{"id":"https://openalex.org/W7223249482","doi":"https://doi.org/10.1016/j.psj.2026.108031","title":"A multi-species synbiotic improves growth performance in broiler chickens under conventional and enteric-challenge conditions: a meta-analysis","display_name":"A multi-species synbiotic improves growth performance in broiler chickens under conventional and enteric-challenge conditions: a meta-analysis","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223249482","doi":"https://doi.org/10.1016/j.psj.2026.108031","pmid":"https://pubmed.ncbi.nlm.nih.gov/42945836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13734907"},"language":"en","primary_location":{"id":"doi:10.1016/j.psj.2026.108031","doi":"https://doi.org/10.1016/j.psj.2026.108031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.psj.2026.108031","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.psj.2026.108031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039092527","display_name":"Guilherme Aguiar Mateus Pasquali","orcid":"https://orcid.org/0000-0003-0745-2707","observed_orcids":["https://orcid.org/0000-0003-0745-2707"]},"institutions":[{"id":"https://openalex.org/I4405267139","display_name":"DSM-Firmenich AG (Switzerland)","ror":"https://ror.org/01c00kj47","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267139"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Guilherme A.M. Pasquali","raw_affiliation_strings":["dsm-firmenich, Animal Nutrition and Health, Kaiseraugst, Switzerland. Electronic address: guilherme.pasquali@dsm-firmenich.com"],"raw_orcid":"https://orcid.org/0000-0003-0745-2707","affiliations":[{"raw_affiliation_string":"dsm-firmenich, Animal Nutrition and Health, Kaiseraugst, Switzerland. Electronic address: guilherme.pasquali@dsm-firmenich.com","institution_ids":["https://openalex.org/I4405267139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006756306","display_name":"Jutta C. Kesselring","orcid":"https://orcid.org/0000-0001-7222-3615","observed_orcids":["https://orcid.org/0000-0001-7222-3615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jutta C. Kesselring","raw_affiliation_strings":["dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria"],"raw_orcid":"https://orcid.org/0000-0001-7222-3615","affiliations":[{"raw_affiliation_string":"dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036938796","display_name":"Michail Evgeniou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michail Evgeniou","raw_affiliation_strings":["dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159292342","display_name":"Ermioni Papadopoulou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ermioni Papadopoulou","raw_affiliation_strings":["dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034965563","display_name":"Michaela Mohnl","orcid":"https://orcid.org/0009-0005-9157-1670","observed_orcids":["https://orcid.org/0009-0005-9157-1670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Mohnl","raw_affiliation_strings":["dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria"],"raw_orcid":"https://orcid.org/0009-0005-9157-1670","affiliations":[{"raw_affiliation_string":"dsm-firmenich, Animal Nutrition and Health R&D Center, Tulln, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039092527"],"corresponding_institution_ids":["https://openalex.org/I4405267139"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57469512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"12","first_page":"108031","last_page":"108031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-performance","display_name":"growth performance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/footpad-dermatitis","display_name":"footpad dermatitis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/clostridium-perfringens","display_name":"Clostridium perfringens","score":0.9309999942779541},{"id":"https://openalex.org/keywords/salmonella-enteritidis","display_name":"Salmonella Enteritidis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibiotic-growth-promoters","display_name":"antibiotic growth promoters","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anticoccidial-drugs","display_name":"anticoccidial drugs","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fructooligosaccharides","display_name":"fructooligosaccharides","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bifidobacterium-animalis","display_name":"Bifidobacterium animalis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.968999981880188},{"id":"https://openalex.org/keywords/limosilactobacillus-reuteri","display_name":"Lactobacillus reuteri","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780289900","wikidata":"https://www.wikidata.org/wiki/Q326301","display_name":"Broiler","level":2,"score":0.8988999724388123},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5611000061035156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5383999943733215},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.4341000020503998},{"id":"https://openalex.org/C22830521","wikidata":"https://www.wikidata.org/wiki/Q649967","display_name":"Feed conversion ratio","level":3,"score":0.39340001344680786},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C2994599422","wikidata":"https://www.wikidata.org/wiki/Q80962","display_name":"Animal production","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2779337445","wikidata":"https://www.wikidata.org/wiki/Q2375654","display_name":"Synbiotics","level":4,"score":0.2759000062942505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.274399995803833}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.psj.2026.108031","doi":"https://doi.org/10.1016/j.psj.2026.108031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.psj.2026.108031","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13734907","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734907/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734907/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poult Sci","raw_type":"Text"},{"id":"pmid:42945836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42945836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7bf0d4a537b145e1a734a8c6c61fe1d3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7bf0d4a537b145e1a734a8c6c61fe1d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Poultry Science, Vol 105, Iss 12, Pp 108031- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.psj.2026.108031","doi":"https://doi.org/10.1016/j.psj.2026.108031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.psj.2026.108031","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.958299994468689},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223249482.pdf","grobid_xml":"https://content.openalex.org/works/W7223249482.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1977421393","https://openalex.org/W1998888063","https://openalex.org/W2112689890","https://openalex.org/W2117781459","https://openalex.org/W2119605658","https://openalex.org/W2122962297","https://openalex.org/W2142126679","https://openalex.org/W2158815301","https://openalex.org/W2163647236","https://openalex.org/W2532414435","https://openalex.org/W2555730290","https://openalex.org/W2569291070","https://openalex.org/W2694487218","https://openalex.org/W2791055437","https://openalex.org/W2795908627","https://openalex.org/W2807598220","https://openalex.org/W2980020392","https://openalex.org/W3010710847","https://openalex.org/W3011210600","https://openalex.org/W3033814948","https://openalex.org/W3043412913","https://openalex.org/W3043663133","https://openalex.org/W3118891119","https://openalex.org/W3146609163","https://openalex.org/W3193726671","https://openalex.org/W3213603402","https://openalex.org/W4307428019","https://openalex.org/W4317211346","https://openalex.org/W4365146184","https://openalex.org/W4377116117","https://openalex.org/W4380485551","https://openalex.org/W4386056766","https://openalex.org/W4386932079","https://openalex.org/W4389508507","https://openalex.org/W4390140053","https://openalex.org/W4399531447","https://openalex.org/W4404629399","https://openalex.org/W4406804518","https://openalex.org/W4407219566","https://openalex.org/W4415617632","https://openalex.org/W4416234246"],"related_works":["https://openalex.org/W3011210600","https://openalex.org/W7156980483","https://openalex.org/W4410326330","https://openalex.org/W3118891119","https://openalex.org/W7163738642","https://openalex.org/W2372387705","https://openalex.org/W4410908481","https://openalex.org/W2077062789","https://openalex.org/W3119884301","https://openalex.org/W3009309302"],"abstract_inverted_index":{"This":[0],"study":[1],"evaluated":[2],"the":[3,74,84,235,274],"efficacy":[4],"of":[5,78,245,282],"a":[6],"multi-species":[7],"synbiotic":[8],"(SYN)":[9],"comprising":[10],"Bifidobacterium":[11],"animalis,":[12],"Enterococcus":[13],"faecium,":[14],"Ligilactobacillus":[15],"salivarius,":[16],"Limosilactobacillus":[17],"reuteri,":[18],"Pediococcus":[19],"acidilactici,":[20],"and":[21,27,37,53,102,106,124,165,208,229],"fructo-oligosaccharides":[22],"on":[23,193,298],"broiler":[24,270],"growth":[25,61,75,221,271,300],"performance":[26,76,222],"footpad":[28,85,246,276],"dermatitis":[29,86,247,277],"across":[30],"multiple":[31],"trials":[32,91],"conducted":[33],"under":[34,38,178,184],"conventional":[35,112,179],"conditions":[36],"experimentally":[39],"induced":[40],"enteric":[41,114],"challenges.":[42],"Challenge":[43],"models":[44],"included":[45,90],"Eimeria":[46],"spp.":[47,117],"(with":[48],"or":[49,64,121,128,231],"without":[50],"Clostridium":[51],"perfringens)":[52],"Salmonella":[54,122],"Enteritidis":[55],"exposure,":[56],"alongside":[57],"comparisons":[58,125],"against":[59],"antibiotic":[60],"promoters":[62],"(AGP)":[63],"coccidiostats":[65],"in":[66,176,234],"selected":[67],"studies.":[68],"Fifteen":[69],"independent":[70],"studies":[71],"contributed":[72,82],"to":[73,83,94,190],"meta-analyses,":[77],"which":[79],"three":[80],"also":[81],"analysis.":[87],"The":[88],"analysis":[89,278],"from":[92],"2011":[93],"2023":[95],"with":[96,126,242],"well-defined":[97],"designs,":[98],"duration":[99],"\u226540":[100],"days,":[101],"reported":[103],"sample":[104],"sizes":[105,144],"standard":[107],"deviations,":[108],"categorizing":[109],"them":[110],"into":[111],"studies,":[113],"challenges":[115],"(Eimeria":[116],"\u00b1":[118],"C.":[119],"perfringens":[120],"Enteritidis),":[123],"AGP":[127,230],"coccidiostats.":[129],"Meta-analysis":[130],"results,":[131],"corrected":[132],"by":[133],"Hedges'":[134],"g,":[135],"showed":[136],"standardized":[137],"mean":[138],"differences":[139],"(SMD)":[140],"indicating":[141],"medium":[142,189],"effect":[143],"for":[145],"body":[146],"weight":[147],"(BW,":[148],"SMD":[149,159,170],"=":[150,160,163,171,196,199,203,206,211,214,249,253,257],"0.74,":[151],"P":[152,162,173,198,205,213,256],"<":[153,174],"0.001),":[154],"average":[155],"daily":[156],"gain":[157],"(ADG,":[158],"0.59,":[161],"0.003),":[164],"feed":[166],"conversion":[167],"ratio":[168],"(FCR,":[169],"-0.56,":[172,212],"0.001)":[175],"broilers":[177],"conditions.":[180],"In":[181],"challenged":[182],"birds":[183],"experimental":[185],"conditions,":[186],"SYN":[187,228,238,267,288],"exhibited":[188],"large":[191],"effects":[192],"BW":[194],"(SMD":[195,202,210],"0.90,":[197],"0.007),":[200],"ADG":[201],"1.26,":[204],"0.002)":[207],"FCR":[209],"0.006),":[215],"significantly":[216,226],"outperforming":[217],"untreated":[218],"controls.":[219],"Moreover,":[220],"did":[223],"not":[224],"differ":[225],"between":[227],"coccidiostat":[232],"treatments":[233],"available":[236],"trials.":[237],"supplementation":[239,268],"was":[240,261],"associated":[241],"lower":[243,280],"odds":[244,281],"(OR":[248],"0.52;":[250],"95%":[251],"CI":[252],"[0.28,":[254],"0.98];":[255],"0.046),":[258],"although":[259],"heterogeneity":[260],"substantial.":[262],"These":[263,284],"results":[264],"demonstrate":[265],"that":[266,287],"enhances":[269],"performance,":[272],"while":[273],"pooled":[275],"indicated":[279],"lesions.":[283],"findings":[285],"suggest":[286],"may":[289],"have":[290],"potential":[291],"within":[292],"strategies":[293],"aimed":[294],"at":[295],"reducing":[296],"reliance":[297],"antimicrobial":[299],"promoters.":[301]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-23T00:00:00"}