{"id":"https://openalex.org/W7223276279","doi":"https://doi.org/10.1007/s00415-026-14214-0","title":"Emotion regulation difficulties are selectively associated with executive and behavioural apathy in Huntington\u2019s disease","display_name":"Emotion regulation difficulties are selectively associated with executive and behavioural apathy in Huntington\u2019s disease","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223276279","doi":"https://doi.org/10.1007/s00415-026-14214-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13694373"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-026-14214-0","doi":"https://doi.org/10.1007/s00415-026-14214-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-14214-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-14214-0.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-14214-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108750743","display_name":"Emilie Poulsen","orcid":"https://orcid.org/0009-0000-7517-2921","observed_orcids":["https://orcid.org/0009-0000-7517-2921"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Emilie Poulsen","raw_affiliation_strings":["Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. emilie.najbjerg.birkebaek.poulsen@regionh.dk","Department of Psychology, University of Copenhagen, Copenhagen, Denmark. emilie.najbjerg.birkebaek.poulsen@regionh.dk"],"raw_orcid":"https://orcid.org/0009-0000-7517-2921","affiliations":[{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. emilie.najbjerg.birkebaek.poulsen@regionh.dk","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark. emilie.najbjerg.birkebaek.poulsen@regionh.dk","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088991069","display_name":"Birna \u00c1sbj\u00f6rnsd\u00f3ttir","orcid":"https://orcid.org/0000-0003-4481-1203","observed_orcids":["https://orcid.org/0000-0003-4481-1203"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birna \u00c1sbj\u00f6rnsd\u00f3ttir","raw_affiliation_strings":["Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110420648","display_name":"Lena E. Hjermind","orcid":"https://orcid.org/0009-0005-3517-3299","observed_orcids":["https://orcid.org/0009-0005-3517-3299"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lena E. Hjermind","raw_affiliation_strings":["Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159302303","display_name":"J\u00f8rgen E. Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J\u00f8rgen E. Nielsen","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058459881","display_name":"Asmus Vogel","orcid":"https://orcid.org/0000-0002-3401-1061","observed_orcids":["https://orcid.org/0000-0002-3401-1061"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Asmus Vogel","raw_affiliation_strings":["Department of Clinical Genetics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","Department of Psychology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108750743"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802567020","https://openalex.org/I2802709434"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70616744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"273","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apathy","display_name":"apathy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/self-regulation","display_name":"self-regulation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.6610000133514404},{"id":"https://openalex.org/keywords/premanifest-huntington-s-disease","display_name":"premanifest Huntington's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gene-expansion-carriers","display_name":"gene expansion carriers","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2776509080","wikidata":"https://www.wikidata.org/wiki/Q309406","display_name":"Apathy","level":3,"score":0.9936000108718872},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7232000231742859},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5498999953269958},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5370000004768372},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4690000116825104},{"id":"https://openalex.org/C2779985164","wikidata":"https://www.wikidata.org/wiki/Q5419936","display_name":"Executive dysfunction","level":4,"score":0.44780001044273376},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4397999942302704},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.4090000092983246},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.39010000228881836},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3725000023841858},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C2776376825","wikidata":"https://www.wikidata.org/wiki/Q5141187","display_name":"Cognitive reappraisal","level":3,"score":0.313400000333786},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.31049999594688416},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C53059260","wikidata":"https://www.wikidata.org/wiki/Q374758","display_name":"Multilevel model","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C86658582","wikidata":"https://www.wikidata.org/wiki/Q1432778","display_name":"Social cognition","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2778119494","wikidata":"https://www.wikidata.org/wiki/Q5141187","display_name":"Cognitive appraisal","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.25220000743865967}],"mesh":[{"descriptor_ui":"D000080103","descriptor_name":"Emotional Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056344","descriptor_name":"Executive Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057565","descriptor_name":"Apathy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00415-026-14214-0","doi":"https://doi.org/10.1007/s00415-026-14214-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-14214-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-14214-0.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13694373","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13694373/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13694373/pdf/415_2026_Article_14214.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol","raw_type":"Text"},{"id":"pmid:42909626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00415-026-14214-0","doi":"https://doi.org/10.1007/s00415-026-14214-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-14214-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-14214-0.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3959160184","display_name":null,"funder_award_id":"R389-2021-1596","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223276279.pdf","grobid_xml":"https://content.openalex.org/works/W7223276279.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1847168837","https://openalex.org/W1896861112","https://openalex.org/W1982437215","https://openalex.org/W1983067887","https://openalex.org/W1995485235","https://openalex.org/W2003220763","https://openalex.org/W2010202486","https://openalex.org/W2010573720","https://openalex.org/W2015683499","https://openalex.org/W2017039362","https://openalex.org/W2047546856","https://openalex.org/W2052137044","https://openalex.org/W2069494943","https://openalex.org/W2074503869","https://openalex.org/W2078320135","https://openalex.org/W2096423181","https://openalex.org/W2098906249","https://openalex.org/W2102748276","https://openalex.org/W2114613490","https://openalex.org/W2125360737","https://openalex.org/W2127093942","https://openalex.org/W2142209350","https://openalex.org/W2152264416","https://openalex.org/W2158359335","https://openalex.org/W2165758561","https://openalex.org/W2460296584","https://openalex.org/W2472775700","https://openalex.org/W2589856099","https://openalex.org/W2600431307","https://openalex.org/W2606710341","https://openalex.org/W2742995083","https://openalex.org/W2787030495","https://openalex.org/W2792868449","https://openalex.org/W2800718150","https://openalex.org/W2899016028","https://openalex.org/W2990110184","https://openalex.org/W3016630399","https://openalex.org/W3021258670","https://openalex.org/W3024401387","https://openalex.org/W3061825730","https://openalex.org/W3120146753","https://openalex.org/W3134239080","https://openalex.org/W3187788036","https://openalex.org/W3196505949","https://openalex.org/W3202834366","https://openalex.org/W3216270801","https://openalex.org/W4200427335","https://openalex.org/W4211081781","https://openalex.org/W4211110682","https://openalex.org/W4225268748","https://openalex.org/W4247326763","https://openalex.org/W4280566567","https://openalex.org/W4296711773","https://openalex.org/W4307724415","https://openalex.org/W4319262254","https://openalex.org/W4393182801","https://openalex.org/W4402997927","https://openalex.org/W4408861545","https://openalex.org/W4410973539","https://openalex.org/W4413051151","https://openalex.org/W4414206265","https://openalex.org/W7128168541","https://openalex.org/W7131248428","https://openalex.org/W7155080536","https://openalex.org/W7169590970"],"related_works":["https://openalex.org/W3198799924","https://openalex.org/W4300689552","https://openalex.org/W7223144592","https://openalex.org/W7222980480","https://openalex.org/W7169590970","https://openalex.org/W3120146753","https://openalex.org/W4402997927","https://openalex.org/W7155080536","https://openalex.org/W4205794962","https://openalex.org/W2283748141"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Apathy":[1,95,100],"occurs":[2],"frequently":[3],"in":[4,90,166,191],"psychiatric":[5],"and":[6,9,19,36,77,98,109,128,144,157,187,206,213,235,249],"neurological":[7],"disorders":[8],"is":[10,34],"associated":[11,74,140,202],"with":[12,75,114,141,203,211],"functional":[13],"impairment,":[14],"reduced":[15],"quality":[16],"of":[17,164,217,233,239],"life,":[18],"caregiver":[20],"burden.":[21],"Its":[22],"underlying":[23,247],"mechanisms":[24,248],"are":[25,73],"incompletely":[26],"understood,":[27],"but":[28,53,147,193],"recent":[29],"studies":[30],"indicate":[31],"that":[32,223],"apathy":[33,159,172,186,205,234,242],"multidimensional":[35,78],"has":[37,56],"heterogeneous":[38,231],"manifestations":[39,232],"across":[40],"disorders.":[41],"Self-regulatory":[42],"processes,":[43],"such":[44],"as":[45],"emotion":[46,70,125,136,167,188],"regulation,":[47],"may":[48,226],"contribute":[49],"to":[50,229],"these":[51],"manifestations,":[52],"this":[54],"relationship":[55],"received":[57],"little":[58],"attention.":[59],"Huntington's":[60],"disease":[61],"(HD)":[62],"provides":[63],"a":[64],"clinical":[65],"model":[66],"for":[67,131,153],"examining":[68,240],"whether":[69],"regulation":[71,126,137,168,189,199],"difficulties":[72,127,138,190,200],"global":[76,171,204],"apathy.":[79,150],"METHODS:":[80],"Eighty-nine":[81],"HD":[82],"gene":[83],"expansion":[84],"carriers":[85],"(HDGECs)":[86],"completed":[87],"the":[88,105,115,208,230,237],"Difficulties":[89],"Emotion":[91,198],"Regulation":[92],"Scale,":[93,97],"Lille":[94],"Rating":[96,118],"Dimensional":[99],"Scale.":[101,119],"Cognitive":[102,107],"screening":[103],"included":[104],"Montreal":[106],"Assessment":[108],"depressive":[110,132,154,218],"symptoms":[111],"were":[112,139,201],"assessed":[113],"Hamilton":[116],"Depression":[117],"Hierarchical":[120],"regressions":[121],"examined":[122],"associations":[123,210],"between":[124,184],"apathy,":[129,146,215],"adjusting":[130],"symptoms.":[133,219],"RESULTS:":[134],"Greater":[135],"global,":[142],"Executive,":[143],"Behaviour/Initiation":[145,158,214],"not":[148,194],"Emotional":[149],"After":[151],"accounting":[152],"symptoms,":[155],"Executive":[156,185,212],"explained":[160,173],"an":[161,174,181],"additional":[162,175],"24.2%":[163],"variance":[165],"difficulties,":[169],"whereas":[170],"5.8%.":[176],"Exploratory":[177],"subgroup":[178],"analyses":[179],"found":[180],"independent":[182,216],"association":[183],"premanifest":[192],"manifest":[195],"HDGECs.":[196],"CONCLUSIONS:":[197],"showed":[207],"strongest":[209],"These":[220],"findings":[221],"suggest":[222],"self-regulatory":[224],"processes":[225],"be":[227],"relevant":[228],"highlight":[236],"importance":[238],"specific":[241],"dimensions":[243],"when":[244],"investigating":[245],"its":[246],"informing":[250],"potential":[251],"treatment":[252],"approaches.":[253]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}
