{"id":"https://openalex.org/W7223301979","doi":"https://doi.org/10.1126/sciadv.aeh1073","title":"Interferon-\u03bb signaling to maternal dendritic cells protects against congenital Zika virus infection","display_name":"Interferon-\u03bb signaling to maternal dendritic cells protects against congenital Zika virus infection","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223301979","doi":"https://doi.org/10.1126/sciadv.aeh1073","pmid":"https://pubmed.ncbi.nlm.nih.gov/41659402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12873797"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aeh1073","doi":"https://doi.org/10.1126/sciadv.aeh1073","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aeh1073","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aeh1073?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aeh1073?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050473914","display_name":"Margaret R. Dedloff","orcid":"https://orcid.org/0000-0002-0175-116X","observed_orcids":["https://orcid.org/0000-0002-0175-116X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret R. Dedloff","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-0175-116X","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124048089","display_name":"Thomas R. Reinhardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Reinhardt","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057979681","display_name":"Tessa\u2010Jonne F. Ropp","orcid":"https://orcid.org/0000-0001-9831-0557","observed_orcids":["https://orcid.org/0000-0001-9831-0557"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tessa-Jonne F. Ropp","raw_affiliation_strings":["Neuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-9831-0557","affiliations":[{"raw_affiliation_string":"Neuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037387383","display_name":"Joel Rivera-Cardona","orcid":"https://orcid.org/0000-0002-2630-6740","observed_orcids":["https://orcid.org/0000-0002-2630-6740"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Rivera-Cardona","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-2630-6740","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123884426","display_name":"Celeste R. Robles","orcid":"https://orcid.org/0000-0002-4854-7676","observed_orcids":["https://orcid.org/0000-0002-4854-7676"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celeste R. Robles","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-4854-7676","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039810124","display_name":"Rebecca L. Casazza","orcid":"https://orcid.org/0000-0002-8271-6947","observed_orcids":["https://orcid.org/0000-0002-8271-6947"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca L. Casazza","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-8271-6947","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051687517","display_name":"J. Ashley Ezzell","orcid":"https://orcid.org/0000-0002-5142-4685","observed_orcids":["https://orcid.org/0000-0002-5142-4685"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Ashley Ezzell","raw_affiliation_strings":["Histology Research Core Facility, Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-5142-4685","affiliations":[{"raw_affiliation_string":"Histology Research Core Facility, Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038764801","display_name":"Michelle S. Itano","orcid":"https://orcid.org/0000-0001-6853-1228","observed_orcids":["https://orcid.org/0000-0001-6853-1228"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle S. Itano","raw_affiliation_strings":["Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Neuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-6853-1228","affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Neuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077153542","display_name":"Helen M. Lazear","orcid":"https://orcid.org/0000-0002-8649-4579","observed_orcids":["https://orcid.org/0000-0002-8649-4579"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helen M. Lazear","raw_affiliation_strings":["Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-8649-4579","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077153542"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.2486,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.91218483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"12","issue":"43","first_page":"eaeh1073","last_page":"eaeh1073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.890999972820282},{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/congenital-zika-virus-infection","display_name":"congenital Zika virus infection","score":0.8220000267028809},{"id":"https://openalex.org/keywords/maternal-fetal-interface","display_name":"maternal-fetal interface","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/transplacental-transmission","display_name":"transplacental transmission","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ifnar1","display_name":"IFNAR1","score":0.7099999785423279},{"id":"https://openalex.org/keywords/interferon-lambda-receptor-1","display_name":"interferon lambda receptor 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/uterus","display_name":"uterus","score":0.6100000143051147},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.890999972820282},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8942999839782715},{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.803600013256073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7412999868392944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.545199990272522},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5296000242233276},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.48890000581741333},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.47839999198913574},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.45170000195503235},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4431000053882599},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4424999952316284},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.43959999084472656},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4180999994277954},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.41179999709129333},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.40619999170303345},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3910999894142151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3799000084400177},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.375},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3292999863624573},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2780197806","wikidata":"https://www.wikidata.org/wiki/Q2531387","display_name":"Decidua","level":5,"score":0.2578999996185303}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1126/sciadv.aeh1073","doi":"https://doi.org/10.1126/sciadv.aeh1073","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aeh1073","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aeh1073?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"doi:10.64898/2026.01.25.701624","doi":"https://doi.org/10.64898/2026.01.25.701624","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.01.25.701624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693664","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693664/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693664/pdf/sciadv.aeh1073.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:41659402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41659402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42912987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42912987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11681397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12873797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.17615/ath2-h107","doi":"https://doi.org/10.17615/ath2-h107","is_oa":true,"landing_page_url":"https://doi.org/10.17615/ath2-h107","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aeh1073","doi":"https://doi.org/10.1126/sciadv.aeh1073","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aeh1073","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aeh1073?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G114980791","display_name":"UNC Initiative for Maximizing Student Development","funder_award_id":"1t32gm152779-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1767435997","display_name":"The role of Interferon lambda signaling in flavivirus transmission and pathogenesis at the maternal-fetal interface","funder_award_id":"R01AI139512","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2522521682","display_name":null,"funder_award_id":"T32 GM152779","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6317168728","display_name":"Clinical Translational Research Center for Neurodevelopmental Disorders","funder_award_id":"P50HD103573","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000880610","display_name":"Molecular Biology of Viral Diseases Predoctoral Training Grant","funder_award_id":"T32AI007419","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893116","display_name":"Antiviral and immunomodulatory effects of interferon lambda in the skin","funder_award_id":"R01AI175708","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320306193","display_name":"John Templeton Foundation","ror":"https://ror.org/035tnyy05"},{"id":"https://openalex.org/F4320306216","display_name":"Paul G. Allen Family Foundation","ror":"https://ror.org/01degd278"},{"id":"https://openalex.org/F4320306437","display_name":"Morris Animal Foundation","ror":"https://ror.org/05pg13f04"},{"id":"https://openalex.org/F4320308535","display_name":"Blue Cross and Blue Shield of Florida Foundation","ror":"https://ror.org/050r4h987"},{"id":"https://openalex.org/F4320308840","display_name":"Leakey Foundation","ror":"https://ror.org/018kdpd27"},{"id":"https://openalex.org/F4320309024","display_name":"National Geographic Society","ror":"https://ror.org/04bqh5m06"},{"id":"https://openalex.org/F4320309342","display_name":"University of North Carolina","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320310121","display_name":"Natural Science Foundation of Jilin Province","ror":null},{"id":"https://openalex.org/F4320311238","display_name":"Fondation Brain Canada","ror":"https://ror.org/01bcmwk98"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320315051","display_name":"Environmental Restoration and Conservation Agency","ror":"https://ror.org/01c9agy38"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320319303","display_name":"Fulbright Norway","ror":"https://ror.org/04zbwa870"},{"id":"https://openalex.org/F4320319387","display_name":"Ministerio de Educaci\u00f3n y Ciencias","ror":"https://ror.org/00821s992"},{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320386","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320320907","display_name":"Japan Science and Technology Corporation","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322243","display_name":"Iran National Science Foundation","ror":"https://ror.org/03sr1ma14"},{"id":"https://openalex.org/F4320322565","display_name":"Stavros Niarchos Foundation","ror":"https://ror.org/0210rze73"},{"id":"https://openalex.org/F4320322665","display_name":"Natural Science Foundation of Jiangxi Province","ror":null},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323078","display_name":"Universitetet i Bergen","ror":"https://ror.org/03zga2b32"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320323955","display_name":"Yildiz Teknik \u00dcniversitesi","ror":"https://ror.org/0547yzj13"},{"id":"https://openalex.org/F4320324278","display_name":"Comisi\u00f3n Interministerial de Ciencia y Tecnolog\u00eda","ror":null},{"id":"https://openalex.org/F4320324811","display_name":"Universit\u00e4t zu K\u00f6ln","ror":"https://ror.org/00rcxh774"},{"id":"https://openalex.org/F4320325269","display_name":"Japan Diabetes Society","ror":"https://ror.org/05mhc7495"},{"id":"https://openalex.org/F4320326644","display_name":"Canada First Research Excellence Fund","ror":"https://ror.org/01ktx4s83"},{"id":"https://openalex.org/F4320327636","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red-Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n","ror":"https://ror.org/02s65tk16"},{"id":"https://openalex.org/F4320329083","display_name":"Fundaci\u00f3n Palarq","ror":"https://ror.org/034mph196"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320333297","display_name":"Peder Sather Center for Advanced Study","ror":"https://ror.org/03ktymy31"},{"id":"https://openalex.org/F4320334290","display_name":"Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare","ror":"https://ror.org/04k9dce70"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320334843","display_name":"Freiburg Institute for Advanced Studies, Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335848","display_name":"Agricultural Science and Technology Innovation Program","ror":null},{"id":"https://openalex.org/F4320335960","display_name":"National Major Science and Technology Projects of China","ror":null},{"id":"https://openalex.org/F4320336551","display_name":"National Defense Science and Technology Innovation Fund of the Chinese Academy of Sciences","ror":null},{"id":"https://openalex.org/F4320336593","display_name":"Henan Provincial Science and Technology Research Project","ror":null},{"id":"https://openalex.org/F4320336613","display_name":"Science and Technology Innovation Talents in Universities of Henan Province","ror":null},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337550","display_name":"Jonsson Comprehensive Cancer Center","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337683","display_name":"School of Medicine, University of North Carolina at Chapel Hill","ror":null},{"id":"https://openalex.org/F4320337684","display_name":"Graduate School, University of North Carolina at Chapel Hill","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223301979.pdf","grobid_xml":"https://content.openalex.org/works/W7223301979.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W116325269","https://openalex.org/W174400507","https://openalex.org/W1531708107","https://openalex.org/W1533496726","https://openalex.org/W1747411925","https://openalex.org/W1841904820","https://openalex.org/W1967106507","https://openalex.org/W1979001015","https://openalex.org/W1993714926","https://openalex.org/W2003907443","https://openalex.org/W2009526445","https://openalex.org/W2022250968","https://openalex.org/W2032980717","https://openalex.org/W2034310945","https://openalex.org/W2052732921","https://openalex.org/W2068455909","https://openalex.org/W2068931925","https://openalex.org/W2083162205","https://openalex.org/W2088793982","https://openalex.org/W2098005560","https://openalex.org/W2100067750","https://openalex.org/W2100396313","https://openalex.org/W2108599038","https://openalex.org/W2109993434","https://openalex.org/W2112988638","https://openalex.org/W2113328354","https://openalex.org/W2114675972","https://openalex.org/W2167924668","https://openalex.org/W2209458064","https://openalex.org/W2299380508","https://openalex.org/W2326233293","https://openalex.org/W2327959547","https://openalex.org/W2328746135","https://openalex.org/W2345009038","https://openalex.org/W2384699986","https://openalex.org/W2395416726","https://openalex.org/W2463722124","https://openalex.org/W2511376151","https://openalex.org/W2521898456","https://openalex.org/W2568604158","https://openalex.org/W2584547672","https://openalex.org/W2593602992","https://openalex.org/W2597176252","https://openalex.org/W2691302849","https://openalex.org/W2693237708","https://openalex.org/W2744384817","https://openalex.org/W2745352569","https://openalex.org/W2746402575","https://openalex.org/W2751783835","https://openalex.org/W2754579053","https://openalex.org/W2759977828","https://openalex.org/W2763533536","https://openalex.org/W2767403146","https://openalex.org/W2767916436","https://openalex.org/W2768804444","https://openalex.org/W2781472954","https://openalex.org/W2787004630","https://openalex.org/W2792390442","https://openalex.org/W2797004612","https://openalex.org/W2800329970","https://openalex.org/W2806583121","https://openalex.org/W2886376271","https://openalex.org/W2888223626","https://openalex.org/W2888398432","https://openalex.org/W2888683909","https://openalex.org/W2889182141","https://openalex.org/W2889979622","https://openalex.org/W2908761681","https://openalex.org/W2931678155","https://openalex.org/W2936804536","https://openalex.org/W2945442113","https://openalex.org/W2953305121","https://openalex.org/W2959449984","https://openalex.org/W2970812056","https://openalex.org/W2981612846","https://openalex.org/W2990693206","https://openalex.org/W2998123150","https://openalex.org/W3002691754","https://openalex.org/W3007313888","https://openalex.org/W3020922568","https://openalex.org/W3022536911","https://openalex.org/W3024471453","https://openalex.org/W3036582528","https://openalex.org/W3047374256","https://openalex.org/W3112391456","https://openalex.org/W3114092281","https://openalex.org/W3127388274","https://openalex.org/W3184500086","https://openalex.org/W3195549289","https://openalex.org/W3205075156","https://openalex.org/W4205304613","https://openalex.org/W4205479701","https://openalex.org/W4205497185","https://openalex.org/W4220656322","https://openalex.org/W4224434437","https://openalex.org/W4235679434","https://openalex.org/W4280598669","https://openalex.org/W4292092760","https://openalex.org/W4323315676","https://openalex.org/W4368357599","https://openalex.org/W4385298758","https://openalex.org/W4385622282","https://openalex.org/W4387492307","https://openalex.org/W4392358126","https://openalex.org/W4399419559","https://openalex.org/W4400031131","https://openalex.org/W4400270377","https://openalex.org/W4400399461","https://openalex.org/W4401543681","https://openalex.org/W4401611854","https://openalex.org/W4408137073","https://openalex.org/W4410292331","https://openalex.org/W4413877449","https://openalex.org/W4417497881","https://openalex.org/W7131401190","https://openalex.org/W7160504863","https://openalex.org/W7167511630"],"related_works":["https://openalex.org/W7125807822","https://openalex.org/W4313358803","https://openalex.org/W4205184829","https://openalex.org/W4224434437","https://openalex.org/W4313384753","https://openalex.org/W6906470912","https://openalex.org/W4399419559","https://openalex.org/W2767916436","https://openalex.org/W4225941923","https://openalex.org/W6944268791"],"abstract_inverted_index":{"Interferon-\u03bb":[0],"(IFN-\u03bb,":[1],"type":[2,183],"III":[3],"IFN)":[4],"mediates":[5],"antiviral":[6,87,215],"immunity":[7],"at":[8,51,74],"anatomic":[9],"barriers,":[10],"including":[11],"the":[12,17,31,40,75,80,94,107,127,147,179,209],"maternal-fetal":[13,76],"interface.":[14,77],"To":[15,78],"investigate":[16,79],"effects":[18],"of":[19,59,72,109,126,149],"IFN-\u03bb":[20,43,61,73,101,198],"during":[21],"congenital":[22,188,220],"Zika":[23],"virus":[24],"(ZIKV)":[25],"infection,":[26],"we":[27,89,173],"infected":[28],"mice":[29],"lacking":[30],"IFN-\u03b1\u03b2":[32,41],"receptor":[33],"(":[34,45],"Ifnar1":[35,46,113,118,150,157],"\u2212/\u2212":[36,47,49,114,119,121,151,153,158],")":[37,50],"or":[38],"both":[39],"and":[42,55,86,98,129,134,141],"receptors":[44],"Ifnlr1":[48,120,152],"embryonic":[52],"day":[53],"9":[54],"found":[56,99,135],"that":[57,100,217],"loss":[58],"maternal":[60,175,201],"signaling":[62,199],"resulted":[63],"in":[64,112,138,146,196,208],"greater":[65],"transplacental":[66],"transmission,":[67],"highlighting":[68],"a":[69,136,194,213],"protective":[70,214],"effect":[71],"spatial":[81],"relationship":[82],"between":[83],"ZIKV":[84,110,187,219],"infection":[85,111],"responses,":[88],"used":[90],"HiPlex":[91],"RNAscope":[92],"on":[93],"entire":[95],"gravid":[96],"uterus":[97,130,148],"was":[102],"expressed":[103],"more":[104],"proximal":[105],"to":[106,117,156,200],"site":[108],"dams":[115,154],"compared":[116,155],"dams.":[122],"We":[123],"performed":[124],"immunophenotyping":[125],"placenta":[128],"by":[131],"flow":[132],"cytometry":[133],"decrease":[137],"dendritic":[139,176,202,205],"cells":[140,145,177,203],"natural":[142],"killer":[143],"(NK)":[144],"dams,":[159],"but":[160],"NK":[161],"cell":[162,182,206],"depletion":[163],"did":[164],"not":[165],"affect":[166],"fetal":[167],"infection.":[168,189,221],"Using":[169],"conditional":[170],"knockout":[171],"mice,":[172],"identified":[174],"as":[178],"key":[180],"IFN-\u03bb\u2013responsive":[181],"mediating":[184],"protection":[185],"against":[186],"Together,":[190],"our":[191],"data":[192],"support":[193],"model":[195],"which":[197,211],"increases":[204],"accumulation":[207],"uterus,":[210],"facilitates":[212],"response":[216],"restricts":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-24T00:00:00"}