{"id":"https://openalex.org/W7223309258","doi":"https://doi.org/10.3390/polym18212625","title":"The Ultimate Icebreaker: The Rhagium mordax Antifreeze Protein as a Universal Ice Nucleation Inhibitor","display_name":"The Ultimate Icebreaker: The Rhagium mordax Antifreeze Protein as a Universal Ice Nucleation Inhibitor","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223309258","doi":"https://doi.org/10.3390/polym18212625"},"language":"en","primary_location":{"id":"doi:10.3390/polym18212625","doi":"https://doi.org/10.3390/polym18212625","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212625","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/polym18212625","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159355063","display_name":"Maria A. Majorina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria A. Majorina","raw_affiliation_strings":["Protein Spectroscopy Group, Institute of Protein Research RAS, Institutskaya 4, 142290 Pushchino, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Spectroscopy Group, Institute of Protein Research RAS, Institutskaya 4, 142290 Pushchino, Russia","institution_ids":["https://openalex.org/I4210137602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["Department of Molecular Medicine and USF Health Byrd Alzheimer\u2019s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0000-0002-4037-5857","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and USF Health Byrd Alzheimer\u2019s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082446057","display_name":"Bogdan S. Melnik","orcid":"https://orcid.org/0000-0002-9176-6452","observed_orcids":["https://orcid.org/0000-0002-9176-6452"]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Bogdan S. Melnik","raw_affiliation_strings":["Protein Spectroscopy Group, Institute of Protein Research RAS, Institutskaya 4, 142290 Pushchino, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9176-6452","affiliations":[{"raw_affiliation_string":"Protein Spectroscopy Group, Institute of Protein Research RAS, Institutskaya 4, 142290 Pushchino, Russia","institution_ids":["https://openalex.org/I4210137602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082446057","https://openalex.org/A5083199032"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210137602","https://openalex.org/I4210140006"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68145558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"2625","last_page":"2625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12202","display_name":"nanoparticles nucleation surface interactions","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12202","display_name":"nanoparticles nucleation surface interactions","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12696","display_name":"Icing and De-icing Technologies","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifreeze-proteins","display_name":"antifreeze proteins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ice-nucleation-inhibition","display_name":"ice nucleation inhibition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ice-nucleating-particles","display_name":"ice nucleating particles","score":0.906000018119812},{"id":"https://openalex.org/keywords/pseudomonas-syringae","display_name":"Pseudomonas syringae","score":0.8420000076293945},{"id":"https://openalex.org/keywords/silver-iodide","display_name":"silver iodide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metal-oxide-powders","display_name":"metal oxide powders","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C141734981","wikidata":"https://www.wikidata.org/wiki/Q421541","display_name":"Antifreeze protein","level":2,"score":0.9402999877929688},{"id":"https://openalex.org/C122409099","wikidata":"https://www.wikidata.org/wiki/Q3136993","display_name":"Ice nucleus","level":3,"score":0.6898999810218811},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6492999792098999},{"id":"https://openalex.org/C2776170207","wikidata":"https://www.wikidata.org/wiki/Q503288","display_name":"Antifreeze","level":2,"score":0.5900999903678894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40149998664855957},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C2780381237","wikidata":"https://www.wikidata.org/wiki/Q311202","display_name":"Pseudomonas syringae","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C2992878202","wikidata":"https://www.wikidata.org/wiki/Q23392","display_name":"Ice formation","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C125388846","wikidata":"https://www.wikidata.org/wiki/Q1325808","display_name":"Ice crystals","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C16335420","wikidata":"https://www.wikidata.org/wiki/Q18205270","display_name":"Antarctic sea ice","level":4,"score":0.2653999924659729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/polym18212625","doi":"https://doi.org/10.3390/polym18212625","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212625","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/polym18212625","doi":"https://doi.org/10.3390/polym18212625","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212625","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1934175277","https://openalex.org/W1968603317","https://openalex.org/W1976545537","https://openalex.org/W1993436181","https://openalex.org/W1994056335","https://openalex.org/W2000402055","https://openalex.org/W2004736225","https://openalex.org/W2041957029","https://openalex.org/W2083918102","https://openalex.org/W2090392341","https://openalex.org/W2092943027","https://openalex.org/W2189751284","https://openalex.org/W2289576126","https://openalex.org/W2548638898","https://openalex.org/W2553811549","https://openalex.org/W2565403369","https://openalex.org/W2775838312","https://openalex.org/W2810415291","https://openalex.org/W2932093865","https://openalex.org/W3009724449","https://openalex.org/W3049094078","https://openalex.org/W3193848627","https://openalex.org/W4214540474","https://openalex.org/W4256010680","https://openalex.org/W4280521256","https://openalex.org/W4280603235","https://openalex.org/W4388536427","https://openalex.org/W4389559407","https://openalex.org/W4390459776","https://openalex.org/W4405466871","https://openalex.org/W4413743282","https://openalex.org/W7170167480","https://openalex.org/W7171324134"],"related_works":["https://openalex.org/W6887874250","https://openalex.org/W199094295","https://openalex.org/W7029119121","https://openalex.org/W1976545537","https://openalex.org/W4390459776","https://openalex.org/W4386820284","https://openalex.org/W2030834781","https://openalex.org/W133173936","https://openalex.org/W1983042327","https://openalex.org/W1987694757"],"abstract_inverted_index":{"Antifreeze":[0],"proteins":[1],"were":[2],"discovered":[3],"quite":[4],"some":[5],"time":[6],"ago.":[7],"The":[8,22],"protein":[9,59,104,135],"from":[10],"Rhagium":[11],"mordax":[12,44,102,133],"is":[13],"considered":[14],"one":[15],"of":[16,34,42,57,64,142],"the":[17,32,40,55,89,100],"most":[18],"active":[19],"among":[20],"them.":[21],"literature":[23],"has":[24,46],"demonstrated":[25,88],"this":[26,51,58,114],"protein\u2019s":[27],"ability":[28,56,90,121],"to":[29,31,60,91,122],"bind":[30],"surface":[33],"ice,":[35],"and":[36,78,108,116],"its":[37,120,127],"effect":[38],"on":[39,126],"survival":[41],"R.":[43,101,132],"larvae":[45],"also":[47],"been":[48],"investigated.":[49],"In":[50],"work,":[52],"we":[53,70,85,129],"examined":[54,112],"inhibit":[61],"ice":[62,68,94,110,143],"nucleators":[63,95,111],"different":[65,97],"origin.":[66],"As":[67],"nucleators,":[69],"selected":[71],"inactivated":[72],"P.":[73],"syringae":[74],"bacteria,":[75],"silver":[76],"iodide,":[77],"insoluble":[79],"metal":[80],"oxide":[81],"powders,":[82],"for":[83],"which":[84],"had":[86],"previously":[87],"act":[92],"as":[93,138],"at":[96],"temperatures.":[98],"Since":[99],"antifreeze":[103,134],"blocks":[105],"all":[106],"biological":[107],"inorganic":[109],"in":[113],"study,":[115],"taking":[117],"into":[118],"account":[119],"structure":[123],"water":[124],"molecules":[125],"surface,":[128],"hypothesized":[130],"that":[131],"can":[136],"serve":[137],"a":[139],"universal":[140],"inhibitor":[141],"nucleator.":[144]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}