{"id":"https://openalex.org/W7223309775","doi":"https://doi.org/10.21037/cdt-2026-0233","title":"Echocardiographic response and predictors of reverse remodeling after sacubitril/valsartan in de novo heart failure with reduced ejection fraction: cohort study","display_name":"Echocardiographic response and predictors of reverse remodeling after sacubitril/valsartan in de novo heart failure with reduced ejection fraction: cohort study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223309775","doi":"https://doi.org/10.21037/cdt-2026-0233","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735876"},"language":"en","primary_location":{"id":"doi:10.21037/cdt-2026-0233","doi":"https://doi.org/10.21037/cdt-2026-0233","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cdt-2026-0233","pdf_url":null,"source":{"id":"https://openalex.org/S2764634846","display_name":"Cardiovascular Diagnosis and Therapy","issn_l":"2223-3652","issn":["2223-3652","2223-3660"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diagnosis and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/cdt-2026-0233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068771104","display_name":"In Tae Moon","orcid":"https://orcid.org/0000-0002-3847-0150","observed_orcids":["https://orcid.org/0000-0002-3847-0150"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Tae Moon","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159369384","display_name":"Sung Hun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Hun Park","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024613549","display_name":"Jung Yeon Chin","orcid":"https://orcid.org/0000-0002-6892-4846","observed_orcids":["https://orcid.org/0000-0002-6892-4846","https://orcid.org/0000-0003-2093-7629"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung Yeon Chin","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeongbu, Republic of Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024613549"],"corresponding_institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80106905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"5","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/reverse-remodeling","display_name":"reverse remodeling","score":0.6850000023841858},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/echocardiographic-response","display_name":"echocardiographic response","score":0.7799999713897705},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.8960000276565552},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.9039999842643738},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":0.9940000176429749},{"id":"https://openalex.org/keywords/heart-failure-readmission","display_name":"heart failure readmission","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7110000252723694},{"id":"https://openalex.org/keywords/angiotensin-receptor-neprilysin-inhibitors","display_name":"angiotensin receptor-neprilysin inhibitors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/de-novo-heart-failure","display_name":"de novo heart failure","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9441999793052673},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.920799970626831},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8192999958992004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8061000108718872},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7547000050544739},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6007000207901001},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5781999826431274},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4823000133037567},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4587000012397766},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.428600013256073},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4032000005245209},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.38269999623298645},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.3693000078201294},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.2759000062942505},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C26635844","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular pressure","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2590000033378601}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/cdt-2026-0233","doi":"https://doi.org/10.21037/cdt-2026-0233","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cdt-2026-0233","pdf_url":null,"source":{"id":"https://openalex.org/S2764634846","display_name":"Cardiovascular Diagnosis and Therapy","issn_l":"2223-3652","issn":["2223-3652","2223-3660"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diagnosis and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735876","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735876/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735876/pdf/cdt-16-5-82.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Diagn Ther","raw_type":"Text"},{"id":"pmid:42990985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular diagnosis and therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/cdt-2026-0233","doi":"https://doi.org/10.21037/cdt-2026-0233","is_oa":true,"landing_page_url":"https://doi.org/10.21037/cdt-2026-0233","pdf_url":null,"source":{"id":"https://openalex.org/S2764634846","display_name":"Cardiovascular Diagnosis and Therapy","issn_l":"2223-3652","issn":["2223-3652","2223-3660"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diagnosis and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223309775.pdf","grobid_xml":"https://content.openalex.org/works/W7223309775.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4388595964"],"related_works":["https://openalex.org/W4306290955","https://openalex.org/W7203874335","https://openalex.org/W2999396658","https://openalex.org/W3213631564","https://openalex.org/W2805015756","https://openalex.org/W4401907831","https://openalex.org/W4200016461","https://openalex.org/W3000253207","https://openalex.org/W2971403573","https://openalex.org/W7221317819"],"abstract_inverted_index":{"Background:":[0],"Sacubitril/valsartan":[1],"(angiotensin":[2],"receptor-neprilysin":[3],"inhibitor,":[4],"ARNI)":[5],"improves":[6],"outcomes":[7,133,290],"in":[8,42,75,105,119,313],"heart":[9,201],"failure":[10,202],"with":[11,44,122,177,205,239,283,305],"reduced":[12],"ejection":[13,79,97],"fraction":[14,80,98],"(HFrEF),":[15],"yet":[16],"treatment":[17,306],"response":[18,23,41,142,269],"varies":[19],"and":[20,36,62,101,113,139,171,226,267,287,299],"predictors":[21,38,140],"of":[22,39,86,141,180,187,195,247,294],"remain":[24],"incompletely":[25],"defined.":[26],"We":[27],"aimed":[28],"to":[29,34],"evaluate":[30],"real-world":[31,276],"echocardiographic":[32,87,241,268],"responses":[33],"ARNI":[35,53,252,265,279,310],"identify":[37],"favorable":[40,240],"patients":[43,50,89,152,248],"newly":[45],"diagnosed":[46],"HFrEF.":[47],"Methods:":[48],"Consecutive":[49],"who":[51,153],"initiated":[52],"at":[54],"Uijeongbu":[55],"Eulji":[56],"University":[57],"Hospital":[58],"between":[59,264],"March":[60],"2021":[61],"August":[63],"2024":[64],"were":[65,90,134,143,164,168,174,236,303],"prospectively":[66],"enrolled.":[67],"Echocardiographic":[68],"reverse":[69,285],"remodeling":[70,286,301],"was":[71,281],"assessed":[72,135],"by":[73],"changes":[74],"left":[76,95],"ventricular":[77,96],"(LV)":[78],"(EF).":[81],"Based":[82],"on":[83],"the":[84],"degree":[85],"response,":[88,307],"categorized":[91],"as":[92],"nonresponders":[93,190],"[follow-up":[94],"(LVEF)":[99],"<40%":[100],"an":[102,116],"absolute":[103,117],"increased":[104],"LVEF":[106,111,120,124,130,181],"<10%],":[107],"partial":[108,169],"responders":[109,128,176,206],"(follow-up":[110,129],"\u226540%":[112],"<50%,":[114],"or":[115,126,200,270],"increase":[118],"\u226510%":[121],"follow-up":[123,155,158,186],"<50%),":[125],"super":[127,175],"\u226550%).":[131],"Clinical":[132],"using":[136,145],"Kaplan-Meier":[137],"analysis,":[138,210],"evaluated":[144],"multivariable":[146,209],"logistic":[147],"regression.":[148],"Results:":[149],"Among":[150],"392":[151],"completed":[154],"echocardiography":[156],"(median":[157],"interval,":[159],"11.0":[160],"months),":[161],"116":[162],"(29.6%)":[163],"nonresponders,":[165],"110":[166],"(28.0%)":[167],"responders,":[170],"166":[172],"(42.3%)":[173],"a":[178,184,244,261],"recovery":[179],"\u226550%.":[182],"During":[183],"median":[185],"708":[188],"days,":[189],"experienced":[191],"significantly":[192],"higher":[193,211],"rates":[194,293],"clinical":[196,271,289,314],"events,":[197],"including":[198],"death":[199],"rehospitalization,":[203],"compared":[204],"(P<0.001).":[207],"In":[208,274],"baseline":[212],"systolic":[213],"blood":[214],"pressure":[215],"[SBP;":[216],"odds":[217],"ratio":[218],"(OR),":[219],"1.249;":[220],"95%":[221,233],"confidence":[222],"interval":[223],"(CI):":[224],"1.120-1.400]":[225],"smaller":[227],"LV":[228,300],"end-diastolic":[229],"volume":[230],"(OR":[231],"0.919;":[232],"CI:":[234],"0.869-0.970)":[235],"independently":[237],"associated":[238,282,304],"response.":[242],"Although":[243],"substantial":[245,284],"proportion":[246],"did":[249,258],"not":[250,259],"achieve":[251],"doses":[253],"\u2265200":[254],"mg/day,":[255],"exploratory":[256],"analysis":[257],"demonstrate":[260],"significant":[262],"association":[263],"dose":[266],"outcomes.":[272],"Conclusions:":[273],"this":[275],"cohort":[277],"study,":[278],"therapy":[280],"improved":[288],"despite":[291],"low":[292],"target-dose":[295],"attainment.":[296],"Baseline":[297],"SBP":[298],"parameters":[302],"supporting":[308],"individualized":[309],"titration":[311],"strategies":[312],"practice.":[315]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-24T00:00:00"}
