{"id":"https://openalex.org/W7223281985","doi":"https://doi.org/10.64898/2026.10.22.760865","title":"Targeted Engineering of Human MxA Yields a Broad-Spectrum Super-Restrictor of Human-Adapted Influenza Viruses","display_name":"Targeted Engineering of Human MxA Yields a Broad-Spectrum Super-Restrictor of Human-Adapted Influenza Viruses","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223281985","doi":"https://doi.org/10.64898/2026.10.22.760865","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996123","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13738725"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.22.760865","doi":"https://doi.org/10.64898/2026.10.22.760865","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760865","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760865.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760865.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104299154","display_name":"Megan E. Levy","orcid":"https://orcid.org/0009-0006-9059-0543","observed_orcids":["https://orcid.org/0009-0006-9059-0543"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan E. Levy","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA","Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":"https://orcid.org/0009-0006-9059-0543","affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053275196","display_name":"Rechel Geiger","orcid":"https://orcid.org/0000-0001-7748-9367","observed_orcids":["https://orcid.org/0000-0001-7748-9367"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rechel A. Geiger","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA","Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":"https://orcid.org/0000-0001-7748-9367","affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159362826","display_name":"Luc America Chi","orcid":"https://orcid.org/0000-0002-2606-0357","observed_orcids":["https://orcid.org/0000-0002-2606-0357"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Am\u00e9rica Chi","raw_affiliation_strings":["Department of Chemical & Biological Engineering, University of Idaho, Moscow, ID 83844, USA"],"raw_orcid":"https://orcid.org/0000-0002-2606-0357","affiliations":[{"raw_affiliation_string":"Department of Chemical & Biological Engineering, University of Idaho, Moscow, ID 83844, USA","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054842500","display_name":"Peter A. Dietzen","orcid":"https://orcid.org/0000-0002-4955-8713","observed_orcids":["https://orcid.org/0000-0002-4955-8713"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Dietzen","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":"https://orcid.org/0000-0002-4955-8713","affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052962791","display_name":"Valentina Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentina Wagner","raw_affiliation_strings":["Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany","Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051442994","display_name":"Michael Emerman","orcid":"https://orcid.org/0000-0002-4181-6335","observed_orcids":["https://orcid.org/0000-0002-4181-6335"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Emerman","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA"],"raw_orcid":"https://orcid.org/0000-0002-4181-6335","affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048016615","display_name":"Jagdish Suresh Patel","orcid":"https://orcid.org/0000-0003-4999-5347","observed_orcids":["https://orcid.org/0000-0003-4999-5347"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jagdish Suresh Patel","raw_affiliation_strings":["Department of Chemical & Biological Engineering, University of Idaho, Moscow, ID 83844, USA","Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID, USA"],"raw_orcid":"https://orcid.org/0000-0003-4999-5347","affiliations":[{"raw_affiliation_string":"Department of Chemical & Biological Engineering, University of Idaho, Moscow, ID 83844, USA","institution_ids":["https://openalex.org/I155093810"]},{"raw_affiliation_string":"Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID, USA","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101798073","display_name":"Laura Graf","orcid":"https://orcid.org/0000-0002-5890-4147","observed_orcids":["https://orcid.org/0000-0002-5890-4147"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Graf","raw_affiliation_strings":["Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany","Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5890-4147","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038631849","display_name":"Harmit Singh Malik","orcid":"https://orcid.org/0000-0001-6005-0016","observed_orcids":["https://orcid.org/0000-0001-6005-0016"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harmit S. Malik","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","Howard Hughes Medical Institute, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA"],"raw_orcid":"https://orcid.org/0000-0001-6005-0016","affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5038631849"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210089486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mxa","display_name":"MxA","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mx1","display_name":"MX1","score":0.7129999995231628},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.5429999828338623},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.5600000023841858},{"id":"https://openalex.org/keywords/broad-spectrum-antiviral-activity","display_name":"broad-spectrum antiviral activity","score":0.800000011920929},{"id":"https://openalex.org/keywords/orthomyxovirus","display_name":"orthomyxoviruses","score":0.8809999823570251},{"id":"https://openalex.org/keywords/h5n1","display_name":"H5N1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/h7n9","display_name":"H7N9","score":0.9459999799728394},{"id":"https://openalex.org/keywords/2009-h1n1","display_name":"2009 H1N1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/h3n2","display_name":"H3N2","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.7415000200271606},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6908000111579895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6014000177383423},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5785999894142151},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5760999917984009},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5504999756813049},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.38769999146461487},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.3750999867916107},{"id":"https://openalex.org/C3018061469","wikidata":"https://www.wikidata.org/wiki/Q2723958","display_name":"Pandemic influenza","level":5,"score":0.3650999963283539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3345000147819519},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.3075999915599823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3046000003814697},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.2906000018119812},{"id":"https://openalex.org/C82988372","wikidata":"https://www.wikidata.org/wiki/Q5628866","display_name":"H5N1 genetic structure","level":5,"score":0.26919999718666077},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.25429999828338623},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.22.760865","doi":"https://doi.org/10.64898/2026.10.22.760865","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760865","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760865.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738725","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738725/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738725/pdf/nihpp-2026.10.22.760865v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42996123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.22.760865","doi":"https://doi.org/10.64898/2026.10.22.760865","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760865","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760865.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1305388156","display_name":null,"funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320308793","funder_display_name":"Fred Hutchinson Cancer Research Center"},{"id":"https://openalex.org/G1713994812","display_name":null,"funder_award_id":"P30 CA015704","funder_id":"https://openalex.org/F4320310094","funder_display_name":"University of Washington"},{"id":"https://openalex.org/G4762835624","display_name":"SFB 1160: Immunpathologie aufgrund eingeschr\u00e4nkter Immunreaktionen (IMPATH)","funder_award_id":"256073931","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5383589093","display_name":null,"funder_award_id":"P30 CA015704","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5491674030","display_name":null,"funder_award_id":"SCR_022606","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G735672719","display_name":null,"funder_award_id":"CRC 1160","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000880123","display_name":"HARC: HIV accessory and regulatory complexes","funder_award_id":"U54AI170792","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000880613","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308793","display_name":"Fred Hutchinson Cancer Research Center","ror":"https://ror.org/007ps6h72"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223281985.pdf","grobid_xml":"https://content.openalex.org/works/W7223281985.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W65101360","https://openalex.org/W1231876666","https://openalex.org/W1525096919","https://openalex.org/W1756712554","https://openalex.org/W1942718106","https://openalex.org/W1965849042","https://openalex.org/W1974784632","https://openalex.org/W1976989737","https://openalex.org/W1978743770","https://openalex.org/W1998800643","https://openalex.org/W1998938204","https://openalex.org/W2012077687","https://openalex.org/W2026219049","https://openalex.org/W2042839660","https://openalex.org/W2045337113","https://openalex.org/W2057836579","https://openalex.org/W2068353535","https://openalex.org/W2080722894","https://openalex.org/W2082314789","https://openalex.org/W2099781711","https://openalex.org/W2100848755","https://openalex.org/W2115112580","https://openalex.org/W2121009566","https://openalex.org/W2138468602","https://openalex.org/W2148429348","https://openalex.org/W2158374311","https://openalex.org/W2164489181","https://openalex.org/W2164655171","https://openalex.org/W2169382411","https://openalex.org/W2169886642","https://openalex.org/W2282909188","https://openalex.org/W2607207548","https://openalex.org/W2621065682","https://openalex.org/W2978782758","https://openalex.org/W3087625651","https://openalex.org/W3098464428","https://openalex.org/W3195396924","https://openalex.org/W4383340354","https://openalex.org/W4400978321","https://openalex.org/W4410026860"],"related_works":["https://openalex.org/W4405279345","https://openalex.org/W7098626997","https://openalex.org/W2169886642","https://openalex.org/W251993244","https://openalex.org/W7099423469","https://openalex.org/W2317891279","https://openalex.org/W2045337113","https://openalex.org/W6940013878","https://openalex.org/W2949621754","https://openalex.org/W2931290528"],"abstract_inverted_index":{"ABSTRACT":[0],"Human":[1],"myxovirus":[2],"resistance":[3],"protein":[4],"A":[5],"(hMxA)":[6],"prevents":[7],"spillover":[8],"of":[9,49,111,138],"influenza":[10,16,40,142],"viruses":[11],"into":[12],"humans.":[13],"Human-adapted":[14],"pandemic":[15],"strains":[17],"carry":[18],"nucleoprotein":[19],"mutations":[20],"to":[21,27,35,56],"evade":[22],"hMxA":[23,34,50,61,74,82,116],"but":[24,96],"remain":[25],"susceptible":[26],"murine":[28],"Mx1":[29],"(mMx1).":[30],"Here,":[31],"we":[32],"engineered":[33],"restrict":[36],"human-adapted":[37],"1918":[38,94],"H1N1":[39,95],"virus":[41],"as":[42,44],"effectively":[43],"mMx1.":[45],"Neither":[46],"combinatorial":[47],"mutagenesis":[48],"loop":[51],"L4":[52,86],"residues,":[53],"previously":[54],"shown":[55],"alter":[57],"antiviral":[58,124],"potency,":[59],"nor":[60],"nuclear":[62,81,132],"relocalization":[63],"could":[64],"achieve":[65],"mMx1":[66,78],"restriction":[67,137],"potency.":[68],"However,":[69],"combining":[70],"both":[71],"strategies":[72],"yielded":[73],"variants":[75],"that":[76],"exceeded":[77],"restriction.":[79],"Indeed,":[80],"with":[83,108,122],"just":[84],"two":[85],"basic":[87],"residue":[88],"changes":[89],"potently":[90],"restricted":[91],"not":[92],"only":[93],"also":[97],"H5N1,":[98],"H7N9,":[99],"2009":[100],"H1N1,":[101],"H3N2,":[102],"and":[103,131],"the":[104],"distantly":[105],"related":[106],"Thogotovirus,":[107],"no":[109],"loss":[110],"breadth.":[112],"Thus,":[113],"modestly":[114],"re-engineered":[115],"restricts":[117],"diverse,":[118],"highly":[119],"pathogenic":[120],"orthomyxoviruses,":[121],"broad":[123],"potential.":[125],"(125)":[126],"One-sentence":[127],"summary":[128],"Basic":[129],"substitutions":[130],"localization":[133],"restore":[134],"potent":[135],"MxA":[136],"multiple":[139],"independently":[140],"escaped":[141],"viruses.":[143]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-24T00:00:00"}
