{"id":"https://openalex.org/W7223300832","doi":"https://doi.org/10.3389/fnagi.2026.2015896","title":"Editorial: Decoding the gut-brain axis: implications for neurodegenerative disease therapies","display_name":"Editorial: Decoding the gut-brain axis: implications for neurodegenerative disease therapies","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223300832","doi":"https://doi.org/10.3389/fnagi.2026.2015896"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2026.2015896","doi":"https://doi.org/10.3389/fnagi.2026.2015896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2015896","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2015896/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2015896/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058173010","display_name":"R. M. Damian Holsinger","orcid":"https://orcid.org/0000-0002-4447-0835","observed_orcids":["https://orcid.org/0000-0002-4447-0835"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"R. M. Damian Holsinger","raw_affiliation_strings":["Laboratory of Molecular Neuroscience and Dementia, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney","Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuroscience and Dementia, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058173010"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9559999704360962},{"id":"https://openalex.org/keywords/microbiome-targeted-therapy","display_name":"microbiome-targeted therapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.765999972820282},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4869999885559082},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.6000000238418579},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/postbiotics","display_name":"postbiotics","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myokines","display_name":"myokines","score":0.871999979019165},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/skeletal-muscle-quality","display_name":"skeletal muscle quality","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.635699987411499},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.59579998254776},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5773000121116638},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5562000274658203},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42480000853538513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4187999963760376},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.4131999909877777},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3822000026702881},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3756999969482422},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.3732999861240387},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.33709999918937683},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C117365660","wikidata":"https://www.wikidata.org/wiki/Q962589","display_name":"Myokine","level":3,"score":0.321399986743927},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.3151000142097473},{"id":"https://openalex.org/C2780502288","wikidata":"https://www.wikidata.org/wiki/Q28838156","display_name":"Expansive","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C70587473","wikidata":"https://www.wikidata.org/wiki/Q7834111","display_name":"Transformative learning","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2913999855518341},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.2840999960899353},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.2793999910354614},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C14224292","wikidata":"https://www.wikidata.org/wiki/Q13600188","display_name":"Conceptual framework","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fnagi.2026.2015896","doi":"https://doi.org/10.3389/fnagi.2026.2015896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2015896","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2015896/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3b783a95c1d44778b9ca9ca8978a4a72","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3b783a95c1d44778b9ca9ca8978a4a72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2026.2015896","doi":"https://doi.org/10.3389/fnagi.2026.2015896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.2015896","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.2015896/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223300832.pdf","grobid_xml":"https://content.openalex.org/works/W7223300832.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415916294","https://openalex.org/W7221806429","https://openalex.org/W4403735154","https://openalex.org/W4392783067","https://openalex.org/W4405137363","https://openalex.org/W4414137494","https://openalex.org/W4412702381","https://openalex.org/W4414168707","https://openalex.org/W4323544496","https://openalex.org/W7214104765"],"abstract_inverted_index":{"This":[0,634,772],"systems-based":[1],"perspective":[2],"has":[3],"stimulated":[4],"interest":[5],"in":[6,21,46,268,395,405,411,447,467,526,697,738,770,801,872,880,974,1004,1031,1082,1274],"microbiome-targeted":[7,498],"interventions,":[8,791],"including":[9,356],"dietary":[10,347,360,393,419,449,544,596,612],"modification,":[11],"prebiotics,":[12,542],"probiotics,":[13,543],"postbiotics":[14],"and":[15,26,39,54,70,76,86,104,124,152,160,167,214,259,265,284,313,325,342,353,359,372,409,486,511,528,546,564,611,617,631,671,681,685,735,742,748,811,820,856,870,893,905,916,943,959,986,1047,1059,1079,1090,1105,1134,1153,1189,1221,1247,1253,1262,1271,1308,1319,1326,1337,1343,1361],"fecal":[16,547],"microbiota":[17,466,548,602,734,868,883,984,1029],"transplantation.":[18],"Simultaneously,":[19],"advances":[20],"high-throughput":[22],"sequencing,":[23],"metabolomics,":[24],"proteomics":[25],"computational":[27],"biology":[28,219,711],"have":[29],"created":[30],"new":[31],"opportunities":[32,1270],"to":[33,140,165,234,380,462,507,513,535,623,731,849,886,996,1130,1205,1228,1239,1284,1314,1351],"characterize":[34],"hostmicrobe":[35],"interactions,":[36],"identify":[37,624],"biomarkers":[38,1171,1360],"explore":[40],"therapeutic":[41,88,381,424,517,582,917,990],"targets.":[42],"The":[43,127,399,567,874,1095,1179,1310],"articles":[44],"assembled":[45],"this":[47,52,295,654,924,1285,1330],"Research":[48,655,925,1207,1286],"Topic":[49,1287],"reflect":[50],"both":[51,1151,1268],"progress":[53],"the":[55,94,173,183,223,238,244,251,279,292,298,334,339,370,388,416,456,464,502,516,530,550,556,571,600,620,637,650,662,688,691,702,751,775,787,797,837,864,881,899,962,980,994,1015,1053,1066,1121,1160,1182,1206,1216,1234,1257,1265,1269,1282],"challenges":[56,572,1227,1272],"of":[57,107,172,240,320,374,390,418,437,443,471,532,555,573,603,640,649,694,704,719,783,789,799,805,831,902,935,982,1124,1162,1168,1250,1259,1301],"translating":[58,574,1275],"gut-brain":[59,175,221,445,524,644,695,832,846,851,903,1011,1290],"research":[60,853,1013,1278,1292],"into":[61,220,577,766,1014,1065,1199,1279],"clinical":[62,79,413,578,610,900,1067,1200,1229,1280],"practice.":[63],"Collectively,":[64],"they":[65,272],"encompass":[66],"original":[67],"research,":[68],"narrative":[69],"systematic":[71],"reviews,":[72],"a":[73,131,169,187,226,269,317,329,366,391,441,460,468,590,594,708,728,802,932,1166,1202],"study":[74,621,752,1096],"protocol":[75,591],"an":[77,422,910],"interventional":[78,1341],"study,":[80],"spanning":[81],"disease":[82,1089,1132],"mechanisms,":[83],"biomarker":[84,1135],"discovery":[85],"emerging":[87,638,1122],"strategies.Several":[89],"overarching":[90],"themes":[91],"emerge":[92],"across":[93,1146,1176],"collection.":[95],"Multiple":[96],"studies":[97,506,1238],"link":[98],"gut":[99,200,293,321,340,406,465,488,601,666,733,817,867,937,983,1028,1060,1076,1143,1217,1276],"microbial":[100,118,201,322,407,489,630,667,678,720,747,818,949,951,1045,1049,1061,1077,1099,1144,1155,1302,1317],"dysbiosis":[101,668,1046,1145],"with":[102,397,403,605,669,740,757,941,971,1026,1033,1084,1102,1128,1219],"motor":[103,809,857],"non-motor":[105,887],"manifestations":[106,888],"neurological":[108,537,1367],"disease.":[109],"Further,":[110],"increasing":[111],"attention":[112],"is":[113,1024,1293,1313],"directed":[114],"toward":[115,137,780,1298],"mechanisms":[116,510,972],"involving":[117],"metabolites,":[119,679],"immune":[120,562,1306],"activation,":[121],"intestinal":[122,557,680,812,882,956],"permeability":[123],"neural":[125],"signaling.":[126],"collection":[128],"also":[129,569,978],"demonstrates":[130],"transition":[132],"from":[133,377,777],"descriptive":[134,717,1296],"microbiome":[135,341,349,938,967,1002,1126,1163,1218,1277],"profiling":[136,1127,1164],"interventions":[138,231,439,499,545,841],"designed":[139],"modify":[141],"disease-related":[142,629],"outcomes.":[143],"Finally,":[144],"many":[145,648],"contributions":[146,922,1283],"emphasize":[147],"standardized":[148,1185,1245,1334],"methodologies,":[149,1335],"longitudinal":[150,1187,1242,1336],"investigations":[151],"multidisciplinary":[153,1344],"collaboration":[154],"as":[155,186,316,421,440,459,909,954,989,1165],"essential":[156,1350],"for":[157,189,332,368,497,504,592,627,913,998,1184,1236,1365],"establishing":[158],"causality":[159],"developing":[161,593],"more":[162],"precise":[163],"approaches":[164,1195,1355],"diagnosis":[166],"treatment.In":[168],"conceptual":[170],"extension":[171],"traditional":[174],"axis":[176,185,645,852,1012,1291],"paradigm,":[177],"Sun":[178],"et":[179,247,384,452,520,585,658,723,793,860,928,1007,1070,1138,1210],"al.":[180,248,385,453,521,586,659,724,794,861,929,1008,1071,1139,1211],"(2026)":[181,327,386,454,522,660,862,930,1009,1072,1140],"introduce":[182],"gut-brain-muscle":[184],"framework":[188,227,331,712],"exercise-mediated":[190],"neuroprotection.":[191],"Their":[192,344,699,1038,1157,1231],"review":[193,345,523,568,661,963,1232],"synthesizes":[194],"evidence":[195,540,664,947,1214],"that":[196,206,274,301,824,839,878,1020,1289],"physical":[197],"activity":[198],"reshapes":[199],"communities":[202],"while":[203,500,815,992,1110,1172,1224],"stimulating":[204],"myokines":[205],"may":[207,232,559,828,842,884,969],"influence":[208,560],"neuroinflammation,":[209,561,677],"oxidative":[210],"stress,":[211],"synaptic":[212],"plasticity":[213],"cognition.":[215,343],"By":[216,607,673,945,1255],"integrating":[217,608,674,946,1125],"muscle":[218,257,275],"communication,":[222],"authors":[224,551,689,1180,1266],"provide":[225,328,365,494,764,931],"through":[228,307,889],"which":[229,1316],"exercise-based":[230],"contribute":[233,885],"healthy":[235],"brain":[236,260,285,311],"aging.Broadening":[237],"concept":[239,300],"inter-organ":[241],"communication":[242,525,696],"beyond":[243,580,716,854,1295],"gut,":[245],"Kim":[246],"(2025)":[249,795,1212],"investigated":[250,387,863,1073],"relationship":[252,865],"between":[253,281,866,1042,1075],"hepatic":[254,282],"steatosis,":[255],"skeletal":[256],"quality":[258],"aging.":[261],"Using":[262],"integrated":[263,1299],"CT":[264],"MRI":[266],"measures":[267],"large":[270],"cohort,":[271],"found":[273],"density":[276],"partially":[277],"mediated":[278],"association":[280],"steatosis":[283],"age.":[286],"Although":[287,426],"not":[288],"focused":[289],"directly":[290],"on":[291,541,599,676,844,919,948],"microbiome,":[294],"work":[296,773],"reinforces":[297,701],"broader":[299,709],"peripheral":[302],"metabolic":[303,632,749,785,892,1050],"organs":[304],"can":[305,763,1196,1356],"interact":[306],"interconnected":[308,890],"pathways":[309,847,1321],"influencing":[310],"health":[312],"aging.Recognizing":[314],"diet":[315],"major":[318,1147],"determinant":[319],"composition,":[323,950],"Raber":[324],"Sharpton":[326],"methodological":[330],"investigating":[333],"complex":[335],"relationships":[336],"among":[337,1055],"nutrition,":[338],"addresses":[346],"assessment,":[348],"profiling,":[350],"cognitive":[351,744,758],"phenotyping":[352],"analytical":[354],"approaches,":[355,450,1264],"causal":[357],"inference":[358],"pattern":[361],"derivation.":[362],"These":[363,491,834,896,1118],"recommendations":[364],"roadmap":[367],"strengthening":[369],"rigor":[371],"reproducibility":[373],"diet-microbiome-cognition":[375],"research.Shifting":[376],"mechanistic":[378,915,1063,1237],"insights":[379,765,1064],"intervention,":[382],"Luo":[383],"effects":[389,798,827],"ketogenic":[392],"intervention":[394,400],"patients":[396,604,739,1032,1083],"PD.":[398,771,806,873,944,1005],"was":[401],"associated":[402,756,940,1025,1101],"changes":[404,968],"composition":[408,819,869,1078],"improvements":[410],"several":[412,920],"measures,":[414],"highlighting":[415,501,1052,1225,1256],"potential":[417,531,639,767,981,1115,1123,1161,1169],"modulation":[420,554,830],"adjunctive":[423],"approach.":[425],"larger":[427],"controlled":[428],"trials":[429,1342],"are":[430,1322],"needed,":[431],"these":[432],"findings":[433,493,675,835,897,1039,1119,1158],"support":[434,496,836],"further":[435,505],"investigation":[436],"nutritional":[438],"means":[442],"modulating":[444,628],"interactions":[446,769,904],"PD.Complementing":[448],"Hughes":[451],"evaluated":[455],"Lab4":[457],"probiotic":[458],"strategy":[461],"modulate":[463],"murine":[469],"model":[470,804],"AD.":[472,606],"Probiotic":[473],"supplementation":[474],"preserved":[475],"hippocampal":[476],"neuronal":[477],"spine":[478],"density,":[479],"improved":[480,808],"recognition":[481],"memory,":[482],"reduced":[483],"inflammatory":[484,960],"markers":[485,1081],"altered":[487,1048],"composition.":[490],"preliminary":[492],"preclinical":[495],"need":[503,995,1183,1235],"establish":[508,1240],"their":[509,987,1114],"relevance":[512,901],"human":[514,1243],"disease.Broadening":[515],"perspective,":[518],"Gao":[519],"stroke":[527],"evaluate":[529],"microecological":[533],"treatments":[534],"improve":[536,1131],"recovery.":[538,566],"Integrating":[539,746],"transplantation,":[549],"highlight":[552,906,1120,1159],"how":[553,761,965],"ecosystem":[558],"regulation":[563],"post-stroke":[565],"emphasizes":[570,1233],"microbiome-based":[575,1193],"strategies":[576,626,1364],"practice.Looking":[579],"generalized":[581],"strategies,":[583],"Clemente-Velasco":[584],"(":[587,725],"2025)":[588,726],"describe":[589],"personalized":[595,1263],"supplement":[597],"based":[598],"microbiota,":[609],"data":[613],"using":[614],"artificial":[615],"intelligence":[616],"network":[618,821],"analyses,":[619],"aims":[622],"individualized":[625],"profiles.":[633],"approach":[635,730],"illustrates":[636],"precision":[641],"nutrition":[642],"within":[643,707,923],"research.Drawing":[646],"together":[647],"concepts":[651],"explored":[652,796],"throughout":[653],"Topic,":[656,926,1208],"Cipriano":[657],"growing":[663],"linking":[665,1215],"AD":[670,706],"dementia.":[672],"bloodbrain":[682],"barrier":[683,813,957],"dysfunction":[684],"protein":[686],"aggregation,":[687],"illustrate":[690],"multifactorial":[692],"nature":[693],"neurodegeneration.":[698],"synthesis":[700],"value":[703],"viewing":[705],"systems":[710],"encompassing":[713],"host-microbiome":[714],"interactions.Moving":[715],"analyses":[718,1112],"dysbiosis,":[721],"Lin":[722,859],"applied":[727],"multiomics":[729],"investigate":[732],"plasma":[736],"metabolites":[737,952,988],"PD":[741,975],"mild":[743],"impairment.":[745],"profiles,":[750],"identified":[753,1097],"distinct":[754,1027],"alterations":[755,879,1003,1030],"impairment,":[759],"illustrating":[760],"metabolomics":[762],"microbiota-metabolite":[768],"exemplifies":[774],"shift":[776],"taxonomic":[778],"descriptions":[779],"functional":[781],"characterization":[782,1133],"microbiomeassociated":[784],"changes.Expanding":[786],"spectrum":[788],"microbiome-directed":[790],"Wu":[792],"electroacupuncture":[800],"mouse":[803],"Electroacupuncture":[807],"function":[810,958],"integrity":[814],"reshaping":[816],"structure,":[822],"suggesting":[823],"its":[825],"neuroprotective":[826],"involve":[829],"communication.":[833],"possibility":[838],"diverse":[840],"converge":[843],"shared":[845,936],"relevant":[848,1325],"neurodegeneration.Extending":[850],"cognition":[855],"dysfunction,":[858],"insomnia":[871],"observed":[875],"associations":[876,1041,1074,1297],"suggest":[877,1040],"immune,":[891],"neurochemical":[894],"pathways.":[895],"broaden":[898],"sleep":[907,1022],"disturbance":[908],"important":[911],"target":[912],"future":[914],"investigations.Building":[918],"PD-focused":[921],"Tng":[927],"comprehensive":[933],"overview":[934],"signatures":[939,1318],"aging":[942,999],"such":[953],"butyrate,":[955],"pathways,":[961],"highlights":[964],"agerelated":[966],"intersect":[970],"implicated":[973],"pathogenesis.":[976],"It":[977],"discusses":[979],"taxa":[985,1100],"targets,":[991],"emphasizing":[993,1173],"account":[997],"when":[1000],"interpreting":[1001],"Liao":[1006],"extend":[1010],"cerebrovascular":[1016],"space":[1017],"by":[1018],"demonstrating":[1019],"obstructive":[1021],"apnea":[1023],"symptomatic":[1034],"intracranial":[1035],"atherosclerotic":[1036],"stenosis.":[1037],"sleep-disordered":[1043],"breathing,":[1044],"functions,":[1051],"interplay":[1054],"sleep,":[1056],"vascular":[1057],"pathology":[1058],"homeostasis.Extending":[1062],"setting,":[1068],"Cai":[1069],"imaging":[1080],"arteriosclerotic":[1085],"cerebral":[1086,1103],"small":[1087],"vessel":[1088],"idiopathic":[1091],"normal":[1092],"pressure":[1093],"hydrocephalus.":[1094],"specific":[1098],"microbleeds":[1104],"deep":[1106],"medullary":[1107],"vein":[1108],"scores,":[1109],"exploratory":[1111],"suggested":[1113],"diagnostic":[1116,1194],"value.":[1117],"neuroimaging":[1129],"development.":[1136],"Espinosa":[1137],"systematically":[1141],"examine":[1142],"psychiatric":[1148],"disorders,":[1149,1223],"identifying":[1150],"disorder-specific":[1152],"overlapping":[1154],"signatures.":[1156],"source":[1167],"non-invasive":[1170],"substantial":[1174],"heterogeneity":[1175],"existing":[1177],"studies.":[1178],"underscore":[1181,1267],"methods,":[1186],"validation":[1188],"independent":[1190],"cohorts":[1191],"before":[1192],"be":[1197,1349],"translated":[1198],"practice.Providing":[1201],"fitting":[1203],"conclusion":[1204],"Yassin":[1209],"synthesize":[1213],"neurodegenerative":[1220],"neuropsychiatric":[1222],"key":[1226],"translation.":[1230],"causality,":[1241],"studies,":[1244,1339],"protocols":[1246],"rigorous":[1248],"evaluation":[1249],"efficacy,":[1251],"safety":[1252,1261],"durability.":[1254],"importance":[1258],"validation,":[1260],"involved":[1273],"practice.Collectively,":[1281],"demonstrate":[1288],"moving":[1294],"models":[1300],"ecology,":[1303],"host":[1304],"metabolism,":[1305],"signaling":[1307],"lifestyle.":[1309],"next":[1311],"challenge":[1312,1331],"determine":[1315,1352],"biological":[1320],"reproducible,":[1323],"causally":[1324],"clinically":[1327],"actionable.":[1328],"Addressing":[1329],"will":[1332,1348],"require":[1333],"multi-omics":[1338],"well-designed":[1340],"collaboration.":[1345],"Such":[1346],"efforts":[1347],"whether":[1353],"microbiome-informed":[1354],"ultimately":[1357],"deliver":[1358],"reliable":[1359],"safe":[1362],"effective":[1363],"improving":[1366],"health.":[1368]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}