{"id":"https://openalex.org/W7223244155","doi":"https://doi.org/10.1016/j.mib.2026.102846","title":"Next-generation probiotics: beyond lactic acid bacteria to untapped taxa and engineered strains for better health","display_name":"Next-generation probiotics: beyond lactic acid bacteria to untapped taxa and engineered strains for better health","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223244155","doi":"https://doi.org/10.1016/j.mib.2026.102846","pmid":"https://pubmed.ncbi.nlm.nih.gov/42913070"},"language":"en","primary_location":{"id":"doi:10.1016/j.mib.2026.102846","doi":"https://doi.org/10.1016/j.mib.2026.102846","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mib.2026.102846","pdf_url":null,"source":{"id":"https://openalex.org/S106299656","display_name":"Current Opinion in Microbiology","issn_l":"1369-5274","issn":["1369-5274","1879-0364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.mib.2026.102846","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135160931","display_name":"Ruben Vazquez Uribe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115377","display_name":"VIB-KU Leuven Center for Microbiology","ror":"https://ror.org/02bpp8r91","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210115377","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Ruben Vazquez Uribe","raw_affiliation_strings":["VIB - KU Leuven Center for Microbiology, Leuven, Belgium. Electronic address: ruben.vazquezuribe@kuleuven.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIB - KU Leuven Center for Microbiology, Leuven, Belgium. Electronic address: ruben.vazquezuribe@kuleuven.be","institution_ids":["https://openalex.org/I4210115377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006476838","display_name":"Shrikrishnan Sankaran","orcid":"https://orcid.org/0000-0001-6251-585X","observed_orcids":["https://orcid.org/0000-0001-6251-585X"]},"institutions":[{"id":"https://openalex.org/I4210091344","display_name":"Leibniz-Institute for New Materials","ror":"https://ror.org/00g656d67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210091344","https://openalex.org/I91712215"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Shrikrishnan Sankaran","raw_affiliation_strings":["INM - Leibniz Institute for New Materials, Saarland University, Campus D2 2, Saarbr\u00fccken 66123, Germany. Electronic address: Shrikrishnan.Sankaran@leibniz-inm.de"],"raw_orcid":"https://orcid.org/0000-0001-6251-585X","affiliations":[{"raw_affiliation_string":"INM - Leibniz Institute for New Materials, Saarland University, Campus D2 2, Saarbr\u00fccken 66123, Germany. Electronic address: Shrikrishnan.Sankaran@leibniz-inm.de","institution_ids":["https://openalex.org/I4210091344","https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041676346","display_name":"Luis G. Berm\u00fadez\u2010Humar\u00e1n","orcid":"https://orcid.org/0000-0001-7525-3131","observed_orcids":["https://orcid.org/0000-0001-7525-3131"]},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Luis G Berm\u00fadez-Humar\u00e1n","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas 78350, France"],"raw_orcid":"https://orcid.org/0000-0001-7525-3131","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas 78350, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113012141","display_name":"Jan Peter van Pijkeren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Peter van Pijkeren","raw_affiliation_strings":["Department of Food Science, University of Wisconsin-Madison, Madison, USA; Food Research Institute, University of Wisconsin-Madison, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, University of Wisconsin-Madison, Madison, USA; Food Research Institute, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159261787","display_name":"Mary O\u2032Connell Motherway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mary O\u2032Connell Motherway","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159293309","display_name":"Paul Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paul Ross","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047441756","display_name":"Colin Hill","orcid":"https://orcid.org/0000-0002-8527-1445","observed_orcids":["https://orcid.org/0000-0002-8527-1445"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Colin Hill","raw_affiliation_strings":["APC Microbiome Ireland, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-8527-1445","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069724602","display_name":"Sarah Lebeer","orcid":"https://orcid.org/0000-0002-9400-6918","observed_orcids":["https://orcid.org/0000-0002-9400-6918"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sarah Lebeer","raw_affiliation_strings":["University of Antwerp, Department of Bioscience Engineering, Laboratory of Applied Microbiology and Biotechnology, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-9400-6918","affiliations":[{"raw_affiliation_string":"University of Antwerp, Department of Bioscience Engineering, Laboratory of Applied Microbiology and Biotechnology, Belgium","institution_ids":["https://openalex.org/I149213910"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5006476838","https://openalex.org/A5135160931"],"corresponding_institution_ids":["https://openalex.org/I4210091344","https://openalex.org/I4210115377","https://openalex.org/I91712215"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45890128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"94","issue":null,"first_page":"102846","last_page":"102846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/next-generation-probiotics","display_name":"next-generation probiotics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.9850000143051147},{"id":"https://openalex.org/keywords/commensal-microbes","display_name":"commensal microorganisms","score":0.8650000095367432},{"id":"https://openalex.org/keywords/live-biotherapeutic-products","display_name":"live biotherapeutic products","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.7269999980926514},{"id":"https://openalex.org/keywords/probiotic-safety","display_name":"probiotic safety","score":0.7599999904632568},{"id":"https://openalex.org/keywords/probiotic-regulation","display_name":"probiotic regulation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/human-health-applications","display_name":"human health applications","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9218999743461609},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.7928000092506409},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.7170000076293945},{"id":"https://openalex.org/C71640776","wikidata":"https://www.wikidata.org/wiki/Q16521","display_name":"Taxon","level":2,"score":0.5899999737739563},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5719000101089478},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3167000114917755},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.25870001316070557},{"id":"https://openalex.org/C2780437316","wikidata":"https://www.wikidata.org/wiki/Q578677","display_name":"Lactobacillaceae","level":4,"score":0.25780001282691956},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.22419999539852142}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mib.2026.102846","doi":"https://doi.org/10.1016/j.mib.2026.102846","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mib.2026.102846","pdf_url":null,"source":{"id":"https://openalex.org/S106299656","display_name":"Current Opinion in Microbiology","issn_l":"1369-5274","issn":["1369-5274","1879-0364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Microbiology","raw_type":"journal-article"},{"id":"pmid:42913070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42913070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.mib.2026.102846","doi":"https://doi.org/10.1016/j.mib.2026.102846","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mib.2026.102846","pdf_url":null,"source":{"id":"https://openalex.org/S106299656","display_name":"Current Opinion in Microbiology","issn_l":"1369-5274","issn":["1369-5274","1879-0364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2032112360","https://openalex.org/W2051083422","https://openalex.org/W2091587044","https://openalex.org/W2095755549","https://openalex.org/W2149074973","https://openalex.org/W2346677585","https://openalex.org/W2526691844","https://openalex.org/W2569823311","https://openalex.org/W2609066137","https://openalex.org/W2764103617","https://openalex.org/W2954124338","https://openalex.org/W3013945470","https://openalex.org/W3015440105","https://openalex.org/W3015666810","https://openalex.org/W3025080937","https://openalex.org/W3111328701","https://openalex.org/W3149804258","https://openalex.org/W3173777885","https://openalex.org/W4210628575","https://openalex.org/W4224950100","https://openalex.org/W4290888047","https://openalex.org/W4310251760","https://openalex.org/W4310436581","https://openalex.org/W4319299737","https://openalex.org/W4321376671","https://openalex.org/W4375956143","https://openalex.org/W4378218648","https://openalex.org/W4384276655","https://openalex.org/W4387140966","https://openalex.org/W4390696068","https://openalex.org/W4391470437","https://openalex.org/W4398207818","https://openalex.org/W4400778887","https://openalex.org/W4401298750","https://openalex.org/W4404044383","https://openalex.org/W4406903857","https://openalex.org/W4406917992","https://openalex.org/W4407157131","https://openalex.org/W4412490658","https://openalex.org/W7160909337","https://openalex.org/W7161109333"],"related_works":["https://openalex.org/W4401504882","https://openalex.org/W7214357512","https://openalex.org/W2912759142","https://openalex.org/W4416897185","https://openalex.org/W4391955640","https://openalex.org/W7205012214","https://openalex.org/W4382752650","https://openalex.org/W4411034556","https://openalex.org/W3185546217","https://openalex.org/W2889616411"],"abstract_inverted_index":{"In":[0],"this":[1],"perspective,":[2],"we":[3,67],"discuss":[4],"the":[5,13,16,24,28,32,70,84,103,139,150,166,169,181,186],"evolving":[6],"landscape":[7],"of":[8,15,34,168,183,188],"next-generation":[9],"probiotics":[10],"(NGPs),":[11],"challenging":[12],"ambiguity":[14],"term":[17,71],"and":[18,41,48,98,107,121,127,145,185,191],"proposing":[19],"a":[20,64,178],"framework":[21],"for":[22,56,160,172],"unifying":[23],"concepts":[25],"associated":[26],"with":[27],"field.":[29],"We":[30,93,111,163],"highlight":[31],"potential":[33],"novel":[35],"candidates,":[36],"including":[37,138],"lactic":[38],"acid":[39],"bacteria":[40],"other":[42],"commensal":[43],"microorganisms":[44],"from":[45],"untapped":[46],"taxa":[47],"genetically":[49],"engineered":[50],"strains,":[51],"while":[52,101],"examining":[53],"their":[54,95,122],"applications":[55],"human":[57],"health.":[58],"Rather":[59],"than":[60],"defining":[61],"NGPs":[62],"as":[63,114],"distinct":[65],"category,":[66],"propose":[68],"using":[69],"to":[72,83],"describe":[73],"microbial-based":[74],"health-promoting":[75],"products":[76,116,153],"in":[77],"development,":[78],"particularly":[79],"where":[80],"novelty":[81],"relates":[82],"organism,":[85],"mechanism,":[86],"engineering":[87],"strategy,":[88],"formulation,":[89],"or":[90,149],"targeted":[91],"function.":[92],"address":[94],"safety":[96,146,190],"concerns":[97],"regulatory":[99,128],"challenges,":[100],"clarifying":[102],"divergence":[104],"between":[105,180],"therapeutic":[106,161],"dietary":[108],"supplement":[109],"pathways.":[110],"argue":[112],"that":[113,165],"these":[115],"become":[117],"more":[118,132],"fully":[119],"characterized":[120],"safety,":[123],"efficacy,":[124],"intended":[125],"use,":[126],"pathway":[129],"are":[130,147,157],"established,":[131,148],"specific":[133],"terminology":[134],"may":[135],"take":[136],"precedence,":[137],"long-accepted":[140],"probiotic":[141],"category":[142,154],"once":[143],"efficacy":[144,192],"live":[151],"biotherapeutic":[152],"if":[155],"they":[156],"specifically":[158],"developed":[159],"applications.":[162],"suggest":[164],"future":[167],"'beneficial":[170],"microbes":[171],"health'":[173],"field":[174],"depends":[175],"on":[176],"striking":[177],"balance":[179],"benefits":[182],"innovation":[184],"necessity":[187],"rigorous":[189],"considerations.":[193]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-23T00:00:00"}