{"id":"https://openalex.org/W7223297974","doi":"https://doi.org/10.21037/jgo-2026-0468","title":"A phase II pilot evaluation of lurbinectedin in patients with advanced gastrointestinal malignancies with DNA repair mutations","display_name":"A phase II pilot evaluation of lurbinectedin in patients with advanced gastrointestinal malignancies with DNA repair mutations","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223297974","doi":"https://doi.org/10.21037/jgo-2026-0468","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740528"},"language":"en","primary_location":{"id":"doi:10.21037/jgo-2026-0468","doi":"https://doi.org/10.21037/jgo-2026-0468","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0468","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/jgo-2026-0468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117013304","display_name":"Alexa F. Viniotis","orcid":"https://orcid.org/0000-0002-8990-4684","observed_orcids":["https://orcid.org/0000-0002-8990-4684"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa F. Viniotis","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003323232","display_name":"Gayle Jameson","orcid":"https://orcid.org/0000-0003-0987-5965","observed_orcids":["https://orcid.org/0000-0003-0987-5965"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayle S. Jameson","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055132722","display_name":"Betsy C. Wertheim","orcid":"https://orcid.org/0000-0003-2470-3440","observed_orcids":["https://orcid.org/0000-0003-2470-3440"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betsy C. Wertheim","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016715621","display_name":"Denise J. Roe","orcid":"https://orcid.org/0000-0001-6989-6579","observed_orcids":["https://orcid.org/0000-0001-6989-6579"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise J. Roe","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122962852","display_name":"Daniel Mocan","orcid":"https://orcid.org/0009-0006-4332-4613","observed_orcids":["https://orcid.org/0009-0006-4332-4613"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Mocan","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114120383","display_name":"Shelby Pearse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelby Pearse","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159339973","display_name":"Sunil Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Sharma","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069690249","display_name":"Michael S. Gordon","orcid":"https://orcid.org/0000-0002-7679-9504","observed_orcids":["https://orcid.org/0000-0002-7679-9504"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Gordon","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080900202","display_name":"Daniel D. Von Hoff","orcid":"https://orcid.org/0000-0003-4723-7681","observed_orcids":["https://orcid.org/0000-0003-4723-7681"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel D. Von Hoff","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA","Translational Genomics Research Institute, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]},{"raw_affiliation_string":"Translational Genomics Research Institute, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070523850","display_name":"Erkut Hasan Borazanci","orcid":"https://orcid.org/0000-0001-5136-5462","observed_orcids":["https://orcid.org/0000-0001-5136-5462"]},"institutions":[{"id":"https://openalex.org/I4210130412","display_name":"HonorHealth","ror":"https://ror.org/03szbwj17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erkut H. Borazanci","raw_affiliation_strings":["HonorHealth Research Institute, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HonorHealth Research Institute, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210130412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"297","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.10830000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lurbinectedin","display_name":"lurbinectedin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.7670000195503235},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.718999981880188},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atm-mutations","display_name":"ATM mutations","score":0.5550000071525574},{"id":"https://openalex.org/keywords/arid1a-mutation","display_name":"ARID1A mutation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chek2-mutation","display_name":"CHEK2 mutation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.6290000081062317},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.7139999866485596},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.925000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6700000166893005},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.30799999833106995},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9478999972343445},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.541100025177002},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43050000071525574},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4034000039100647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4016000032424927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C2909513124","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA Damage Repair","level":4,"score":0.30300000309944153},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2775000035762787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.2741999924182892}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/jgo-2026-0468","doi":"https://doi.org/10.21037/jgo-2026-0468","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0468","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740528","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740528/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740528/pdf/jgo-17-5-297.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:42996844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jgo-2026-0468","doi":"https://doi.org/10.21037/jgo-2026-0468","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0468","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320312570","display_name":"Jazz Pharmaceuticals","ror":"https://ror.org/055mhsv54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223297974.pdf","grobid_xml":"https://content.openalex.org/works/W7223297974.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1603105736","https://openalex.org/W2019607817","https://openalex.org/W2029409133","https://openalex.org/W2130862071","https://openalex.org/W2532380331","https://openalex.org/W2739132742","https://openalex.org/W2794157907","https://openalex.org/W2890750408","https://openalex.org/W2900129760","https://openalex.org/W2905299787","https://openalex.org/W2947826965","https://openalex.org/W3013383466","https://openalex.org/W3014713533","https://openalex.org/W3167245086","https://openalex.org/W3199788287","https://openalex.org/W3206428600","https://openalex.org/W4200332430","https://openalex.org/W4205409567","https://openalex.org/W4223510971","https://openalex.org/W4293375172","https://openalex.org/W4293697317","https://openalex.org/W4307553136","https://openalex.org/W4385296543","https://openalex.org/W4386815932","https://openalex.org/W4388078138","https://openalex.org/W4391943898","https://openalex.org/W4404254474","https://openalex.org/W4404784379","https://openalex.org/W4410947809","https://openalex.org/W4411988258","https://openalex.org/W4414269980"],"related_works":["https://openalex.org/W7154754516","https://openalex.org/W4387812156","https://openalex.org/W4234891216","https://openalex.org/W2515256178","https://openalex.org/W1981146581","https://openalex.org/W7017690156","https://openalex.org/W4256542193","https://openalex.org/W2051030007","https://openalex.org/W2188208797","https://openalex.org/W2056158730"],"abstract_inverted_index":{"Background:":[0],"Over":[1],"17%":[2],"of":[3,113,145,153,169,203,340,355,368,381,396],"gastrointestinal":[4],"(GI)":[5],"malignancies":[6,121,345],"involve":[7],"deficient":[8],"DNA":[9,73,86],"damage":[10,87],"repair":[11],"(DDR)":[12],"mechanisms":[13],"that":[14,41,388],"have":[15],"poor":[16],"outcomes":[17,200],"on":[18,59,127,139,166,363],"standard":[19],"chemotherapy":[20],"but":[21],"are":[22],"sensitive":[23],"to":[24,188],"targeted":[25],"therapies":[26],"like":[27],"immune":[28],"checkpoint":[29],"inhibitors":[30],"and":[31,81,89,134,143,148,150,214,248,261,272,288,293,308,312,315,322,331,387],"poly":[32],"(ADP-ribose)":[33],"polymerase":[34],"inhibitors.":[35],"Lurbinectedin":[36],"is":[37,371],"an":[38],"alkylating":[39],"agent":[40,365],"demonstrated":[42],"a":[43],"35.2%":[44],"overall":[45,211],"response":[46],"rate":[47],"(ORR)":[48],"as":[49,357],"second-line":[50],"therapy":[51,244],"in":[52,68,91,103,116,193,252],"small-cell":[53],"lung":[54],"cancer":[55],"patients":[56,117,326],"who":[57,122],"progressed":[58],"platinum-based":[60],"chemotherapies.":[61],"The":[62,182,276,298],"drug":[63],"inhibits":[64],"DDR,":[65],"promoting":[66],"apoptosis":[67],"tumor":[69,93,205],"cells":[70],"through":[71],"double-stranded":[72],"breaks":[74],"(DSBs).":[75],"Since":[76],"repair-deficient":[77],"tumors":[78],"cannot":[79],"efficiently":[80],"adequately":[82],"fix":[83],"these":[84],"DSBs,":[85],"accumulates":[88],"results":[90],"enhanced":[92],"killing.":[94],"Therefore,":[95],"lurbinectedin's":[96],"mechanism":[97],"makes":[98],"it":[99],"suitable":[100],"for":[101,224],"use":[102],"cancers":[104,383],"with":[105,118,239,342,346],"DDR":[106,124,250,348],"mutations.":[107,125],"Our":[108],"study":[109,370],"evaluated":[110],"the":[111,189,217,364,369,374,397],"efficacy":[112],"lurbinectedin":[114],"monotherapy":[115],"advanced":[119,343],"GI":[120,344,382],"harbored":[123],"Methods:":[126],"day":[128,151,167],"1":[129,147,152,168,236,307],"every":[130,154,179],"3":[131,330],"weeks.":[132],"Hematology":[133],"chemistry":[135],"labs":[136],"were":[137,164,246,270,274,290,305],"obtained":[138],"days":[140],"1,":[141],"8,":[142],"15":[144],"cycles":[146],"2,":[149],"subsequent":[155],"cycle.":[156,171],"Tumor":[157,172],"markers":[158],"(CA":[159],"19-9":[160],"or":[161],"carcinoembryonic":[162],"antigen)":[163],"collected":[165],"each":[170],"assessment":[173],"via":[174],"imaging":[175],"occurred":[176],"at":[177,240,278],"least":[178,241],"three":[180],"cycles.":[181],"primary":[183],"outcome":[184],"was":[185,266,281,351],"ORR":[186,277],"according":[187],"Response":[190],"Evaluation":[191],"Criteria":[192,223],"Solid":[194],"Tumors":[195],"(RECIST)":[196],"version":[197,228],"1.1.":[198],"Secondary":[199],"included":[201],"duration":[202],"response,":[204],"marker":[206],"normalization,":[207],"progression-free":[208],"survival":[209,212],"(PFS),":[210],"(OS),":[213],"safety":[215],"using":[216],"National":[218],"Cancer":[219],"Institute":[220],"Common":[221],"Terminology":[222],"Adverse":[225],"Events":[226],"(NCI-CTCAE)":[227],"5.0.":[229],"Results:":[230],"Eight":[231],"participants":[232,390],"(7":[233],"pancreatic":[234],"cancer,":[235],"rectal":[237],"cancer)":[238],"two":[242,379],"prior":[243],"lines":[245],"enrolled":[247],"had":[249],"mutations":[251],"ATM":[253],"(25.0%),":[254,258,321],"ARID1A":[255],"(62.5%),":[256],"BRCA1":[257],"CHEK2":[259],"(12.5%),":[260],"FANC":[262],"(12.5%).":[263],"Median":[264,283],"age":[265],"63.5":[267],"years,":[268],"62.5%":[269],"female,":[271],"87.5%":[273],"white.":[275],"12":[279],"weeks":[280],"0%.":[282],"(95%":[284],"confidence":[285],"interval)":[286],"PFS":[287],"OS":[289],"1.2":[291],"(0.7-2.8)":[292],"2.4":[294],"(1.2-4.1)":[295],"months,":[296],"respectively.":[297],"most":[299,389],"common":[300],"related":[301],"adverse":[302],"events":[303],"(AEs)":[304],"grade":[306,316,329],"2":[309,317],"anorexia":[310],"(50.0%)":[311],"constipation":[313],"(25.0%);":[314],"nausea":[318],"(37.5%),":[319],"anemia":[320],"fatigue":[323],"(25.0%).":[324],"Two":[325],"(25.0%)":[327],"experienced":[328,359],"4":[332],"neutropenia":[333],"(1":[334],"each).":[335],"Conclusions:":[336],"In":[337],"this":[338],"trial":[339],"individuals":[341],"known":[347],"mutations,":[349],"there":[350],"no":[352],"clinical":[353],"benefit":[354],"lurbinectedin,":[356],"all":[358],"progressive":[360],"disease":[361],"while":[362],"(NCT05229588).":[366],"Interpretation":[367],"limited":[372],"by":[373],"small":[375],"sample":[376],"size,":[377],"only":[378,392],"types":[380],"represented,":[384],"early":[385],"termination,":[386],"(62.5%)":[391],"completed":[393],"one":[394],"dose":[395],"drug.":[398]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-24T00:00:00"}