{"id":"https://openalex.org/W7223261272","doi":"https://doi.org/10.64898/2026.10.22.760951","title":"Dysregulated mechanoregulation of load-induced bone adaptation in prematurely aged mice: insights from a micro-multiphysics agent-based model","display_name":"Dysregulated mechanoregulation of load-induced bone adaptation in prematurely aged mice: insights from a micro-multiphysics agent-based model","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223261272","doi":"https://doi.org/10.64898/2026.10.22.760951"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.22.760951","doi":"https://doi.org/10.64898/2026.10.22.760951","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760951","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760951.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760951.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050311471","display_name":"Daniele Boaretti","orcid":"https://orcid.org/0000-0001-8411-7465","observed_orcids":["https://orcid.org/0000-0001-8411-7465"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniele Boaretti","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159168750","display_name":"Francisco C. Marques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francisco C. Marques","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059680717","display_name":"Gisela Anna Kuhn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gisela A Kuhn","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010355097","display_name":"Amit Singh","orcid":"https://orcid.org/0000-0001-9979-7221","observed_orcids":["https://orcid.org/0000-0001-9979-7221"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Amit Singh","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083521468","display_name":"Friederike A. Schulte","orcid":"https://orcid.org/0009-0002-1404-3928","observed_orcids":["https://orcid.org/0009-0002-1404-3928"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Friederike A. Schulte","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037956106","display_name":"Ralph M\u00fcller","orcid":"https://orcid.org/0000-0002-5811-7725","observed_orcids":["https://orcid.org/0000-0002-5811-7725","https://orcid.org/0000-0002-5906-9454","https://orcid.org/0000-0002-9120-0168"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253168","display_name":"Institute for Biomechanics","ror":"https://ror.org/00cepxd71","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253168"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ralph M\u00fcller","raw_affiliation_strings":["Institute for Biomechanics, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5811-7725","affiliations":[{"raw_affiliation_string":"Institute for Biomechanics, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083521468"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253168"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mechanobiology","display_name":"bone mechanobiology","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bone-aging","display_name":"bone aging","score":0.6499999761581421},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.6990000009536743},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/osteoblast-activity","display_name":"osteoblast activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9639999866485596},{"id":"https://openalex.org/keywords/trabecular-thickness","display_name":"trabecular thickness","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mechanoregulation","display_name":"mechanoregulation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9879999756813049},{"id":"https://openalex.org/keywords/agent-based-modeling","display_name":"agent-based modeling","score":0.6060000061988831},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.7674999833106995},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7436000108718872},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7325000166893005},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6685000061988831},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.666700005531311},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5684000253677368},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5268999934196472},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4805999994277954},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.33390000462532043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3239000141620636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3188999891281128},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3000999987125397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2906000018119812},{"id":"https://openalex.org/C2775843772","wikidata":"https://www.wikidata.org/wiki/Q17152799","display_name":"Senile osteoporosis","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27300000190734863},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26570001244544983},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.22.760951","doi":"https://doi.org/10.64898/2026.10.22.760951","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760951","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760951.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.22.760951","doi":"https://doi.org/10.64898/2026.10.22.760951","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.22.760951","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/23/2026.10.22.760951.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223261272.pdf","grobid_xml":"https://content.openalex.org/works/W7223261272.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1535567782","https://openalex.org/W1582533387","https://openalex.org/W1913879018","https://openalex.org/W1973326188","https://openalex.org/W1976100126","https://openalex.org/W1976824675","https://openalex.org/W1985227590","https://openalex.org/W1988697339","https://openalex.org/W2012697645","https://openalex.org/W2028065902","https://openalex.org/W2055142018","https://openalex.org/W2065308524","https://openalex.org/W2066342271","https://openalex.org/W2070427701","https://openalex.org/W2073878227","https://openalex.org/W2085390592","https://openalex.org/W2106138685","https://openalex.org/W2135972368","https://openalex.org/W2136984874","https://openalex.org/W2148851290","https://openalex.org/W2152997696","https://openalex.org/W2153029275","https://openalex.org/W2164443365","https://openalex.org/W2195625763","https://openalex.org/W2276767714","https://openalex.org/W2552211559","https://openalex.org/W2612670960","https://openalex.org/W2735040342","https://openalex.org/W2748602690","https://openalex.org/W2774486220","https://openalex.org/W2782944579","https://openalex.org/W2950217960","https://openalex.org/W2982146958","https://openalex.org/W3016358164","https://openalex.org/W3037987622","https://openalex.org/W3043814793","https://openalex.org/W3084164734","https://openalex.org/W3093228612","https://openalex.org/W3136945091","https://openalex.org/W3146457438","https://openalex.org/W3195275176","https://openalex.org/W3200069387","https://openalex.org/W3203190979","https://openalex.org/W3209096993","https://openalex.org/W4285029040","https://openalex.org/W4293567789","https://openalex.org/W4322772811","https://openalex.org/W4364365708"],"related_works":["https://openalex.org/W7166829972","https://openalex.org/W7223088233","https://openalex.org/W4322772811","https://openalex.org/W2152997696","https://openalex.org/W4309264197","https://openalex.org/W2946550968","https://openalex.org/W7153313990","https://openalex.org/W2499319061","https://openalex.org/W2066999131","https://openalex.org/W7127273959"],"abstract_inverted_index":{"Abstract":[0],"Bone":[1],"exhibits":[2],"remarkable":[3],"ability":[4],"to":[5,7,14,50,52,83,113,193],"adapt":[6],"varying":[8],"mechanical":[9,90,103,161],"demands.":[10],"Aging":[11],"can":[12,237],"lead":[13],"changes":[15,243],"in":[16,40,44,70,74,115,137,197,211,234,244],"distribution":[17],"of":[18,33,56,73,79,87,118,127,157,170,191],"cells":[19,94,172],"and":[20,27,37,61,89,95,131,144,163,173,201,208,214,220,246,252],"proteins":[21],"that":[22,123,167,233],"directly":[23],"affect":[24],"bone":[25,59,93,129,138,176],"formation":[26,130,139],"resorption.":[28],"Given":[29],"the":[30,54,85,98,135,164,168,189,198,242],"inherent":[31],"challenges":[32],"quantifying":[34],"these":[35],"cellular":[36,63,100,247],"protein":[38],"alterations":[39],"vivo":[41,75,116],",":[42],"innovative":[43],"silico":[45,71,235],"tools":[46,236],"have":[47],"proven":[48],"useful":[49],"contribute":[51],"studying":[53],"impact":[55],"aging":[57,88,120,124,253],"on":[58,92],"mechanobiology":[60],"associated":[62,187],"mechanisms.":[64],"Here,":[65],"we":[66],"employed":[67],"an":[68,114],"agent-based":[69,111],"analysis":[72],"micro-computed":[76],"tomography":[77],"data":[78],"prematurely":[80,150],"aged":[81,151,199,202],"mice":[82,152],"examine":[84],"effects":[86],"loading":[91,203,215],"their":[96],"mechanome,":[97],"intrinsic":[99],"system":[101],"sensing":[102],"forces.":[104],"Our":[105],"results":[106,231],"from":[107],"applying":[108],"a":[109,154],"micro-multiphysics":[110],"model":[112,117],"premature":[119],"(PolG)":[121],"showed":[122,166],"disrupts":[125],"mechanoregulation":[126,245],"load-induced":[128],"resorption":[132],"by":[133],"eliminating":[134],"increase":[136],"through":[140],"diminished":[141],"osteoblast":[142,192],"activity":[143],"mineralization,":[145],"alongside":[146],"mechanomic":[147],"alterations.":[148],"Specifically,":[149],"exhibited":[153],"higher":[155,160],"frequency":[156],"quiescence":[158],"at":[159],"signals":[162],"simulations":[165],"number":[169,195],"lining":[171],"osteoclasts":[174],"per":[175],"surface":[177],"increased":[178],"with":[179,188],"age.":[180],"Normalized":[181],"trabecular":[182],"thickness":[183],"was":[184],"more":[185],"positively":[186],"ratio":[190],"osteoclast":[194],"(Ob.N/Oc.N)":[196],"control":[200,213],"groups":[204,216],"(R":[205,217],"2":[206,218],"=0.58":[207],"0.61),":[209],"than":[210],"young":[212],"=0.06":[219],"0.27),":[221],"indicating":[222],"dysregulated":[223],"remodeling":[224],"dynamics":[225],"during":[226],"aging.":[227],"In":[228],"conclusion,":[229],"our":[230],"show":[232],"give":[238],"valuable":[239],"insights":[240],"into":[241],"mechanisms":[248],"occurring":[249],"under":[250],"physiological":[251],"conditions.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-24T00:00:00"}
