{"id":"https://openalex.org/W7223326850","doi":"https://doi.org/10.1038/s41598-026-77276-0","title":"Time-domain NMR enables non-invasive longitudinal monitoring of intrahepatic cholangiocarcinoma in mice","display_name":"Time-domain NMR enables non-invasive longitudinal monitoring of intrahepatic cholangiocarcinoma in mice","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223326850","doi":"https://doi.org/10.1038/s41598-026-77276-0"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-77276-0","doi":"https://doi.org/10.1038/s41598-026-77276-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77276-0","pdf_url":"https://www.nature.com/articles/s41598-026-77276-0_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-77276-0_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157933980","display_name":"Aldric Jandia","orcid":"https://orcid.org/0009-0007-6514-2543","observed_orcids":["https://orcid.org/0009-0007-6514-2543"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aldric Jandia","raw_affiliation_strings":["Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"],"raw_orcid":"https://orcid.org/0009-0007-6514-2543","affiliations":[{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France","institution_ids":["https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058637025","display_name":"C\u00e9leste Plantureux","orcid":"https://orcid.org/0000-0003-4437-0479","observed_orcids":["https://orcid.org/0000-0003-4437-0479"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9leste Plantureux","raw_affiliation_strings":["Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France","Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Kremlin-Bic\u00eatre, France"],"raw_orcid":"https://orcid.org/0000-0003-4437-0479","affiliations":[{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France","institution_ids":["https://openalex.org/I204730241"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044723181","display_name":"Manuela Lizarralde-Guerrero","orcid":"https://orcid.org/0009-0004-0737-0941","observed_orcids":["https://orcid.org/0009-0004-0737-0941"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manuela Lizarralde-Guerrero","raw_affiliation_strings":["Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Kremlin-Bic\u00eatre, France"],"raw_orcid":"https://orcid.org/0009-0004-0737-0941","affiliations":[{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Facult\u00e9 de M\u00e9decine, Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035491910","display_name":"Christophe Klein","orcid":"https://orcid.org/0000-0001-8015-287X","observed_orcids":["https://orcid.org/0000-0001-8015-287X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Klein","raw_affiliation_strings":["Cordeliers Histology Imaging Cytometry & Spatial-Omics (CHICS) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-8015-287X","affiliations":[{"raw_affiliation_string":"Cordeliers Histology Imaging Cytometry & Spatial-Omics (CHICS) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025897918","display_name":"Georges Zadigue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Georges Zadigue","raw_affiliation_strings":["Cordeliers Functional Explorations (CFE) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cordeliers Functional Explorations (CFE) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117553637","display_name":"Lionel Deroche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Deroche","raw_affiliation_strings":["Cordeliers Functional Explorations (CFE) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cordeliers Functional Explorations (CFE) Core Facility, CRC, UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050674453","display_name":"Gwennha\u00ebl Autret","orcid":"https://orcid.org/0000-0001-7335-350X","observed_orcids":["https://orcid.org/0000-0001-7335-350X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gwennhael Autret","raw_affiliation_strings":["Plateforme Imageries du Vivant (PIV), Universit\u00e9 Paris Cit\u00e9, Centre de Recherche Cardiovasculaire de Paris (PARCC), INSERM, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-7335-350X","affiliations":[{"raw_affiliation_string":"Plateforme Imageries du Vivant (PIV), Universit\u00e9 Paris Cit\u00e9, Centre de Recherche Cardiovasculaire de Paris (PARCC), INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085340395","display_name":"Maria Chiara Maiuri","orcid":"https://orcid.org/0000-0001-9760-7674","observed_orcids":["https://orcid.org/0000-0001-9760-7674"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Maria Chiara Maiuri","raw_affiliation_strings":["Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Naples, Italy","Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-9760-7674","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France"],"raw_orcid":"https://orcid.org/0000-0002-9334-4405","affiliations":[{"raw_affiliation_string":"Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]},{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020643567","display_name":"Mar\u00eda P\u00e9rez-Lanz\u00f3n","orcid":"https://orcid.org/0000-0002-6306-6520","observed_orcids":["https://orcid.org/0000-0002-6306-6520"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Maria Perez-Lanzon","raw_affiliation_strings":["Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-6306-6520","affiliations":[{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006320965","display_name":"Jonathan G. Pol","orcid":"https://orcid.org/0000-0002-8355-7562","observed_orcids":["https://orcid.org/0000-0002-8355-7562"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jonathan G. Pol","raw_affiliation_strings":["Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-8355-7562","affiliations":[{"raw_affiliation_string":"Team \u201cMetabolism, Cancer & Immunity\u201d, Centre de Recherche Des Cordeliers (CRC), UMRS 1138, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5006320965","https://openalex.org/A5020643567"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83012652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/time-domain-nmr","display_name":"time-domain NMR","score":0.972000002861023},{"id":"https://openalex.org/keywords/longitudinal-tumor-monitoring","display_name":"longitudinal tumor monitoring","score":0.7279999852180481},{"id":"https://openalex.org/keywords/whole-body-composition","display_name":"whole-body composition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.6380000114440918},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.6100000143051147},{"id":"https://openalex.org/keywords/biliary-tract-cancer","display_name":"biliary tract cancer","score":0.5139999985694885},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6140000224113464},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"receiver operating characteristic","score":0.7379999756813049},{"id":"https://openalex.org/keywords/humane-endpoints","display_name":"humane endpoints","score":0.47699999809265137},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.9165999889373779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5029000043869019},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40720000863075256},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40560001134872437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2858999967575073},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.24789999425411224},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.23569999635219574},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2312999963760376}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-77276-0","doi":"https://doi.org/10.1038/s41598-026-77276-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77276-0","pdf_url":"https://www.nature.com/articles/s41598-026-77276-0_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-77276-0","doi":"https://doi.org/10.1038/s41598-026-77276-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-77276-0","pdf_url":"https://www.nature.com/articles/s41598-026-77276-0_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223326850.pdf","grobid_xml":"https://content.openalex.org/works/W7223326850.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2067472606","https://openalex.org/W2067651633","https://openalex.org/W2212939218","https://openalex.org/W3023756129","https://openalex.org/W3031145400","https://openalex.org/W3083935156","https://openalex.org/W3197804636","https://openalex.org/W4200330738","https://openalex.org/W4280531966","https://openalex.org/W4319459121","https://openalex.org/W4362466219","https://openalex.org/W4391256731","https://openalex.org/W4391545760","https://openalex.org/W4391545790"],"related_works":["https://openalex.org/W3008231142","https://openalex.org/W2010108621","https://openalex.org/W3200839571","https://openalex.org/W4401574673","https://openalex.org/W3030003928","https://openalex.org/W3083180897","https://openalex.org/W2533527037","https://openalex.org/W2503010486","https://openalex.org/W7213787899","https://openalex.org/W7127655191"],"abstract_inverted_index":{"Intrahepatic":[0],"cholangiocarcinoma":[1],"(iCCA)":[2],"is":[3],"an":[4],"aggressive":[5],"biliary":[6],"malignancy":[7],"for":[8],"which":[9],"longitudinal":[10,163],"non-invasive":[11],"monitoring":[12],"remains":[13],"challenging":[14],"in":[15,30,45,55,137,172,182],"preclinical":[16],"models.":[17],"Using":[18],"time-domain":[19],"nuclear":[20],"magnetic":[21],"resonance":[22],"(TD-NMR),":[23],"we":[24],"characterized":[25],"disease-associated":[26],"whole-body":[27,46],"composition":[28],"changes":[29,136,167],"the":[31,73],"pNICD/pAKT":[32],"hydrodynamic":[33],"injection":[34],"mouse":[35],"model":[36],"of":[37,75,149,165,177],"iCCA.":[38],"Tumor-bearing":[39],"mice":[40,110],"developed":[41],"a":[42,53,83,89],"progressive":[43],"increase":[44],"fluid":[47,157],"relative":[48,58,135],"to":[49,59],"body":[50,60,69],"weight":[51,61],"and":[52,101,144,158,179],"decrease":[54],"fat":[56,102,159],"mass":[57],"compared":[62],"with":[63,169],"tumor-free":[64,109],"controls,":[65],"despite":[66],"stable":[67],"total":[68],"weight.":[70],"Ultrasound":[71],"confirmed":[72],"presence":[74],"cystic":[76],"hepatic":[77],"lesions":[78],"but":[79],"was":[80],"used":[81],"as":[82,111,161],"qualitative":[84],"structural":[85],"assessment":[86],"rather":[87],"than":[88],"serial":[90],"quantitative":[91],"comparator.":[92],"Day-specific":[93],"receiver":[94],"operating":[95],"characteristic":[96],"analyses":[97,116],"showed":[98,118,140],"that":[99,119],"fluid/weight":[100,124],"mass/weight":[103],"ratios":[104,160],"increasingly":[105],"discriminated":[106],"iCCA-bearing":[107],"from":[108,130],"disease":[112],"progressed.":[113],"Exploratory":[114],"within-animal":[115],"further":[117],"absolute":[120],"body-composition":[121],"ratios,":[122],"particularly":[123],"ratio,":[125],"distinguished":[126],"terminal":[127,150],"clinical":[128,151],"assessments":[129],"predefined":[131],"earlier":[132],"assessments.":[133],"Daily":[134],"normalized":[138],"parameters":[139],"more":[141],"variable":[142],"performance":[143],"did":[145],"not":[146],"improve":[147],"classification":[148],"status.":[152],"These":[153],"findings":[154],"identify":[155],"TD-NMR-derived":[156],"practical":[162],"markers":[164],"physiological":[166],"associated":[168],"iCCA":[170],"progression":[171],"this":[173],"model.":[174],"Direct":[175],"quantification":[176],"ascites":[178],"prospective":[180],"validation":[181],"independent":[183],"cohorts":[184],"will":[185],"be":[186],"required":[187],"before":[188],"deriving":[189],"generalizable":[190],"diagnostic":[191],"or":[192],"humane-endpoint":[193],"thresholds.":[194]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}
