{"id":"https://openalex.org/W7223299031","doi":"https://doi.org/10.1016/j.bbrep.2026.102855","title":"Association of HSD3B1 rs1047303 polymorphism with prognosis in metastatic prostate cancer: A systematic review and meta-analysis","display_name":"Association of HSD3B1 rs1047303 polymorphism with prognosis in metastatic prostate cancer: A systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223299031","doi":"https://doi.org/10.1016/j.bbrep.2026.102855","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13720604"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrep.2026.102855","doi":"https://doi.org/10.1016/j.bbrep.2026.102855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102855","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580826004152/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2405580826004152/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056402725","display_name":"Fupeng Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fupeng Feng","raw_affiliation_strings":["Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159344767","display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125165314","display_name":"Feng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Yang","raw_affiliation_strings":["Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159332464","display_name":"Yidan Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yidan Nie","raw_affiliation_strings":["Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159332464"],"corresponding_institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52442903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"102855","last_page":"102855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsd3b1","display_name":"HSD3B1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.6990000009536743},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9710000157356262},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6922000050544739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6090999841690063},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5956000089645386},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4796999990940094},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4553000032901764},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4410000145435333},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.44020000100135803},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.3411000072956085},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.30469998717308044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29899999499320984},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2904999852180481},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2628999948501587}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbrep.2026.102855","doi":"https://doi.org/10.1016/j.bbrep.2026.102855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102855","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580826004152/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13720604","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720604/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13720604/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem Biophys Rep","raw_type":"Text"},{"id":"pmid:42964743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and biophysics reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2df8675981824110bd6f13b1f417fb93","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2df8675981824110bd6f13b1f417fb93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry and Biophysics Reports, Vol 48, Iss , Pp 102855- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrep.2026.102855","doi":"https://doi.org/10.1016/j.bbrep.2026.102855","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102855","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580826004152/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223299031.pdf","grobid_xml":"https://content.openalex.org/works/W7223299031.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1584828549","https://openalex.org/W1996592956","https://openalex.org/W2100965400","https://openalex.org/W2107991694","https://openalex.org/W2404460725","https://openalex.org/W2514486754","https://openalex.org/W2588655921","https://openalex.org/W2765319709","https://openalex.org/W2890727330","https://openalex.org/W2915440535","https://openalex.org/W2955965693","https://openalex.org/W3005901626","https://openalex.org/W3022118302","https://openalex.org/W3036749792","https://openalex.org/W3081529667","https://openalex.org/W3135591602","https://openalex.org/W3155481565","https://openalex.org/W3212146379","https://openalex.org/W4220740285","https://openalex.org/W4388541037","https://openalex.org/W4392986723","https://openalex.org/W4402482734","https://openalex.org/W4404374485","https://openalex.org/W4409241774","https://openalex.org/W4409282329","https://openalex.org/W4414426870","https://openalex.org/W4414992917","https://openalex.org/W7133509419","https://openalex.org/W7166319514"],"related_works":["https://openalex.org/W2891864841","https://openalex.org/W2792508178","https://openalex.org/W3212146379","https://openalex.org/W2915440535","https://openalex.org/W3031402932","https://openalex.org/W2955488619","https://openalex.org/W4391302552","https://openalex.org/W4289545933","https://openalex.org/W4415941123","https://openalex.org/W4392986723"],"abstract_inverted_index":{"Background":[0],"The":[1],"HSD3B1":[2,50,207],"rs1047303":[3,51,208],"(1245A":[4],">":[5],"C)":[6],"polymorphism":[7,29,92],"encodes":[8],"a":[9,221],"gain-of-function":[10],"variant":[11,119,209],"in":[12,30,56,93,215],"3\u03b2-hydroxysteroid":[13],"dehydrogenase-1":[14],"that":[15,205],"enhances":[16],"extragonadal":[17],"androgen":[18],"synthesis.":[19],"Conflicting":[20],"evidence":[21],"exists":[22],"regarding":[23],"the":[24,28,47,87,91,118,206,226,232,236],"prognostic":[25,88,222,227],"value":[26,228],"of":[27,40,90,235],"metastatic":[31,57,96,102],"prostate":[32,58,98,104],"cancer.":[33,59],"Methods":[34],"We":[35,60],"systematically":[36],"searched":[37],"PubMed,":[38],"Web":[39],"Science,":[41],"and":[42,53,74,101,143,243],"Embase":[43],"for":[44,70],"studies":[45,110],"evaluating":[46],"association":[48,89],"between":[49],"genotype":[52,120],"clinical":[54],"outcomes":[55],"pooled":[61],"hazard":[62],"ratios":[63],"(HRs)":[64],"with":[65,95,123,199,212],"95%":[66,133,152,170,186],"confidence":[67],"intervals":[68],"(CIs)":[69],"overall":[71,126],"survival":[72,76,127,146,214],"(OS)":[73,128],"progression-free":[75,145],"(PFS)":[77,147],"using":[78],"random-effects":[79],"models.":[80],"Subgroup":[81],"analyses":[82],"were":[83,114],"conducted":[84],"to":[85],"assess":[86],"patients":[94,113],"castration-sensitive":[97],"cancer":[99,105],"(mHSPC)":[100],"castration-resistant":[103],"(mCRPC),":[106],"respectively.":[107],"Results":[108],"Nine":[109],"involving":[111],"1947":[112],"included.":[115],"In":[116,162,224],"mHSPC,":[117,216],"was":[121,196],"associated":[122,198,211],"significantly":[124,197],"worse":[125,144,213],"(pooled":[129,148,166,182],"HR":[130,149,167,183],"=":[131,137,141,150,156,160,168,174,178,184,190,194],"1.49,":[132],"CI:":[134,153,171,187],"1.15\u20131.92,":[135],"P":[136,155,173,189],"0.002;":[138],"I":[139,158,176,192],"2":[140,159,177,193],"11%)":[142],"1.69,":[151],"1.15\u20132.49,":[154],"0.008;":[157],"61%).":[161],"mCRPC,":[163,225],"neither":[164],"OS":[165],"1.01,":[169],"0.33\u20133.15,":[172],"0.98;":[175],"76%)":[179],"nor":[180],"PFS":[181],"1.06,":[185],"0.31\u20133.59,":[188],"0.93;":[191],"85%)":[195],"genotype.":[200],"Conclusions":[201],"This":[202],"meta-analysis":[203],"suggests":[204],"is":[210],"supporting":[217],"its":[218],"potential":[219],"as":[220],"biomarker.":[223],"remains":[229],"inconclusive.":[230],"Given":[231],"observational":[233],"nature":[234],"included":[237],"studies,":[238],"these":[239],"findings":[240],"are":[241],"hypothesis-generating":[242],"require":[244],"prospective":[245],"validation.":[246]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}
