{"id":"https://openalex.org/W7223267430","doi":"https://doi.org/10.1016/j.ctro.2026.101334","title":"FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia","display_name":"FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223267430","doi":"https://doi.org/10.1016/j.ctro.2026.101334","pmid":"https://pubmed.ncbi.nlm.nih.gov/42244584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13232302"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctro.2026.101334","doi":"https://doi.org/10.1016/j.ctro.2026.101334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2026.101334","pdf_url":"https://www.ctro.science/article/S2405-6308(26)00229-6/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ctro.science/article/S2405-6308(26)00229-6/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052709874","display_name":"Phoebe E. Loo","orcid":"https://orcid.org/0009-0000-5603-4056","observed_orcids":["https://orcid.org/0009-0000-5603-4056"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phoebe Loo","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132863719","display_name":"Margaret Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Pan","raw_affiliation_strings":["Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159308678","display_name":"Man Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Man Zhao","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032293589","display_name":"Stavros Melemenidis","orcid":"https://orcid.org/0000-0002-3941-8784","observed_orcids":["https://orcid.org/0000-0002-3941-8784"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stavros Melemenidis","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038715824","display_name":"Joseph B. Schulz","orcid":"https://orcid.org/0000-0003-3005-6585","observed_orcids":["https://orcid.org/0000-0003-3005-6585"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph B. Schulz","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159310089","display_name":"Dixin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dixin Chen","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048678913","display_name":"Lucy Whitmore","orcid":"https://orcid.org/0000-0002-7079-7073","observed_orcids":["https://orcid.org/0000-0002-7079-7073"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Whitmore","raw_affiliation_strings":["Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051378632","display_name":"Sara A. Richter","orcid":"https://orcid.org/0000-0003-1643-691X","observed_orcids":["https://orcid.org/0000-0003-1643-691X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Richter","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029016301","display_name":"Frederick M. Dirbas","orcid":"https://orcid.org/0000-0003-3576-6404","observed_orcids":["https://orcid.org/0000-0003-3576-6404"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick M. Dirbas","raw_affiliation_strings":["Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072806273","display_name":"Kerriann M. Casey","orcid":"https://orcid.org/0000-0003-4228-928X","observed_orcids":["https://orcid.org/0000-0003-4228-928X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerriann M. Casey","raw_affiliation_strings":["Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159307436","display_name":"Edward E. Graves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward E. Graves","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110681586","display_name":"Michael W. Epperly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Epperly","raw_affiliation_strings":["Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112817468","display_name":"Joel S. Greenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Greenberger","raw_affiliation_strings":["Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016420174","display_name":"Billy W. Loo","orcid":"https://orcid.org/0000-0002-2521-0544","observed_orcids":["https://orcid.org/0000-0002-2521-0544"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Billy W. Loo","raw_affiliation_strings":["Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014755259","display_name":"Erinn B. Rankin","orcid":"https://orcid.org/0000-0002-2045-2296","observed_orcids":["https://orcid.org/0000-0002-2045-2296"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erinn B. Rankin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014755259","https://openalex.org/A5016420174"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"],"apc_list":{"value":2430,"currency":"USD","value_usd":2430},"apc_paid":{"value":2430,"currency":"USD","value_usd":2430},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77635855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":null,"first_page":"101334","last_page":"101334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.10589999705553055,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flash-radiotherapy","display_name":"FLASH radiotherapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7490000128746033},{"id":"https://openalex.org/keywords/normal-tissue-sparing","display_name":"normal tissue sparing","score":0.5879999995231628},{"id":"https://openalex.org/keywords/electron-beam-therapy","display_name":"electron beam therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5989999771118164},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.847000002861023},{"id":"https://openalex.org/keywords/tongue-ulcer","display_name":"tongue ulcer","score":0.6119999885559082},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8626000285148621},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.7825999855995178},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.6837999820709229},{"id":"https://openalex.org/C2777526259","wikidata":"https://www.wikidata.org/wiki/Q221836","display_name":"Flash (photography)","level":2,"score":0.641700029373169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3831999897956848},{"id":"https://openalex.org/C2778993383","wikidata":"https://www.wikidata.org/wiki/Q17927056","display_name":"FANCA","level":5,"score":0.34599998593330383},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31130000948905945},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C2779179668","wikidata":"https://www.wikidata.org/wiki/Q7193408","display_name":"Pigmentation disorder","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2563999891281128},{"id":"https://openalex.org/C2779950389","wikidata":"https://www.wikidata.org/wiki/Q4746440","display_name":"Aminoaciduria","level":3,"score":0.2554999887943268}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1016/j.ctro.2026.101334","doi":"https://doi.org/10.1016/j.ctro.2026.101334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2026.101334","pdf_url":"https://www.ctro.science/article/S2405-6308(26)00229-6/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.7208010","doi":"https://doi.org/10.2139/ssrn.7208010","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7208010","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.64898/2026.05.25.727748","doi":"https://doi.org/10.64898/2026.05.25.727748","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.25.727748","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/28/2026.05.25.727748.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13232302","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13232302/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13232302/pdf/nihpp-2026.05.25.727748v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:13721873","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721873/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721873/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Radiat Oncol","raw_type":"Text"},{"id":"pmid:42244584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42244584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42964716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational radiation oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cbb772d95c5749509bb56389900f9fd4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cbb772d95c5749509bb56389900f9fd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Radiation Oncology, Vol 62, Iss , Pp 101334- (2027)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ctro.2026.101334","doi":"https://doi.org/10.1016/j.ctro.2026.101334","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctro.2026.101334","pdf_url":"https://www.ctro.science/article/S2405-6308(26)00229-6/pdf","source":{"id":"https://openalex.org/S2898297225","display_name":"Clinical and Translational Radiation Oncology","issn_l":"2405-6308","issn":["2405-6308"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2655983247","display_name":"Increasing the therapeutic index of brain tumor treatment through innovative FLASH radiotherapy","funder_award_id":"P01CA244091","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223267430.pdf","grobid_xml":"https://content.openalex.org/works/W7223267430.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1975544004","https://openalex.org/W1991841649","https://openalex.org/W2000067413","https://openalex.org/W2004125597","https://openalex.org/W2011291904","https://openalex.org/W2015805015","https://openalex.org/W2021861978","https://openalex.org/W2025967759","https://openalex.org/W2038739812","https://openalex.org/W2061254282","https://openalex.org/W2066602623","https://openalex.org/W2112146005","https://openalex.org/W2123315833","https://openalex.org/W2147774152","https://openalex.org/W2166957473","https://openalex.org/W2168104423","https://openalex.org/W2274695480","https://openalex.org/W2346731093","https://openalex.org/W2516135243","https://openalex.org/W2619354600","https://openalex.org/W2620329934","https://openalex.org/W2795128393","https://openalex.org/W2805362264","https://openalex.org/W2954064807","https://openalex.org/W2992224702","https://openalex.org/W3082935350","https://openalex.org/W3112195456","https://openalex.org/W4200505889","https://openalex.org/W4213380235","https://openalex.org/W4242109965","https://openalex.org/W4248148231","https://openalex.org/W4281259150","https://openalex.org/W4380681798","https://openalex.org/W4387440799","https://openalex.org/W4394622621","https://openalex.org/W4399701577","https://openalex.org/W4402639139","https://openalex.org/W4414787286"],"related_works":["https://openalex.org/W7148811539","https://openalex.org/W6889552111","https://openalex.org/W2140731277","https://openalex.org/W2279014361","https://openalex.org/W2907974285","https://openalex.org/W2013097340","https://openalex.org/W2346639783","https://openalex.org/W2324935464","https://openalex.org/W2124033286","https://openalex.org/W2972425367"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,36,107,128,142,185,213,218,235,247],"Fanconi":[3,248],"anemia":[4,249],"(FA)":[5],"are":[6],"particularly":[7],"susceptible":[8],"to":[9,20,28,40,65,113,172,195,216],"developing":[10],"squamous":[11],"cell":[12],"carcinoma":[13],"of":[14,76,80,89,134,177,199,245],"the":[15,74,81,167,178,243],"head":[16,82,251],"and":[17,44,83,94,122,130,149,189,237,250,252],"neck":[18,84,253],"due":[19,39],"impaired":[21],"DNA":[22,29],"repair":[23],"pathways.":[24],"However,":[25],"their":[26],"hypersensitivity":[27],"damaging":[30],"agents":[31],"can":[32],"limit":[33],"effective":[34],"treatment":[35,79,244],"standard":[37],"radiotherapy":[38,51,69],"severe":[41],"side":[42],"effects":[43],"complications.":[45],"In":[46],"pre-clinical":[47],"models,":[48],"ultra-rapid":[49],"FLASH":[50,77,110,135,214,236],"(FLASH)":[52],"reduces":[53],"radiation-induced":[54,115],"toxicity":[55,116],"in":[56,85,117,159,191,209,223],"normal":[57,232],"tissues":[58],"while":[59],"maintaining":[60],"similar":[61,220],"tumor":[62],"control":[63],"compared":[64,171,194,215],"conventional":[66],"dose":[67],"rate":[68],"(CONV).":[70],"Here,":[71],"we":[72],"investigated":[73],"safety":[75],"for":[78,242],"a":[86,219,230],"mouse":[87],"model":[88],"FA.":[90],"129/Sv":[91],"wild-type":[92],"(WT)":[93],"Fanca":[95,98,120,123,224],"-deficient":[96],"(":[97],"-/-":[99,124,225],")":[100],"mice":[101,125,211],"received":[102],"single-dose":[103],"oral":[104],"cavity":[105],"irradiation":[106],"electron":[108],"beam":[109],"or":[111,138],"CONV":[112,139],"evaluate":[114],"non-tumor-bearing":[118],"mice.":[119,226],"WT":[121,210],"were":[126],"irradiated":[127],"25":[129],"18":[131],"Gy,":[132],"respectively,":[133],"(190":[136],"Gy/sec)":[137],"(0.2":[140],"Gy/sec),":[141],"tongues":[143,158,193],"harvested":[144],"at":[145,166,203],"12":[146,204],"hours":[147],"(hpi)":[148],"10":[150,155],"days":[151],"(dpi)":[152],"post-irradiation.":[153],"At":[154],"dpi,":[156],"FLASH-irradiated":[157,192],"both":[160],"genetic":[161],"backgrounds":[162],"demonstrated":[163,206],"reduced":[164],"ulceration":[165,190],"dorsal":[168],"tongue":[169,179],"surface":[170],"CONV-irradiated":[173,196],"counterparts.":[174],"Histopathological":[175],"analysis":[176],"revealed":[180],"lower":[181],"mucositis":[182],"severity":[183],"scores":[184],"decreased":[186],"epithelial":[187],"thinning":[188],"ones.":[197],"Analysis":[198],"\u03b3-H2AX":[200],"foci":[201,208],"formation":[202],"hpi":[205],"fewer":[207],"treated":[212],"CONV,":[217],"trend":[221],"observed":[222],"These":[227],"findings":[228],"suggest":[229],"potential":[231],"tissue-sparing":[233],"effect":[234],"hold":[238],"important":[239],"clinical":[240],"implications":[241],"patients":[246],"cancers.":[254]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-24T00:00:00"}