{"id":"https://openalex.org/W7223339155","doi":"https://doi.org/10.1371/journal.pone.0352911","title":"Structure bioinformatics of eight human ATP synthase F0 subunits and their AlphaFold3-predicted reduced-hydrophobicity QTY analogues","display_name":"Structure bioinformatics of eight human ATP synthase F0 subunits and their AlphaFold3-predicted reduced-hydrophobicity QTY analogues","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223339155","doi":"https://doi.org/10.1371/journal.pone.0352911","pmid":"https://pubmed.ncbi.nlm.nih.gov/42912741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693945"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0352911","doi":"https://doi.org/10.1371/journal.pone.0352911","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0352911","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0352911&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0352911&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138922641","display_name":"Ziyu Wang","orcid":"https://orcid.org/0009-0003-5883-5705","observed_orcids":["https://orcid.org/0009-0003-5883-5705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziyu Wang","raw_affiliation_strings":["Deerfield Academy"],"raw_orcid":"https://orcid.org/0009-0003-5883-5705","affiliations":[{"raw_affiliation_string":"Deerfield Academy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008105452","display_name":"Edward Chen","orcid":"https://orcid.org/0000-0001-8008-8097","observed_orcids":["https://orcid.org/0000-0001-8008-8097","https://orcid.org/0009-0002-1734-5702"]},"institutions":[{"id":"https://openalex.org/I4405268810","display_name":"MIT Media Lab","ror":"https://ror.org/0253jyq40","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268810"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Chen","raw_affiliation_strings":["Media Lab, Massachusetts Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Media Lab, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I4405268810","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061928018","display_name":"Shuguang Zhang","orcid":"https://orcid.org/0000-0002-3856-3752","observed_orcids":["https://orcid.org/0000-0002-3856-3752"]},"institutions":[{"id":"https://openalex.org/I4405268810","display_name":"MIT Media Lab","ror":"https://ror.org/0253jyq40","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268810"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuguang Zhang","raw_affiliation_strings":["Media Lab, Massachusetts Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0002-3856-3752","affiliations":[{"raw_affiliation_string":"Media Lab, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I4405268810","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061928018"],"corresponding_institution_ids":["https://openalex.org/I4405268810","https://openalex.org/I63966007"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69592822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e0352911","last_page":"e0352911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f0-subunit","display_name":"F0 subunit","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hydrophobicity-reduction","display_name":"hydrophobicity reduction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/membrane-protein-solubilization","display_name":"membrane protein solubilization","score":0.6029999852180481},{"id":"https://openalex.org/keywords/atp6","display_name":"ATP6","score":0.6240000128746033},{"id":"https://openalex.org/keywords/atp8","display_name":"ATP8","score":0.9150000214576721},{"id":"https://openalex.org/keywords/alphafold-3","display_name":"AlphaFold3","score":0.6110000014305115},{"id":"https://openalex.org/keywords/structure-prediction","display_name":"structure prediction","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.8507999777793884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6355999708175659},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5752999782562256},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.5285999774932861},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5153999924659729},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.483599990606308},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4702000021934509},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42570000886917114},{"id":"https://openalex.org/C2779882130","wikidata":"https://www.wikidata.org/wiki/Q2307998","display_name":"Tryptophan synthase","level":4,"score":0.420199990272522},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.4097999930381775},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4081000089645386},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.40070000290870667},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3801000118255615},{"id":"https://openalex.org/C119120687","wikidata":"https://www.wikidata.org/wiki/Q4654890","display_name":"ATP synthase gamma subunit","level":5,"score":0.37779998779296875},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C191678065","wikidata":"https://www.wikidata.org/wiki/Q7905656","display_name":"V-ATPase","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.2648000121116638}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0352911","doi":"https://doi.org/10.1371/journal.pone.0352911","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0352911","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0352911&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"doi:10.64898/2026.06.18.733091","doi":"https://doi.org/10.64898/2026.06.18.733091","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.18.733091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/18/2026.06.18.733091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693945","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693945/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693945/pdf/pone.0352911.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:42912741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42912741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:013d49d88dbf433dbd552c7737a48b92","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/013d49d88dbf433dbd552c7737a48b92","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 21, Iss 10, p e0352911 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0352911","doi":"https://doi.org/10.1371/journal.pone.0352911","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0352911","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0352911&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223339155.pdf","grobid_xml":"https://content.openalex.org/works/W7223339155.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1999739751","https://openalex.org/W2008708467","https://openalex.org/W2015214828","https://openalex.org/W2024795840","https://openalex.org/W2072138640","https://openalex.org/W2102663456","https://openalex.org/W2140673705","https://openalex.org/W2154714625","https://openalex.org/W2158810120","https://openalex.org/W2164480567","https://openalex.org/W2164944202","https://openalex.org/W2170982393","https://openalex.org/W2334138598","https://openalex.org/W2498179566","https://openalex.org/W2524041289","https://openalex.org/W2551028694","https://openalex.org/W2790526261","https://openalex.org/W2792218846","https://openalex.org/W2888893666","https://openalex.org/W2914746958","https://openalex.org/W2914997541","https://openalex.org/W2949369162","https://openalex.org/W2949471915","https://openalex.org/W2990767092","https://openalex.org/W3015680978","https://openalex.org/W3083406432","https://openalex.org/W3084135130","https://openalex.org/W3093082026","https://openalex.org/W3106051637","https://openalex.org/W3111411981","https://openalex.org/W3149706243","https://openalex.org/W3160754573","https://openalex.org/W3177828909","https://openalex.org/W3206131184","https://openalex.org/W3210500140","https://openalex.org/W3211795435","https://openalex.org/W3217332298","https://openalex.org/W4206488622","https://openalex.org/W4220831022","https://openalex.org/W4225253156","https://openalex.org/W4226402868","https://openalex.org/W4282563965","https://openalex.org/W4283216900","https://openalex.org/W4292473109","https://openalex.org/W4293475204","https://openalex.org/W4309728777","https://openalex.org/W4376602838","https://openalex.org/W4378417682","https://openalex.org/W4381436817","https://openalex.org/W4385059687","https://openalex.org/W4390508037","https://openalex.org/W4391034370","https://openalex.org/W4391815336","https://openalex.org/W4392563914","https://openalex.org/W4393079690","https://openalex.org/W4396721167","https://openalex.org/W4400251428","https://openalex.org/W4407688659","https://openalex.org/W6907575688","https://openalex.org/W6907659084","https://openalex.org/W6945170058","https://openalex.org/W6945297209"],"related_works":["https://openalex.org/W7165159744","https://openalex.org/W7212057566","https://openalex.org/W7128525492","https://openalex.org/W1539851897","https://openalex.org/W7164186655","https://openalex.org/W4407181469","https://openalex.org/W1593528019","https://openalex.org/W7084027258","https://openalex.org/W7223184632","https://openalex.org/W1982233883"],"abstract_inverted_index":{"Human":[0],"mitochondrial":[1],"ATP":[2,16,47,96,144,242,272],"synthase":[3,48,97,145,243,273],"is":[4,239],"an":[5],"essential":[6],"rotary":[7],"motor":[8],"enzyme":[9],"that":[10,29,217,235],"produces":[11],"most":[12],"of":[13,172,262,271],"the":[14,41,137,156,169,193,201,218,236,260,263,267],"cellular":[15],"through":[17],"oxidative":[18],"phosphorylation.":[19],"Its":[20],"membrane-embedded":[21,268],"F0":[22,49,146,244,269],"sector":[23,270],"contains":[24],"highly":[25],"hydrophobic":[26,223],"transmembrane":[27,73,194],"subunits":[28,89,108,147,173,245],"are":[30],"challenging":[31],"to":[32,44,165,182,199,241,246,266],"study":[33],"in":[34,72,192],"aqueous":[35],"environments":[36],"without":[37,109,174],"detergents.":[38],"We":[39],"applied":[40],"QTY":[42,105,121,153,190,202,219,237,264,284],"code":[43,238,265],"eight":[45,186],"human":[46,95],"subunits:":[50],"ATP6,":[51],"ATP8,":[52],"ATPK,":[53],"ATP68,":[54],"ATPMK,":[55],"AT5G1,":[56],"AT5G2,":[57],"and":[58,69,84,128,131,136,210,274,288],"AT5G3.":[59],"Hydrophobic":[60,213],"amino":[61],"acids":[62],"leucine":[63],"(L),":[64],"isoleucine":[65],"(I),":[66],"valine":[67],"(V),":[68],"phenylalanine":[70],"(F)":[71],"regions":[74],"were":[75,100,116,126,140],"systematically":[76],"replaced":[77],"with":[78,90,102,118,150,226],"hydrophilic":[79],"glutamine":[80],"(Q),":[81],"threonine":[82],"(T),":[83],"tyrosine":[85],"(Y).":[86],"Four":[87],"native":[88,114,143,228],"available":[91],"CryoEM":[92,111,175],"structures":[93,115],"from":[94,162,180,197],"(PDB:":[98],"8H9S)":[99],"superposed":[101,117,148],"their":[103,119,151,227],"AlphaFold3-predicted":[104,113,120],"analogues.":[106,122,154],"For":[107,155,168],"complete":[110],"structures,":[112,176],"Additional":[123],"structural":[124,130,231,255],"analyses":[125],"included,":[127],"key":[129],"functional":[132],"regions,":[133,195],"including":[134],"ATP68":[135],"ATP6-c-ring":[138],"interface,":[139],"modeled.":[141],"The":[142],"well":[149],"respective":[152],"CryoEM-native":[157],"comparisons,":[158],"RMSD":[159,177],"values":[160,178],"ranged":[161,179],"0.565":[163],"\u00c5":[164],"6.952":[166],"\u00c5.":[167],"AlphaFold3-native":[170],"comparisons":[171],"0.204\u00c5":[181],"0.297\u00c5.":[183],"Considering":[184],"all":[185],"subunits,":[187],"despite":[188],"substantial":[189],"substitutions":[191],"ranging":[196],"38.89%":[198],"50.79%,":[200],"analogues":[203,220,251,285],"retained":[204],"similar":[205],"overall":[206,254],"folds,":[207],"molecular":[208],"weights,":[209],"isoelectric":[211],"points.":[212],"surface":[214],"analysis":[215],"showed":[216],"had":[221],"reduced":[222],"surfaces":[224],"compared":[225],"counterparts.":[229],"These":[230,257],"bioinformatics":[232],"studies":[233,281],"suggest":[234],"applicable":[240],"generate":[247],"more":[248],"hydrophilic,":[249],"water-soluble":[250],"while":[252],"preserving":[253],"similarity.":[256],"results":[258],"extend":[259],"application":[261],"provide":[275],"a":[276],"foundation":[277],"for":[278,282,290],"future":[279],"experimental":[280],"these":[283],"expressed,":[286],"purified,":[287],"evaluated":[289],"self-assembly.":[291]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}