{"id":"https://openalex.org/W7223289653","doi":"https://doi.org/10.3389/fneur.2026.1910335","title":"A prognostic inflammation-nutrition reserve index for 180-day functional-survival outcomes after acute ischemic stroke in patients aged 80 years or older","display_name":"A prognostic inflammation-nutrition reserve index for 180-day functional-survival outcomes after acute ischemic stroke in patients aged 80 years or older","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223289653","doi":"https://doi.org/10.3389/fneur.2026.1910335"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1910335","doi":"https://doi.org/10.3389/fneur.2026.1910335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1910335","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1910335/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1910335/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159323417","display_name":"Lianhong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099041","display_name":"Jiujiang First People's Hospital","ror":"https://ror.org/0140x9678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099041"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianhong Zhang","raw_affiliation_strings":["Department of Neurology, Jiujiang First People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Jiujiang First People's Hospital","institution_ids":["https://openalex.org/I4210099041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159306741","display_name":"Jinghua Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099041","display_name":"Jiujiang First People's Hospital","ror":"https://ror.org/0140x9678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099041"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinghua Peng","raw_affiliation_strings":["Department of Neurology, Jiujiang First People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Jiujiang First People's Hospital","institution_ids":["https://openalex.org/I4210099041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5159306741"],"corresponding_institution_ids":["https://openalex.org/I4210099041"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79018117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.4844000041484833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.4844000041484833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.4691999852657318,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.921999990940094},{"id":"https://openalex.org/keywords/c-reactive-protein-albumin-ratio","display_name":"C-reactive protein to albumin ratio","score":0.8180000185966492},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-index","display_name":"systemic inflammation response index","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prognostic-nutritional-index","display_name":"prognostic nutritional index","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.34599998593330383},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.8889999985694885},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6039999723434448},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6179999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7480000257492065},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dependence","display_name":"dependency","score":0.4009999930858612},{"id":"https://openalex.org/keywords/optimism-correction","display_name":"optimism correction","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9315999746322632},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.8059999942779541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5666000247001648},{"id":"https://openalex.org/C2991681754","wikidata":"https://www.wikidata.org/wiki/Q2273097","display_name":"Barthel index","level":3,"score":0.5299000144004822},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.515500009059906},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46720001101493835},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.41830000281333923},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4077000021934509},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.3625999987125397},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3212999999523163},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29809999465942383},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C2779915747","wikidata":"https://www.wikidata.org/wiki/Q17058619","display_name":"Inverse probability weighting","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.27129998803138733},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fneur.2026.1910335","doi":"https://doi.org/10.3389/fneur.2026.1910335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1910335","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1910335/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:51747e568d62400e9fda27d34c4c1193","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/51747e568d62400e9fda27d34c4c1193","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1910335","doi":"https://doi.org/10.3389/fneur.2026.1910335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1910335","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1910335/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223289653.pdf","grobid_xml":"https://content.openalex.org/works/W7223289653.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2020074777","https://openalex.org/W2080504768","https://openalex.org/W2110065044","https://openalex.org/W2115098571","https://openalex.org/W2150130690","https://openalex.org/W2756752218","https://openalex.org/W2896185502","https://openalex.org/W2977262858","https://openalex.org/W3012413426","https://openalex.org/W4214637352","https://openalex.org/W4220745026","https://openalex.org/W4292229870","https://openalex.org/W4296736555","https://openalex.org/W4321088343","https://openalex.org/W4384932649","https://openalex.org/W4390508072","https://openalex.org/W4392900137","https://openalex.org/W4394857110","https://openalex.org/W4396889337","https://openalex.org/W4401455568","https://openalex.org/W4402643366","https://openalex.org/W4403400227","https://openalex.org/W4403659822","https://openalex.org/W4405078499","https://openalex.org/W4406163160","https://openalex.org/W4407048032","https://openalex.org/W4411871863","https://openalex.org/W7171358944"],"related_works":["https://openalex.org/W7159654977","https://openalex.org/W7167636405","https://openalex.org/W4412202132","https://openalex.org/W4406506340","https://openalex.org/W7140118796","https://openalex.org/W4414429098","https://openalex.org/W4384501644","https://openalex.org/W4390796603","https://openalex.org/W135391225","https://openalex.org/W4387056663"],"abstract_inverted_index":{"Background":[0],"Patients":[1],"aged":[2],"80":[3],"years":[4],"or":[5,100,125],"older":[6],"with":[7,33,49,135,181,242],"acute":[8],"ischemic":[9],"stroke":[10],"(AIS)":[11],"have":[12],"heterogeneous":[13],"functional-survival":[14],"outcomes":[15],"despite":[16],"similar":[17],"clinical":[18,84,145,256],"severity.":[19],"We":[20],"evaluated":[21],"whether":[22],"a":[23,136,182,243],"routine":[24],"laboratory-derived":[25],"Prognostic":[26],"Inflammation-Nutrition":[27],"Reserve":[28],"Index":[29],"(PINRI)":[30],"was":[31,86,91,133,167],"associated":[32,134,180,241],"the":[34,68,75,78,162,201,255],"180-day":[35,92,245],"ordinal":[36],"functional":[37,138,246],"survival":[38,139,247],"state.":[39],"Methods":[40],"This":[41],"single-center":[42],"cohort":[43],"study":[44],"screened":[45],"consecutive":[46],"patients":[47],"admitted":[48],"suspected":[50],"AIS":[51],"from":[52,207,224],"January":[53],"2021":[54],"through":[55],"December":[56],"2024.":[57],"Admission":[58],"PINRI":[59,132,177,199,225,235,238],"combined":[60],"an":[61],"internally":[62,202],"standardized":[63],"logarithmic":[64,69],"C-reactive":[65],"protein-to-albumin":[66],"ratio,":[67],"systemic":[70],"inflammatory":[71],"response":[72],"index,":[73],"and":[74,117,236,249,260],"inverse":[76],"of":[77],"prognostic":[79],"nutritional":[80],"index;":[81],"no":[82],"transportable":[83],"threshold":[85],"proposed.":[87],"The":[88,159,175],"primary":[89],"outcome":[90,184],"modified":[93],"Rankin":[94],"Scale":[95],"(mRS)":[96],"0\u20132,":[97,111],"mRS":[98,110,115],"3\u20135,":[99,116],"death.":[101,126],"Results":[102],"Among":[103],"278":[104],"analyzable":[105],"patients,":[106],"111":[107],"(39.9%)":[108],"achieved":[109],"114":[112],"(41.0%)":[113],"had":[114],"53":[118],"(19.1%)":[119],"died;":[120],"167":[121],"(60.1%)":[122],"experienced":[123],"dependency":[124],"Each":[127],"1-SD":[128],"increase":[129],"in":[130],"admission":[131,234],"worse":[137,183,244],"state":[140,248],"after":[141,226],"adjusting":[142],"for":[143,161,205],"selected":[144],"covariates":[146],"(adjusted":[147],"common":[148],"odds":[149],"ratio":[150],"[aOR],":[151],"1.98;":[152],"95%":[153,192],"CI,":[154,170,193],"1.48\u20132.65;":[155],"p":[156,172,195,213],"<":[157,173],"0.001).":[158,174],"aOR":[160],"highest":[163],"versus":[164],"lowest":[165],"tertile":[166],"3.43":[168],"(95%":[169],"1.74\u20136.74;":[171],"first-week":[176,237],"burden":[178,239],"remained":[179],"among":[185],"241":[186],"day-7":[187],"landmark":[188],"survivors":[189],"(aOR,":[190],"1.80;":[191],"1.19\u20132.72;":[194],"=":[196,214],"0.005).":[197],"Adding":[198],"improved":[200],"optimism-corrected":[203],"C-statistic":[204],"dependency/death":[206],"0.810":[208],"to":[209],"0.834":[210],"(difference,":[211],"0.024;":[212],"0.033).":[215],"Comparator":[216],"single-marker":[217],"C-statistics":[218],"were":[219,240],"0.821\u20130.825;":[220],"none":[221],"differed":[222],"significantly":[223],"false":[227],"discovery":[228],"rate":[229],"(FDR)":[230],"control.":[231],"Conclusion":[232],"Higher":[233],"provided":[250],"modest":[251],"incremental":[252],"information":[253],"beyond":[254],"model.":[257],"Multicenter":[258],"validation":[259],"local":[261],"calibration":[262],"are":[263],"required":[264],"before":[265],"implementation.":[266]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-24T00:00:00"}