{"id":"https://openalex.org/W7223294746","doi":"https://doi.org/10.1182/blood.2026033885","title":"CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist","display_name":"CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223294746","doi":"https://doi.org/10.1182/blood.2026033885","pmid":"https://pubmed.ncbi.nlm.nih.gov/42913488"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2026033885","doi":"https://doi.org/10.1182/blood.2026033885","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026033885","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2026033885/2596851/blood.2026033885.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2026033885/2596851/blood.2026033885.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013565229","display_name":"Kotaro Arita","orcid":"https://orcid.org/0000-0003-2838-5961","observed_orcids":["https://orcid.org/0000-0003-2838-5961"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kotaro Arita","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0003-2838-5961","affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100911907","display_name":"Enyu Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enyu Dai","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016101372","display_name":"Xubin Li","orcid":"https://orcid.org/0000-0003-1727-9215","observed_orcids":["https://orcid.org/0000-0003-1727-9215"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xubin Li","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States","UT MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0003-1727-9215","affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]},{"raw_affiliation_string":"UT MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014091805","display_name":"Irtiza N. Sheikh","orcid":"https://orcid.org/0000-0003-4869-8818","observed_orcids":["https://orcid.org/0000-0003-4869-8818"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irtiza N. Sheikh","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034799610","display_name":"Patrick Kevin Reville","orcid":"https://orcid.org/0000-0001-8433-3360","observed_orcids":["https://orcid.org/0000-0001-8433-3360"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick K Reville","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0001-8433-3360","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038988779","display_name":"Jared M. Henderson","orcid":"https://orcid.org/0000-0002-5121-5234","observed_orcids":["https://orcid.org/0000-0002-5121-5234"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Henderson","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0002-5121-5234","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023585989","display_name":"Ashley Lauren Wilson","orcid":"https://orcid.org/0000-0002-4440-001X","observed_orcids":["https://orcid.org/0000-0002-4440-001X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Lauren Wilson","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008558375","display_name":"C.Q. Dillard-Ilboudo","orcid":"https://orcid.org/0000-0002-4046-6847","observed_orcids":["https://orcid.org/0000-0002-4046-6847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christan Dillard","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0002-4046-6847","affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077971705","display_name":"Kevin Bowman","orcid":"https://orcid.org/0000-0003-4307-6446","observed_orcids":["https://orcid.org/0000-0003-4307-6446"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Bowman","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125130536","display_name":"Haopeng Yang","orcid":"https://orcid.org/0000-0002-3870-2679","observed_orcids":["https://orcid.org/0000-0002-3870-2679"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haopeng Yang","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083650558","display_name":"Fuliang Chu","orcid":"https://orcid.org/0000-0002-1664-5386","observed_orcids":["https://orcid.org/0000-0002-1664-5386"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuliang Chu","raw_affiliation_strings":["UT MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033833794","display_name":"Robert Andrew Harkins","orcid":"https://orcid.org/0000-0003-2231-3940","observed_orcids":["https://orcid.org/0000-0003-2231-3940"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Andrew Harkins","raw_affiliation_strings":["University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0003-2231-3940","affiliations":[{"raw_affiliation_string":"University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058446702","display_name":"Nathan Pate","orcid":"https://orcid.org/0000-0003-0409-4190","observed_orcids":["https://orcid.org/0000-0003-0409-4190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathan Michael Pate","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0003-0409-4190","affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087531691","display_name":"Katie Malley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie Malley","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063202464","display_name":"Dinesh S. Bangari","orcid":"https://orcid.org/0000-0002-9909-1146","observed_orcids":["https://orcid.org/0000-0002-9909-1146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dinesh S Bangari","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0002-9909-1146","affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017312411","display_name":"Estela Rojas","orcid":"https://orcid.org/0009-0006-4878-9815","observed_orcids":["https://orcid.org/0009-0006-4878-9815"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Estela Rojas","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021496101","display_name":"Jason R. Westin","orcid":"https://orcid.org/0000-0002-1824-2337","observed_orcids":["https://orcid.org/0000-0002-1824-2337"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R Westin","raw_affiliation_strings":["The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0002-1824-2337","affiliations":[{"raw_affiliation_string":"The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039574726","display_name":"Sairah Ahmed","orcid":"https://orcid.org/0000-0001-7302-8299","observed_orcids":["https://orcid.org/0000-0001-7302-8299"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sairah Ahmed","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0001-7302-8299","affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064752432","display_name":"Sattva Swarup Neelapu","orcid":"https://orcid.org/0000-0003-1045-4914","observed_orcids":["https://orcid.org/0000-0003-1045-4914"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sattva S. Neelapu","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0003-1045-4914","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006947975","display_name":"Francisco Vega","orcid":"https://orcid.org/0000-0001-5956-452X","observed_orcids":["https://orcid.org/0000-0001-5956-452X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Vega","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0001-5956-452X","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159337373","display_name":"Rui Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159311556","display_name":"Xiangming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangming Li","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States","UT MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]},{"raw_affiliation_string":"UT MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066035608","display_name":"Donald R. Shaffer","orcid":"https://orcid.org/0000-0003-4668-5810","observed_orcids":["https://orcid.org/0000-0003-4668-5810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Shaffer","raw_affiliation_strings":["Sanofi, Cambridge, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0003-4668-5810","affiliations":[{"raw_affiliation_string":"Sanofi, Cambridge, Massachusetts, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182441","display_name":"Linghua Wang","orcid":"https://orcid.org/0000-0001-9380-0266","observed_orcids":["https://orcid.org/0000-0001-9380-0266","https://orcid.org/0000-0003-3117-1390"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linghua Wang","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0001-9380-0266","affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060605798","display_name":"Michael R. Green","orcid":"https://orcid.org/0000-0003-3017-3298","observed_orcids":["https://orcid.org/0000-0003-3017-3298","https://orcid.org/0000-0001-6309-9472"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R Green","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":"https://orcid.org/0000-0001-6309-9472","affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060605798"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7902952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/large-b-cell-lymphoma","display_name":"large B-cell lymphoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.875},{"id":"https://openalex.org/keywords/il-2-signaling","display_name":"IL-2 signaling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cns-relapse","display_name":"central nervous system relapse","score":0.7630000114440918},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cell-line-models","display_name":"cell line models","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5498999953269958},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5141000151634216},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5087000131607056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48190000653266907},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4449999928474426},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.41269999742507935},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.36660000681877136},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.35749998688697815},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.35019999742507935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3476000130176544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3034999966621399},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.30230000615119934},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2962000072002411},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.2809999883174896},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2720000147819519},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.27160000801086426},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.26080000400543213},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.25839999318122864}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.2026033885","doi":"https://doi.org/10.1182/blood.2026033885","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026033885","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2026033885/2596851/blood.2026033885.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},{"id":"pmid:42913488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42913488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.2026033885","doi":"https://doi.org/10.1182/blood.2026033885","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2026033885","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2026033885/2596851/blood.2026033885.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8867410416","display_name":"Multiplexed epigenome engineering to address major CAR T cell barriers","funder_award_id":"RP260118","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306239","display_name":"Conquer Cancer Foundation","ror":"https://ror.org/027327e78"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223294746.pdf","grobid_xml":"https://content.openalex.org/works/W7223294746.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386242240","https://openalex.org/W4362542635","https://openalex.org/W4310125410","https://openalex.org/W4393084616","https://openalex.org/W4387233417","https://openalex.org/W2979075452","https://openalex.org/W4402533817","https://openalex.org/W4417015807","https://openalex.org/W2319520988","https://openalex.org/W2910655165"],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2,200],"T-cell":[3,104,119,204],"(CART19)":[4],"therapy":[5],"represents":[6],"a":[7,45,111,134,139,206],"breakthrough":[8],"for":[9,194],"relapsed":[10],"or":[11],"refractory":[12],"large":[13],"B-cell":[14],"lymphoma":[15],"(rrLBCL).":[16],"However,":[17],"suboptimal":[18],"CART19":[19,56,88,116,157,181,210],"activity":[20],"can":[21],"lead":[22],"to":[23,78,160,180,183],"therapeutic":[24],"failure":[25,94,148],"and":[26,52,70,106,121,147,166],"dismal":[27],"outcomes.":[28],"Through":[29],"single":[30],"cell":[31,68,135],"RNA-sequencing":[32],"of":[33,38,47,55,62,65,87,95,103,178,187,197,209],"tumors":[34],"at":[35],"the":[36,145,152,176,184,195],"time":[37],"progression":[39,141,165],"from":[40,138],"CART19,":[41],"we":[42,82,132],"show":[43,83],"that":[44,58,84,143],"subset":[46],"tumor":[48,67,96,122,142],"contain":[49],"clonally":[50],"expanded":[51],"proliferating":[53],"populations":[54],"cells":[57,89,92],"acquire":[59],"transcriptional":[60],"features":[61,102],"dysfunction,":[63,117],"suggestive":[64],"ongoing":[66],"engagement":[69],"chronic":[71],"stimulation.":[72],"Using":[73],"an":[74],"in":[75,124,130,151,172,202],"vitro":[76],"system":[77,170],"model":[79,137],"this":[80,128,173],"process,":[81],"iterative":[85],"rechallenge":[86],"with":[90,99],"target":[91],"drives":[93],"control":[97,123],"associated":[98],"acquired":[100],"transcriptomic":[101],"dysfunction":[105],"reduced":[107],"IL2":[108,199],"signaling.":[109],"Pegenzileukin,":[110],"non-alpha":[112,198],"IL2-receptor":[113],"agonist,":[114],"prevented":[115],"improving":[118],"expansion":[120],"vitro.":[125],"To":[126],"test":[127],"concept":[129],"vivo,":[131],"developed":[133],"line":[136],"post-CART19":[140],"reproduces":[144],"response":[146,162],"kinetics":[149],"observed":[150],"originating":[153],"patient.":[154],"In":[155],"vivo":[156],"alone":[158],"led":[159,182],"transient":[161],"followed":[163],"by":[164],"secondary":[167],"central":[168],"nervous":[169],"relapse":[171],"model,":[174],"while":[175],"addition":[177],"pegenzileukin":[179],"complete":[185],"eradication":[186],"tumors.":[188],"This":[189],"provides":[190],"mechanism-informed":[191],"pre-clinical":[192],"rationale":[193],"use":[196],"agonists":[201],"combating":[203],"exhaustion,":[205],"critical":[207],"mechanism":[208],"failure.":[211]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-24T00:00:00"}