],"(AAV)2/9-mediated":[100],"gene":[101],"transfer":[102],"was":[103,164],"employed":[104],"for":[105,271],"targeted":[106],"vivo":[108,184],"overexpression":[109,185],"SPOCK2":[111,162,187,206,218,236,257],"mouse":[113],"aortas.":[114],"transition,":[117],"remodeling,":[119],"extracellular":[120,244],"matrix":[121,245],"(ECM)":[122],"integrity,":[123],"local":[125],"cytokine":[126],"production":[127],"were":[128],"assessed":[129],"using":[130],"immunofluorescence,":[131],"RNA":[132],"sequencing,":[133],"quantitative":[134],"RT-PCR,":[135],"co-immunoprecipitation":[137],"assays":[138],"to":[139,220,238],"delineate":[140],"SPOCK2-MMP2":[141],"structural":[142],"functional":[144],"interactions.":[145],"Results:":[146],"consistently":[148],"downregulated":[149],"acute":[152],"phase":[153],"disease.":[156,282],"In":[157,226],"murine":[158],"KD":[159],"models,":[161],"expression":[163],"notably":[165],"depleted":[166],"both":[168],"aortic":[169,202],"root":[170],"abdominal":[172,201],"aorta,":[173],"correlating":[174],"with":[175],"severe":[176],"inflammation":[178],"formation.":[181,204],"Targeted":[182],"via":[188],"AAV2/9":[189],"effectively":[190],"restored":[191],"contractile":[193],"phenotype,":[195],"thereby":[196],"attenuating":[197],"preventing":[200],"Mechanistically,":[205],"acts":[207],"as":[208,258],"endogenous":[211],"inhibitor":[212],"MMP2.":[214],"Through":[215],"physical":[216],"interaction,":[217],"binds":[219],"MMP2,":[221],"hindering":[222],"its":[223],"enzymatic":[224],"activation.":[225],"microenvironment":[229],"KD,":[231],"loss":[234],"leads":[237],"unchecked":[239],"MMP2":[240],"activity,":[241],"promoting":[242],"uncontrolled":[243],"degradation":[246],"pathogenic":[248],"contractile-to-synthetic":[249],"VSMCs.":[252],"Conclusion:":[253],"Our":[254],"findings":[255],"establish":[256],"novel":[260],"protective":[261],"factor":[262],"potential":[269],"candidate":[270],"preventive":[272],"strategies":[273],"targeting":[274],"systemic":[278]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-24T00:00:00"}