{"id":"https://openalex.org/W7223323739","doi":"https://doi.org/10.1080/14756366.2026.2742479","title":"Recent advances in the development of tag-targeted protein degradation systems","display_name":"Recent advances in the development of tag-targeted protein degradation systems","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223323739","doi":"https://doi.org/10.1080/14756366.2026.2742479","pmid":"https://pubmed.ncbi.nlm.nih.gov/42924619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13700540"},"language":"en","primary_location":{"id":"doi:10.1080/14756366.2026.2742479","doi":"https://doi.org/10.1080/14756366.2026.2742479","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2026.2742479","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14756366.2026.2742479?needAccess=true","source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/14756366.2026.2742479?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100513784","display_name":"B. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bizhi Li","raw_affiliation_strings":["Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159333626","display_name":"Yang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400573310","display_name":"Hangzhou City University","ror":"https://ror.org/01wck0s05","country_code":"CN","type":"education","lineage":["https://openalex.org/I4400573310"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Lu","raw_affiliation_strings":["Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University","Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University","institution_ids":["https://openalex.org/I4400573310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091684426","display_name":"Jinxin Che","orcid":"https://orcid.org/0000-0001-7202-9214","observed_orcids":["https://orcid.org/0000-0001-7202-9214"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinxin Che","raw_affiliation_strings":["Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159372076","display_name":"Xiaowu Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaowu Dong","raw_affiliation_strings":["Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091684426","https://openalex.org/A5159333626","https://openalex.org/A5159372076"],"corresponding_institution_ids":["https://openalex.org/I4400573310","https://openalex.org/I76130692"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4847934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":"2742479","last_page":"2742479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/protein-depletion","display_name":"protein depletion","score":0.6539999842643738},{"id":"https://openalex.org/keywords/target-validation","display_name":"target validation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/degradation-mechanism","display_name":"degradation mechanism","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6068999767303467},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.44119998812675476},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.43619999289512634},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.42239999771118164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34279999136924744},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32429999113082886},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3133000135421753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30379998683929443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28209999203681946},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.27300000190734863},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2563999891281128}],"mesh":[{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/14756366.2026.2742479","doi":"https://doi.org/10.1080/14756366.2026.2742479","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2026.2742479","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14756366.2026.2742479?needAccess=true","source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13700540","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13700540/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13700540/pdf/IENZ_41_2742479.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Enzyme Inhib Med Chem","raw_type":"Text"},{"id":"pmid:42924619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42924619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of enzyme inhibition and medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:241ad679f365401ca81caff2ea3df06a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/241ad679f365401ca81caff2ea3df06a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 41, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/14756366.2026.2742479","doi":"https://doi.org/10.1080/14756366.2026.2742479","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2026.2742479","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14756366.2026.2742479?needAccess=true","source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3438256615","display_name":null,"funder_award_id":"22477111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223323739.pdf","grobid_xml":"https://content.openalex.org/works/W7223323739.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1043004949","https://openalex.org/W1527383154","https://openalex.org/W1565539350","https://openalex.org/W1965813899","https://openalex.org/W1976672416","https://openalex.org/W1982166691","https://openalex.org/W1985124617","https://openalex.org/W1985563834","https://openalex.org/W1995497547","https://openalex.org/W1995701587","https://openalex.org/W2007110714","https://openalex.org/W2015345028","https://openalex.org/W2042710439","https://openalex.org/W2068412287","https://openalex.org/W2078434863","https://openalex.org/W2093088422","https://openalex.org/W2099062342","https://openalex.org/W2103180477","https://openalex.org/W2105582260","https://openalex.org/W2114668514","https://openalex.org/W2124833370","https://openalex.org/W2127386766","https://openalex.org/W2134178604","https://openalex.org/W2135450099","https://openalex.org/W2151683271","https://openalex.org/W2292464399","https://openalex.org/W2310030657","https://openalex.org/W2397093333","https://openalex.org/W2400416067","https://openalex.org/W2403950404","https://openalex.org/W2409640222","https://openalex.org/W2470671857","https://openalex.org/W2530823928","https://openalex.org/W2544450870","https://openalex.org/W2592787461","https://openalex.org/W2610481986","https://openalex.org/W2611401896","https://openalex.org/W2612257694","https://openalex.org/W2618306819","https://openalex.org/W2763042654","https://openalex.org/W2769995426","https://openalex.org/W2774733631","https://openalex.org/W2792069216","https://openalex.org/W2792453707","https://openalex.org/W2803948950","https://openalex.org/W2890393959","https://openalex.org/W2890477656","https://openalex.org/W2899147964","https://openalex.org/W2901209536","https://openalex.org/W2914579980","https://openalex.org/W2920438880","https://openalex.org/W2938455624","https://openalex.org/W2943797269","https://openalex.org/W2979273775","https://openalex.org/W2982422273","https://openalex.org/W3014346297","https://openalex.org/W3024928082","https://openalex.org/W3025173962","https://openalex.org/W3027679488","https://openalex.org/W3030331522","https://openalex.org/W3032034681","https://openalex.org/W3035733113","https://openalex.org/W3043369247","https://openalex.org/W3045619116","https://openalex.org/W3087526660","https://openalex.org/W3102624934","https://openalex.org/W3120313360","https://openalex.org/W3120439501","https://openalex.org/W3120553915","https://openalex.org/W3136546688","https://openalex.org/W3139364923","https://openalex.org/W3165173500","https://openalex.org/W3183875458","https://openalex.org/W3195114088","https://openalex.org/W3199510140","https://openalex.org/W3207463170","https://openalex.org/W4205379795","https://openalex.org/W4205640844","https://openalex.org/W4206552026","https://openalex.org/W4224291212","https://openalex.org/W4225094344","https://openalex.org/W4225687325","https://openalex.org/W4229042075","https://openalex.org/W4283015985","https://openalex.org/W4296691508","https://openalex.org/W4296700653","https://openalex.org/W4296773465","https://openalex.org/W4304080843","https://openalex.org/W4327677475","https://openalex.org/W4362602075","https://openalex.org/W4385880349","https://openalex.org/W4386156220","https://openalex.org/W4389454610","https://openalex.org/W4389894233","https://openalex.org/W4392796894","https://openalex.org/W4396230754","https://openalex.org/W4401174128","https://openalex.org/W4401948466","https://openalex.org/W4416741047","https://openalex.org/W7147109961","https://openalex.org/W7160667503","https://openalex.org/W7162803310","https://openalex.org/W7170192108","https://openalex.org/W7171529387"],"related_works":["https://openalex.org/W4405825800","https://openalex.org/W4387107225","https://openalex.org/W4407121572","https://openalex.org/W3094307007","https://openalex.org/W4409638356","https://openalex.org/W7108219790","https://openalex.org/W3107578376","https://openalex.org/W4414563341","https://openalex.org/W7157711228","https://openalex.org/W3217408331"],"abstract_inverted_index":{"Targeted":[0],"protein":[1,12,41,48,62,73,92],"degradation":[2,49,68,114],"(TPD)":[3],"has":[4],"emerged":[5],"as":[6],"an":[7,52],"important":[8],"strategy":[9],"for":[10,19,91,132],"regulating":[11],"abundance":[13],"and":[14,36,65,84,95,119,137],"exploring":[15],"therapeutic":[16],"targets.":[17],"However,":[18],"many":[20],"candidate":[21],"targets,":[22],"the":[23,37,61,76,103,124],"lack":[24],"of":[25,40,63,82,126],"suitable":[26],"small-molecule":[27],"ligands":[28],"makes":[29],"it":[30],"difficult":[31],"to":[32,70,108,139],"assess":[33],"their":[34,112,141],"degradability":[35],"biological":[38],"consequences":[39],"depletion":[42],"before":[43],"developing":[44,133],"target-specific":[45],"degraders.":[46],"Tag-targeted":[47],"(tTPD)":[50],"provides":[51],"alternative":[53],"approach":[54],"by":[55],"introducing":[56],"a":[57,80],"specific":[58],"tag":[59],"into":[60],"interest":[64],"using":[66],"tag-directed":[67],"systems":[69,87,106],"achieve":[71],"controlled":[72],"depletion.":[74],"Over":[75],"past":[77],"two":[78],"decades,":[79],"variety":[81],"ligand-based":[83],"nanobody-based":[85],"tTPD":[86,105,128,135],"have":[88],"been":[89],"developed":[90],"function":[93],"studies":[94],"target":[96],"validation.":[97],"In":[98],"this":[99],"review,":[100],"we":[101],"summarise":[102],"major":[104],"reported":[107],"date,":[109],"focusing":[110],"on":[111],"design,":[113],"mechanisms,":[115],"representative":[116],"applications,":[117],"advantages,":[118],"limitations.":[120],"We":[121],"further":[122],"discuss":[123],"selection":[125],"appropriate":[127],"systems,":[129],"potential":[130],"strategies":[131],"new":[134],"tools,":[136],"opportunities":[138],"expand":[140],"applications.":[142]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}
