{"id":"https://openalex.org/W7223248151","doi":"https://doi.org/10.3390/cancers18213420","title":"Human Papillomavirus-Associated Cancers and the Potential Role of Local Bacterial Populations","display_name":"Human Papillomavirus-Associated Cancers and the Potential Role of Local Bacterial Populations","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223248151","doi":"https://doi.org/10.3390/cancers18213420"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18213420","doi":"https://doi.org/10.3390/cancers18213420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213420","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers18213420","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101624471","display_name":"Amitabha Ray","orcid":"https://orcid.org/0000-0003-1240-6887","observed_orcids":["https://orcid.org/0000-0003-1240-6887"]},"institutions":[{"id":"https://openalex.org/I163086451","display_name":"Ponce Health Sciences University","ror":"https://ror.org/0022qva30","country_code":"PR","type":"education","lineage":["https://openalex.org/I163086451"]}],"countries":["PR"],"is_corresponding":true,"raw_author_name":"Amitabha Ray","raw_affiliation_strings":["Basic Sciences, Ponce Health Sciences University, Tortola VG1110, British Virgin Islands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Sciences, Ponce Health Sciences University, Tortola VG1110, British Virgin Islands","institution_ids":["https://openalex.org/I163086451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075643117","display_name":"Daniel M. Borsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140491907","display_name":"Community College of Allegheny County","ror":"https://ror.org/044n8q784","country_code":"US","type":"education","lineage":["https://openalex.org/I140491907"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Borsch","raw_affiliation_strings":["Department of Biology, The Community College of Allegheny County-Allegheny Campus, Pittsburgh, PA 15212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Community College of Allegheny County-Allegheny Campus, Pittsburgh, PA 15212, USA","institution_ids":["https://openalex.org/I140491907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010336463","display_name":"Rajashree Pandit","orcid":"https://orcid.org/0000-0002-3219-1126","observed_orcids":["https://orcid.org/0000-0002-3219-1126"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajashree Pandit","raw_affiliation_strings":["School of Public Health, Boston University, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Boston University, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101624471"],"corresponding_institution_ids":["https://openalex.org/I163086451"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80595831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"3420","last_page":"3420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8149999976158142},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hpv-16-18","display_name":"HPV 16/18","score":0.878000020980835},{"id":"https://openalex.org/keywords/e6-and-e7-oncoproteins","display_name":"HPV E6 and E7 oncoproteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8939999938011169},{"id":"https://openalex.org/keywords/l1-major-capsid-protein","display_name":"L1 capsid protein","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cervical-microbiota","display_name":"cervical microbiota","score":0.5379999876022339},{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/fusobacterium","display_name":"Fusobacterium","score":0.9539999961853027},{"id":"https://openalex.org/keywords/prevotella","display_name":"Prevotella","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gardnerella","display_name":"Gardnerella","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lactobacillus-depletion","display_name":"Lactobacillus depletion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anaerobic-bacteria","display_name":"anaerobic bacteria","score":0.7599999904632568},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.5429999828338623},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6837999820709229},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6464999914169312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.580299973487854},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.5766000151634216},{"id":"https://openalex.org/C2910786375","wikidata":"https://www.wikidata.org/wiki/Q604261","display_name":"Viral Oncogene","level":3,"score":0.5006999969482422},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.49790000915527344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47909998893737793},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.4489000141620636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44699999690055847},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.414900004863739},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4002000093460083},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.3970000147819519},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39629998803138733},{"id":"https://openalex.org/C2780009117","wikidata":"https://www.wikidata.org/wiki/Q900189","display_name":"HPV vaccines","level":5,"score":0.3849000036716461},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.3831999897956848},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.37229999899864197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3361999988555908},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.33180001378059387},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.3237000107765198},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.26330000162124634}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cancers18213420","doi":"https://doi.org/10.3390/cancers18213420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213420","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cancers18213420","doi":"https://doi.org/10.3390/cancers18213420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213420","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W3899478","https://openalex.org/W1899676658","https://openalex.org/W2014972306","https://openalex.org/W2016735068","https://openalex.org/W2019054269","https://openalex.org/W2054613203","https://openalex.org/W2069149723","https://openalex.org/W2096605259","https://openalex.org/W2118975989","https://openalex.org/W2119264365","https://openalex.org/W2128281435","https://openalex.org/W2159625951","https://openalex.org/W2168924589","https://openalex.org/W2256618532","https://openalex.org/W2340805857","https://openalex.org/W2515538704","https://openalex.org/W2522693709","https://openalex.org/W2565448904","https://openalex.org/W2599642236","https://openalex.org/W2601323532","https://openalex.org/W2605365014","https://openalex.org/W2626550929","https://openalex.org/W2729126358","https://openalex.org/W2767524518","https://openalex.org/W2775715535","https://openalex.org/W2883260705","https://openalex.org/W2889494305","https://openalex.org/W2889942007","https://openalex.org/W2904369145","https://openalex.org/W2904635536","https://openalex.org/W2944746248","https://openalex.org/W2954761095","https://openalex.org/W2989150632","https://openalex.org/W3005980962","https://openalex.org/W3016736052","https://openalex.org/W3033938981","https://openalex.org/W3085942695","https://openalex.org/W3094904088","https://openalex.org/W3121106137","https://openalex.org/W3126915257","https://openalex.org/W3135795993","https://openalex.org/W3139219464","https://openalex.org/W3142594159","https://openalex.org/W3171210303","https://openalex.org/W3173966027","https://openalex.org/W3180332462","https://openalex.org/W3183879676","https://openalex.org/W3200227051","https://openalex.org/W3207811959","https://openalex.org/W3216628161","https://openalex.org/W4200351408","https://openalex.org/W4200457036","https://openalex.org/W4205649825","https://openalex.org/W4210432500","https://openalex.org/W4212888063","https://openalex.org/W4220805857","https://openalex.org/W4221024005","https://openalex.org/W4281994446","https://openalex.org/W4283695057","https://openalex.org/W4284713549","https://openalex.org/W4285588720","https://openalex.org/W4296009452","https://openalex.org/W4307188078","https://openalex.org/W4311471872","https://openalex.org/W4311689616","https://openalex.org/W4311848845","https://openalex.org/W4313471341","https://openalex.org/W4316653819","https://openalex.org/W4318485000","https://openalex.org/W4318592064","https://openalex.org/W4362507430","https://openalex.org/W4377011574","https://openalex.org/W4379644157","https://openalex.org/W4380681798","https://openalex.org/W4383345430","https://openalex.org/W4386415370","https://openalex.org/W4387770823","https://openalex.org/W4389475497","https://openalex.org/W4389572565","https://openalex.org/W4390976620","https://openalex.org/W4392351687","https://openalex.org/W4392754680","https://openalex.org/W4392955532","https://openalex.org/W4393944473","https://openalex.org/W4394617921","https://openalex.org/W4394868992","https://openalex.org/W4395676193","https://openalex.org/W4396759982","https://openalex.org/W4396987385","https://openalex.org/W4398254974","https://openalex.org/W4399224139","https://openalex.org/W4400019425","https://openalex.org/W4400068916","https://openalex.org/W4400881673","https://openalex.org/W4400973732","https://openalex.org/W4401289100","https://openalex.org/W4401980019","https://openalex.org/W4402598885","https://openalex.org/W4402600891","https://openalex.org/W4402859449","https://openalex.org/W4403400083","https://openalex.org/W4403791222","https://openalex.org/W4403886530","https://openalex.org/W4404774396","https://openalex.org/W4405221083","https://openalex.org/W4405283849","https://openalex.org/W4405674469","https://openalex.org/W4406410510","https://openalex.org/W4406580941","https://openalex.org/W4407557436","https://openalex.org/W4407602593","https://openalex.org/W4407808505","https://openalex.org/W4407972691","https://openalex.org/W4408042492","https://openalex.org/W4408382237","https://openalex.org/W4408660751","https://openalex.org/W4408779685","https://openalex.org/W4408972426","https://openalex.org/W4409328028","https://openalex.org/W4409515271","https://openalex.org/W4409557434","https://openalex.org/W4410092582","https://openalex.org/W4410122333","https://openalex.org/W4410456084","https://openalex.org/W4410540850","https://openalex.org/W4410775048","https://openalex.org/W4410847120","https://openalex.org/W4411179617","https://openalex.org/W4411571014","https://openalex.org/W4411955922","https://openalex.org/W4412424857","https://openalex.org/W4412465904","https://openalex.org/W4412538101","https://openalex.org/W4412619762","https://openalex.org/W4412778774","https://openalex.org/W4413024558","https://openalex.org/W4413378335","https://openalex.org/W4413883727","https://openalex.org/W4414446764","https://openalex.org/W4415111962","https://openalex.org/W4415141524","https://openalex.org/W4415428059","https://openalex.org/W4415723042","https://openalex.org/W4415962284","https://openalex.org/W4416222245","https://openalex.org/W4416344110","https://openalex.org/W4416759351","https://openalex.org/W7116114381","https://openalex.org/W7117770706","https://openalex.org/W7118167920","https://openalex.org/W7119481424","https://openalex.org/W7128811958","https://openalex.org/W7131264167","https://openalex.org/W7131780562","https://openalex.org/W7131876659","https://openalex.org/W7132821572","https://openalex.org/W7134846393","https://openalex.org/W7142595691","https://openalex.org/W7148232690","https://openalex.org/W7152560956","https://openalex.org/W7154613392","https://openalex.org/W7159974880","https://openalex.org/W7162694123","https://openalex.org/W7164741028","https://openalex.org/W7165652778","https://openalex.org/W7168156198"],"related_works":["https://openalex.org/W2058375382","https://openalex.org/W2169027433","https://openalex.org/W145023134","https://openalex.org/W1972400785","https://openalex.org/W979329386","https://openalex.org/W615228602","https://openalex.org/W7029167460","https://openalex.org/W2889494305","https://openalex.org/W2016107980","https://openalex.org/W7095507119"],"abstract_inverted_index":{"Human":[0],"papillomavirus":[1],"(HPV)":[2],"is":[3,72,81,171,186,413,447],"the":[4,12,35,41,73,84,92,103,108,132,139,160,167,190,234,240,244,266,284,293,299,305,315,333,383,388,395,408,448,453,474,486],"most":[5,74],"common":[6],"sexually":[7],"transmitted":[8],"infectious":[9],"agent":[10],"in":[11,67,77,180,204,209,252,259,265,273,280,292,346,355,375,387,420,478,494],"United":[13],"States":[14],"as":[15,17,99,271,372],"well":[16],"globally.":[18],"This":[19],"review":[20],"aims":[21],"to":[22,57,126,188,216,226,298,332,468],"examine":[23],"neoplastic":[24],"diseases":[25],"associated":[26,228,424],"with":[27,29,194,229,425],"HPV":[28,49,59,76,85,193],"special":[30],"emphasis":[31],"on":[32,434],"cancers":[33],"of":[34,43,48,131,155,192,238,268,289,301,307,322,339,417,456,464,485],"uterine":[36],"cervix":[37],"and":[38,62,101,107,117,121,147,179,212,243,278,349,360,398,406,472],"oropharynx.":[39],"Among":[40],"group":[42],"high-risk":[44],"HPVs,":[45],"i.e.,":[46],"types":[47],"that":[50,83,367],"can":[51],"cause":[52],"abnormal":[53],"cellular":[54],"changes":[55],"leading":[56],"malignancies,":[58],"genotypes":[60],"16":[61],"18":[63],"are":[64,124,224,380,466],"commonly":[65],"found":[66],"cervical":[68,205,217,302,308],"cancer,":[69,218,309],"whereas":[70],"HPV-16":[71],"detected":[75],"oropharyngeal":[78,220,274],"cancer.":[79],"It":[80],"known":[82],"genome":[86],"comprises":[87],"three":[88],"major":[89,168],"functional":[90],"regions:":[91],"early":[93],"region,":[94,110],"which":[95,111,451],"encodes":[96,112],"proteins":[97,115,123],"such":[98,270],"E6":[100,120,128],"E7;":[102],"long":[104],"control":[105],"region;":[106],"late":[109],"structural":[113],"capsid":[114,169],"L1":[116],"L2.":[118],"The":[119,164,320,410],"E7":[122,137],"pivotal":[125],"carcinogenesis.":[127],"promotes":[129],"degradation":[130],"tumor":[133],"suppressor":[134],"p53,":[135],"while":[136],"inactivates":[138],"retinoblastoma":[140],"protein,":[141],"critically":[142],"disrupting":[143],"cell":[144],"cycle":[145],"regulation":[146],"enabling":[148],"uncontrolled":[149],"proliferation.":[150],"These":[151],"disruptions":[152],"promote":[153],"survival":[154],"HPV-infected":[156],"cells\u2013a":[157],"requirement":[158],"for":[159,173],"viral":[161,165],"life":[162],"cycle.":[163],"L1,":[166],"component,":[170],"used":[172],"classification,":[174],"PCR":[175],"detection,":[176],"antigenic":[177],"tests,":[178],"prophylactic":[181],"vaccine":[182],"preparation.":[183],"However,":[184],"it":[185,421],"important":[187],"correlate":[189],"role":[191,251],"different":[195,210,347,437],"risk":[196,222,311],"factors,":[197],"particularly":[198,386],"when":[199],"considering":[200],"a":[201,249,287,414,461,479],"wide":[202],"variation":[203],"cancer":[206,221,253,275,373,429],"incidence":[207],"rates":[208],"nations":[211],"geographic":[213],"regions.":[214,377],"Compared":[215],"HPV-positive":[219,359],"factors":[223,312],"thought":[225],"be":[227,423],"sexual":[230],"behavior":[231],"primarily.":[232],"Overall,":[233],"local":[235,487],"microbial":[236,317,454,476,488],"environment":[237,295,489],"both":[239,404],"cervicovaginal":[241,294,316,475],"region":[242],"oral":[245,376],"cavity":[246],"may":[247,296],"play":[248],"significant":[250],"development.":[254,430],"For":[255],"example,":[256],"an":[257,336,495],"increase":[258],"certain":[260,368],"bacteria":[261,291,324,369,379],"has":[262,342],"been":[263,343,442],"documented":[264,353],"course":[267],"disease,":[269],"Fusobacterium":[272],"or":[276],"Prevotella":[277],"Gardnerella":[279],"bacterial":[281,356],"vaginosis.":[282],"On":[283],"other":[285,435],"hand,":[286],"depletion":[288,341],"beneficial":[290],"contribute":[297],"development":[300],"neoplasia.":[303],"In":[304,330],"case":[306],"all":[310],"possibly":[313],"alter":[314],"flora":[318,477],"adversely.":[319],"dominance":[321],"anaerobic":[323],"could":[325,370,422,490],"bring":[326],"about":[327],"pathological":[328,426,492],"changes.":[329],"relation":[331],"disease":[334],"progression,":[335],"increasing":[337],"level":[338],"Lactobacillus":[340],"reported.":[344],"Similarly,":[345],"head":[348],"neck":[350],"cancers,":[351],"investigators":[352,365],"differences":[354],"genera":[357],"between":[358],"HPV-negative":[361],"cases.":[362],"Furthermore,":[363],"some":[364],"suggested":[366],"serve":[371],"biomarkers":[374],"Various":[378],"present":[381],"throughout":[382],"gastrointestinal":[384],"tract,":[385],"large":[389],"intestine":[390],"(colon),":[391],"where":[392],"they":[393,399],"form":[394],"largest":[396],"populations,":[397],"influence":[400],"diverse":[401],"pathophysiological":[402],"processes":[403,493],"inside":[405],"outside":[407],"gut.":[409],"gut":[411],"microbiota":[412],"typical":[415],"example":[416,446],"how":[418],"alterations":[419],"processes,":[427],"including":[428],"Regarding":[431],"their":[432],"impact":[433],"organs,":[436],"bidirectional":[438],"communication":[439],"networks":[440],"have":[441],"proposed.":[443],"One":[444],"pertinent":[445],"gut\u2013vaginal":[449],"axis,":[450],"connects":[452],"communities":[455],"these":[457],"two":[458],"organs.":[459],"Currently,":[460],"growing":[462],"number":[463],"studies":[465],"trying":[467],"manipulate":[469],"this":[470],"axis":[471],"reconstitute":[473],"favorable":[480],"manner.":[481],"Therefore,":[482],"appropriate":[483],"modifications":[484],"prevent":[491],"economical":[496],"way.":[497]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-23T00:00:00"}